Kwon J, Bakhoum SF. The cytosolic DNA-sensing cGAS-STING pathway in cancer. Cancer Discov. 2020;10(1):26–39.

Article  PubMed  CAS  Google Scholar 

Dvorkin S, Cambier S, Volkman HE, Stetson DB. New frontiers in the cGAS-STING intracellular DNA-sensing pathway. Immunity. 2024;57(4):718–30.

Article  PubMed  CAS  Google Scholar 

Coventry BJ, Henneberg M. The immune system and responses to cancer: coordinated. Evolution. 2015;4:552.

Google Scholar 

Whiteside TL. Tumor-infiltrating lymphocytes and their role in solid tumor progression. Exp Suppl. 2022;113:89–106.

PubMed  PubMed Central  CAS  Google Scholar 

Dinarello CA. Historical insights into cytokines. Eur J Immunol. 2007;37(Suppl 1):S34-45.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hunter P. The fourth pillar: despite some setbacks in the clinic, immunotherapy has made notable progress toward becoming an additional therapeutic option against cancer. EMBO Rep. 2017;18(11):1889–92.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhou J, Ventura CJ, Fang RH, Zhang L. Nanodelivery of STING agonists against cancer and infectious diseases. Mol Aspects Med. 2022;83:101007.

Article  PubMed  CAS  Google Scholar 

Sun Y, Patterson-Fortin J, Han S, Li Z, Nowicka Z, Hirohashi Y, et al. 53BP1 loss elicits cGAS-STING-dependent antitumor immunity in ovarian and pancreatic cancer. Nat Commun. 2024;15(1):6676.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hussain B, Xie Y, Jabeen U, Lu D, Yang B, Wu C, Shang G. Activation of STING based on its structural features. Front Immunol. 2022;13:808607.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhang ZD, Zhong B. Regulation and function of the cGAS-MITA/STING axis in health and disease. Cell Insight. 2022;1(1):100001.

Article  PubMed  PubMed Central  Google Scholar 

Zhao H, Wu L, Yan G, Chen Y, Zhou M, Wu Y, Li Y. Inflammation and tumor progression: signaling pathways and targeted intervention. Signal Transduct Target Ther. 2021;6(1):263.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Tang W, Zhou W, Ji M, Yang X. Role of STING in the treatment of non-small cell lung cancer. Cell Commun Signal. 2024;22(1):202.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhang J, Yu S, Peng Q, Wang P, Fang L. Emerging mechanisms and implications of cGAS-STING signaling in cancer immunotherapy strategies. Cancer Biol Med. 2024;21(1):45–64.

PubMed  PubMed Central  CAS  Google Scholar 

Hines JB, Kacew AJ, Sweis RF. The development of STING agonists and emerging results as a cancer immunotherapy. Curr Oncol Rep. 2023;25(3):189–99.

Article  PubMed  PubMed Central  Google Scholar 

Barrueto L, Caminero F, Cash L, Makris C, Lamichhane P, Deshmukh RR. Resistance to checkpoint inhibition in cancer immunotherapy. Transl Oncol. 2020;13(3):100738.

Article  PubMed  PubMed Central  Google Scholar 

Jiang M, Chen P, Wang L, Li W, Chen B, Liu Y, et al. cGAS-STING, an important pathway in cancer immunotherapy. J Hematol Oncol. 2020;13(1):81.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Decout A, Katz JD, Venkatraman S, Ablasser A. The cGAS-STING pathway as a therapeutic target in inflammatory diseases. Nat Rev Immunol. 2021;21(9):548–69.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Paludan SR, Pradeu T, Masters SL, Mogensen TH. Constitutive immune mechanisms: mediators of host defence and immune regulation. Nat Rev Immunol. 2021;21(3):137–50.

Article  PubMed  CAS  Google Scholar 

Li Y, Wilson HL, Kiss-Toth E. Regulating STING in health and disease. J Inflamm (Lond). 2017;14:11.

Article  PubMed  Google Scholar 

Yu L, Liu P. Cytosolic DNA sensing by cGAS: regulation, function, and human diseases. Signal Transduct Target Ther. 2021;6(1):170.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Wheeler OPG, Unterholzner L. DNA sensing in cancer: pro-tumour and anti-tumour functions of cGAS-STING signalling. Essays Biochem. 2023;67(6):905–18.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Herzner AM, Hagmann CA, Goldeck M, Wolter S, Kubler K, Wittmann S, et al. Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA. Nat Immunol. 2015;16(10):1025–33.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Pan J, Fei CJ, Hu Y, Wu XY, Nie L, Chen J. Current understanding of the cGAS-STING signaling pathway: structure, regulatory mechanisms, and related diseases. Zool Res. 2023;44(1):183–218.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Mosallanejad K, Kagan JC. Control of innate immunity by the cGAS-STING pathway. Immunol Cell Biol. 2022;100(6):409–23.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Barral PM, Sarkar D, Su ZZ, Barber GN, DeSalle R, Racaniello VR, Fisher PB. Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: key regulators of innate immunity. Pharmacol Ther. 2009;124(2):219–34.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Brisse M, Ly H. Comparative structure and function analysis of the RIG-I-like receptors: RIG-I and MDA5. Front Immunol. 2019;10:1586.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Balka KR, Louis C, Saunders TL, Smith AM, Calleja DJ, D’Silva DB, et al. TBK1 and IKKepsilon act redundantly to mediate STING-induced NF-kappaB responses in myeloid cells. Cell Rep. 2020;31(1):107492.

Article  PubMed  CAS  Google Scholar 

Yang J, Ding H, Shuai B, Zhang Y, Zhang Y. Mechanism and effects of STING-IFN-I pathway on nociception: a narrative review. Front Mol Neurosci. 2022;15:1081288.

Article  PubMed  CAS  Google Scholar 

Srikanth S, Woo JS, Wu B, El-Sherbiny YM, Leung J, Chupradit K, et al. The Ca(2+) sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum. Nat Immunol. 2019;20(2):152–62.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Uhlorn BL, Gamez ER, Li S, Campos SK. Attenuation of cGAS/STING activity during mitosis. Life Sci Alliance. 2020;3(9):e201900.

Article  Google Scholar 

B