Belperio JA, Shaikh F, Abtin FG, Fishbein MC, Weigt SS, Saggar R, Lynch JR (2022) Diagnosis and treatment of pulmonary sarcoidosis: a review. Jama 327:856–867

Article  CAS  PubMed  Google Scholar 

Vazquez Z, Klinger JR (2020) Guidelines for the treatment of pulmonary arterial hypertension. Lung 198:581–596

Article  PubMed  Google Scholar 

Zhang L, Wang Y, Wu G, Rao L, Wei Y, Yue H, Yuan T, Yang P, Xiong F, Zhang S, Zhou Q, Chen Z, Li J, Mo BW, Zhang H, Xiong W, Wang CY (2020) Blockade of JAK2 protects mice against hypoxia-induced pulmonary arterial hypertension by repressing pulmonary arterial smooth muscle cell proliferation. Cell Prolif 53:e12742

Article  PubMed  PubMed Central  Google Scholar 

Hu Y, Chi L, Kuebler WM, Goldenberg NM (2020) Perivascular Inflammation in Pulmonary Arterial Hypertension. Cells-Basel 9

Tian L, Wu D, Dasgupta A, Chen KH, Mewburn J, Potus F, Lima P, Hong Z, Zhao YY, Hindmarch C, Kutty S, Provencher S, Bonnet S, Sutendra G, Archer SL (2020) Epigenetic metabolic reprogramming of right ventricular fibroblasts in pulmonary arterial hypertension: a pyruvate dehydrogenase kinase-dependent shift in mitochondrial metabolism promotes right ventricular fibrosis. Circ Res 126:1723–1745

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Y, Tang BL, Lu ML, Wang HX (2023) Astragaloside IV improves pulmonary arterial hypertension by increasing the expression of CCN1 and activating the ERK1/2 pathway. J Cell Mol Med 27:622–633

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun SC (2008) Deubiquitylation and regulation of the immune response. Nat Rev Immunol 8:501–511

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sobol A, Askonas C, Alani S, Weber MJ, Ananthanarayanan V, Osipo C, Bocchetta M (2017) Deubiquitinase OTUD6B isoforms are important regulators of growth and proliferation. MOL CANCER RES 15:117–127

Article  CAS  PubMed  Google Scholar 

Zhao G, Song D, Wu J, Yang S, Shi S, Cui X, Ren H, Zhang B (2022) Identification of OTUD6B as a new biomarker for prognosis and immunotherapy by pan-cancer analysis. Front Immunol 13:955091

Takata M, Pachera E, Frank-Bertoncelj M, Kozlova A, Jungel A, Whitfield ML, Assassi S, Calcagni M, de Vries-Bouwstra J, Huizinga TW, Kurreeman F, Kania G, Distler O (2019) OTUD6B-AS1 might be a Novel Regulator of apoptosis in systemic sclerosis. Front Immunol 10:1100

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Z, Zhang L, Li L, Zhou M (2022) Loss of OTUD6B stimulates angiogenesis and promotes Diabetic Atherosclerosis. Diabetes Metab Syndr Obes 15:3027–3038

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mevissen TE, Hospenthal MK, Geurink PP, Elliott PR, Akutsu M, Arnaudo N, Ekkebus R, Kulathu Y, Wauer T, El OF, Freund SM, Ovaa H, Komander D (2013) OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. Cell 154:169–184

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dai X, Liu J, Wei W (2020) DUB-independent regulation of pVHL by OTUD6B suppresses hepatocellular carcinoma. Protein Cell 11:546–548

Article  PubMed  PubMed Central  Google Scholar 

Wang Z, Xia F, Feng T, Jiang B, Wang W, Li X (2020) OTUD6B-AS1 inhibits viability, Migration, and Invasion of thyroid carcinoma by targeting mir-183-5p and miR-21. Front Endocrinol (Lausanne) 11:136

Article  CAS  PubMed  Google Scholar 

Wang W, Cheng X, Zhu J (2021) Long non-coding RNA OTUD6B-AS1 overexpression inhibits the proliferation, invasion and migration of colorectal cancer cells via downregulation of microRNA-3171. Oncol Lett 21:193

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu X, Li M, Chen Z, Yu Y, Shi H, Yu Y, Wang Y, Chen R, Ge J (2022) Mitochondrial calpain-1 activates NLRP3 inflammasome by cleaving ATP5A1 and inducing mitochondrial ROS in CVB3-induced myocarditis. Basic Res Cardiol 117:40

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goll DE, Thompson VF, Li H, Wei W, Cong J (2003) The calpain system. Physiol Rev 83:731–801

Li Y, Ma J, Zhu H, Singh M, Hill D, Greer PA, Arnold JM, Abel ED, Peng T (2011) Targeted inhibition of calpain reduces myocardial hypertrophy and fibrosis in mouse models of type 1 diabetes. Diabetes 60:2985–2994

Article  CAS  PubMed  PubMed Central  Google Scholar 

Donkor IO (2020) An update on the therapeutic potential of calpain inhibitors: a patent review. Expert Opin Ther Pat 30:659–675

Article  CAS  PubMed  Google Scholar 

Deng H, Tian X, Sun H, Liu H, Lu M, Wang H (2022) Calpain-1 mediates vascular remodelling and fibrosis via HIF-1alpha in hypoxia-induced pulmonary hypertension. J Cell Mol Med 26:2819–2830

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun Y, Lu M, Sun T, Wang H (2021) Astragaloside IV attenuates inflammatory response mediated by NLRP-3/calpain-1 is involved in the development of pulmonary hypertension. J Cell Mol Med 25:586–590

Article  CAS  PubMed  Google Scholar 

Li HS, Zhou YN, Li L, Li SF, Long D, Chen XL, Zhang JB, Feng L, Li YP (2019) HIF-1alpha protects against oxidative stress by directly targeting mitochondria. Redox Biol 25:101109

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schofield CJ, Ratcliffe PJ (2005) Signalling hypoxia by HIF hydroxylases. Biochem Biophys Res Commun 338:617–626

Article  CAS  PubMed  Google Scholar 

Semenza GL (2012) Hypoxia-inducible factors in physiology and medicine. Cell 148:399–408

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lei W, He Y, Shui X, Li G, Yan G, Zhang Y, Huang S, Chen C, Ding Y (2016) Expression and analyses of the HIF-1 pathway in the lungs of humans with pulmonary arterial hypertension. Mol Med Rep 14:4383–4390

Article  CAS  PubMed  Google Scholar 

Luna-Lopez R, Ruiz MA, Escribano SP (2022) Pulmonary arterial hypertension. Med Clin (Barc) 158:622–629

Article  PubMed  Google Scholar 

Beshay S, Sahay S, Humbert M (2020) Evaluation and management of pulmonary arterial hypertension. Respir Med 171:106099

Article  PubMed  Google Scholar 

Burki TK (2020) Pharmacotherapy for pulmonary arterial hypertension. Lancet Respir Med 8:e81

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bordenave J, Tu L, Savale L, Huertas A, Humbert M, Guignabert C (2019) [New insights in the pathogenesis of pulmonary arterial hypertension]. Rev Mal Respir 36:433–437

Article  CAS  PubMed  Google Scholar 

Maron BA, Abman SH, Elliott CG, Frantz RP, Hopper RK, Horn EM, Nicolls MR, Shlobin OA, Shah SJ, Kovacs G, Olschewski H (2021) Rosenzweig, Pulmonary arterial hypertension: diagnosis, treatment, and novel advances. Am J Respir Crit Care Med 203:1472–1487

Article  CAS  PubMed  PubMed Central  Google Scholar 

Weatherald J, Boucly A, Peters A, Montani D, Prasad K, Psotka MA, Zannad F, Gomberg-Maitland M, McLaughlin V, Simonneau G, Humbert M (2022) The evolving landscape of pulmonary arterial hypertension clinical trials. Lancet 400:1884–1898

Article  PubMed