Rescue in vitro maturation using ovarian support cells of human oocytes from conventional stimulation cycles yields oocytes with improved nuclear maturation and transcriptomic resemblance to in vivo matured oocytes

Edwards RG. Maturation in vitro of mouse, sheep, cow, pig, rhesus monkey and human ovarian oocytes. Nature. 1965;208:349–51.

Article  CAS  PubMed  Google Scholar 

Strączyńska P, Papis K, Morawiec E, Czerwiński M, Gajewski Z, Olejek A, et al. Signaling mechanisms and their regulation during in vivo or in vitro maturation of mammalian oocytes. Reprod Biol Endocrinol. 2022;20:37.

Article  PubMed  PubMed Central  Google Scholar 

Liu W, Xin Q, Wang X, Wang S, Wang H, Zhang W, et al. Estrogen receptors in granulosa cells govern meiotic resumption of pre-ovulatory oocytes in mammals. Cell Death Dis. 2017;8:e2662–e2662.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang H, Lu S, Xu R, Tang Y, Liu J, Li C, et al. Mechanisms of estradiol-induced EGF-like factor expression and oocyte maturation via G protein-coupled estrogen receptor. Endocrinology. 2020;161:bqaa190.

Article  PubMed  Google Scholar 

Grøndahl ML, Borup R, Vikeså J, Ernst E, Andersen CY, Lykke-Hartmann K. The dormant and the fully competent oocyte: comparing the transcriptome of human oocytes from primordial follicles and in metaphase II. Mol Hum Reprod. 2013;19:600–17.

Article  PubMed  Google Scholar 

An H, Wang X, Li J, Sun H, Zhu S, Ge J, et al. KAS-seq profiling captures transcription dynamics during oocyte maturation. J Ovarian Res. 2024;17:23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu W, Zeng H, Shi Y, Zhou C, Huang J, Jia L, et al. Single-cell transcriptome and translatome dual-omics reveals potential mechanisms of human oocyte maturation. Nat Commun. 2022;13:5114.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Takeuchi H, Yamamoto M, Fukui M, Inoue A, Maezawa T, Nishioka M, et al. Single-cell profiling of transcriptomic changes during in vitro maturation of human oocytes. Reprod Med Biol. 2022;21:e12464.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jones GM, Cram DS, Song B, Magli MC, Gianaroli L, Lacham-Kaplan O, et al. Gene expression profiling of human oocytes following in vivo or in vitro maturation. Hum Reprod. 2008;23:1138–44.

Article  CAS  PubMed  Google Scholar 

Gonzalez XV, Almutlaq A, Gupta SS. Systematic review of mRNA expression in human oocytes: understanding the molecular mechanisms underlying oocyte competence. J Assist Reprod Genet. 2023;40:2283–95.

Article  PubMed  PubMed Central  Google Scholar 

Pincus G, Enzmann EV. The comparative behavior of mammalian eggs in vivo and in vitro : I. The activation of ovarian eggs. J Exp Med. 1935;62:665–75.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grynberg M, Sermondade N, Sellami I, Benoit A, Mayeur A, Sonigo C. In vitro maturation of oocytes for fertility preservation: a comprehensive review. F&S Rev. 2022;3:211–26.

Article  Google Scholar 

Saenz-de-Juano MD, Ivanova E, Romero S, Lolicato F, Sánchez F, Van Ranst H, et al. DNA methylation and mRNA expression of imprinted genes in blastocysts derived from an improved in vitro maturation method for oocytes from small antral follicles in polycystic ovary syndrome patients. Hum Reprod. 2019;34:1640–9.

Article  CAS  PubMed  Google Scholar 

Akin N, Le AH, Ha UDT, Romero S, Sanchez F, Pham TD, et al. Positive effects of amphiregulin on human oocyte maturation and its molecular drivers in patients with polycystic ovary syndrome. Hum Reprod. 2021;37:30–43.

Article  PubMed  Google Scholar 

Vuong LN, Le AH, Ho VNA, Pham TD, Sanchez F, Romero S, et al. Live births after oocyte in vitro maturation with a prematuration step in women with polycystic ovary syndrome. J Assist Reprod Genet. 2020;37:347–57.

Article  PubMed  PubMed Central  Google Scholar 

Sanchez F, Le AH, Ho VNA, Romero S, Van Ranst H, De Vos M, et al. Biphasic in vitro maturation (CAPA-IVM) specifically improves the developmental capacity of oocytes from small antral follicles. J Assist Reprod Genet. 2019;36:2135–44.

Article  PubMed  PubMed Central  Google Scholar 

Lin Y-H, Hwang J-L, Huang L-W, Mu S-C, Seow K-M, Chung J, et al. Combination of FSH priming and hCG priming for in-vitro maturation of human oocytes. Hum Reprod. 2003;18:1632–6.

Article  CAS  PubMed  Google Scholar 

Roesner S, Von Wolff M, Eberhardt I, Beuter-Winkler P, Toth B, Strowitzki T. In vitro maturation: a five-year experience. Acta Obstet Gynecol Scand. 2012;91:22–7.

Article  PubMed  Google Scholar 

De Vos M, Ortega-Hrepich C, Albuz FK, Guzman L, Polyzos NP, Smitz J, et al. Clinical outcome of non-hCG-primed oocyte in vitro maturation treatment in patients with polycystic ovaries and polycystic ovary syndrome. Fertil Steril. 2011;96:860–4.

Article  PubMed  Google Scholar 

Mohsenzadeh M, Khalili MA, Anbari F, Vatanparast M. High efficiency of homemade culture medium supplemented with GDF9-β in human oocytes for rescue in vitro maturation. Clin Exp Reprod Med. 2022;49:149–58.

Article  PubMed  PubMed Central  Google Scholar 

De Vos M, Smitz J, Thompson JG, Gilchrist RB. The definition of IVM is clear-variations need defining. Hum Reprod. 2016;31:2411–5.

Article  PubMed  Google Scholar 

Guzman L, Ortega-Hrepich C, Albuz FK, Verheyen G, Devroey P, Smitz J, et al. Developmental capacity of in vitro-matured human oocytes retrieved from polycystic ovary syndrome ovaries containing no follicles larger than 6 mm. Fertil Steril. 2012;98(503–7):e1-2.

Google Scholar 

Braam SC, Consten D, Smeenk JMJ, Cohlen BJ, Curfs MHJM, Hamilton CJCM, et al. In vitro maturation of oocytes in women at risk of ovarian hyperstimulation syndrome-a prospective multicenter cohort study. Int J Fertil Steril. 2019;13:38–44.

CAS  PubMed  PubMed Central  Google Scholar 

Wei J, Luo Z, Dong X, Jin H, Zhu L, Ai J. Cut-off point of mature oocyte for routine clinical application of rescue IVM: a retrospective cohort study. J Ovarian Res. 2023;16:226.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yuan Y, Reed L, Abeyta MJ, Holmes R, Swain JE, Schoolcraft WB, et al. Rescue-IVM and the transfer of a euploid blastocyst provided improved odds for patients with poor prognosis to conceive. Fertil Steril. 2021;116:e135.

Article  Google Scholar 

Vanhoutte L, Nogueira D, De Sutter P. Prematuration of human denuded oocytes in a three-dimensional co-culture system: effects on meiosis progression and developmental competence. Hum Reprod. 2008;24:658–69.

Article  PubMed  Google Scholar 

Torre ML, Munari E, Albani E, Levi-Setti PE, Villani S, Faustini M, et al. In vitro maturation of human oocytes in a follicle-mimicking three-dimensional coculture. Fertil Steril. 2006;86:572–6.

Article  PubMed  Google Scholar 

Ferrer-Vaquer A, Barragán M, Rodríguez A, Vassena R. Altered cytoplasmic maturation in rescued in vitro matured oocytes. Hum Reprod. 2019;34:1095–105.

Article  CAS  PubMed  Google Scholar 

Jie H, Zhao M, Alqawasmeh OAM, Chan CPS, Lee TL, Li T, et al. In vitro rescue immature oocytes – a literature review. Hum Fertil. 2022;25:640–50.

Article  CAS  Google Scholar 

Pierson Smela MD, Kramme CC, Fortuna PRJ, Adams JL, Su R, Dong E, et al. Directed differentiation of human iPSCs to functional ovarian granulosa-like cells via transcription factor overexpression. Elife. 2023;12:e83291.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Piechota S, Marchante M, Giovannini A, Paulsen B, Potts KS, Rockwell G, et al. Human-induced pluripotent stem cell-derived ovarian support cell co-culture improves oocyte maturation in vitro after abbreviated gonadotropin stimulation. Hum Reprod. 2023;38:2456–69.

Article  CAS  PubMed  PubMed Central 

Comments (0)

No login
gif