Diagnosis and management of secondary adrenal crisis

Bornstein SR, Allolio B, Arlt W, Barthel A, Don-Wauchope A, Hammer GD, Husebye ES, Merke DP, Murad MH, Stratakis CA, et al. Diagnosis and treatment of primary adrenal insufficiency: An endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2016;101(2):364–89.

Article  CAS  PubMed  Google Scholar 

Woodcock T, Barker P, Daniel S, Fletcher S, Wass JAH, Tomlinson JW, Misra U, Dattani M, Arlt W, Vercueil A. Guidelines for the management of glucocorticoids during the peri-operative period for patients with adrenal insufficiency: Guidelines from the Association of Anaesthetists, the Royal College of Physicians and the Society for Endocrinology UK. Anaesthesia. 2020;75(5):654–63.

Article  CAS  PubMed  Google Scholar 

Araujo Castro M, Currás Freixes M, de Miguel Novoa P, Gracia Gimeno P, Álvarez Escolá C, Hanzu FA. SEEN guidelines for the management and prevention of acute adrenal insufficiency. Endocrinol diabetes y Nutr. 2020 Jan 1 [cited 2023 Oct 3];67(1):53–60. Available from: https://pubmed.ncbi.nlm.nih.gov/31003863/.

Pastores SM, Annane D, Rochwerg B. Guidelines for the Diagnosis and Management of Critical Illness-Related Corticosteroid Insufficiency (CIRCI) in Critically Ill Patients (Part II): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017. Vol. 46, Critical Care Medicine. Lippincott Williams and Wilkins; 2018. p. 146–8.

Rushworth RL, Torpy DJ. Adrenal Insufficiency in Australia: Is it Possible that the Use of Lower Dose, Short-Acting Glucocorticoids has Increased the Risk of Adrenal Crises? Horm Metab Res. 2015 Nov 18 [cited 2023 Aug 19];47(6):427–32. Available from: https://pubmed.ncbi.nlm.nih.gov/25738995/.

Hahner S, Loeffler M, Bleicken B, Drechsler C, Milovanovic D, Fassnacht M, Ventz M, Quinkler M, Allolio B. Epidemiology of adrenal crisis in chronic adrenal insufficiency: the need for new prevention strategies. Eur J Endocrinol. 2010 [cited 2023 Aug 19];162(3):597–602. Available from: https://pubmed.ncbi.nlm.nih.gov/19955259/.

Rushworth RL, Torpy DJ, Falhammar H. Adrenal crises: perspectives and research directions. Endocrine. 2017 Feb 1 [cited 2023 Aug 19];55(2):336–45. Available from: https://pubmed.ncbi.nlm.nih.gov/27995500/.

Smans LCCJ, Van Der Valk ES, Hermus ARMM, Zelissen PMJ. Incidence of adrenal crisis in patients with adrenal insufficiency. Clin Endocrinol (Oxf). 2016 [cited 2023 Aug 19];84(1):17–22. Available from: https://pubmed.ncbi.nlm.nih.gov/26208266/.

Rushworth RL, Chrisp GL, Torpy DJ. Glucocorticoid-induced Adrenal Insufficiency: A Study of the Incidence in Hospital Patients and a Review of Peri-operative Management. Endocr Pract. 2018 [cited 2023 Sep 27];24(5):437–45. Available from: https://pubmed.ncbi.nlm.nih.gov/29498915/.

Li D, Genere N, Behnken E, Xhikola M, Abbondanza T, Vaidya A, Bancos I. Determinants of Self-reported Health Outcomes in Adrenal Insufficiency: A Multisite Survey Study. J Clin Endocrinol Metab. 2021 [cited 2023 Aug 24];106(3):E1408–19. Available from: https://pubmed.ncbi.nlm.nih.gov/32995875/.

Rushworth RL, Torpy DJ. The Changing Epidemiology of Adrenal Insufficiency: Iatrogenic Factors Predominate. J Endocr Soc. 2023 Mar 1 [cited 2023 Oct 9];7(3). Available from: https://pubmed.ncbi.nlm.nih.gov/36777466/.

Husebye ES, Pearce SH, Krone NP, Kämpe O. Adrenal insufficiency. Lancet Elsevier BV. 2021;397:613–29.

Article  CAS  Google Scholar 

Mebrahtu TF, Morgan AW, Keeley A, Baxter PD, Stewart PM, Pujades-Rodriguez M. Dose Dependency of Iatrogenic Glucocorticoid Excess and Adrenal Insufficiency and Mortality: A Cohort Study in England. J Clin Endocrinol Metab. 2019 [cited 2023 Sep 2];104(9):3757–67. Available from: https://pubmed-ncbi-nlm-nih-gov.myaccess.library.utoronto.ca/31009052/.

Li T, Donegan D, Hooten WM, Bancos I. Clinical Presentation and Outcomes of Opioid-Induced Adrenal Insufficiency. Endocr Pract. 2020 Nov 1 [cited 2023 Aug 24];26(11):1291–7. Available from: https://pubmed.ncbi.nlm.nih.gov/33471659/.

Woods CP, Argese N, Chapman M, Boot C, Webster R, Dabhi V, Grossman AB, Toogood AA, Arlt W, Stewart PM, et al. Adrenal suppression in patients taking inhaled glucocorticoids is highly prevalent and management can be guided by morning cortisol. Eur J Endocrinol. 2015 [cited 2023 Sep 2];173(5):633–42. Available from: https://pubmed.ncbi.nlm.nih.gov/26294794/.

Chang LS, Barroso-Sousa R, Tolaney SM, Hodi FS, Kaiser UB, Min L. Endocrine Toxicity of Cancer Immunotherapy Targeting Immune Checkpoints. Endocr Rev. 2019 [cited 2023 Aug 22];40(1):17–65. Available from: https://pubmed.ncbi.nlm.nih.gov/30184160/.

Tan MH, Iyengar R, Mizokami-Stout K, Yentz S, MacEachern MP, Shen LY, Redman B, Gianchandani R. Spectrum of immune checkpoint inhibitors-induced endocrinopathies in cancer patients: a scoping review of case reports. Clin diabetes Endocrinol. 2019 [cited 2023 Aug 22];5(1). Available from: https://pubmed.ncbi.nlm.nih.gov/30693099/.

Oelkers W. Adrenal insufficiency. N Engl J Med. 1996 [cited 2023 Aug 22];335(16):1206–12. Available from: https://pubmed.ncbi.nlm.nih.gov/8815944/.

Allolio B. Extensive expertise in Endocrinology: Adrenal crisis. Eur J Endocrinol. 2015 [cited 2023 Aug 22];172(3):R115–24. Available from: https://doi.org/10.1530/EJE-14-0824.

Rushworth RL, Torpy DJ, Falhammar H. Adrenal Crisis. Ingelfinger JR, editor. N Engl J Med. 2019;381(9):852–61. Available from: http://www.nejmhttps://doi.org/10.1056/NEJMra1807486.

Puar THK, Stikkelbroeck NMML, Smans LCCJ, Zelissen PMJ, Hermus ARMM. Adrenal Crisis: Still a Deadly Event in the 21st Century. Am J Med. 2016 [cited 2023 Aug 22];129(3):339.e1–339.e9. Available from: https://pubmed.ncbi.nlm.nih.gov/26363354/.

Hahner S, Spinnler C, Fassnacht M, Burger-Stritt S, Lang K, Milovanovic D, Beuschlein F, Willenberg HS, Quinkler M, Allolio B. High incidence of adrenal crisis in educated patients with chronic adrenal insufficiency: a prospective study. J Clin Endocrinol Metab. 2015 [cited 2023 Aug 19];100(2):407–16. Available from: https://pubmed.ncbi.nlm.nih.gov/25419882/.

Notter A, Jenni S, Christ E. Evaluation of the frequency of adrenal crises and preventive measures in patients with primary and secondary adrenal insufficiency in Switzerland. Swiss Med Wkly. 2018 [cited 2023 Aug 22];148:w14586. Available from: https://pubmed-ncbi-nlm-nih-gov.myaccess.library.utoronto.ca/29376554/.

Rushworth RL, Torpy DJ. A descriptive study of adrenal crises in adults with adrenal insufficiency: increased risk with age and in those with bacterial infections. BMC Endocr Disord. 2014 [cited 2023 Aug 19];14(1). Available from: https://pubmed.ncbi.nlm.nih.gov/25273066/.

Ono Y, Ono S, Yasunaga H, Matsui H, Fushimi K, Tanaka Y. Clinical features and practice patterns of treatment for adrenal crisis: a nationwide cross-sectional study in Japan. Eur J Endocrinol. 2017 [cited 2023 Aug 22];176(3):329–37. Available from: https://pubmed-ncbi-nlm-nih-gov.myaccess.library.utoronto.ca/28130352/.

Quinkler M, Ekman B, Zhang P, Isidori AM, Murray RD. Mortality data from the European Adrenal Insufficiency Registry-Patient characterization and associations. Clin Endocrinol (Oxf). 2018 [cited 2023 Aug 19];89(1):30–5. Available from: https://pubmed.ncbi.nlm.nih.gov/29682773/.

Bollag WB. Regulation of aldosterone synthesis and secretion. Compr Physiol. 2014 [cited 2023 Oct 5];4(3):1017–55. Available from: https://pubmed.ncbi.nlm.nih.gov/24944029/.

Erkut ZA, Pool C, Swaab DF. Glucocorticoids suppress corticotropin-releasing hormone and vasopressin expression in human hypothalamic neurons. J Clin Endocrinol Metab. 1998 [cited 2023 Oct 5];83(6):2066–73. Available from: https://pubmed.ncbi.nlm.nih.gov/9626140/.

Kim JK, Summer SN, Wood WM, Schrier RW. Role of glucocorticoid hormones in arginine vasopressin gene regulation. Biochem Biophys Res Commun. 2001 [cited 2023 Oct 5];289(5):1252–6. Available from: https://pubmed.ncbi.nlm.nih.gov/11741329/.

Bancos I, Hahner S, Tomlinson J, Arlt W. Diagnosis and management of adrenal insufficiency. lancet Diabetes Endocrinol. 2015 [cited 2023 Oct 9];3(3):216–26. Available from: https://pubmed.ncbi.nlm.nih.gov/25098712/.

Malbon CC, Rapiejko PJ, Watkins DC. Permissive hormone regulation of hormone-sensitive effector systems. Trends Pharmacol Sci. 1988 [cited 2023 Oct 5];9(1):33–6. Available from: https://pubmed.ncbi.nlm.nih.gov/3072728/.

Ueland T, Kristo C, Godang K, Aukrust P, Bollerslev J. Interleukin-1 Receptor Antagonist Is Associated with Fat Distribution in Endogenous Cushing’s Syndrome: A Longitudinal Study. J Clin Endocrinol Metab. 2003 [cited 2019 Sep 3];88(4):1492–6. Available from: https://academic.oup.com/jcem/article-abstract/88/4/1492/2845156.

Bellavance MA, Rivest S. The HPA - Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain. Front Immunol. 2014 [cited 2023 Oct 5];5(MAR). Available from: https://pubmed.ncbi.nlm.nih.gov/24744759/.

Pariante CM, Pearce BD, Pisell TL, Sanchez CI, Po C, Su C, Miller AH. The proinflammatory cytokine, interleukin-1alpha, reduces glucocorticoid receptor translocation and function. Endocrinology. 1999 [cited 2023 Oct 5];140(9):4359–66. Available from: https://pubmed.ncbi.nlm.nih.gov/10465310/.

A E Barber 1, S M Coyle, M A Marano, E Fischer, S E Calvano, Y Fong, L L Moldawer SFL. Glucocorticoid therapy alters hormonal and cytokine responses to endotoxin in man - PubMed. J Immunol. 1993 [cited 2024 Jan 16];150(5):1999–2006. Available from: https://pubmed.ncbi.nlm.nih.gov/8436830/.

Morrow LE, McClellan JL, Conn CA, Kluger MJ. Glucocorticoids alter fever and IL-6 responses to psychological stress and to lipopolysaccharide. Am J Physiol. 1993 [cited 2024 Jan 16];264(5 Pt 2). Available from: https://pubmed.ncbi.nlm.nih.gov/8498588/.

Kuo T, McQueen A, Chen TC, Wang JC. Regulation of Glucose Homeostasis by Glucocorticoids. Adv Exp Med Biol. 2015 [cited 2023 Oct 5];872:99. Available from: /pmc/articles/PMC6185996/

DeVile CJ, Stanhope R. Hydrocortisone replacement therapy in children and adolescents with hypopituitarism. Clin Endocrinol (Oxf). 1997 [cited 2024 Jan 16];47(1):37–41. Available from: https://pubmed.ncbi.nlm.nih.gov/9302370/.

Fischer JE, Stallmach T, Fanconi S. Adrenal crisis presenting as hypoglycemic coma. Intensive Care Med. 2000 [cited 2024 Jan 16];26(1):105–8. Available from: https://pubmed.ncbi.nlm.nih.gov/10663290/.

Sominsky L, Spencer SJ. Eating behavior and stress: a pathway to obesity. Front Psychol. 2014 [cited 2023 Oct 5];5(MAY). Available from: https://pubmed.ncbi.nlm.nih.gov/24860541/.

Samuels ME, Gallo-Payet N, Pinard S, Hasselmann C, Magne F, Patry L, Chouinard L, Schwartzentruber J, Patricia René, Sawyer N, et al. Bioinactive ACTH causing glucocorticoid deficiency. J Clin Endocrinol Metab. 2013 Feb [cited 2023 Sep 9];98(2):736–42. Available from: https://pubmed.ncbi.nlm.nih.gov/23293326/.

Laugesen K, Lunde Jørgensen JO, Petersen I, Sørensen HT. Fifteen-year nationwide trends in systemic glucocorticoid drug use in Denmark. Eur J Endocrinol. 2019 [cited 2023 Aug 26];181(3):267–73. Available from: https://pubmed.ncbi.nlm.nih.gov/31269470/.

Fardet L, Petersen I, Nazareth I. Prevalence of long-term oral glucocorticoid prescriptions in the UK over the past 20 years. Rheumatology (Oxford). 2011 [cited 2023 Aug 26];50(11):1982–90. Available from: https://pubmed.ncbi.nlm.nih.gov/21393338/.

Van Staa TP, Leufkens HGM, Abenhaim L, Begaud B, Zhang B, Cooper C. Use of oral corticosteroids in the United Kingdom. QJM - Mon J Assoc Physicians. 2000;93(2):105–11.

Article  Google Scholar 

Overman RA, Yeh JY, Deal CL. Prevalence of oral glucocorticoid usage in the United States: a general population perspective. Arthritis Care Res (Hoboken). 2013 [cited 2023 Aug 19];65(2):294–8. Available from: https://pubmed.ncbi.nlm.nih.gov/22807233/.

Meikle AW, Tyler FH. Potency and duration of action of glucocorticoids. Effects of hydrocortisone, prednisone and dexamethasone on human pituitary-adrenal function. Am J Med. 1977 [cited 2023 Sep 9];63(2):200–7. Available from: https://pubmed.ncbi.nlm.nih.gov/888843/.

Einaudi S, Bertorello N, Masera N, Farinasso L, Barisone E, Rizzari C, Corrias A, Villa A, Riva F, Saracco P, et al. Adrenal axis function after high-dose steroid therapy for childhood acute lymphoblastic leukemia. Pediatr Blood Cancer. 2008 [cited 2023 Sep 9];50(3):537–41. Available from: https://pubmed.ncbi.nlm.nih.gov/17828747/.

Kuperman H, Odone Filho V, Cristofani LM, Assis De Almeida MT, Setian N, Damiani D. Evaluation of adrenal reserve in children with acute lymphocytic leukemia treated with prednisone or dexamethasone. Horm Res Paediatr. 2012 [cited 2023 Sep 9];78(2):73–80. Available from: https://pubmed.ncbi.nlm.nih.gov/22922775/.

Dinsen S, Baslund B, Klose M, Rasmussen AK, Friis-Hansen L, Hilsted L, Feldt-Rasmussen U. Why glucocorticoid withdrawal may sometimes be as dangerous as the treatment itself. Eur J Intern Med. 2013 [cited 2023 Sep 2];24(8):714–20. Available from: https://pubmed.ncbi.nlm.nih.gov/23806261/.

Broersen LHA, Pereira AM, Jørgensen JOL, Dekkers OM. Adrenal Insufficiency in Corticosteroids Use: Systematic Review and Meta-Analysis. J Clin Endocrinol Metab. 2015 Jun 1 [cited 2023 Aug 26];100(6):2171–80. Available from: https://pubmed.ncbi.nlm.nih.gov/25844620/.

Joseph RM, Hunter AL, Ray DW, Dixon WG. Systemic glucocorticoid therapy and adrenal insufficiency in adults: A systematic review. Semin Arthritis Rheum. 2016 [cited 2023 Aug 26];46(1):133–41. Available from: https://pubmed.ncbi.nlm.nih.gov/27105755/.

Einarsdottir MJ, Bankvall M, Robledo-Sierra J, Rödström PO, Bergthorsdottir R, Trimpou P, Hasséus B, Ragnarsson O. Topical clobetasol treatment for oral lichen planus can cause adrenal insufficiency. Oral Dis. 2023 [cited 2024 Jan 19]; Available from: https://pubmed.ncbi.nlm.nih.gov/37103329/.

Grossmann C, Scholz T, Rochel M, Bumke-Vogt C, Oelkers W, Pfeiffer AFH, Diederich S, Bähr V. Transactivation via the human glucocorticoid and mineralocorticoid receptor by therapeutically used steroids in CV-1 cells: a comparison of their glucocorticoid and mineralocorticoid properties. Eur J Endocrinol. 2004 [cited 2023 Sep 9];151(3):397–406. Available from: https://pubmed.ncbi.nlm.nih.gov/15362971/.

Lipworth BJ. Systemic adverse effects of inhaled corticosteroid therapy: A systematic review and meta-analysis. Arch Intern Med. 1999 [cited 2024 Jan 16];159(9):941–55. Available from: https://pubmed.ncbi.nlm.nih.gov/10326936/.

LaRochelle GE, LaRochelle AG, Ratner RE, Borenstein DG. Recovery of the hypothalamic-pituitary-adrenal (HPA) axis in patients with rheumatic diseases receiving low-dose prednisone. Am J Med. 1993 [cited 2023 Sep 10];95(3):258–64. Available from: https://pubmed.ncbi.nlm.nih.gov/8368224/.

Schlaghecke R, Kornely E, Santen RT, Ridderskamp P. The effect of long-term glucocorticoid therapy on pituitary-adrenal responses to exogenous corticotropin-releasing hormone. N Engl J Med. 1992 [cited 2023 Aug 26];326(4):226–30. Available from: https://pubmed.ncbi.nlm.nih.gov/1309389/.

Borresen SW, Klose M, Baslund B, Rasmussen ÅK, Hilsted L, Friis-Hansen L, Locht H, Hansen A, Hetland ML, Lydolph MC, et al. Adrenal insufficiency is seen in more than one-third of patients during ongoing low-dose prednisolone treatment for rheumatoid arthritis. Eur J Endocrinol. 2017 [cited 2023 Aug 26];177(4):287–95. Available from: https://pubmed.ncbi.nlm.nih.gov/28877961/.

Henzen C, Suter A, Lerch E, Urbinelli R, Schorno XH, Briner VA. Suppression and recovery of adrenal response after short-term, high-dose glucocorticoid treatment. Lancet (London, England). 2000 [cited 2023 Aug 26];355(9203):542–5. Available from: https://pubmed.ncbi.nlm.nih.gov/10683005/.

Dineen R, Stewart PM, Sherlock M. Factors impacting on the action of glucocorticoids in patients receiving glucocorticoid therapy. Clin Endocrinol (Oxf). 2019 [cited 2023 Aug 26];90(1):3–14. Available from: https://pubmed.ncbi.nlm.nih.gov/30120786/.

Nicolaides NC, Charmandari E, Chrousos GP, Kino T. Recent advances in the molecular mechanisms determining tissue sensitivity to glucocorticoids: novel mutations, circadian rhythm and ligand-induced repression of the human glucocorticoid receptor. BMC Endocr Disord. 2014 [cited 2023 Aug 26];14(1). Available from: https://pubmed.ncbi.nlm.nih.gov/25155432/.

Quax RA, Manenschijn L, Koper JW, Hazes JM, Lamberts SWJ, Van Rossum EFC, Feelders RA. Glucocorticoid sensitivity in health and disease. Nat Rev Endocrinol. 2013 [cited 2023 Aug 26];9(11):670–86. Available from: https://pubmed.ncbi.nlm.nih.gov/24080732/.

Huizenga NATM, Koper JW, de Lange P, Pols HAP, Stolk RP, Grobbee DE, de Jong FH, Lamberts SWJ. Interperson variability but intraperson stability of baseline plasma cortisol concentrations, and its relation to feedback sensitivity of the hypothalamo-pituitary-adrenal axis to a low dose of dexamethasone in elderly individuals. J Clin Endocrinol Metab. 1998 [cited 2023 Aug 26];83(1):47–54. Available from: https://pubmed.ncbi.nlm.nih.gov/9435415/.

Neidert S, Schuetz P, Mueller B, Christ-Crain M. Dexamethasone suppression test predicts later development of an impaired adrenal function after a 14-day course of prednisone in healthy volunteers. Eur J Endocrinol. 2010 [cited 2023 Aug 26];162(5):943–9. Available from: https://pubmed.ncbi.nlm.nih.gov/20142368/.

Bolton JL, Hayward C, Direk N, Lewis JG, Hammond GL, Hill LA, Anderson A, Huffman J, Wilson JF, Campbell H, et al. Genome wide association identifies common variants at the SERPINA6/SERPINA1 locus influencing plasma cortisol and corticosteroid binding globulin. PLoS Genet. 2014 [cited 2023 Sep 2];10(7). Available from: https://pubmed.ncbi.nlm.nih.gov/25010111/.

Hawcutt DB, Francis B, Carr DF, Jorgensen AL, Yin P, Wallin N, O’Hara N, Zhang EJ, Bloch KM, Ganguli A, et al. Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study. Lancet Respir Med. 2018 [cited 2023 Sep 2];6(6):442–50. Available from: https://pubmed.ncbi.nlm.nih.gov/29551627/.

Van Keulen BJ, Dolan C V., Andrew R, Walker BR, Hulshoff Pol HE, Boomsma DI, Rotteveel J, Finken MJJ. Heritability of Cortisol Production and Metabolism Throughout Adolescence. J Clin Endocrinol Metab. 2020 [cited 2023 Sep 2];105(2). Available from: https://pubmed.ncbi.nlm.nih.gov/31608377/.

Sagar R, Mackie S, W. Morgan A, Stewart P, Abbas A. Evaluating tertiary adrenal insufficiency in rheumatology patients on long-term systemic glucocorticoid treatment. Clin Endocrinol (Oxf). 2021 [cited 2023 Aug 26];94(3):361–70. Available from: https://pubmed.ncbi.nlm.nih.gov/33370485/.

Borresen SW, Thorgrimsen TB, Jensen B, Hilsted L, Bartels EM, Feldt-Rasmussen U, Locht H. Adrenal insufficiency in prednisolone-treated patients with polymyalgia rheumatica or giant cell arteritis-prevalence and clinical approach. Rheumatology (Oxford). 2020 [cited 2023 Aug 26];59(10):2764–73. Available from: https://pubmed.ncbi.nlm.nih.gov/32031663/.

Valentin A, Borresen SW, Rix M, Elung-Jensen T, Sørensen SS, Feldt-Rasmussen U. Adrenal insufficiency in kidney transplant patients during low-dose prednisolone therapy: a cross-sectional case-control study. Nephrol Dial Transplant. 2020 [cited 2023 Aug 26];35(12):2191–7. Available from: https://pubmed.ncbi.nlm.nih.gov/31539081/.

Derendorf H. Pharmacokinetic and pharmacodynamic properties of inhaled corticosteroids in relation to efficacy and safety. Respir Med. 1997 [cited 2023 Aug 26];91 Suppl A(SUPPL. A):22–8. Available from: https://pubmed.ncbi.nlm.nih.gov/9474364/.

Zöllner EW, Lombard CJ, Galal U, Hough FS, Irusen EM, Weinberg E. Hypothalamic-pituitary-adrenal axis suppression in asthmatic school children. Pediatrics. 2012 [cited 2023 Aug 26];130(6). Available from: https://pubmed.ncbi.nlm.nih.gov/23147980/.

Czock D, Keller F, Rasche FM, Häussler U. Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids. Clin Pharmacokinet. 2005 [cited 2023 Aug 26];44(1):61–98. Available from: https://pubmed.ncbi.nlm.nih.gov/15634032/.

Jasani KM, Boyle JA, Dick WC, Williamson J, Taylor AK, Buchanan WW. Corticosteroid-induced hypothalamo-pituitary-adrenal axis suppression. Prospective study using two regimens of corticosteroid therapy. Ann Rheum Dis. 1968 [cited 2023 Aug 26];27(4):352–9. Available from: https://pubmed.ncbi.nlm.nih.gov/5666676/.

Ekman B, Bachrach-Lindström M, Lindström T, Wahlberg J, Blomgren J, Arnqvist HJ. A randomized, double-blind, crossover study comparing two- and four-dose hydrocortisone regimen with regard to quality of life, cortisol and ACTH profiles in patients with primary adrenal insufficiency. Clin Endocrinol (Oxf). 2012 [cited 2023 Aug 26];77(1):18–25. Available from: https://pubmed.ncbi.nlm.nih.gov/22288685/.

Li T, Cunningham JL, Gilliam WP, Loukianova L, Donegan DM, Bancos I. Prevalence of Opioid-Induced Adrenal Insufficiency in Patients Taking Chronic Opioids. J Clin Endocrinol Metab. 2020 [cited 2023 Aug 24];105(10):e3766. Available from: /pmc/articles/PMC7470471/.

Nanus DE, Filer AD, Hughes B, Fisher BA, Taylor PC, Stewart PM, Buckley CD, McInnes I, Cooper MS, Raza K. TNFα regulates cortisol metabolism in vivo in patients with inflammatory arthritis. Ann Rheum Dis. 2015 [cited 2023 Aug 26];74(2):464–9. Available from: https://pubmed.ncbi.nlm.nih.gov/24385202/.

Einarsdottir MJ, Kristjansdottir HL, Bergthorsdottir R, Johannsson G, Trimpou P, Lewerin C, Ragnarsson O. Intermittent high-dose glucocorticoid treatment does not cause adrenal insufficiency in patients with diffuse large B-cell lymphoma - a prospective study. Acta Haematol. 2023 [cited 2024 Jan 19]; Available from: https://pubmed.ncbi.nlm.nih.gov/37757784/.

Jespersen S, Nygaard B, Kristensen LØ. Methylprednisolone Pulse Treatment of Graves’ Ophthalmopathy Is Not Associated with Secondary Adrenocortical Insufficiency. Eur Thyroid J. 2015 [cited 2024 Jan 19];4(4):222–5. Available from: https://pubmed.ncbi.nlm.nih.gov/26835424/.

Mehta P, Meeran K, Macphie E, Abbas A, Rippin J, Jeffery RC, Reddy V, Leandro MJ, Ciurtin C, Simpson HL, et al. Variability in counselling for adrenal insufficiency in COVID-19 and beyond: a survey of rheumatology practice. Lancet Rheumatol. 2021 [cited 2023 Aug 26];3(2):e92–4. Available from: https://pubmed.ncbi.nlm.nih.gov/33521672/.

Gibb FW, Stewart A, Walker BR, Strachan MWJ. Adrenal insufficiency in patients on long-term opioid analgesia. Clin Endocrinol (Oxf). 2016 [cited 2023 Aug 24];85(6):831–5. Available from: https://pubmed.ncbi.nlm.nih.gov/27260138/.

Tennant F, Hermann L. Normalization of serum cortisol concentration with opioid treatment of severe chronic pain. Pain Med. 2002 [cited 2023 Aug 24];3(2):132–4. Available from: https://pubmed.ncbi.nlm.nih.gov/15102160/.

Demarest SP, Gill RS, Adler RA. Opioid endocrinopathy. Endocr Pract. 2015 [cited 2023 Aug 24];21(2):190–8. Available from: https://pubmed.ncbi.nlm.nih.gov/25536970/.

de Vries F, Bruin M, Lobatto DJ, Dekkers OM, Schoones JW, van Furth WR, Pereira AM, Karavitaki N, Biermasz NR, Zamanipoor Najafabadi AH. Opioids and Their Endocrine Effects: A Systematic Review and Meta-analysis. J Clin Endocrinol Metab. 2020 [cited 2023 Aug 26];105(3):1020–9. Available from: https://pubmed.ncbi.nlm.nih.gov/31511863/.

Lamprecht A, Sorbello J, Jang C, Torpy DJ, Inder WJ. Secondary adrenal insufficiency and pituitary dysfunction in oral/transdermal opioid users with non-cancer pain. Eur J Endocrinol. 2018 [cited 2023 Aug 19];179(6):353–62. Available from: https://pubmed.ncbi.nlm.nih.gov/30324794/.

Abs R, Verhelst J, Maeyaert J, Van Buyten JP, Opsomer F, Adriaensen H, Verlooy J, Van Havenbergh T, Smet M, Van Acker K. Endocrine Consequences of Long-Term Intrathecal Administration of Opioids. J Clin Endocrinol Metab. 2000 [cited 2023 Aug 26];85(6):2215–22. Available from: https://doi.org/10.1210/jcem.85.6.6615.

Donegan D, Bancos I. Opioid-Induced Adrenal Insufficiency. Mayo Clin Proc. 2018 [cited 2023 Aug 26];93(7):937–44. Available from: https://pubmed.ncbi.nlm.nih.gov/29976376/.

García García E, Ramírez Villar GL, Quiroga Cantero E. Megestrol-induced adrenal insufficiency in children and adolescents. Med Clin (Barc). 2022 [cited 2023 Oct 9];158(5):241–2. Available from: https://pubmed.ncbi.nlm.nih.gov/34074479/.

Han HS, Shim YK, Kim JE, Jeon HJ, Lim SN, Oh TK, Lee KH, Kim ST. A pilot study of adrenal suppression after dexamethasone therapy as an antiemetic in cancer patients. Support Care Cancer. 2012 [cited 2023 Sep 2];20(7):1565–72. Available from: https://pubmed-ncbi-nlm-nih-gov.myaccess.library.utoronto.ca/21850416/.

Bancos I, Hahner S, Tomlinson J, Arlt W. Diagnosis and management of adrenal insufficiency. Vol. 3, The Lancet Diabetes and Endocrinology. Lancet Publishing Group 2015:216–26.

Crowley RK, Hamnvik OP, O’Sullivan EP, Behan LA, Smith D, Agha A, Thompson CJ. Morbidity and mortality in patients with craniopharyngioma after surgery. Clin Endocrinol (Oxf). 2010 [cited 2023 Sep 9];73(4):516–21. Available from: https://pubmed.ncbi.nlm.nih.gov/20550527/.

O’Sullivan EP, Woods C, Glynn N, Behan LA, Crowley R, O’Kelly P, Smith D, Thompson CJ, Agha A. The natural history of surgically treated but radiotherapy-naïve nonfunctioning pituitary adenomas. Clin Endocrinol (Oxf). 2009 [cited 2023 Oct 9];71(5):709–14. Available from: https://pubmed.ncbi.nlm.nih.gov/19302582/.

Faria M, Nascimento GC, Faria AM, Martins MRA. Hypopituitarism. Endocrinol Diabetes A Probl Oriented Approach Second Ed. 2022 [cited 2024 Jan 16];61–78. Available from: https://www.ncbi.nlm.nih.gov/books/NBK278989/.

Agha A, Thompson CJ. Anterior pituitary dysfunction following traumatic brain injury (TBI). Clin Endocrinol (Oxf). 2006 [cited 2023 Sep 9];64(5):481–8. Available from: https://pubmed.ncbi.nlm.nih.gov/16649964/.

Agha A, Sherlock M, Brennan S, O’Connor SA, O’Sullivan E, Rogers B, Faul C, Rawluk D, Tormey W, Thompson CJ. Hypothalamic-pituitary dysfunction after irradiation of nonpituitary brain tumors in adults. J Clin Endocrinol Metab. 2005 [cited 2023 Sep 9];90(12):6355–60. Available from: https://pubmed.ncbi.nlm.nih.gov/16144946/.

Hassan-Smith ZK, Sherlock M, Reulen RC, Arlt W, Ayuk J, Toogood AA, Cooper MS, Johnson AP, Stewart PM. Outcome of Cushing’s disease following transsphenoidal surgery in a single center over 20 years. J Clin Endocrinol Metab. 2012 [cited 2023 Sep 10];97(4):1194–201. Available from: https://pubmed.ncbi.nlm.nih.gov/22278423/.

Abdelmannan D, Chaiban J, Selman WR, Arafah BM. Recurrences of ACTH-secreting adenomas after pituitary adenomectomy can be accurately predicted by perioperative measurements of plasma ACTH levels. J Clin Endocrinol Metab. 2013 [cited 2023 Sep 10];98(4):1458–65. Available from:

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