On Behalf of Endo ERN (MTG1), Nowotny H, Ahmed SF, Bensing S, Beun JG, Brösamle M, et al. Therapy options for adrenal insufficiency and recommendations for the management of adrenal crisis. Endocrine. 2021;71(3):586–94.

Article  Google Scholar 

Alexandraki KI, Sanpawithayakul K, Grossman A et al. Adrenal Insufficiency. In: Feingold KR, Anawalt B, Blackman MR, Boyce A, Chrousos G, Corpas E, editors. Endotext. South Dartmouth (MA): MDText.com, Inc.; 2000 [cited 2024 Jul 18]. http://www.ncbi.nlm.nih.gov/books/NBK279083/

Kara C, Ucaktürk A, Aydin ÖF, Aydin M. Adverse effect of phenytoin on glucocorticoid replacement in a child with adrenal insufficiency. J Pediatr Endocrinol Metab. 2010 [cited 2024 Jul 18];23(9). https://www.degruyter.com/document/doi/https://doi.org/10.1515/jpem.2010.154/html

Burke CW. 8 - Adrenocortical insufficiency.

Charmandari E, Nicolaides NC, Chrousos GP. Adrenal insufficiency. Lancet. 2014;383(9935):2152–67.

Article  PubMed  CAS  Google Scholar 

Mohd Azmi NAS, Juliana N, Azmani S, Mohd Effendy N, Abu IF, Mohd Fahmi Teng NI, et al. Cortisol on circadian rhythm and its effect on cardiovascular system. Int J Environ Res Public Health. 2021;18(2):676.

Article  PubMed  PubMed Central  Google Scholar 

Debono M, Ghobadi C, Rostami-Hodjegan A, Huatan H, Campbell MJ, Newell-Price J, et al. Modified-release hydrocortisone to provide circadian cortisol profiles. J Clin Endocrinol Metab. 2009;94(5):1548–54.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Khanna A, Khurana R, Kyriacou A, Davies R, Ray D. Management of adrenocortical insufficiency with continuous subcutaneous hydrocortisone infusion: long-term experience in three patients. Endocrinol Diabetes Metab Case Rep. 2015 [cited 2024 Feb 13];2015. https://edm.bioscientifica.com/view/journals/edm/2015/1/EDM15-0005.xml

Mortensen ML, Ornstrup MJ, Gravholt CH. Patients with hypocortisolism treated with continuous subcutaneous hydrocortisone infusion (CSHI): an option for poorly controlled patients. Falhammar H, editor. Int J Endocrinol. 2023;2023:1–8.

Gagliardi L, Nenke MA, Thynne TRJ, Von Der Borch J, Rankin WA, Henley DE, et al. Continuous subcutaneous hydrocortisone infusion therapy in Addison’s disease: a randomized, placebo-controlled clinical trial. J Clin Endocrinol Metab. 2014;99(11):4149–57.

Article  PubMed  CAS  Google Scholar 

Page MJ, Moher D, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD et al. PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews. BMJ. 2021;n160.

Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan—a web and mobile app for systematic reviews. Syst Rev. 2016;5(1):210.

Article  PubMed  PubMed Central  Google Scholar 

Sterne JAC, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;l4898.

Munn Z, Barker TH, Moola S, Tufanaru C, Stern C, McArthur A et al. Methodological quality of case series studies: an introduction to the JBI critical appraisal tool. JBI Database Syst Rev Implement Rep. 2019 [cited 2024 May 10];Publish Ahead of Print. https://journals.lww.com/https://doi.org/10.11124/JBISRIR-D-19-00099

Øksnes M, Björnsdottir S, Isaksson M, Methlie P, Carlsen S, Nilsen RM, et al. Continuous subcutaneous hydrocortisone infusion versus oral hydrocortisone replacement for treatment of Addison’s disease: a randomized clinical trial. J Clin Endocrinol Metab. 2014;99(5):1665–74.

Article  PubMed  Google Scholar 

Løvås K, Husebye ES. Continuous subcutaneous hydrocortisone infusion in Addison’s disease. Eur J Endocrinol. 2007;157(1):109–12.

Article  PubMed  Google Scholar 

Cardini F, Torlone E, Bini V, Falorni A. Continuous subcutaneous hydrocortisone infusion in a woman with secondary adrenal insufficiency. Endocrine. 2019;63(2):398–400.

Article  PubMed  CAS  Google Scholar 

Ebrahimi F, Widmer A, Wagner U, Mueller B, Schuetz P, Christ-Crain M, et al. Association of adrenal insufficiency with patient-oriented health-care outcomes in adult medical inpatients. Eur J Endocrinol. 2019;181(6):701–9.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gunnarsson C, Ryan MP, Marelli C, Baker ER, Stewart PM, Johannsson G, et al. Health care burden in patients with adrenal insufficiency. J Endocr Soc. 2017;1(5):512–23.

Article  PubMed  PubMed Central  Google Scholar 

Bornstein SR, Allolio B, Arlt W, Barthel A, Don-Wauchope A, Hammer GD, et al. Diagnosis and treatment of primary adrenal insufficiency: an endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2016;101(2):364–89.

Article  PubMed  CAS  Google Scholar 

Mah PM, Jenkins RC, Rostami-Hodjegan A, Newell‐Price J, Doane A, Ibbotson V, et al. Weight‐related dosing, timing and monitoring hydrocortisone replacement therapy in patients with adrenal insufficiency. Clin Endocrinol (Oxf). 2004;61(3):367–75.

Article  PubMed  CAS  Google Scholar 

Yasir M, Goyal A, Sonthalia S. Corticosteroid adverse effects. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024 [cited 2024 May 23]. http://www.ncbi.nlm.nih.gov/books/NBK531462/

Caetano CM, Malchoff CD. Daily glucocorticoid replacement dose in adrenal insufficiency, a mini review. Front Endocrinol. 2022;13:897211.

Article  Google Scholar 

Johannsson G, Bergthorsdottir R, Nilsson AG, Lennernas H, Hedner T, Skrtic S. Improving glucocorticoid replacement therapy using a novel modified-release hydrocortisone tablet: a pharmacokinetic study. Eur J Endocrinol. 2009;161(1):119–30.

Article  PubMed  CAS  Google Scholar 

Chabre O, Goichot B, Zenaty D, Bertherat J. Group 1. Epidemiology of primary and secondary adrenal insufficiency: prevalence and incidence, acute adrenal insufficiency, long-term morbidity and mortality. Ann Endocrinol. 2017;78(6):490–4.

Article  Google Scholar 

Stewart PM, Biller BMK, Marelli C, Gunnarsson C, Ryan MP, Johannsson G. Exploring inpatient hospitalizations and morbidity in patients with adrenal insufficiency. J Clin Endocrinol Metab. 2016;101(12):4843–50.

Article  PubMed  CAS  Google Scholar 

Rushworth RL, Torpy DJ. The changing epidemiology of adrenal insufficiency: iatrogenic factors predominate. J Endocr Soc. 2023;7(3):bvad017.

Article  PubMed  PubMed Central  Google Scholar 

Hahner S, Loeffler M, Fassnacht M, Weismann D, Koschker AC, Quinkler M, et al. Impaired subjective health status in 256 patients with adrenal insufficiency on standard therapy based on cross-sectional analysis. J Clin Endocrinol Metab. 2007;92(10):3912–22.

Article  PubMed  CAS  Google Scholar 

Li D, Brand S, Hamidi O, Westfall AA, Suresh M, Else T, et al. Quality of life and its determinants in patients with adrenal insufficiency: a survey study at 3 centers in the United States. J Clin Endocrinol Metab. 2022;107(7):e2851–61.

Article  PubMed  PubMed Central  Google Scholar 

Løvås K, Loge JH, Husebye ES. Subjective health status in Norwegian patients with Addison’s disease*. Clin Endocrinol (Oxf). 2002;56(5):581–8.

Article  PubMed  Google Scholar