Guillemin R, Brazeau P, Bohlen P, Esch F, Ling N, Wehrenberg WB. Growth hormone-releasing factor from a human pancreatic tumor that caused acromegaly. Science. 1982;218(4572):585–7. https://doi.org/10.1126/science.6812220.
Schally AV, Zhang X, Cai R, Hare JM, Granata R, Bartoli M. Actions and potential therapeutic applications of growth hormone-releasing hormone agonists. Endocrinology. 2019;160(7):1600–12. https://doi.org/10.1210/en.2019-00111.
Granata R. Peripheral activities of growth hormone-releasing hormone. J Endocrinol Invest. 2016;39(7):721–7. https://doi.org/10.1007/s40618-016-0440-x.
Article PubMed CAS Google Scholar
Frohman LA, Kineman RD. Growth hormone-releasing hormone and pituitary development, hyperplasia and tumorigenesis. Trends Endocrinol Metab. 2002;13(7):299–303. https://doi.org/10.1016/s1043-2760(02)00613-6.
Gesmundo I, Miragoli M, Carullo P, Trovato L, Larcher V, Di Pasquale E, Brancaccio M, Mazzola M, Villanova T, Sorge M, Taliano M, Gallo MP, Alloatti G, Penna C, Hare JM, Ghigo E, Schally AV, Condorelli G, Granata R. Growth hormone-releasing hormone attenuates cardiac hypertrophy and improves heart function in pressure overload-induced heart failure. Proc Natl Acad Sci U S A. 2017;114(45):12033–8. https://doi.org/10.1073/pnas.1712612114.
Article PubMed PubMed Central CAS Google Scholar
Liu Y, Yang J, Che X, Huang J, Zhang X, Fu X, Cai J, Yao Y, Zhang H, Cai R, Su X, Xu Q, Ren F, Cai R, Schally AV, Zhou MS. Agonistic analog of growth hormone-releasing hormone promotes neurofunctional recovery and neural regeneration in ischemic stroke. Proc Natl Acad Sci U S A. 2021;118(47). https://doi.org/10.1073/pnas.2109600118.
Ludwig B, Ziegler CG, Schally AV, Richter C, Steffen A, Jabs N, Funk RH, Brendel MD, Block NL, Ehrhart-Bornstein M, Bornstein SR. Agonist of growth hormone-releasing hormone as a potential effector for survival and proliferation of pancreatic islets. Proc Natl Acad Sci U S A. 2010;107(28):12623–8. https://doi.org/10.1073/pnas.1005098107.
Article PubMed PubMed Central Google Scholar
Boido M, Gesmundo I, Caretto A, Pedrolli F, Schellino R, Leone S, Cai R, Sha W, Ghigo E, Schally AV, Vercelli A, Granata R. Agonist of growth hormone-releasing hormone improves the disease features of spinal muscular atrophy mice. Proc Natl Acad Sci U S A. 2023;120(2):e2216814120. https://doi.org/10.1073/pnas.2216814120.
Article PubMed PubMed Central CAS Google Scholar
Schally AV, Varga JL, Engel JB. Antagonists of growth-hormone-releasing hormone: an emerging new therapy for cancer. Nat Clin Pract Endocrinol Metab. 2008;4(1):33–43. https://doi.org/10.1038/ncpendmet0677.
Rekasi Z, Czompoly T, Schally AV, Halmos G. Isolation and sequencing of cDNAs for splice variants of growth hormone-releasing hormone receptors from human cancers. Proc Natl Acad Sci U S A. 2000;97(19):10561–6. https://doi.org/10.1073/pnas.180313297.
Article PubMed PubMed Central CAS Google Scholar
Havt A, Schally AV, Halmos G, Varga JL, Toller GL, Horvath JE, Szepeshazi K, Koster F, Kovitz K, Groot K, Zarandi M, Kanashiro CA. The expression of the pituitary growth hormone-releasing hormone receptor and its splice variants in normal and neoplastic human tissues. Proc Natl Acad Sci U S A. 2005;102(48):17424–9. https://doi.org/10.1073/pnas.0506844102.
Article PubMed Central CAS Google Scholar
Kiaris H, Chatzistamou I, Schally AV, Halmos G, Varga JL, Koutselini H, Kalofoutis A. Ligand-dependent and -independent effects of splice variant 1 of growth hormone-releasing hormone receptor. Proc Natl Acad Sci U S A. 2003;100(16):9512–7. https://doi.org/10.1073/pnas.1533185100.
Article PubMed PubMed Central CAS Google Scholar
Xiong X, Ke X, Wang L, Yao Z, Guo Y, Zhang X, Chen Y, Pang CP, Schally AV, Zhang H. Splice variant of growth hormone-releasing hormone receptor drives esophageal squamous cell carcinoma conferring a therapeutic target. Proc Natl Acad Sci U S A. 2020;117(12):6726–32. https://doi.org/10.1073/pnas.1913433117.
Article PubMed PubMed Central CAS Google Scholar
Schally AV, Varga JL. Antagonistic analogs of growth hormone-releasing hormone: new potential antitumor agents. Trends Endocrinol Metab. 1999;10(10):383–91. https://doi.org/10.1016/s1043-2760(99)00209-x.
Article PubMed CAS Google Scholar
Cai R, Schally AV, Cui T, Szalontay L, Halmos G, Sha W, Kovacs M, Jaszberenyi M, He J, Rick FG, Popovics P, Kanashiro-Takeuchi R, Hare JM, Block NL, Zarandi M. Synthesis of new potent agonistic analogs of growth hormone-releasing hormone (GHRH) and evaluation of their endocrine and cardiac activities. Peptides. 2014;52:104–12. https://doi.org/10.1016/j.peptides.2013.12.010.
Zarandi M, Cai R, Kovacs M, Popovics P, Szalontay L, Cui T, Sha W, Jaszberenyi M, Varga J, Zhang X, Block NL, Rick FG, Halmos G, Schally AV. Synthesis and structure-activity studies on novel analogs of human growth hormone releasing hormone (GHRH) with enhanced inhibitory activities on tumor growth. Peptides. 2017;89:60–70. https://doi.org/10.1016/j.peptides.2017.01.009.
Cai R, Zhang X, Wang H, Cui T, Halmos G, Sha W, He J, Popovics P, Vidaurre I, Zhang C, Mirsaeidi M, Schally AV. Synthesis of potent antagonists of receptors for growth hormone-releasing hormone with antitumor and anti-inflammatory activity. Peptides. 2022;150:170716. https://doi.org/10.1016/j.peptides.2021.170716.
Article PubMed CAS Google Scholar
Barabutis N, Akhter MS, Kubra KT, Jackson K. Growth hormone-releasing hormone in endothelial inflammation. Endocrinology. 2022;164(2):bqac209. https://doi.org/10.1210/endocr/bqac209.
Zhang C, Cui T, Cai R, Wangpaichitr M, Mirsaeidi M, Schally AV, Jackson RM. Growth hormone-releasing hormone in lung physiology and pulmonary disease. Cells. 2020;9(10):2331. https://doi.org/10.3390/cells9102331.
Article PubMed PubMed Central CAS Google Scholar
Barabutis N, Schally AV, Siejka A. P53, GHRH, inflammation and cancer. EBioMedicine. 2018;37:557–62. https://doi.org/10.1016/j.ebiom.2018.10.034.
Schally AV, Perez R, Block NL, Rick FG. Potentiating effects of GHRH analogs on the response to chemotherapy. Cell Cycle. 2015;14(5):699–704. https://doi.org/10.1080/15384101.2015.1010893.
Article PubMed CAS Google Scholar
Gaumond SI, Abdin R, Costoya J, Schally AV, Jimenez JJ. Exploring the role of GHRH antagonist MIA-602 in overcoming Doxorubicin-resistance in acute myeloid leukemia. Oncotarget. 2024;15:248–54. https://doi.org/10.18632/oncotarget.28579.
Schally AV, Wang H, He J, Cai R, Sha W, Popovics P, Perez R, Vidaurre I, Zhang X. Agonists of growth hormone-releasing hormone (GHRH) inhibit human experimental cancers in vivo by down-regulating receptors for GHRH. Proc Natl Acad Sci U S A. 2018;115(47):12028–33. https://doi.org/10.1073/pnas.1813375115.
Article PubMed CAS Google Scholar
Matsoukas MT, Radomsky T, Panagiotopoulos V, Preez RD, Papadourakis M, Tsianakas K, Millar RP, Anderson RC, Spyroulias GA, Newton CL. Identification of small-molecule antagonists targeting the Growth Hormone Releasing Hormone Receptor (GHRHR). J Chem Inf Model. 2024. https://doi.org/10.1021/acs.jcim.4c00577.
Kiaris H, Schally AV, Varga JL, Groot K, Armatis P. Growth hormone-releasing hormone: an autocrine growth factor for small cell lung carcinoma. Proc Natl Acad Sci U S A. 1999;96(26):14894–8. https://doi.org/10.1073/pnas.96.26.14894.
Article PubMed Central CAS Google Scholar
Kiaris H, Schally AV, Varga JL. Suppression of tumor growth by growth hormone-releasing hormone antagonist JV-1-36 does not involve the inhibition of autocrine production of insulin-like growth factor II in H-69 small cell lung carcinoma. Cancer Lett. 2000;161(2):149–55. https://doi.org/10.1016/s0304-3835(00)00580-2.
Article PubMed CAS Google Scholar
Kubra KT, Akhter MS, Apperley K, Barabutis N. Growth hormone-releasing hormone antagonist JV-1-36 suppresses reactive oxygen species generation in A549 lung cancer cells. Endocrines. 2022;3(4):813–20. https://doi.org/10.3390/endocrines3040067.
Article PubMed CAS Google Scholar
Szereday Z, Schally AV, Varga JL, Kanashiro CA, Hebert F, Armatis P, Groot K, Szepeshazi K, Halmos G, Busto R. Antagonists of growth hormone-releasing hormone inhibit the proliferation of experimental non-small cell lung carcinoma. Cancer Res. 2003;63(22):7913–9.
Comments (0)