Mitrov-Winkelmolen, L. et al. The effect of Roux-en-Y gastric bypass surgery in morbidly obese patients on pharmacokinetics of (acetyl) salicylic acid and omeprazole: the ERY-PAO study. Obes. Surg. 26, 2051–2058 (2016).

Article  PubMed  Google Scholar 

Miedziaszczyk, M., Ciabach, P. & Szałek, E. The effects of bariatric surgery and gastrectomy on the absorption of drugs, vitamins, and mineral elements. Pharmaceutics 13, 2111 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Valgimigli, M. et al. Trade-off of myocardial infarction vs. bleeding types on mortality after acute coronary syndrome: lessons from the Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRACER) randomized trial. Eur. Heart J. 38, 804–810 (2017).

CAS  PubMed  Google Scholar 

Abraham, N. S. et al. American College of Gastroenterology-Canadian Association of Gastroenterology Clinical Practice Guideline: management of anticoagulants and antiplatelets during acute gastrointestinal bleeding and the periendoscopic period. J. Can. Assoc. Gastroenterol. 5, 100–101 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Mehran, R. et al. Associations of major bleeding and myocardial infarction with the incidence and timing of mortality in patients presenting with non-ST-elevation acute coronary syndromes: a risk model from the ACUITY trial. Eur. Heart J. 30, 1457–1466 (2009).

Article  PubMed  PubMed Central  Google Scholar 

Yasuda, H. et al. Treatment and prevention of gastrointestinal bleeding in patients receiving antiplatelet therapy. World J. Crit. Care Med. 4, 40–46 (2015).

Article  PubMed  PubMed Central  Google Scholar 

Abrignani, M. G. et al. Gastroprotection in patients on antiplatelet and/or anticoagulant therapy: a position paper of National Association of Hospital Cardiologists (ANMCO) and the Italian Association of Hospital Gastroenterologists and Endoscopists (AIGO). Eur. J. Intern. Med. 85, 1–13 (2021).

Article  CAS  PubMed  Google Scholar 

Kido, K. & Scalese, M. J. Management of oral anticoagulation therapy after gastrointestinal bleeding: whether to, when to, and how to restart an anticoagulation therapy. Ann. Pharmacother. 51, 1000–1007 (2017).

Article  CAS  PubMed  Google Scholar 

Scott, M. J., Veitch, A. & Thachil, J. Reintroduction of anti‐thrombotic therapy after a gastrointestinal haemorrhage: if and when? Br. J. Haematol. 177, 185–197 (2017).

Article  PubMed  Google Scholar 

Sengupta, N. et al. Management of patients with acute lower gastrointestinal bleeding: an updated ACG guideline. Am. J. Gastroenterol. 118, 208–231 (2023).

Article  PubMed  Google Scholar 

Abraham, N. S. et al. American College of Gastroenterology-Canadian Association of Gastroenterology Clinical Practice Guideline: management of anticoagulants and antiplatelets during acute gastrointestinal bleeding and the periendoscopic period. Am. J. Gastroenterol. 117, 542–558 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tomaselli, G. F. et al. 2020 ACC expert consensus decision pathway on management of bleeding in patients on oral anticoagulants: a report of the American College of Cardiology Solution Set Oversight Committee. J. Am. Coll. Cardiol. 76, 594–622 (2020).

Article  CAS  PubMed  Google Scholar 

European Association for the Study of the Liver EASL Clinical Practice Guidelines on prevention and management of bleeding and thrombosis in patients with cirrhosis. J. Hepatol. 76, 1151–1184 (2022).

Article  Google Scholar 

Sandercock, P. A., Counsell, C., Gubitz, G. J. & Tseng, M. C. Antiplatelet therapy for acute ischaemic stroke. Cochrane Database Syst. Rev. 1, CD000029 (2022).

Google Scholar 

Zafar, M. U., Farkouh, M. E., Fuster, V. & Chesebro, J. H. Crushed clopidogrel administered via nasogastric tube has faster and greater absorption than oral whole tablets. J. Interv. Cardiol. 22, 385–389 (2009).

Article  PubMed  Google Scholar 

Parodi, G. et al. Ticagrelor crushed tablets administration in STEMI patients: the MOJITO study. J. Am. Coll. Cardiol. 65, 511–512 (2015).

Article  PubMed  Google Scholar 

Rollini, F. et al. Crushed prasugrel tablets in patients with STEMI undergoing primary percutaneous coronary intervention: the CRUSH Study. J. Am. Coll. Cardiol. 67, 1994–2004 (2016).

Article  CAS  PubMed  Google Scholar 

Vlachojannis, G. J. et al. Effect of prehospital crushed prasugrel tablets in patients with ST-segment-elevation myocardial infarction planned for primary percutaneous coronary intervention: the randomized COMPARE CRUSH trial. Circulation 142, 2316–2328 (2020).

Article  CAS  PubMed  Google Scholar 

Gargiulo, G. et `al. Cangrelor, tirofiban, and chewed or standard prasugrel regimens in patients with ST-segment-elevation myocardial infarction: primary results of the FABOLUS-FASTER trial. Circulation 142, 441–454 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Angiolillo, D. J. et al. Bridging antiplatelet therapy with cangrelor in patients undergoing cardiac surgery. JAMA 307, 265–274 (2012).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vaduganathan, M. et al. Cangrelor with and without glycoprotein IIb/IIIa inhibitors in patients undergoing percutaneous coronary intervention. J. Am. Coll. Cardiol. 69, 176–185 (2017).

Article  CAS  PubMed  Google Scholar 

Ferreira Silva, R. & Rita Carvalho Garbi Novaes, M. Interactions between drugs and drug-nutrient in enteral nutrition: a review based on evidences. Nutr. Hosp. 30, 514–518 (2014).

PubMed  Google Scholar 

Klang, M., Graham, D. & McLymont, V. Warfarin bioavailability with feeding tubes and enteral formula. JPEN J. Parenter. Enter. Nutr. 34, 300–304 (2010).

Article  CAS  Google Scholar 

Hankey, G. J. & Eikelboom, J. W. Dabigatran etexilate: a new oral thrombin inhibitor. Circulation 123, 1436–1450 (2011).

Article  PubMed  Google Scholar 

Peterson, J. J. & Hoehns, J. D. Administration of direct oral anticoagulants through enteral feeding tubes. J. Pharm. Technol. 32, 196–200 (2016).

Article  CAS  PubMed Central  Google Scholar 

Duchin, K. et al. An open-label crossover study of the pharmacokinetics of the 60-mg edoxaban tablet crushed and administered either by a nasogastric tube or in apple puree in healthy adults. Clin. Pharmacokinet. 57, 221–228 (2018).

Article  CAS  PubMed  Google Scholar 

Moore, K. T. et al. Rivaroxaban crushed tablet suspension characteristics and relative bioavailability in healthy adults when administered orally or via nasogastric tube. Clin. Pharmacol. Drug. Dev. 3, 321–327 (2014).

Article  CAS  PubMed  Google Scholar 

Hobl, E. L. et al. Morphine decreases clopidogrel concentrations and effects: a randomized, double-blind, placebo-controlled trial. J. Am. Coll. Cardiol. 63, 630–635 (2014).

Article  CAS  PubMed  Google Scholar 

McEvoy, J. W. et al. Effect of intravenous fentanyl on ticagrelor absorption and platelet inhibition among patients undergoing percutaneous coronary intervention: the PACIFY randomized clinical trial (Platelet Aggregation With Ticagrelor Inhibition and Fentanyl). Circulation 137, 307–309 (2018).

Article  CAS  PubMed  Google Scholar 

Iglesias, J. F. et al. Effects of fentanyl versus morphine on ticagrelor-induced platelet inhibition in patients with ST-segment elevation myocardial infarction: the PERSEUS randomized trial. Circulation 142, 2479–2481 (2020).

Article  CAS  PubMed  Google Scholar 

Tavenier, A. H. et al. Impact of opioids on P2Y12 receptor inhibition in patients with ST-elevation myocardial infarction who are pre-treated with crushed ticagrelor: Opioids aNd crushed Ticagrelor In Myocardial infarction Evaluation (ON-TIME 3) trial. Eur. Heart J. Cardiovasc. Pharmacother. 8, 4–12 (2022).

Article  PubMed  Google Scholar 

Fernando, H. et al. Effects of lignocaine vs. opioids on antiplatelet activity of ticagrelor: the LOCAL trial. Eur. Heart J. 42, 4025–4036 (2021).

Article  CAS  PubMed  Google Scholar 

Fernando, H. et al. Lidocine versus opioids in myocardial infarction: the AVOID-2 randomized controlled trial. Eur. Heart J. Acute Cardiovasc. Care 12, 2–11 (2023).

Article  PubMed  Google Scholar 

Holm, M. et al. The MOVEMENT trial. J. Am. Heart Assoc. 8, e010152 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Franchi, F. et al. Effects of methylnaltrexone on ticagrelor-induced antiplatelet effects in coronary artery disease patients treated with morphine. JACC Cardiovasc. Interv. 12, 1538–1549 (2019).

Article  PubMed  Google Scholar 

Niezgoda, P. et al. Oral naloxone to overcome the morphine effect in acute coronary syndrome patients treated with ticagrelor – NARCOTIC trial. Cardiol. J. 29, 432–440 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Sikora, J. et al. Metoclopramide administration as a strategy to overcome morpHine-ticagrelor interaction in patients with unstable angina pectorIs – the METAMORPHOSIS trial. Thromb. Haemost. 118, 2126–2133 (2018).

Article  PubMed  Google Scholar 

Saad, M. et al. Impact of morphine treatment with and without metoclopramide coadministration on ticagrelor-induced platelet inhibition in acute myocardial infarction: the randomized MonAMI trial. Circulation 141, 1354–1356 (2020).