Bahit MC, Kochar A, Granger CB (2018) Post-myocardial infarction heart failure. JACC Heart Fail 6(3):179–186. https://doi.org/10.1016/j.jchf.2017.09.015

Article  PubMed  Google Scholar 

Berulava T, Buchholz E, Elerdashvili V, Pena T, Islam MR, Lbik D et al (2020) Changes in m6A RNA methylation contribute to heart failure progression by modulating translation. Eur J Heart Fail 22(1):54–66. https://doi.org/10.1002/ejhf.1672

Article  CAS  PubMed  Google Scholar 

Borlaug BA (2020) Evaluation and management of heart failure with preserved ejection fraction. Nat Rev Cardiol 17(9):559–573. https://doi.org/10.1038/s41569-020-0363-2

Article  CAS  PubMed  Google Scholar 

Chen X, Xu S, Zhao C, Liu B (2019) Role of TLR4/NADPH oxidase 4 pathway in promoting cell death through autophagy and ferroptosis during heart failure. Biochem Biophys Res Commun 516(1):37–43. https://doi.org/10.1016/j.bbrc.2019.06.015

Article  CAS  PubMed  Google Scholar 

Chien CS, Li JY, Chien Y, Wang ML, Yarmishyn AA, Tsai PH et al (2021) METTL3-dependent N6-methyladenosine RNA modification mediates the atherogenic inflammatory cascades in vascular endothelium. Proc Natl Acad Sci U S A 118(7):e2025070118. https://doi.org/10.1073/pnas.2025070118

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cruz MS, da Silva AMG, de Souza KSC, Luchessi AD, Silbiger VN (2020) miRNAs emerge as circulating biomarkers of post-myocardial infarction heart failure. Heart Fail Rev 25(2):321–329. https://doi.org/10.1007/s10741-019-09821-1

Article  PubMed  Google Scholar 

Del Re DP, Amgalan D, Linkermann A, Liu Q, Kitsis RN (2019) Fundamental mechanisms of regulated cell death and implications for Heart Disease. Physiol Rev 99(4):1765–1817. https://doi.org/10.1152/physrev.00022.2018

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dixit D, Prager BC, Gimple RC, Poh HX, Wang Y, Wu Q et al (2021) The RNA m6A reader YTHDF2 maintains Oncogene expression and is a targetable dependency in Glioblastoma Stem cells. Cancer Discov 11(2):480–499. https://doi.org/10.1158/2159-8290.CD-20-0331

Article  CAS  PubMed  Google Scholar 

Dorn LE, Lasman L, Chen J, Xu X, Hund TJ, Medvedovic M et al (2019) The N6-Methyladenosine mRNA methylase METTL3 controls Cardiac Homeostasis and Hypertrophy. Circulation 139(4):533–545. https://doi.org/10.1161/CIRCULATIONAHA.118.036146

Article  CAS  PubMed  Google Scholar 

Fan Z, Yang G, Zhang W, Liu Q, Liu G, Liu P et al (2021) Hypoxia blocks ferroptosis of hepatocellular carcinoma via suppression of METTL14 triggered YTHDF2-dependent silencing of SLC7A11. J Cell Mol Med 25(21):10197–10212. https://doi.org/10.1111/jcmm.16957

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fang X, Wang H, Han D, Xie E, Yang X, Wei J et al (2019) Ferroptosis as a target for protection against cardiomyopathy. Proc Natl Acad Sci U S A 116(7):2672–2680. https://doi.org/10.1073/pnas.1821022116

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Fang X, Cai Z, Wang H, Han D, Cheng Q, Zhang P et al (2020) Loss of Cardiac Ferritin H facilitates Cardiomyopathy via Slc7a11-Mediated ferroptosis. Circ Res 127(4):486–501. https://doi.org/10.1161/CIRCRESAHA.120.316509

Article  CAS  PubMed  Google Scholar 

Guan X, Li Z, Zhu S, Cheng M, Ju Y, Ren L et al (2021) Galangin attenuated cerebral ischemia-reperfusion injury by inhibition of ferroptosis through activating the SLC7A11/GPX4 axis in gerbils. Life Sci 264:118660. https://doi.org/10.1016/j.lfs.2020.118660

Article  CAS  PubMed  Google Scholar 

Hu H, Chen Y, Jing L, Zhai C, Shen L (2021) The Link between Ferroptosis and Cardiovascular diseases: a novel target for treatment. Front Cardiovasc Med 8:710963. https://doi.org/10.3389/fcvm.2021.710963

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ilieșiu AM, Hodorogea AS (2018) Treatment of Heart failure with preserved ejection fraction. Adv Exp Med Biol 1067:67–87. https://doi.org/10.1007/5584_2018_149

Article  PubMed  Google Scholar 

Jenča D, Melenovský V, Stehlik J, Staněk V, Kettner J, Kautzner J et al (2021) Heart failure after myocardial infarction: incidence and predictors. ESC Heart Fail 8(1):222–237. https://doi.org/10.1002/ehf2.13144

Article  PubMed  Google Scholar 

Koppula P, Zhuang L, Gan B (2021) Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy. Protein Cell 12(8):599–620. https://doi.org/10.1007/s13238-020-00789-5

Article  CAS  PubMed  Google Scholar 

Li N, Jiang W, Wang W, Xiong R, Wu X, Geng Q (2021) Ferroptosis and its emerging roles in cardiovascular diseases. Pharmacol Res 166:105466. https://doi.org/10.1016/j.phrs.2021.105466

Article  CAS  PubMed  Google Scholar 

Li N, Yi X, He Y, Huo B, Chen Y, Zhang Z et al (2022) Targeting Ferroptosis as a Novel Approach to alleviate aortic dissection. Int J Biol Sci 18(10):4118–4134. https://doi.org/10.7150/ijbs.72528

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin Y, Shen X, Ke Y, Lan C, Chen X, Liang B et al (2022) Activation of osteoblast ferroptosis via the METTL3/ASK1-p38 signaling pathway in high glucose and high fat (HGHF)-induced diabetic bone loss. FASEB J 36(3):e22147. https://doi.org/10.1096/fj.202101610R

Article  CAS  PubMed  Google Scholar 

Ma WQ, Sun XJ, Zhu Y, Liu NF (2021) Metformin attenuates hyperlipidaemia-associated vascular calcification through anti-ferroptotic effects. Free Radic Biol Med 165:229–242. https://doi.org/10.1016/j.freeradbiomed.2021.01.033

Article  CAS  PubMed  Google Scholar 

Melenovsky V, Petrak J, Mracek T, Benes J, Borlaug BA, Nuskova H et al (2017) Myocardial iron content and mitochondrial function in human heart failure: a direct tissue analysis. Eur J Heart Fail 19(4):522–530. https://doi.org/10.1002/ejhf.640

Article  CAS  PubMed  Google Scholar 

Pietrangelo A (2010) Hereditary hemochromatosis: pathogenesis, diagnosis, and treatment. Gastroenterology 139(2):393–408. 408.e1-2

Article  PubMed  Google Scholar 

Qin Y, Li L, Luo E, Hou J, Yan G, Wang D et al (2020) Role of m6A RNA methylation in cardiovascular disease (review). Int J Mol Med 46(6):1958–1972. https://doi.org/10.3892/ijmm.2020.4746

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qin Y, Qiao Y, Li L, Luo E, Wang D, Yao Y et al (2021) The m6A methyltransferase METTL3 promotes hypoxic pulmonary arterial hypertension. Life Sci 274:119366. https://doi.org/10.1016/j.lfs.2021.119366

Article  CAS  PubMed  Google Scholar 

Qiu Y, Cao Y, Cao W, Jia Y, Lu N (2020) The application of ferroptosis in diseases. Pharmacol Res 159:104919. https://doi.org/10.1016/j.phrs.2020.104919

Article  CAS  PubMed  Google Scholar 

Tomasoni D, Adamo M, Lombardi CM, Metra M (2019) Highlights in heart failure. ESC Heart Fail 6(6):1105–1127. https://doi.org/10.1002/ehf2.12555

Article  PubMed  Google Scholar 

Vausort M, Niedolistek M, Lumley AI, Oknińska M, Paterek A, Mączewski M et al (2022) Regulation of N6-Methyladenosine after myocardial infarction. Cells 11(15):2271. https://doi.org/10.3390/cells11152271

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xie Y, Hou W, Song X, Yu Y, Huang J, Sun X et al (2016) Ferroptosis: process and function. Cell Death Differ 23(3):369–379. https://doi.org/10.1038/cdd.2015.158

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu Y, Lv D, Yan C, Su H, Zhang X, Shi Y et al (2022) METTL3 promotes lung adenocarcinoma tumor growth and inhibits ferroptosis by stabilizing SLC7A11 m6A modification. Cancer Cell Int 22(1):11. https://doi.org/10.1186/s12935-021-02433-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu Y, Yan Y, Niu F, Wang Y, Chen X, Su G et al (2021) Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases. Cell Death Discov 7(1):193. https://doi.org/10.1038/s41420-021-00579-w

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang B, Xu Y, Cui X, Jiang H, Luo W, Weng X et al (2021) Alteration of m6A RNA methylation in heart failure with preserved ejection fraction. Front Cardiovasc Med 8:647806. https://doi.org/10.3389/fcvm.2021.647806

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang X, Zheng C, Gao Z, Chen H, Li K, Wang L et al (2022) SLC7A11/xCT prevents Cardiac Hypertrophy by inhibiting ferroptosis. Cardiovasc Drugs Ther 36(3):437–447. https://doi.org/10.1007/s10557-021-07220-z