The SOX2/PDIA6 axis mediates aerobic glycolysis to promote stemness in non-small cell lung cancer cells

Bai Y, Liu X, Qi X, Liu X, Peng F, Li H et al (2019) PDIA6 modulates apoptosis and autophagy of non-small cell lung cancer cells via the MAP4K1/JNK signaling pathway. EBioMedicine 42:311–325

Article  PubMed  PubMed Central  Google Scholar 

Bi L, Ren Y, Feng M, Meng P, Wang Q, Chen W et al (2021) HDAC11 regulates Glycolysis through the LKB1/AMPK Signaling Pathway to maintain Hepatocellular Carcinoma Stemness. Cancer Res 81:2015–2028

Article  CAS  PubMed  Google Scholar 

Cai S, Li N, Bai X, Liu L, Banerjee A, Lavudi K et al (2022) ERK inactivation enhances stemness of NSCLC cells via promoting slug-mediated epithelial-to-mesenchymal transition. Theranostics 12:7051–7066

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chaudhary S, Islam Z, Mishra V, Rawat S, Ashraf GM, Kolatkar PR (2019) Sox2: a Regulatory factor in Tumorigenesis and metastasis. Curr Protein Pept Sci 20:495–504

Article  CAS  PubMed  Google Scholar 

Fujimoto J, Wistuba II (2014) Current concepts on the molecular pathology of non-small cell lung carcinoma. Semin Diagn Pathol 31:306–313

Article  PubMed  PubMed Central  Google Scholar 

He H, Xiao L, Wang J, Guo D, Lu Z (2023) Aerobic glycolysis promotes tumor immune evasion and tumor cell stemness through the noncanonical function of hexokinase 2. Cancer Commun (Lond) 43:387–390

Article  PubMed  Google Scholar 

Kasashima H, Duran A, Martinez-Ordonez A, Nakanishi Y, Kinoshita H, Linares JF et al (2021) Stromal SOX2 Upregulation promotes tumorigenesis through the generation of a SFRP1/2-Expressing Cancer-Associated Fibroblast Population. Dev Cell 56:95–110e10

Article  CAS  PubMed  Google Scholar 

Kikuchi M, Doi E, Tsujimoto I, Horibe T, Tsujimoto Y (2002) Functional analysis of human P5, a protein disulfide isomerase homologue. J Biochem 132:451–455

Article  CAS  PubMed  Google Scholar 

Li SN, Wu JF (2020) TGF-beta/SMAD signaling regulation of mesenchymal stem cells in adipocyte commitment. Stem Cell Res Ther 11:41

Article  PubMed  PubMed Central  Google Scholar 

Ma Y, Xia P, Wang Z, Xu J, Zhang L, Jiang Y (2021) PDIA6 promotes pancreatic cancer progression and immune escape through CSN5-mediated deubiquitination of beta-catenin and PD-L1. Neoplasia 23:912–928

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma Y, Zhu Y, Shang L, Qiu Y, Shen N, Wang J et al (2023) LncRNA XIST regulates breast cancer stem cells by activating proinflammatory IL-6/STAT3 signaling. Oncogene 42:1419–1437

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mamun MA, Mannoor K, Cao J, Qadri F, Song X (2020) SOX2 in cancer stemness: tumor malignancy and therapeutic potentials. J Mol Cell Biol 12:85–98

Article  PubMed  Google Scholar 

Mao L, Wu X, Gong Z, Yu M, Huang Z (2021) PDIA6 contributes to aerobic glycolysis and cancer progression in oral squamous cell carcinoma. World J Surg Oncol 19:88

Article  PubMed  PubMed Central  Google Scholar 

Meshulami N, Tavolacci S, de Miguel-Perez D, Rolfo C, Mack PC, Hirsch FR (2023) Predictive capability of PD-L1 protein expression for patients with Advanced NSCLC: any differences based on histology? Clin Lung Cancer 24:401–406

Article  CAS  PubMed  Google Scholar 

Mestre-Farras N, Guerrero S, Bley N, Rivero E, Coll O, Borras E et al (2022) Melanoma RBPome identification reveals PDIA6 as an unconventional RNA-binding protein involved in metastasis. Nucleic Acids Res 50:8207–8225

Article  CAS  PubMed  PubMed Central  Google Scholar 

Novak D, Huser L, Elton JJ, Umansky V, Altevogt P, Utikal J (2020) SOX2 in development and cancer biology. Semin Cancer Biol 67:74–82

Article  CAS  PubMed  Google Scholar 

Pajak B, Siwiak E, Soltyka M, Priebe A, Zielinski R, Fokt I et al (2019) 2-Deoxy-d-Glucose and its analogs: from Diagnostic to Therapeutic agents. Int J Mol Sci. ; 21

Rao CV, Mohammed A (2015) New insights into pancreatic cancer stem cells. World J Stem Cells 7:547–555

Article  PubMed  PubMed Central  Google Scholar 

Rodriguez-Canales J, Parra-Cuentas E, Wistuba II (2016) Diagnosis and molecular classification of Lung Cancer. Cancer Treat Res 170:25–46

Article  PubMed  Google Scholar 

Siegel RL, Miller KD, Wagle NS, Jemal A (2023) Cancer statistics, 2023. CA Cancer J Clin 73:17–48

Article  PubMed  Google Scholar 

Sikandar SS, Pate KT, Anderson S, Dizon D, Edwards RA, Waterman ML et al (2010) NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancer. Cancer Res 70:1469–1478

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun WH, Chen YH, Lee HH, Tang YW, Sun KH (2022) PDK1- and PDK2-mediated metabolic reprogramming contributes to the TGFbeta1-promoted stem-like properties in head and neck cancer. Cancer Metab 10:23

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A et al (2021) Global Cancer statistics 2020: GLOBOCAN estimates of incidence and Mortality Worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71:209–249

Article  PubMed  Google Scholar 

Takebe N, Miele L, Harris PJ, Jeong W, Bando H, Kahn M et al (2015) Targeting notch, hedgehog, and wnt pathways in cancer stem cells: clinical update. Nat Rev Clin Oncol 12:445–464

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tang Q, Chen J, Di Z, Yuan W, Zhou Z, Liu Z et al (2020) TM4SF1 promotes EMT and cancer stemness via the Wnt/beta-catenin/SOX2 pathway in colorectal cancer. J Exp Clin Cancer Res 39:232

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang L, Wang X, Wang CC (2015) Protein disulfide-isomerase, a folding catalyst and a redox-regulated chaperone. Free Radic Biol Med 83:305–313

Article  CAS  PubMed  Google Scholar 

Wang X, Chen Y, Wang X, Tian H, Wang Y, Jin J et al (2021) Stem cell factor SOX2 confers ferroptosis resistance in Lung Cancer via Upregulation of SLC7A11. Cancer Res 81:5217–5229

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang J, Shao F, Yang Y, Wang W, Yang X, Li R et al (2022) A non-metabolic function of hexokinase 2 in small cell lung cancer: promotes cancer cell stemness by increasing USP11-mediated CD133 stability. Cancer Commun (Lond) 42:1008–1027

Article  PubMed  Google Scholar 

Xie Q, Zhao S, Liu W, Cui Y, Li F, Li Z et al (2021) YBX1 enhances metastasis and stemness by transcriptionally regulating MUC1 in Lung Adenocarcinoma. Front Oncol 11:702491

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu Q, Zhang Q, Ishida Y, Hajjar S, Tang X, Shi H et al (2017) EGF induces epithelial-mesenchymal transition and cancer stem-like cell properties in human oral cancer cells via promoting Warburg effect. Oncotarget 8:9557–9571

Article  PubMed  Google Scholar 

Yan C, Song X, Wang S, Wang J, Li L (2020) Knockdown of PDIA6 inhibits cell proliferation and enhances the Chemosensitivity in Gastric Cancer cells. Cancer Manag Res 12:11051–11062

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu JM, Sun W, Wang ZH, Liang X, Hua F, Li K et al (2019) TRIB3 supports breast cancer stemness by suppressing FOXO1 degradation and enhancing SOX2 transcription. Nat Commun 10:5720

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Zhu T, Zheng J, Zhuo W, Pan P, Li M, Zhang W et al (2021) ETV4 promotes breast cancer cell stemness by activating glycolysis and CXCR4-mediated sonic hedgehog signaling. Cell Death Discov 7:126

Article  CAS  PubMed  PubMed Central  Google Scholar 

Comments (0)

No login
gif