Atrial Fibrillation Complicating Acute Myocardial Infarction: Prevalence, Impact, and Management Considerations

Frederiksen TC, Dahm CC, Preis SR, Lin H, Trinquart L, Benjamin EJ, Kornej J. The bidirectional association between atrial fibrillation and myocardial infarction. Nat Rev Cardiol. 2023;20(9):631–44. https://doi.org/10.1038/s41569-023-00857-3. This study showed the risk of incident AF was higher in patients with MI vs no MI. The risk of incident MI was higher in patients with AF vs no AF. Coexisting AF and MI was associated with higher mortality compared to only MI or AF.

Article  PubMed  Google Scholar 

Jabre P, Roger VL, Murad MH, Chamberlain AM, Prokop L, Adnet F, Jouven X. Mortality associated with atrial fibrillation in patients with myocardial infarction: a systematic review and meta-analysis. Circulation. 2011;123(15):1587–93. https://doi.org/10.1161/CIRCULATIONAHA.110.986661.

Article  PubMed  PubMed Central  Google Scholar 

Angeli F, Reboldi G, Garofoli M, Ramundo E, Poltronieri C, Mazzotta G, Verdecchia P. Atrial fibrillation and mortality in patients with acute myocardial infarction: a systematic overview and meta-analysis. Curr Cardiol Rep. 2012;14(5):601–10. https://doi.org/10.1007/s11886-012-0289-3.

Article  PubMed  Google Scholar 

Lind L, Sundström J, Ärnlöv J, Ingelsson M, Henry A, Lumbers RT, Lampa E. Life-time covariation of major cardiovascular diseases: A 40-year longitudinal study and genetic studies. Circulation Genomic and Precision Medicine. 2021;14(2): e002963. https://doi.org/10.1161/CIRCGEN.120.002963.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Axelrod M, Gilutz H, Plakht Y, Greenberg D, Novack L. Early atrial fibrillation during acute myocardial infarction may not be an indication for long-term anticoagulation. Angiology. 2020;71(6):559–66. https://doi.org/10.1177/0003319720908760.

Article  CAS  PubMed  Google Scholar 

Asanin MR, Vasiljevic ZM, Matic MD, Mrdovic IB, Perunicic JP, Matic DP, Ostojic MC. The long-term risk of stroke in patients with acute myocardial infarction complicated with new-onset atrial fibrillation. Clin Cardiol. 2009;32(8):467–70. https://doi.org/10.1002/clc.20603.

Article  PubMed  Google Scholar 

Mori H, Fukui K, Maeda A, Akashi Y, Ako J, Ikari Y, Suzuki H. Impact of atrial fibrillation and the clinical outcomes in patients with acute myocardial infarction from the K-ACTIVE registry. J Cardiol. 2022;79(6):768–75. https://doi.org/10.1016/j.jjcc.2022.02.007.

Article  PubMed  Google Scholar 

Zeymer U, Annemans L, Danchin N, Pocock S, Newsome S, Van de Werf F, Bueno H. Impact of known or new-onset atrial fibrillation on 2-year cardiovascular event rate in patients with acute coronary syndromes: results from the prospective EPICOR Registry. Eur Heart J Acute Cardiovasc Care. 2019;8(2):121–9. https://doi.org/10.1177/2048872618769057.

Article  PubMed  Google Scholar 

• Obayashi Y, Shiomi H, Morimoto T, Tamaki Y, Inoko M, Yamamoto K, … CREDO-Kyoto AMI Registry Wave-2 Investigators. Newly diagnosed atrial fibrillation in acute myocardial infarction. J Am Heart Assoc. 2021;10(18):e021417. https://doi.org/10.1161/JAHA.121.021417This study showed newly diagnosed AF increased risk of mortality, HF hospitalization, and major bleeding higher than no AF and comparable to prior AF.

Dai Y, On behalf of the CAMI Registry study group, Yang J, Gao Z, Xu H, Sun Y, … Yang Y. Atrial fibrillation in patients hospitalized with acute myocardial infarction: analysis of the china acute myocardial infarction (CAMI) registry. BMC Cardiovasc Disord. 2017;17(1). https://doi.org/10.1186/s12872-016-0442-9

Luo J, Xu S, Li H, Li Z, Liu B, Qin X, … Wei Y. Long-term impact of new-onset atrial fibrillation complicating acute myocardial infarction on heart failure. ESC Heart Failure 2020;7(5):2762–2772. https://doi.org/10.1002/ehf2.12872

McIntyre WF, Um KJ, Cheung CC, Belley-Côté EP, Dingwall O, Devereaux PJ, … Healey JS.  Atrial fibrillation detected initially during acute medical illness: A systematic review. Eur Heart J Acute Cardiovasc Care 2019;8(2):130–141. https://doi.org/10.1177/2048872618799748.

McIntyre WF, Vadakken ME, Rai AS, Thach T, Syed W, Um KJ, … Belley-Côté EP. Incidence and recurrence of new-onset atrial fibrillation detected during hospitalization for non-cardiac surgery: a systematic review and meta-analysis. Journal Canadien d’anesthesie [Can J Anaesth]. 2021;68(7):1045–1056. https://doi.org/10.1007/s12630-021-01944-0.

Obayashi Y, Shiomi H, Morimoto T, Tamaki Y, Inoko M, Yamamoto K, … CREDO-Kyoto AMI Registry Wave-2 Investigators. Newly diagnosed atrial fibrillation in acute myocardial infarction. J Am Heart Associ. 2021;10(18):e021417. https://doi.org/10.1161/JAHA.121.021417.

Jons, C., Jacobsen, U. G., Joergensen, R. M., Olsen, N. T., Dixen, U., Johannessen, A., … Cardiac Arrhythmias and Risk Stratification after Acute Myocardial Infarction (CARISMA) Study Group. The incidence and prognostic significance of new-onset atrial fibrillation in patients with acute myocardial infarction and left ventricular systolic dysfunction: a CARISMA substudy. Heart Rhythm: Official J Heart Rhythm Soc. 2011;8(3):342–8. https://doi.org/10.1016/j.hrthm.2010.09.090.

Fauchier L, Bisson A, Bodin A, Herbert J, Angoulvant D, Danchin N, Cottin Y. Outcomes in patients with acute myocardial infarction and new atrial fibrillation: a nationwide analysis. Clinical Research in Cardiology: Official Journal of the German Cardiac Society. 2021;110(9):1431–8. https://doi.org/10.1007/s00392-021-01805-2.

Article  PubMed  Google Scholar 

Luo J, Liu B, Li H, Xu S, Gong M, Li Z, … We, Y. Prognostic impact of the symptom of New-onset atrial fibrillation in acute myocardial infarction: Insights from the NOAFCAMI-SH registry. Frontiers in Cardiovascular Medicine 2021;8:677695. https://doi.org/10.3389/fcvm.2021.677695.

Frederiksen, T. C., Trinquart, L., Lin, H., Dahm, C. C., Christiansen, M. K., Jensen, H. K., … Kornej, J. (). Po-05–167 The bidirectional association between atrial fibrillation and myocardial infarction in the Framingham heart study. Heart Rhythm: Official J Heart Rhythm Soc. 2023;20(5):S661–S662. https://doi.org/10.1016/j.hrthm.2023.03.1381.

Romanov A, Martinek M, Pürerfellner H, et al. Incidence of atrial fibrillation detected by continuous rhythm monitoring after acute myocardial infarction in patients with preserved left ventricular ejection fraction: results of the ARREST study [published correction appears in Europace. 2017 May 1;19(5):811]. Europace. 2018;20(2):263–270. https://doi.org/10.1093/europace/euw344

Bauer A, Sappler N, von Stülpnagel L, Klemm M, Schreinlechner M, Wenner F, … SMART-MI-DZHK9 investigators. Telemedical cardiac risk assessment by implantable cardiac monitors in patients after myocardial infarction with autonomic dysfunction (SMART-MI-DZHK9): a prospective investigator-initiated, randomised, multicentre, open-label, diagnostic trial. Lancet Digital Health. 2022;4(2):e105–e116. https://doi.org/10.1016/S2589-7500(21)00253-3

Bloch Thomsen, P. E., Jons, C., Raatikainen, M. J. P., Moerch Joergensen, R., Hartikainen, J., Virtanen, V., … Cardiac Arrhythmias and Risk Stratification After Acute Myocardial Infarction (CARISMA) Study Group. Long-term recording of cardiac arrhythmias with an implantable cardiac monitor in patients with reduced ejection fraction after acute myocardial infarction: the Cardiac Arrhythmias and Risk Stratification After Acute Myocardial Infarction (CARISMA) study. Circulation. 2010;122(13):1258–64. https://doi.org/10.1161/CIRCULATIONAHA.109.902148.

Article  Google Scholar 

Rubenstein JC, Cinquegrani MP, Wright J. Atrial fibrillation in acute coronary syndrome. J Atri Fibrillation. 2012;5(1):551. https://doi.org/10.4022/jafib.551.

Article  Google Scholar 

Skalidis EI, Hamilos MI, Karalis IK, Chlouverakis G, Kochiadakis GE, Vardas PE. Isolated atrial microvascular dysfunction in patients with lone recurrent atrial fibrillation. J Am Coll Cardiol. 2008;51(21):2053–7. https://doi.org/10.1016/j.jacc.2008.01.055.

Article  PubMed  Google Scholar 

Sagnard A, Guenancia C, Mouhat B, Maza M, Fichot M, Moreau D, … Zeller M. Involvement of autonomic nervous system in new-onset atrial fibrillation during acute myocardial infarction. JClin Med. 2020;9(5):1481. https://doi.org/10.3390/jcm9051481.

Karabağ Y, Rencuzogullari I, Çağdaş M, Karakoyun S, Yesin M, Uluganyan M, … Tanboğa Hİ.  Association between BNP levels and new-onset atrial fibrillation. Herz. 2018;43(6):548–554. https://doi.org/10.1007/s00059-017-4598-6.

Parashar S, Kella D, Reid KJ, Spertus JA, Tang F, Langberg J, … Lloyd MS. New-onset atrial fibrillation after acute myocardial infarction and its relation to admission biomarkers (from the TRIUMPH registry). Am J Cardiol. 2013;112(9):1390–1395. https://doi.org/10.1016/j.amjcard.2013.07.006.

Corban MT, Godo S, Burczak DR, Noseworthy PA, Toya T, Lewis BR, … Lerman A. Coronary endothelial dysfunction is associated with increased risk of incident atrial fibrillation. J Am Heart Assoc. 2020;9(8):e014850. https://doi.org/10.1161/JAHA.119.014850.

Díez-Delhoyo F, Gutiérrez-Ibañes E, Sanz-Ruiz R, Vázquez-Álvarez ME, González Saldívar H, Rivera Juárez A, … Fernández-Avilés F. Prevalence of microvascular and endothelial dysfunction in the nonculprit territory in patients with acute myocardial infarction. Circ Cardiovasc Interv. 2019;12(2):e007257. https://doi.org/10.1161/CIRCINTERVENTIONS.118.007257.

Aronson D, Mutlak D, Bahouth F, Bishara R, Hammerman H, Lessick J, … Agmon Y. Restrictive left ventricular filling pattern and risk of new-onset atrial fibrillation after acute myocardial infarction. Am J Cardiol. 2011;107(12):1738–1743. https://doi.org/10.1016/j.amjcard.2011.02.334.

Psychari SN, Apostolou TS, Sinos L, Hamodraka E, Liakos G, Kremastinos DT. Relation of elevated C-reactive protein and interleukin-6 levels to left atrial size and duration of episodes in patients with atrial fibrillation. Am J Cardiol. 2005;95(6):764–7. https://doi.org/10.1016/j.amjcard.2004.11.032.

Article  CAS  PubMed  Google Scholar 

Stacy, M. R., Lin, B. A., Thorn, S. L., Lobb, D. C., Maxfield, M. W., Novack, C., … Spinale, F. G. (2022). Regional heterogeneity in determinants of atrial matrix remodeling and association with atrial fibrillation vulnerability postmyocardial infarction. Heart Rhythm: The Official J Heart Rhythm Soc. 2022;19(5):847–855. https://doi.org/10.1016/j.hrthm.2022.01.022.

Zhang E-Y, Cui L, Li Z-Y, Liu T, Li G-P. High Killips class as a predictor of new-onset atrial fibrillation following acute myocardial infarction: Systematic review and meta-analysis. Chin Med J. 2015;128(14):1964–8. https://doi.org/10.4103/0366-6999.160565.

Article  PubMed  PubMed Central  Google Scholar 

Li Y.-G, Bisson A, Bodin A, Herbert J, Grammatico-Guillon L, Joung B, … Fauchier L. C2 HEST score and prediction of incident atrial fibrillation in poststroke patients: A French nationwide study. J Am Heart Assoc. 2019;8(13):e012546. https://doi.org/10.1161/JAHA.119.012546.

Li Y-G, Pastori D, Farcomeni A, Yang P-S, Jang E, Joung B, … Lip GYH. A simple clinical risk score (C2HEST) for predicting incident atrial fibrillation in Asian subjects: Derivation in 471,446 Chinese subjects, with internal validation and external application in 451,199 Korean subjects. Chest. 2019;155(3):510–518. https://doi.org/10.1016/j.chest.2018.09.011.

Ruwald AC, Gang U, Thomsen PEB, Jørgensen RM, Ruwald MH, Huikuri HV, Jons C. The predictive value of CHADS2 risk score in post myocardial infarction arrhythmias - a Cardiac Arrhythmias and RIsk Stratification after Myocardial infArction (CARISMA) substudy. Int J Cardiol. 2014;173(3):441–6. https://doi.org/10.1016/j.ijcard.2014.03.010.

Article  PubMed  Google Scholar 

Biccirè FG, Tanzilli G, Prati F, Sammartini E, Gelfusa M, Celeski M, … Pastori D. Prediction of new onset atrial fibrillation in patients with acute coronary syndrome undergoing percutaneous coronary intervention using the C2HEST and mC2HEST scores: A report from the multicenter REALE-ACS registry. Int J Cardiol. 2023;386:45–49. https://doi.org/10.1016/j.ijcard.2023.05.023This study showed the C2HEST score may be a valuable tool to identify ACS patients who are at higher risk of new onset atrial fibrillation.

Asanin M, Stankovic S, Mrdovic I, Matic D, Savic L, Majkic-Singh N, … Vasiljevic Z. B-type natriuretic peptide predicts new-onset atrial fibrillation in patients with ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention. Peptides. 2012;35(1):74–77. https://doi.org/10.1016/j.peptides.2012.02.022.

Wang J, Hu S, Liang C, Ling Y. The association between systemic inflammatory response index and new-onset atrial fibrillation in patients with ST-elevated myocardial infarction treated with percutaneous coronary intervention. BMC Cardiovasc Disord. 2022;22(1):525. https://doi.org/10.1186/s12872-022-02989-9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ling Y, Fu C, Fan Q, Liu J, Jiang L, Tang S. Triglyceride-glucose index and new-onset atrial fibrillation in ST-segment elevation myocardial infarction patients after percutaneous coronary intervention. Front Cardiovasc Med. 2022;9:838761. https://doi.org/10.3389/fcvm.2022.838761.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lancini D, Prasad A, Thomas L, Atherton J, Martin P, Prasad S. Predicting new onset atrial fibrillation post acute myocardial infarction: Echocardiographic assessment of left atrial size. Echocardiography. 2023;40(6):456–3. https://doi.org/10.1111/echo.15574.

Article  PubMed  Google Scholar 

Reinstadler SJ, Stiermaier T, Eitel C, Fuernau G, Saad M, Pöss J, … Eitel I. Impact of atrial fibrillation during ST-segment-elevation myocardial infarction on infarct characteristics and prognosis. Circ Cardiovasc Imaging. 2018;11(2):e006955. https://doi.org/10.1161/CIRCIMAGING.117.006955.

Yildirim E, Ermis E, Allahverdiyev S, Ucar H, Cengiz M. Value of syntax score II in prediction of new-onset atrial fibrillation in patients with NSTE-ACS undergoing percutaneous coronary intervention. Angiology. 2019;70(9):860–6. https://doi.org/10.1177/0003319719854242.

Article  PubMed  Google Scholar 

Thomsen AF, Jøns C, Jabbari R, Jacobsen MR, Stampe NK, Butt JH, ... Jacobsen PK. Long-term risk of new-onset arrhythmia in ST-segment elevation myocardial infarction according to revascularization status. EP Europace. 2023;25(3):931–9. https://doi.org/10.1093/europace/euac242.

Article  Google Scholar 

Luo J, Xu S, Li H, Li Z, Liu B, Qin X, Gong M, Shi B, Wei Y. Long-term impact of new-onset atrial fibrillation complicating acute myocardial infarction on heart failure. ESC Heart Failure. 2020;7:2762–72. https://doi.org/10.1002/ehf2.12872.

Article  PubMed  PubMed Central  Google Scholar 

Guenancia C, Toucas C, Fauchier L, Stamboul K, Garnier F, Mouhat B, ... Cottin Y. High rate of recurrence at long-term follow-up after new-onset atrial fibrillation during acute myocardial infarction. EP Europace. 2018;20(12):e179–88. https://doi.org/10.1093/europace/euy168.

Article  PubMed  Google Scholar 

Mohamed MO, Kirchhof P, Vidovich M, Savage M, Rashid M, Kwok CS, … Mamas MA. Effect of concomitant atrial fibrillation on in-hospital outcomes of non-ST-elevation-acute coronary syndrome-related hospitalizations in the United States.  Am J Cardiol. 2019;124(4):465–475. https://doi.org/10.1016/j.amjcard.2019.05.040.

Fernandes GC, Kovacs R, Abbott JD, Subacius H, Dyal MD, Goldberger JJ, Outcomes of Beta-Blocker Therapy After Myocardial Infarction (OBTAIN) Investigators. Determinants of early and late in-hospital mortality after acute myocardial infarction: A subanalysis of the OBTAIN registry. Can J Cardiol. 2023;39(4):531–537. https://doi.org/10.1016/j.cjca.2022.10.019.

Schmitt J, Duray G, Gersh BJ, Hohnloser SH. Atrial fibrillation in acute myocardial infarction: a systematic review of the incidence, clinical features and prognostic implications. Eur Heart J. 2009;30(9):1038–45. https://doi.org/10.1093/eurheartj/ehn579.

Article  PubMed  Google Scholar 

Siu C-W, Jim M-H, Ho H-H, Miu R, Lee SWL, Lau C-P, Tse H-F. Transient atrial fibrillation complicating acute inferior myocardial infarction: implications for future risk of ischemic stroke. Chest. 2007;132(1):44–9. https://doi.org/10.1378/chest.06-2733.

Article  PubMed 

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