Serum and salivary inflammatory biomarkers in juvenile idiopathic arthritis—an explorative cross-sectional study

Ravelli A, Martini A. Juvenile idiopathic arthritis. Lancet. 2007;369(9563):767–78.

Article  CAS  PubMed  Google Scholar 

Petty RE, Southwood TR, Manners P, Baum J, Glass DN, Goldenberg J, et al. International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001. J Rheumatol. 2004;31(2):390–2.

PubMed  Google Scholar 

Thierry S, Fautrel B, Lemelle I, Guillemin F. Prevalence and incidence of juvenile idiopathic arthritis: a systematic review. Joint Bone Spine. 2014;81(2):112–7.

Article  PubMed  Google Scholar 

Zaripova LN, Midgley A, Christmas SE, Beresford MW, Baildam EM, Oldershaw RA. Juvenile idiopathic arthritis: from aetiopathogenesis to therapeutic approaches. Pediatr Rheumatol Online J. 2021;19(1):135.

Article  PubMed  PubMed Central  Google Scholar 

de Jager W, Hoppenreijs EP, Wulffraat NM, Wedderburn LR, Kuis W, Prakken BJ. Blood and synovial fluid cytokine signatures in patients with juvenile idiopathic arthritis: a cross-sectional study. Ann Rheum Dis. 2007;66(5):589–98.

Article  PubMed  Google Scholar 

Qu H, Sundberg E, Aulin C, Neog M, Palmblad K, Horne AC, et al. Immunoprofiling of active and inactive systemic juvenile idiopathic arthritis reveals distinct biomarkers: a single-center study. Pediatr Rheumatol Online J. 2021;19(1):173.

Article  PubMed  PubMed Central  Google Scholar 

Cimaz R, Maioli G, Calabrese G. Current and emerging biologics for the treatment of juvenile idiopathic arthritis. Expert Opin Biol Ther. 2020;20(7):725–40.

Article  CAS  PubMed  Google Scholar 

Ringold S, Angeles-Han ST, Beukelman T, Lovell D, Cuello CA, Becker ML, et al. 2019 American College of Rheumatology/Arthritis Foundation Guideline for the treatment of juvenile idiopathic arthritis: therapeutic approaches for non-systemic polyarthritis, sacroiliitis, and enthesitis. Arthritis Care Res (Hoboken). 2019;71(6):717–34.

Article  PubMed  Google Scholar 

Armaroli G, Klein A, Ganser G, Ruehlmann MJ, Dressler F, Hospach A, et al. Long-term safety and effectiveness of etanercept in JIA: an 18-year experience from the BiKeR registry. Arthritis Res Ther. 2020;22(1):258.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Elfving A, Harila-Saari A, Nilsson L, Berntson L. An explorative study on proteomic analyses related to inflammation and pain in children with juvenile idiopathic arthritis. BMC Pediatr. 2023;23(1):365.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gerss J, Tedy M, Klein A, Horneff G, Miranda-Garcia M, Kessel C, et al. Prevention of disease flares by risk-adapted stratification of therapy withdrawal in juvenile idiopathic arthritis: results from the PREVENT-JIA trial. Ann Rheum Dis. 2022;81(7):990–7.

Article  PubMed  Google Scholar 

Ganeva M, Fuehner S, Kessel C, Klotsche J, Niewerth M, Minden K, et al. Trajectories of disease courses in the inception cohort of newly diagnosed patients with JIA (ICON-JIA): the potential of serum biomarkers at baseline. Pediatr Rheumatol Online J. 2021;19(1):64.

Article  PubMed  PubMed Central  Google Scholar 

Hinze CH, Foell D, Johnson AL, Spalding SJ, Gottlieb BS, Morris PW, et al. Serum S100A8/A9 and S100A12 levels in children with polyarticular forms of juvenile idiopathic arthritis: relationship to maintenance of clinically inactive disease during anti-tumor necrosis factor therapy and occurrence of disease flare after discontinuation of therapy. Arthritis Rheumatol. 2019;71(3):451–9.

Article  PubMed  PubMed Central  Google Scholar 

Consolaro A, Ruperto N, Bazso A, Pistorio A, Magni-Manzoni S, Filocamo G, et al. Development and validation of a composite disease activity score for juvenile idiopathic arthritis. Arthritis Rheum. 2009;61(5):658–66.

Article  PubMed  Google Scholar 

Wallace CA, Giannini EH, Huang B, Itert L, Ruperto N. American College of Rheumatology provisional criteria for defining clinical inactive disease in select categories of juvenile idiopathic arthritis. Arthritis Care Res (Hoboken). 2011;63(7):929–36.

Article  PubMed  Google Scholar 

Wallace CA, Ruperto N, Giannini E. Preliminary criteria for clinical remission for select categories of juvenile idiopathic arthritis. J Rheumatol. 2004;31(11):2290–4.

PubMed  Google Scholar 

Giancane G, Muratore V, Marzetti V, Quilis N, Benavente BS, Bagnasco F, et al. Disease activity and damage in juvenile idiopathic arthritis: methotrexate era versus biologic era. Arthritis Res Ther. 2019;21(1):168.

Article  PubMed  PubMed Central  Google Scholar 

Ravelli A, Consolaro A, Horneff G, Laxer RM, Lovell DJ, Wulffraat NM, et al. Treating juvenile idiopathic arthritis to target: recommendations of an international task force. Ann Rheum Dis. 2018;77(6):819–28.

PubMed  Google Scholar 

Glerup M, Rypdal V, Arnstad ED, Ekelund M, Peltoniemi S, Aalto K, et al. Long-term outcomes in juvenile idiopathic arthritis: eighteen years of follow-up in the population-based Nordic juvenile idiopathic arthritis cohort. Arthritis Care Res (Hoboken). 2020;72(4):507–16.

Article  PubMed  Google Scholar 

Otten MH, Prince FH, Armbrust W, ten Cate R, Hoppenreijs EP, Twilt M, et al. Factors associated with treatment response to etanercept in juvenile idiopathic arthritis. JAMA. 2011;306(21):2340–7.

Article  CAS  PubMed  Google Scholar 

Brown A, Hirsch R, Laor T, Hannon MJ, Levesque MC, Starz T, et al. Do patients with juvenile idiopathic arthritis in clinical remission have evidence of persistent inflammation on 3T magnetic resonance imaging? Arthritis Care Res (Hoboken). 2012;64(12):1846–54.

Article  PubMed  Google Scholar 

Loo JA, Yan W, Ramachandran P, Wong DT. Comparative human salivary and plasma proteomes. J Dent Res. 2010;89(10):1016–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Collin M, Ernberg M, Christidis N, Hedenberg-Magnusson B. Salivary biomarkers in children with juvenile idiopathic arthritis and healthy age-matched controls: a prospective observational study. Sci Rep. 2022;12(1):3240.

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Brik R, Rosen I, Savulescu D, Borovoi I, Gavish M, Nagler R. Salivary antioxidants and metalloproteinases in juvenile idiopathic arthritis. Mol Med. 2010;16(3–4):122–8.

Article  CAS  PubMed  Google Scholar 

Gil EG, Åstrøm AN, Lie SA, Rygg M, Fischer J, Rosén A, et al. Dental caries in children and adolescents with juvenile idiopathic arthritis and controls: a multilevel analysis. BMC Oral Health. 2021;21(1):417.

Article  PubMed  PubMed Central  Google Scholar 

Cetrelli L, Bletsa A, Lundestad A, Gil EG, Fischer J, Halbig J, et al. Vitamin D, oral health, and disease characteristics in juvenile idiopathic arthritis: a multicenter cross-sectional study. BMC Oral Health. 2022;22(1):333.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cole TJ, Lobstein T. Extended international (IOTF) body mass index cut-offs for thinness, overweight and obesity. Pediatr Obes. 2012;7(4):284–94.

Article  CAS  PubMed  Google Scholar 

Júlíusson PB, Hjelmesæth J, Bjerknes R, Roelants M. New curves for body mass index among children and adolescents. Tidsskr Nor Laegeforen. 2017;137(18):1397–98.

Jonsson MV, Reksten TR, Delaleu N, Marthinussen MC. Diagnostikk av munntørrhet og bruk av saliva som diagnostisk verktøy. Norsk Tannlegeforenings Tidende. 2011;121(14):908–13.

Google Scholar 

Assarsson E, Lundberg M, Holmquist G, Björkesten J, Thorsen SB, Ekman D, et al. Homogenous 96-plex PEA immunoassay exhibiting high sensitivity, specificity, and excellent scalability. PLoS ONE. 2014;9(4):e95192.

Article  ADS  PubMed  PubMed Central  Google Scholar 

West RM. Best practice in statistics: Use the Welch t-test when testing the difference between two groups. Ann Clin Biochem. 2021;58(4):267–9.

Article  PubMed  Google Scholar 

Funk RS, Chan MA, Becker ML. Cytokine biomarkers of disease activity and therapeutic response after initiating methotrexate therapy in patients with juvenile idiopathic arthritis. Pharmacotherapy. 2017;37(6):700–11.

Article  CAS  PubMed  Google Scholar 

Spîrchez M, Samaşca G, Iancu M, Bolba C, Miu N. Relation of interleukin-6, TNF-alpha and interleukin-1alpha with disease activity and severity in juvenile idiopathic arthritis patients. Clin Lab. 2012;58(3–4):253–60.

PubMed  Google Scholar 

Walters HM, Pan N, Lehman TJ, Adams A, Kalliolias GD, Zhu YS, et al. The impact of disease activity and tumour necrosis factor-α inhibitor therapy on cytokine levels in juvenile idiopathic arthritis. Clin Exp Immunol. 2016;184(3):308–17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kaminiarczyk-Pyzalka D, Adamczak K, Mikos H, Klimecka I, Moczko J, Niedziela M. Proinflammatory cytokines in monitoring the course of disease and effectiveness of treatment with etanercept (ETN) of children with oligo- and polyarticular juvenile idiopathic arthritis (JIA). Clin Lab. 2014;60(9):1481–90.

CAS  PubMed  Google Scholar 

Yilmaz M, Kendirli SG, Altintas D, Bingöl G, Antmen B. Cytokine levels in serum of patients with juvenile rheumatoid arthritis. Clin Rheumatol. 2001;20(1):30–5.

Article  CAS  PubMed  Google Scholar 

Majster M, Lira-Junior R, Höög CM, Almer S, Boström EA. Salivary and serum inflammatory profiles reflect different aspects of inflammatory bowel disease activity. Inflamm Bowel Dis. 2020;26(10):1588–96.

Article  PubMed  PubMed Central 

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