A therapeutical insight into the correlation between circRNAs and signaling pathways involved in cancer pathogenesis

Palazzo AF, Lee ES. Non-coding RNA: what is functional and what is junk? Front Genet. 2015;6:2.

Article  PubMed  PubMed Central  Google Scholar 

Anastasiadou E, Jacob LS, Slack FJ. Non-coding RNA networks in cancer. Nat Rev Cancer. 2018;18:5–18.

Article  CAS  PubMed  Google Scholar 

Kos A, Dijkema R, Arnberg A, Van der Meide P, Schellekens H. The hepatitis delta (δ) virus possesses a circular RNA. Nature. 1986;323:558–60.

Article  ADS  CAS  PubMed  Google Scholar 

Rybak-Wolf A, Stottmeister C, Glažar P, Jens M, Pino N, Giusti S, Hanan M, Behm M, Bartok O, Ashwal-Fluss R. Circular RNAs in the mammalian brain are highly abundant, conserved, and dynamically expressed. Mol Cell. 2015;58:870–85.

Article  CAS  PubMed  Google Scholar 

Pisignano G, Michael DC, Visal TH, Pirlog R, Ladomery M, Calin GA. Going circular: history, present, and future of circRNAs in cancer. Oncogene. 2023;42:1–18.

Article  Google Scholar 

Garikipati VNS, Verma SK, Cheng Z, Liang D, Truongcao MM, Cimini M, Yue Y, Huang G, Wang C, Benedict C. Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis. Nat Commun. 2019;10:4317.

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Wu F, Han B, Wu S, Yang L, Leng S, Li M, Liao J, Wang G, Ye Q, Zhang Y. Circular RNA TLK1 aggravates neuronal injury and neurological deficits after ischemic stroke via miR-335-3p/TIPARP. J Neurosci. 2019;39:7369–93.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang F, Zhang R, Zhang X, Wu Y, Li X, Zhang S, Hou W, Ding Y, Tian J, Sun L. Comprehensive analysis of circRNA expression pattern and circRNA-miRNA-mRNA network in the pathogenesis of atherosclerosis in rabbits. Aging (Albany NY). 2018;10:2266.

Article  CAS  PubMed  Google Scholar 

Hu F, Peng Y, Fan X, Zhang X, Jin Z. Circular RNAs: implications of signaling pathways and bioinformatics in human cancer. Cancer Biol Med. 2023;20:104.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang C, Liu W-R, Tan S, Zhou J-K, Xu X, Ming Y, Cheng J, Li J, Zeng Z, Zuo Y. Characterization of distinct circular RNA signatures in solid tumors. Mol Cancer. 2022;21:1–16.

Article  CAS  Google Scholar 

Jeck WR, Sorrentino JA, Wang K, Slevin MK, Burd CE, Liu J, Marzluff WF, Sharpless NE. Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA. 2013;19:141–57.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ashwal-Fluss R, Meyer M, Pamudurti NR, Ivanov A, Bartok O, Hanan M, Evantal N, Memczak S, Rajewsky N, Kadener S. circRNA biogenesis competes with pre-mRNA splicing. Mol Cell. 2014;56:55–66.

Article  CAS  PubMed  Google Scholar 

Li X, Yang L, Chen L-L. The biogenesis, functions, and challenges of circular RNAs. Mol Cell. 2018;71:428–42.

Article  CAS  PubMed  Google Scholar 

Tagawa T, Gao S, Koparde VN, Gonzalez M, Spouge JL, Serquiña AP, Lurain K, Ramaswami R, Uldrick TS, Yarchoan R. Discovery of Kaposi’s sarcoma herpesvirus-encoded circular RNAs and a human antiviral circular RNA. Proc Natl Acad Sci. 2018;115:12805–10.

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Qiao Y, Zhao X, Liu J, Yang W. Epstein-Barr virus circRNAome as host miRNA sponge regulates virus infection, cell cycle, and oncogenesis. Bioengineered. 2019;10:593–603.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schmidt CA, Giusto JD, Bao A, Hopper AK, Matera AG. Molecular determinants of metazoan tricRNA biogenesis. Nucleic Acids Res. 2019;47:6452–65.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zeng K, Chen X, Xu M, Liu X, Hu X, Xu T, Sun H, Pan Y, He B, Wang S. CircHIPK3 promotes colorectal cancer growth and metastasis by sponging miR-7. Cell Death Dis. 2018;9:417.

Article  PubMed  PubMed Central  Google Scholar 

Huang A, Zheng H, Wu Z, Chen M, Huang Y. Circular RNA-protein interactions: functions, mechanisms, and identification. Theranostics. 2020;10:3503–17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang Y, Wang X. Targeting the Wnt/β-catenin signaling pathway in cancer. J Hematol Oncol. 2020;13:1–16.

Article  Google Scholar 

Ma J-h, Qin L, Li X. Role of STAT3 signaling pathway in breast cancer. Cell Commun Signal. 2020;18:1–13.

Article  Google Scholar 

Zou Z, Tao T, Li H, Zhu X. mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges. Cell Biosci. 2020;10:1–11.

Article  CAS  Google Scholar 

Wang S, Cheng L, Wu H, Li G. Mechanisms and prospects of circular RNAs and their interacting signaling pathways in colorectal cancer. Front Oncol. 2022;12: 949656.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang Z, Xie L, Han L, Qu X, Yang Y, Zhang Y, He Z, Wang Y, Li J. Circular RNAs: regulators of cancer-related signaling pathways and potential diagnostic biomarkers for human cancers. Theranostics. 2017;7:3106.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang L, Tong X, Zhou Z, Wang S, Lei Z, Zhang T, Liu Z, Zeng Y, Li C, Zhao J. Circular RNA hsa_circ_0008305 (circPTK2) inhibits TGF-β-induced epithelial-mesenchymal transition and metastasis by controlling TIF1γ in non-small cell lung cancer. Mol Cancer. 2018;17:1–18.

Article  Google Scholar 

Tong S. Circular RNA SMARCA5 may serve as a tumor suppressor in non-small cell lung cancer. J Clin Lab Anal. 2020;34: e23195.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang J, Liu H, Hou L, Wang G, Zhang R, Huang Y, Chen X, Zhu J. Circular RNA_LARP4 inhibits cell proliferation and invasion of gastric cancer by sponging miR-424-5p and regulating LATS1 expression. Mol Cancer. 2017;16:1–16.

Article  Google Scholar 

Lu J, Zhang P-y, Li P, Xie J-w, Wang J-b, Lin J-x, Chen Q-y, Cao L-l, Huang C-m, Zheng C-h. Circular RNA hsa_circ_0001368 suppresses the progression of gastric cancer by regulating miR-6506–5p/FOXO3 axis. Biochem Biophys Res Commun. 2019;512:29–33.

Article  CAS  PubMed  Google Scholar 

Shi Y, Han T, Liu C. CircRNA hsa_circ_0006220 acts as a tumor suppressor gene by regulating miR-197–5p/CDH19 in triple-negative breast cancer. Ann Transl Med. 2021;9:1236.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cao S, Yin Y, Hu H, Hong S, He W, Lv W, Liu R, Li Y, Yu S, Xiao H. CircGLIS3 inhibits thyroid cancer invasion and metastasis through miR-146b-3p/AIF1L axis. Cell Oncol. 2023;43:1–13.

Google Scholar 

Deng YY, Min YJ, Zhou K, Yang QS, Peng M, Cui ZR, Zhu XL, Liu H, Wang M, Zhang X, Liu LX. Identification of the tumor-suppressive role of circular RNA-FOXO3 in colorectal cancer via regulation of miR-543/LATS1 axis. Oncol Rep. 2021. https://doi.org/10.3892/or.2021.8190.

Article  PubMed  PubMed Central  Google Scholar 

Deng Y-Y, Min Y-J, Zhou K, Yang Q-S, Peng M, Cui Z-R, Zhu X-L, Liu H, Wang M, Zhang X. Identification of the tumor-suppressive role of circular RNA-FOXO3 in colorectal cancer via regulation of miR-543/LATS1 axis. Oncol Rep. 2021;46:1–11.

Article  Google Scholar 

Li J, Lv J, Chen Y, Li L. Tumor suppressor circPDE4D inhibits the progression of colorectal cancer and regulates oxaliplatin chemoresistance. Gene. 2023;864: 147323.

Article  CAS  PubMed  Google Scholar 

Feng H, Deng Z, Peng W, Wei X, Liu J, Wang T. Circular RNA EPHA3 suppresses progression and metastasis in prostate cancer through the miR-513a-3p/BMP2 axis. J Transl Med. 2023;21:1–15.

Article  Google Scholar 

Zhang B, Yang S, Wang J. Circ_0084615 is an oncogenic circular RNA in colorectal cancer and promotes DNMT3A expression via repressing miR-599. Pathol Res Pract. 2021;224: 153494.

Article  CAS  PubMed  Google Scholar 

Ye Q, Liu S, Lin S, Xie W. Circular RNA circSEMA5A facilitates colorectal cancer development by regulating microRNA-195-5p to target CCNE1 axis. Cell Signal. 2023;107: 110649.

Article  CAS  PubMed  Google Scholar 

Yi H, Han Y, Li S. Oncogenic circular RNA circ_0007534 contributes to paclitaxel resistance in endometrial cancer by sponging miR-625 and promoting ZEB2 expression. Front Oncol. 2022;12: 985470.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu L, Gong X, Sun L, Zhou Q, Lu B, Zhu L. The circular RNA Cdr1as act as an oncogene in hepatocellular carcinoma through

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