Haylen BT, de Ridder D, Freeman RM, Swift SE, Berghmans B, Lee J, et al. An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint report on the terminology for female pelvic floor dysfunction. Neurourol Urodyn. 2010;29(1):4–20.

Article  PubMed  Google Scholar 

Aoki Y, Brown HW, Brubaker L, Cornu JN, Daly JO, Cartwright R. Urinary incontinence in women. Nat Rev Dis Prim. 2017;3:17042.

Article  PubMed  Google Scholar 

Wennberg AL, Molander U, Fall M, Edlund C, Peeker R, Milsom I. A longitudinal population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in women. Eur Urol. 2009;55(4):783–91.

Article  PubMed  Google Scholar 

Lee YS, Lee KS, Jung JH, Han DH, Oh SJ, Seo JT, et al. Prevalence of overactive bladder, urinary incontinence, and lower urinary tract symptoms: results of Korean EPIC study. World J Urol. 2011;29(2):185–90.

Article  PubMed  Google Scholar 

Malmsten UG, Molander U, Peeker R, Irwin DE, Milsom I. Urinary incontinence, overactive bladder, and other lower urinary tract symptoms: a longitudinal population-based survey in men aged 45–103 years. Eur Urol. 2010;58(1):149–56.

Article  PubMed  Google Scholar 

Holroyd-Leduc JM, Tannenbaum C, Thorpe KE, Straus SE. What type of urinary incontinence does this woman have? JAMA. 2008;299(12):1446–56.

Article  PubMed  Google Scholar 

Handler SJ, Rosenman AE. Urinary incontinence: evaluation and management. Clin Obstet Gynecol. 2019;62(4):700–11.

Article  PubMed  Google Scholar 

Moller DE, Kaufman KD. Metabolic syndrome: a clinical and molecular perspective. Annu Rev Med. 2005;56:45–62.

Article  PubMed  Google Scholar 

Eckel RH, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet. 2005;365(9468):1415–28.

Article  PubMed  Google Scholar 

Lee SH, Park SY, Choi CS. Insulin resistance: from mechanisms to therapeutic strategies. Diabetes Metab J. 2022;46(1):15–37.

Article  PubMed  Google Scholar 

Lebovitz HE. Insulin resistance: definition and consequences. Exp Clin Endocrinol Diabetes. 2001;109(Suppl 2):135–48.

Article  Google Scholar 

Bello-Chavolla OY, Almeda-Valdes P, Gomez-Velasco D, Viveros-Ruiz T, Cruz-Bautista I, Romo-Romo A, et al. METS-IR, a novel score to evaluate insulin sensitivity, is predictive of visceral adiposity and incident type 2 diabetes. Eur J Endocrinol. 2018;178(5):533–44.

Article  PubMed  Google Scholar 

Huang H, Han X, Liu Q, Xue J, Yu Z, Miao S. Associations between metabolic syndrome and female stress urinary incontinence: a meta-analysis. Int Urogynecol J. 2022;33(8):2073–9.

Article  PubMed  Google Scholar 

Yoon BI, Han KD, Lee KW, Kwon HS, Kim SW, Sohn DW, et al. Insulin resistance is associated with prevalence of physician-diagnosed urinary incontinence in postmenopausal non-diabetic adult women: data from the fourth Korea national health and nutrition examination survey. PLoS ONE. 2015;10(11): e0141720.

Article  PubMed  PubMed Central  Google Scholar 

DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol. 1979;237(3):E214–23.

PubMed  Google Scholar 

Borai A, Livingstone C, Ferns GA. The biochemical assessment of insulin resistance. Ann Clin Biochem. 2007;44(Pt 4):324–42.

Article  PubMed  Google Scholar 

Cheng H, Yu X, Li YT, Jia Z, Wang JJ, Xie YJ, et al. Association between METS-IR and prediabetes or type 2 diabetes mellitus among elderly subjects in China: a large-scale population-based study. Int J Environ Res Public Health. 2023;20(2):1053.

Article  PubMed  PubMed Central  Google Scholar 

Wang Z, Hui X, Huang X, Li J, Liu N. Relationship between a novel non-insulin-based metabolic score for insulin resistance (METS-IR) and coronary artery calcification. BMC Endocr Disord. 2022;22(1):274.

Article  PubMed  PubMed Central  Google Scholar 

Han KY, Gu J, Wang Z, Liu J, Zou S, Yang CX, et al. Association between METS-IR and prehypertension or hypertension among normoglycemia subjects in Japan: a retrospective study. Front Endocrinol. 2022;13: 851338.

Article  Google Scholar 

Vaughan CP, Markland AD. Urinary incontinence in women. Ann Intern Med. 2020;172(3):ITC17–32.

Article  PubMed  Google Scholar 

Dandona P, Aljada A, Mohanty P, Ghanim H, Hamouda W, Assian E, et al. Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect? J Clin Endocrinol Metab. 2001;86(7):3257–65.

PubMed  Google Scholar 

Dandona P, Aljada A, Bandyopadhyay A. Inflammation: the link between insulin resistance, obesity and diabetes. Trends Immunol. 2004;25(1):4–7.

Article  PubMed  Google Scholar 

Yaribeygi H, Farrokhi FR, Butler AE, Sahebkar A. Insulin resistance: review of the underlying molecular mechanisms. J Cell Physiol. 2019;234(6):8152–61.

Article  PubMed  Google Scholar 

Shinohara M, Sumino Y, Sato F, Kiyono T, Hashimoto N, Mimata H. Tumor necrosis factor-alpha inhibits differentiation of myogenic cells in human urethral rhabdosphincter. Int J Urol. 2017;24(6):461–7.

Article  PubMed  Google Scholar 

Chung SD, Liu HT, Lin H, Kuo HC. Elevation of serum c-reactive protein in patients with OAB and IC/BPS implies chronic inflammation in the urinary bladder. Neurourol Urodyn. 2011;30(3):417–20.

Article  PubMed  Google Scholar 

He Q, Wang Z, Liu G, Daneshgari F, MacLennan GT, Gupta S. Metabolic syndrome, inflammation and lower urinary tract symptoms: possible translational links. Prostate Cancer Prostatic Dis. 2016;19(1):7–13.

Article  PubMed  Google Scholar 

Guillet C, Boirie Y. Insulin resistance: a contributing factor to age-related muscle mass loss? Diabetes Metab. 2005;31(Spec No 2):5s20–6.

PubMed  Google Scholar 

Liu ZJ, Zhu CF. Causal relationship between insulin resistance and sarcopenia. Diabetol Metab Syndr. 2023;15(1):46.

Article  PubMed  PubMed Central  Google Scholar 

Radzimińska A, Strączyńska A, Weber-Rajek M, Styczyńska H, Strojek K, Piekorz Z. The impact of pelvic floor muscle training on the quality of life of women with urinary incontinence: a systematic literature review. Clin Interv Aging. 2018;13:957–65.

Article  PubMed  PubMed Central  Google Scholar 

Nunes EFC, Sampaio LMM, Biasotto-Gonzalez DA, Nagano R, Lucareli PRG, Politti F. Biofeedback for pelvic floor muscle training in women with stress urinary incontinence: a systematic review with meta-analysis. Physiotherapy. 2019;105(1):10–23.

Article  PubMed  Google Scholar 

Erdogan T, Bahat G, Kilic C, Kucukdagli P, Oren MM, Erdogan O, et al. The relationship between sarcopenia and urinary incontinence. Eur Geriatr Med. 2019;10(6):923–9.

Article  PubMed  Google Scholar 

Tinahones FJ, Murri-Pierri M, Garrido-Sánchez L, García-Almeida JM, García-Serrano S, García-Arnés J, et al. Oxidative stress in severely obese persons is greater in those with insulin resistance. Obesity. 2009;17(2):240–6.

Article  PubMed  Google Scholar 

Shin MJ, Park E. Contribution of insulin resistance to reduced antioxidant enzymes and vitamins in nonobese Korean children. Clin Chim Acta. 2006;365(1–2):200–5.

Article  PubMed  Google Scholar 

Mattei L, Francisqueti-Ferron FV, Garcia JL, Ferron AJT, Silva C, Gregolin CS, et al. Antioxidant and anti-inflammatory properties of gamma-oryzanol attenuates insulin resistance by increasing GLUT-4 expression in skeletal muscle of obese animals. Mol Cell Endocrinol. 2021;537:111423.

Article  PubMed  Google Scholar 

Nocchi L, Daly DM, Chapple C, Grundy D. Induction of oxidative stress causes functional alterations in mouse urothelium via a TRPM8-mediated mechanism: implications for aging. Aging Cell. 2014;13(3):540–50.

Article  PubMed  PubMed Central  Google Scholar 

Phelan S, Grodstein F, Brown JS. Clinical research in diabetes and urinary incontinence: what we know and need to know. J Urol. 2009;182(6 Suppl):14–7.

Google Scholar