Prognostic Signature Constructed of Seven Ferroptosis-Related lncRNAs Predicts the Prognosis of HBV-Related HCC

Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA Cancer J Clin. 2022;72:7–33.

Article  PubMed  Google Scholar 

Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209–49.

Article  PubMed  Google Scholar 

Wei X, Yi X, Zhu XH, Jiang DS. Posttranslational modifications in ferroptosis. Oxid Med Cell Longev. 2020;2020:8832043.

Article  PubMed  PubMed Central  Google Scholar 

Ma S, Henson ES, Chen Y, Gibson SB. Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells. Cell Death Dis. 2016;7:e2307.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ghoochani A, Hsu EC, Aslan M, et al. Ferroptosis inducers are a novel therapeutic approach for advanced prostate cancer. Can Res. 2021;81:1583–94.

Article  CAS  Google Scholar 

Yao F, Deng Y, Zhao Y, et al. A targetable LIFR-NF-kappaB-LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis. Nat Commun. 2021;12:7333.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao R, Kalathur RKR, Coto-Llerena M, et al. YAP/TAZ and ATF4 drive resistance to sorafenib in hepatocellular carcinoma by preventing ferroptosis. EMBO Mol Med. 2021;13:e14351.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang H, Deng T, Liu R, et al. CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer. Mol Cancer. 2020;19:43.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tsagakis I, Douka K, Birds I, Aspden JL. Long non-coding RNAs in development and disease: conservation to mechanisms. J Pathol. 2020;250:480–95.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schmitz SU, Grote P, Herrmann BG. Mechanisms of long noncoding RNA function in development and disease. Cell Mol Life Sci. 2016;73:2491–509.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang Z, Zhou JK, Peng Y, He W, Huang C. The role of long noncoding RNAs in hepatocellular carcinoma. Mol Cancer. 2020;19:77.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nia A, Dhanasekaran R. Genomic landscape of HCC. Curr Hepatol Rep. 2020;19:448–61.

Article  PubMed  PubMed Central  Google Scholar 

Woo Y, Lee HJ, Jung YM, Jung YJ. Regulated necrotic cell death in alternative tumor therapeutic strategies. Cells. 2020;9.

Zhu Y, Zhou B, Hu X, et al. lncRNA LINC00942 promotes chemoresistance in gastric cancer by suppressing MSI2 degradation to enhance c-Myc mRNA stability. Clin Transl Med. 2022;12:e703.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang R, Wang X, Zhang J, Liu Y. LINC00942 Promotes tumor proliferation and metastasis in lung adenocarcinoma via FZD1 upregulation. Technol Cancer Res Treat. 2021;20:1533033820977526. https://doi.org/10.1177/1533033820977526.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang W, Ye Y, Zhang X, Ye X, Liu C, Bao L. Construction of a necroptosis-associated long non-coding RNA signature to predict prognosis and immune response in hepatocellular carcinoma. Front Mol Biosci. 2022;9:937979.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tang Y, Zhang H, Chen L, Zhang T, Xu N, Huang Z. Identification of hypoxia-related prognostic signature and competing endogenous RNA regulatory axes in hepatocellular carcinoma. Int J Mol Sci. 2022;23.

Guo C, Zhou S, Yi W, et al. SOX9/MKLN1-AS axis induces hepatocellular carcinoma proliferation and epithelial-mesenchymal transition. Biochem Genet. 2022;60:1914–33.

Article  CAS  PubMed  Google Scholar 

Guo C, Zhou S, Yi W, et al. Long non-coding RNA muskelin 1 antisense RNA (MKLN1-AS) is a potential diagnostic and prognostic biomarker and therapeutic target for hepatocellular carcinoma. Exp Mol Pathol. 2021;120:104638. https://doi.org/10.1016/j.yexmp.2021.104638. Epub 102021 Apr 104618.

Article  CAS  PubMed  Google Scholar 

Pan G, Zhang J, You F, et al. ETS proto-oncogene 1-activated muskelin 1 antisense RNA drives the malignant progression of hepatocellular carcinoma by targeting miR-22-3p to upregulate ETS proto-oncogene 1. Bioengineered. 2022;13:1346–58. https://doi.org/10.1080/21655979.2021.2017565.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu ZH, Li ZW, Yang DL, Liu J. Development and validation of a pyroptosis-related long non-coding RNA signature for hepatocellular carcinoma. Front Cell Dev Biol. 2021;9:713925.

Article  PubMed  PubMed Central  Google Scholar 

Wei H, Xu Z, Chen L, et al. Long non-coding RNA PAARH promotes hepatocellular carcinoma progression and angiogenesis via upregulating HOTTIP and activating HIF-1н╠/VEGF signaling. Cell Death Dis. 2022;13:102. https://doi.org/10.1038/s41419-022-04505-5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen H, Nio K, Tang H, et al. BMP9-ID1 signaling activates HIF-1н╠ and VEGFA expression to promote tumor angiogenesis in hepatocellular carcinoma. Int J Mol Sci. 2022;23:1475. https://doi.org/10.3390/ijms23031475.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dixon SJ, Patel DN, Welsch M, et al. Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis. Elife. 2014;3:e02523. https://doi.org/10.7554/eLife.02523.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu Z, Li L, Li M, et al. miR-21–5p inhibits ferroptosis in hepatocellular carcinoma cells by regulating the AKT/mTOR signaling pathway through MELK. J Immunol Res. 2023;2023:8929525. https://doi.org/10.1155/2023/8929525.eCollection8922023.

Article  PubMed  PubMed Central  Google Scholar 

Abdolmohammadi MH, Roozbehani M, Hamzeloo-Moghadam M, Heidari F, Fallahian F. Targeting PPARнЁ/ NF-н╨B signaling pathway by Britannin, a sesquiterpene lactone from Inula aucheriana DC., in Gastric Cancer. Anticancer Agents Med Chem. 2023;18:1.871520623666231e+24.

Google Scholar 

Liu X, Qian D, Liu H, et al. Genetic variants of the peroxisome proliferator-activated receptor (PPAR) signaling pathway genes and risk of pancreatic cancer. Mol Carcinog. 2020;59:930–9. https://doi.org/10.1002/mc.23208. Epub 22020 May 23205.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang X, Yang R, Zhang Y, et al. Xianlinglianxiafang Inhibited the growth and metastasis of triple-negative breast cancer via activating PPARн Ё/AMPK signaling pathway. Biomed Pharmacother. 2023;165:115164. https://doi.org/10.1016/j.biopha.2023.115164. Epub 112023 Jul 115119.

Article  CAS  PubMed  Google Scholar 

Lu P, Li X, Li B, et al. The mitochondrial-derived peptide MOTS-c suppresses ferroptosis and alleviates acute lung injury induced by myocardial ischemia reperfusion via PPARн Ё signaling pathway. Eur J Pharmacol. 2023;953:175835. https://doi.org/10.1016/j.ejphar.2023.175835. Epub 172023 Jun 175837.

Article  CAS  PubMed  Google Scholar 

Liao P, Wang W, Wang W, et al. CD8(+) Tб═cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4. Cancer Cell. 2022;40:365-378.e366. https://doi.org/10.1016/j.ccell.2022.02.003. Epub 2022 Feb 1024.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang W, Green M, Choi JE, et al. CD8(+) T cells regulate tumour ferroptosis during cancer immunotherapy. Nature. 2019;569:270–4. https://doi.org/10.1038/s41586-019-1170-y. Epub 42019 May 41581.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tao L, Li D, Mu S, Tian G, Yan G. lncRNA MAPKAPK5_AS1 facilitates cell proliferation in hepatitis B virus -related hepatocellular carcinoma. Lab Invest. 2022;102:494–504. https://doi.org/10.1038/s41374-022-00731-9. Epub 42022 Mar 41379.

Article  CAS  PubMed  Google Scholar 

Jiang Z, Lim SO, Yan M, et al. TYRO3 induces anti-PD-1/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis. J Clin Invest. 2021;131:e139434. https://doi.org/10.1172/JCI139434.

Article  PubMed  PubMed Central  Google Scholar 

Hao X, Zheng Z, Liu H, et al. Inhibition of APOC1 promotes the transformation of M2 into M1 macrophages via the ferroptosis pathway and enhances anti-PD1 immunotherapy in hepatocellular carcinoma based on single-cell RNA sequencing. Redox Biol. 2022;56:102463. https://doi.org/10.1016/j.redox.2022.102463. Epub 102022 Sep 102462.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shi L, Liu Y, Li M, Luo Z. Emerging roles of ferroptosis in the tumor immune landscape: from danger signals to anti-tumor immunity. FEBS J. 2022;289:3655–65. https://doi.org/10.1111/febs.16034. Epub 12021 Jun 16011.

Article  CAS  PubMed 

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