Muller TG, Zila V, Muller B, Krausslich HG. Nuclear capsid uncoating and reverse transcription of HIV-1. Annu Rev Virol. 2022;9(1):261–84.
Shun M-C, Raghavendra NK, Vandegraaff N, Daigle JE, Hughes S, Kellam P, et al. LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration. Genes Dev. 2007;21(14):1767–78.
Article CAS PubMed PubMed Central Google Scholar
Tchasovnikarova IA, Marr SK, Damle M, Kingston RE. TRACE generates fluorescent human reporter cell lines to characterize epigenetic pathways. Mol Cell. 2022;82(2):479-91.e7.
Article CAS PubMed Google Scholar
Williams SA, Greene WC. Host factors regulating post-integration latency of HIV. Trends Microbiol. 2005;13(4):137–9.
Article CAS PubMed Google Scholar
Li JZ, Aga E, Bosch RJ, Pilkinton M, Kroon E, MacLaren L, et al. Time to viral rebound after interruption of modern antiretroviral therapies. Clin Infect Dis. 2022;74(5):865–70.
Article CAS PubMed Google Scholar
Rothenberger MK, Keele BF, Wietgrefe SW, Fletcher CV, Beilman GJ, Chipman JG, et al. Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption. Proc Natl Acad Sci. 2015;112(10):E1126-E34.
Capeau J. Premature aging and premature age-related comorbidities in HIV-infected patients: facts and hypotheses. Clin Infect Dis. 2011;53(11):1127–9.
Lerner AM, Eisinger RW, Fauci AS. Comorbidities in persons with HIV: the lingering challenge. JAMA. 2020;323(1):19–20.
Schlachetzki JCM, Zhou Y, Glass CK. Human microglia phenotypes in the brain associated with HIV infection. Curr Opin Neurobiol. 2022;77:102637.
Article CAS PubMed Google Scholar
Li Q, Barres BA. Microglia and macrophages in brain homeostasis and disease. Nat Rev Immunol. 2018;18(4):225–42.
Article CAS PubMed Google Scholar
Heaton RK, Clifford DB, Franklin DR Jr, Woods SP, Ake C, Vaida F, et al. HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER study. Neurology. 2010;75(23):2087–96.
Article CAS PubMed PubMed Central Google Scholar
Heaton RK, Franklin DR, Ellis RJ, McCutchan JA, Letendre SL, Leblanc S, et al. HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors. J Neurovirol. 2011;17(1):3–16.
Article CAS PubMed Google Scholar
Sacktor N, Skolasky RL, Seaberg E, Munro C, Becker JT, Martin E, et al. Prevalence of HIV-associated neurocognitive disorders in the Multicenter AIDS cohort study. Neurology. 2016;86(4):334–40.
Article CAS PubMed PubMed Central Google Scholar
Simioni S, Cavassini M, Annoni JM, Rimbault Abraham A, Bourquin I, Schiffer V, et al. Cognitive dysfunction in HIV patients despite long-standing suppression of viremia. AIDS (London, England). 2010;24(9):1243–50.
Cho A, Gaebler C, Olveira T, Ramos V, Saad M, Lorenzi JCC, et al. Longitudinal clonal dynamics of HIV-1 latent reservoirs measured by combination quadruplex polymerase chain reaction and sequencing. Proc Natl Acad Sci. 2022;119(4):e2117630119.
Pinzone MR, VanBelzen DJ, Weissman S, Bertuccio MP, Cannon L, Venanzi-Rullo E, et al. Longitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansion. Nat Commun. 2019;10(1):728.
Article CAS PubMed Google Scholar
Einkauf KB, Osborn MR, Gao C, Sun W, Sun X, Lian X, et al. Parallel analysis of transcription, integration, and sequence of single HIV-1 proviruses. Cell. 2022;185(2):266–82.
Article CAS PubMed PubMed Central Google Scholar
Chen H, Wood C, Petito CK. Comparisons of HIV-1 viral sequences in brain, choroid plexus and spleen: potential role of choroid plexus in the pathogenesis of HIV encephalitis. J Neurovirol. 2000;6(6):498–506.
Article CAS PubMed Google Scholar
Byrnes SJ, Angelovich TA, Busman-Sahay K, Cochrane CR, Roche M, Estes JD, et al. Non-human primate models of HIV brain infection and cognitive disorders. Viruses. 2022;14(9):1997.
Article CAS PubMed PubMed Central Google Scholar
Gorantla S, Poluektova L, Gendelman HE. Rodent models for HIV-associated neurocognitive disorders. Trends Neurosci. 2012;35(3):197–208.
Article CAS PubMed PubMed Central Google Scholar
Waight E, Zhang C, Mathews S, Kevadiya BD, Lloyd KCK, Gendelman HE, et al. Animal models for studies of HIV-1 brain reservoirs. J Leukoc Biol. 2022;112(5):1285–95.
Article CAS PubMed Google Scholar
Hammond ER, Crum RM, Treisman GJ, Mehta SH, Clifford DB, Ellis RJ, et al. Persistent CSF but not plasma HIV RNA is associated with increased risk of new-onset moderate-to-severe depressive symptoms; a prospective cohort study. J Neurovirol. 2016;22(4):479–87.
Article CAS PubMed PubMed Central Google Scholar
Plaza-Jennings AL, Valada A, O’Shea C, Iskhakova M, Hu B, Javidfar B, et al. HIV integration in the human brain is linked to microglial activation and 3D genome remodeling. Mol Cell. 2022;82(24):4647–63.e8.
Article CAS PubMed Google Scholar
Cochrane CR, Angelovich TA, Byrnes SJ, Waring E, Guanizo AC, Trollope GS, et al. Intact HIV proviruses persist in the brain despite viral suppression with ART. Ann Neurol. 2022;92(4):532–44.
Article CAS PubMed PubMed Central Google Scholar
Kincer LP, Joseph SB, Gilleece MM, Hauser BM, Sizemore S, Zhou S, et al. Rebound HIV-1 in cerebrospinal fluid after antiviral therapy interruption is mainly clonally amplified R5 T cell-tropic virus. Nat Microbiol. 2023;8(2):260–71.
CAS PubMed PubMed Central Google Scholar
Albalawi YA, Narasipura SD, Olivares LJ, Al-Harthi L. CD4(dim) CD8(bright) T cells home to the brain and mediate HIV neuroinvasion. J Virol. 2022;96(15):e0080422.
Hsu J, Van Besien K, Glesby MJ, Pahwa S, Coletti A, Warshaw MG, et al. HIV-1 remission and possible cure in a woman after haplo-cord blood transplant. Cell. 2023;186(6):1115-26 e8.
Article CAS PubMed Google Scholar
Michael NL, Chang G, Louie LG, Mascola JR, Dondero D, Birx DL, et al. The role of viral phenotype and CCR-5 gene defects in HIV-1 transmission and disease progression. Nat Med. 1997;3(3):338–40.
Article CAS PubMed Google Scholar
Gupta RK, Peppa D, Hill AL, Gálvez C, Salgado M, Pace M, et al. Evidence for HIV-1 cure after <em>CCR5</em>Δ32/Δ32 allogeneic haemopoietic stem-cell transplantation 30 months post analytical treatment interruption: a case report. Lancet HIV. 2020;7(5):e340–7.
Article PubMed PubMed Central Google Scholar
Jensen B-EO, Knops E, Cords L, Lübke N, Salgado M, Busman-Sahay K, et al. In-depth virological and immunological characterization of HIV-1 cure after CCR5Δ32/Δ32 allogeneic hematopoietic stem cell transplantation. Nat Med. 2023;29(3):583–7.
Article CAS PubMed PubMed Central Google Scholar
Tang Y, Chaillon A, Gianella S, Wong LM, Li D, Simermeyer TL, Porrachia M, Ignacio C, Woodworth B, Zhong D, Du J, de la Parra Polina E, Kirchherr J, Allard B, Clohosey ML, Moeser M, Sondgeroth AL, Whitehill GD, Singh V, Dashti A, Smith DM, Eron JJ, Bar KJ, Chahroudi A, Joseph SB, Archin NM, Margolis DM, Jiang G. Brain microglia serve as a persistent HIV reservoir despite durable antiretroviral therapy. J Clin Invest. 2023;133(12):e167417.
Avalos CR, Abreu CM, Queen SE, Li M, Price S, Shirk EN, et al. Brain macrophages in simian immunodeficiency virus-infected, antiretroviral-suppressed macaques: a functional latent reservoir. mBio. 2017;8(4):e01186–17
Reu P, Khosravi A, Bernard S, Mold JE, Salehpour M, Alkass K, et al. The lifespan and turnover of microglia in the human brain. Cell Rep. 2017;20(4):779–84.
Enick PN, Brooker JP, Tumiotto CM, Staines BT, Eron JJ, McMahon DK, et al. Comparison of methods to quantify inducible HIV-1 outgrowth. J Virus Erad. 2021;7(2):100043.
Article CAS PubMed PubMed Central Google Scholar
Mizee MR, Miedema SS, van der Poel M, Adelia, Schuurman KG, van Strien ME, et al. Isolation of primary microglia from the human post-mortem brain: effects of ante- and post-mortem variables. Acta Neuropathol Commun. 2017;5(1):16.
Hiener B, Eden JS, Horsburgh BA, Palmer S. Amplification of near full-length HIV-1 proviruses for next-generation sequencing. J Vis Exp. 2018;(140):58016.
Hiener B, Horsburgh BA, Eden JS, Barton K, Schlub TE, Lee E, et al. Identification of genetically intact HIV-1 proviruses in specific CD4(+) T cells from effectively treated participants. Cell Rep. 2017;21(3):813–22.
Article CAS PubMed PubMed Central Google Scholar
Grau-Expósito J, Serra-Peinado C, Miguel L, Navarro J, Curran A, Burgos J, et al. A novel single-cell FISH-flow assay identifies effector memory CD4+ T cells as a major niche for HIV-1 transcription in HIV-infected patients. mBio. 2017;8(4):e00876-17.
Article PubMed PubMed Central Google Scholar
Bruner KM, Wang Z, Simonetti FR, Bender AM, Kwon KJ, Sengupta S, et al. A quantitative approach for measuring the reservoir of latent HIV-1 proviruses. Nature. 2019;566(7742):120–5.
Article CAS PubMed PubMed Central Google Scholar
von Bartheld CS, Bahney J, Herculano-Houzel S. The search for true numbers of neurons and glial cells in the human brain: a review of 150 years of cell counting. J Comp Neurol. 2016;524(18):3865–95.
Dos Santos SE, Medeiros M, Porfirio J, Tavares W, Pessoa L, Grinberg L, et al. Similar microglial cell densities across brain structures and mammalian species: impl
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