Weller M, Wick W, Aldape K, Brada M, Berger M, Pfister SM, et al. Glioma. Nature Rev Disease Primers. 2015;1(1):15017.

Article  PubMed  Google Scholar 

Stupp R, Hegi ME, Mason WP, van den Bent MJ, Taphoorn MJ, Janzer RC, et al. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol. 2009;10(5):459–66.

Article  CAS  PubMed  Google Scholar 

Mohammed S, Dinesan M, Ajayakumar T. Survival and quality of life analysis in glioblastoma multiforme with adjuvant chemoradiotherapy: a retrospective study. Rep Pract Oncol Radiother. 2022;27(6):1026–36. https://doi.org/10.5603/RPOR.a2022.0113.

Xia S, Lal B, Tung B, Wang S, Goodwin CR, Laterra J. Tumor microenvironment tenascin-C promotes glioblastoma invasion and negatively regulates Tumor proliferation. Neurooncology. 2016;18(4):507–17.

CAS  Google Scholar 

Iliff JJ, Lee H, Yu M, Feng T, Logan J, Nedergaard M, et al. Brain-wide pathway for waste clearance captured by contrast-enhanced MRI. J Clin Investig. 2013;123(3):1299–309.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta. Sci Transl Med. 2012;4(147):147ra11.

Article  Google Scholar 

Iliff JJ, Wang M, Zeppenfeld DM, Venkataraman A, Plog BA, Liao Y, et al. Cerebral arterial pulsation drives paravascular CSF-interstitial fluid exchange in the murine brain. J Neurosci. 2013;33(46):18190–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Louveau A, Plog BA, Antila S, Alitalo K, Nedergaard M, Kipnis J. Understanding the functions and relationships of the glymphatic system and meningeal lymphatics. J Clin Investig. 2017;127(9):3210–9.

Article  PubMed  PubMed Central  Google Scholar 

Ueno M, Chiba Y, Murakami R, Matsumoto K, Kawauchi M, Fujihara R. Blood-brain barrier and blood-cerebrospinal fluid barrier in normal and pathological conditions. Brain Tumor Pathol. 2016;33(2):89–96.

Article  CAS  PubMed  Google Scholar 

Hladky SB, Barrand MA. Elimination of substances from the brain parenchyma: efflux via perivascular pathways and via the blood-brain barrier. Fluids Barriers CNS. 2018;15(1):30.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma Q, Ineichen BV, Detmar M, Proulx ST. Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice. Nat Commun. 2017;8(1):1434.

Article  PubMed  PubMed Central  Google Scholar 

Kaur J, Davoodi-Bojd E, Fahmy LM, Zhang L, Ding G, Hu J, et al. Magnetic Resonance Imaging and modeling of the Glymphatic System. Diagnostics (Basel). 2020;10(6):344.

Article  CAS  PubMed  Google Scholar 

Kaur J, Fahmy LM, Davoodi-Bojd E, Zhang L, Ding G, Hu J, et al. Waste Clearance in the brain. Front Neuroanat. 2021;15:53.

Article  Google Scholar 

Simon MJ, Iliff JJ. Regulation of cerebrospinal fluid (CSF) flow in neurodegenerative, neurovascular and neuroinflammatory Disease. Biochim Biophys Acta. 2016;1862(3):442–51.

Article  CAS  PubMed  Google Scholar 

Tarasoff-Conway JM, Carare RO, Osorio RS, Glodzik L, Butler T, Fieremans E, et al. Clearance systems in the brain-implications for Alzheimer Disease. Nat Rev Neurol. 2015;11(8):457–70.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zarow C, Lyness SA, Mortimer JA, Chui HC. Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson Diseases. Arch Neurol. 2003;60(3):337–41.

Article  PubMed  Google Scholar 

Reeves BC, Karimy JK, Kundishora AJ, Mestre H, Cerci HM, Matouk C, et al. Glymphatic System Impairment in Alzheimer’s Disease and idiopathic normal pressure Hydrocephalus. Trends Mol Med. 2020;26(3):285–95.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peng W, Achariyar TM, Li B, Liao Y, Mestre H, Hitomi E, et al. Suppression of glymphatic fluid transport in a mouse model of Alzheimer’s Disease. Neurobiol Dis. 2016;93:215–25.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mestre H, Kostrikov S, Mehta RI, Nedergaard M. Perivascular spaces, glymphatic dysfunction, and small vessel Disease. Clin Sci (Lond). 2017;131(17):2257–74.

Article  CAS  PubMed  Google Scholar 

Charidimou A, Pantoni L, Love S. The concept of sporadic cerebral small vessel Disease: a road map on key definitions and current concepts. Int J Stroke. 2016;11(1):6–18.

Article  PubMed  Google Scholar 

Plog BA, Dashnaw ML, Hitomi E, Peng W, Liao Y, Lou N, et al. Biomarkers of traumatic injury are transported from brain to blood via the glymphatic system. J Neuroscience. 2015;35(2):518–26.

Article  PubMed  Google Scholar 

Mondello S, Muller U, Jeromin A, Streeter J, Hayes RL, Wang KK. Blood-based diagnostics of traumatic brain injuries. Expert Rev Mol Diagn. 2011;11(1):65–78.

Article  PubMed  PubMed Central  Google Scholar 

Jessen NA, Munk AS, Lundgaard I, Nedergaard M. The Glymphatic System: a beginner’s guide. Neurochem Res. 2015;40(12):2583–99.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tsitsopoulos PP, Marklund N. Amyloid-beta peptides and Tau Protein as biomarkers in cerebrospinal and interstitial fluid following traumatic Brain Injury: a review of experimental and clinical studies. Front Neurol. 2013;4:79.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Magnoni S, Esparza TJ, Conte V, Carbonara M, Carrabba G, Holtzman DM, et al. Tau elevations in the brain extracellular space correlate with reduced amyloid-beta levels and predict adverse clinical outcomes after severe traumatic brain injury. Brain. 2012;135(Pt 4):1268–80.

Article  PubMed  Google Scholar 

Iliff JJ, Chen MJ, Plog BA, Zeppenfeld DM, Soltero M, Yang L, et al. Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury. J Neuroscience. 2014;34(49):16180–93.

Article  PubMed  Google Scholar 

Morris M, Maeda S, Vossel K, Mucke L. The many faces of tau. Neuron. 2011;70(3):410–26.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gaberel T, Gakuba C, Goulay R, Martinez De Lizarrondo S, Hanouz JL, Emery E, et al. Impaired glymphatic perfusion after strokes revealed by contrast-enhanced MRI: a new target for fibrinolysis? Stroke. 2014;45(10):3092–6.

Article  CAS  PubMed  Google Scholar 

Goulay R, Flament J, Gauberti M, Naveau M, Pasquet N, Gakuba C, et al. Subarachnoid Hemorrhage severely impairs brain parenchymal cerebrospinal fluid circulation in Nonhuman Primate. Stroke. 2017;48(8):2301–5.

Article  PubMed  Google Scholar 

Mestre H, Du T, Sweeney AM, Liu G, Samson AJ, Peng W, et al. Cerebrospinal fluid influx drives acute ischemic tissue swelling. Science. 2020;367(6483):eaax7171. https://doi.org/10.1126/science.aax7171.

Jiang Q, Zhang L, Ding G, Davoodi-Bojd E, Li Q, Li L, et al. Impairment of the glymphatic system after Diabetes. J Cereb Blood flow Metabol. 2017;37(4):1326–37.

Article  Google Scholar 

Schain AJ, Melo-Carrillo A, Strassman AM, Burstein R. Cortical spreading depression closes Paravascular Space and impairs glymphatic Flow: implications for Migraine Headache. J Neurosci. 2017;37(11):2904.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Venkat P, Chopp M, Zacharek A, Cui C, Zhang L, Li Q, et al. White matter damage and glymphatic dysfunction in a model of vascular Dementia in rats with no prior vascular pathologies. Neurobiol Aging. 2017;50:96–106.

Article  PubMed  Google Scholar 

Wang M, Ding F, Deng S, Guo X, Wang W, Iliff JJ, et al. Focal solute trapping and global glymphatic pathway impairment in a murine model of multiple microinfarcts. J Neuroscience. 2017;37(11):2870–7.

Article  CAS  PubMed  Google Scholar 

Wostyn P, Killer HE, De Deyn PP. Glymphatic stasis at the site of the lamina cribrosa as a potential mechanism underlying open-angle glaucoma. Clin Exp Ophthalmol. 2017;45(5):539–47.

Article  PubMed  Google Scholar 

Hu X, Deng Q, Ma L, Li Q, Chen Y, Liao Y, et al. Meningeal lymphatic vessels regulate Brain Tumor drainage and immunity. Cell Res. 2020;30(3):229–43.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ahn JH, Cho H, Kim JH, Kim SH, Ham JS, Park I, et al. Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid. Nature. 2019;572(7767):62–6.

Article  CAS  PubMed  Google Scholar 

Aspelund A, Antila S, Proulx ST, Karlsen TV, Karaman S, Detmar M, et al. A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules. J Exp Med. 2015;212(7):991–9.

Article