Conrad K, Roggenbuck D, Laass MW. Diagnosis and classification of ulcerative colitis. Autoimmun Rev. 2014;13:463–6. https://doi.org/10.1016/j.autrev.2014.01.028.

Article  CAS  PubMed  Google Scholar 

Christensen B, Hanauer SB, Erlich J, Kassim O, Gibson PR, Turner JR, Hart J, Rubin DT. Histologic normalization occurs in ulcerative colitis and is associated with improved clinical outcomes. Clin Gastroenterol Hepatol. 2017;15:1557-1564.e1. https://doi.org/10.1016/j.cgh.2017.02.016.

Article  PubMed  PubMed Central  Google Scholar 

Luo H, Cao G, Luo C, Tan D, Vong CT, Xu Y, Wang S, Lu H, Wang Y, Jing W. Emerging pharmacotherapy for inflammatory bowel diseases. Pharmacol Res. 2022;178: 106146. https://doi.org/10.1016/j.phrs.2022.106146.

Article  CAS  PubMed  Google Scholar 

de Souza HSP, Fiocchi C. Immunopathogenesis of IBD: current state of the art. Nat Rev Gastroenterol Hepatol. 2016;13:13–27. https://doi.org/10.1038/nrgastro.2015.186.

Article  CAS  PubMed  Google Scholar 

Park JH, Peyrin-Biroulet L, Eisenhut M, Shin JI. IBD immunopathogenesis: a comprehensive review of inflammatory molecules. Autoimmun Rev. 2017;16:416–26. https://doi.org/10.1016/j.autrev.2017.02.013.

Article  CAS  PubMed  Google Scholar 

Lai LJ, Shen J, Ran ZH. Natural killer T cells and ulcerative colitis. Cell Immunol. 2019;335:1–5. https://doi.org/10.1016/j.cellimm.2018.08.010.

Article  CAS  PubMed  Google Scholar 

Lockhart A, Mucida D, Parsa R. Immunity to enteric viruses. Immunity. 2022;55:800–18. https://doi.org/10.1016/j.immuni.2022.04.007.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pandolfini L, Barbieri I, Bannister AJ, Hendrick A, Andrews B, Webster N, Murat P, Mach P, Brandi R, Robson SC, Migliori V, Alendar A, d’Onofrio M, Balasubramanian S, Kouzarides T. METTL1 promotes let-7 MicroRNA processing via m7G methylation. Mol Cell. 2019;74:1278-1290.e9. https://doi.org/10.1016/j.molcel.2019.03.040.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Luo Y, Yao Y, Wu P, Zi X, Sun N, He J. The potential role of N7-methylguanosine (m7G) in cancer. J Hematol Oncol. 2022;15:63. https://doi.org/10.1186/s13045-022-01285-5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang S, Zhou J, Chen Z, Sun Q, Zhang D, Feng Y, Wang X, Sun Y. A novel m7G-related lncRNA risk model for predicting prognosis and evaluating the tumor immune microenvironment in colon carcinoma. Front Oncol. 2022;12: 934928. https://doi.org/10.3389/fonc.2022.934928.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li X-Y, Wang S-L, Chen D-H, Liu H, You J-X, Su L-X, Yang X-T. Construction and validation of a m7G-related gene-based prognostic model for gastric cancer. Front Oncol. 2022;12: 861412. https://doi.org/10.3389/fonc.2022.861412.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cai X, Shi W, Lian J, Zhang G, Cai Y, Zhu L. Characterization of immune landscape and development of a novel N7-methylguanine-related gene signature to aid therapy in recurrent aphthous stomatitis. Inflamm Res. 2023;72:133–48. https://doi.org/10.1007/s00011-022-01665-0.

Article  CAS  PubMed  Google Scholar 

Dong K, Gu D, Shi J, Bao Y, Fu Z, Fang Y, Qu L, Zhu W, Jiang A, Wang L. Identification and verification of m7G modification patterns and characterization of tumor microenvironment infiltration via multi-omics analysis in clear cell renal cell carcinoma. Front Immunol. 2022;13: 874792. https://doi.org/10.3389/fimmu.2022.874792.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao Z, Qing Y, Dong L, Han L, Wu D, Li Y, Li W, Xue J, Zhou K, Sun M, Tan B, Chen Z, Shen C, Gao L, Small A, Wang K, Leung K, Zhang Z, Qin X, Deng X, Xia Q, Su R, Chen J. QKI shuttles internal m7G-modified transcripts into stress granules and modulates mRNA metabolism. Cell. 2023;S0092–8674(23):00598–606. https://doi.org/10.1016/j.cell.2023.05.047.

Article  CAS  Google Scholar 

Comprehensive analysis of cuproptosis-related genes in immune infiltration and diagnosis in ulcerative colitis—PubMed, (n.d.). https://pubmed.ncbi.nlm.nih.gov/36389705/ (Accessed 14 July 2023).

Kim Y, Kang JW, Kang J, Kwon EJ, Ha M, Kim YK, Lee H, Rhee J-K, Kim YH. Novel deep learning-based survival prediction for oral cancer by analyzing tumor-infiltrating lymphocyte profiles through CIBERSORT. Oncoimmunology. 2021;10:1904573. https://doi.org/10.1080/2162402X.2021.1904573.

Article  PubMed  PubMed Central  Google Scholar 

Yu G, Wang L-G, Han Y, He Q-Y. clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS. 2012;16:284–7. https://doi.org/10.1089/omi.2011.0118.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Langfelder P, Horvath S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics. 2008;9:559. https://doi.org/10.1186/1471-2105-9-559.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Langfelder P, Luo R, Oldham MC, Horvath S. Is my network module preserved and reproducible? PLoS Comput Biol. 2011;7: e1001057. https://doi.org/10.1371/journal.pcbi.1001057.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zuo T, Lu X-J, Zhang Y, Cheung CP, Lam S, Zhang F, Tang W, Ching JYL, Zhao R, Chan PKS, Sung JJY, Yu J, Chan FKL, Cao Q, Sheng J-Q, Ng SC. Gut mucosal virome alterations in ulcerative colitis. Gut. 2019;68:1169–79. https://doi.org/10.1136/gutjnl-2018-318131.

Article  CAS  PubMed  Google Scholar 

Xia X, Wang Y, Zheng JC. Internal m7G methylation: a novel epitranscriptomic contributor in brain development and diseases. Mol Ther Nucleic Acids. 2023;31:295–308. https://doi.org/10.1016/j.omtn.2023.01.003.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Emerging roles of RNA methylation in gastrointestinal cancers - PubMed, (n.d.). https://pubmed.ncbi.nlm.nih.gov/33372610/ (Accessed 14 July 2023).

Montañés-Agudo P, Aufiero S, Schepers EN, van der Made I, Cócera-Ortega L, Ernault AC, Richard S, Kuster DWD, Christoffels VM, Pinto YM, Creemers EE. The RNA-binding protein QKI governs a muscle-specific alternative splicing program that shapes the contractile function of cardiomyocytes. Cardiovasc Res. 2023;119:1161–74. https://doi.org/10.1093/cvr/cvad007.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tian Y, Xu J, Li Y, Zhao R, Du S, Lv C, Wu W, Liu R, Sheng X, Song Y, Bi X, Li G, Li M, Wu X, Lou P, You H, Cui W, Sun J, Shuai J, Ren F, Zhang B, Guo M, Hou X, Wu K, Xue L, Zhang H, Plikus MV, Cong Y, Lengner CJ, Liu Z, Yu Z. MicroRNA-31 reduces inflammatory signaling and promotes regeneration in colon epithelium, and delivery of mimics in microspheres reduces colitis in mice. Gastroenterology. 2019;156:2281-2296.e6. https://doi.org/10.1053/j.gastro.2019.02.023.

Article  CAS  PubMed  Google Scholar 

Xie Z, Wang Y, Yang G, Han J, Zhu L, Li L, Zhang S. The role of the Hippo pathway in the pathogenesis of inflammatory bowel disease. Cell Death Dis. 2021;12:79. https://doi.org/10.1038/s41419-021-03395-3.

Article  PubMed  PubMed Central  Google Scholar 

Neumann DP, Goodall GJ, Gregory PA. The quaking RNA-binding proteins as regulators of cell differentiation. Wiley Interdiscip Rev RNA. 2022;13: e1724. https://doi.org/10.1002/wrna.1724.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang L, Wu G, Wu Q, Peng L, Yuan L. METTL3 overexpression aggravates LPS-induced cellular inflammation in mouse intestinal epithelial cells and DSS-induced IBD in mice. Cell Death Discov. 2022;8:62. https://doi.org/10.1038/s41420-022-00849-1.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang L, Zhai D-S, Ruan B-J, Xu C-M, Ye Z-C, Lu H-Y, Jiang Y-H, Wang Z-Y, Xiang A, Yang Y, Yuan J-L, Lu Z-F. Quaking deficiency amplifies inflammation in experimental endotoxemia via the aryl hydrocarbon receptor/signal transducer and activator of transcription 1-NF-κB pathway. Front Immunol. 2017;8:1754. https://doi.org/10.3389/fimmu.2017.01754.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Roffey J, Rosse C, Linch M, Hibbert A, McDonald NQ, Parker PJ. Protein kinase C intervention: the state of play. Curr Opin Cell Biol. 2009;21:268–79. https://doi.org/10.1016/j.ceb.2009.01.019.

Article  CAS  PubMed  Google Scholar 

Patergnani S, Marchi S, Rimessi A, Bonora M, Giorgi C, Mehta KD, Pinton P. PRKCB/protein kinase C, beta and the mitochondrial axis as key regulators of autophagy. Autophagy. 2013;9:1367–85. https://doi.org/10.4161/auto.25239.

Article  CAS  PubMed  Google Scholar 

Deretic V. Autophagy in inflammation, infection, and immunometabolism. Immunity. 2021;54:437–53. https://doi.org/10.1016/j.immuni.2021.01.018.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Foerster EG, Mukherjee T, Cabral-Fernandes L, Rocha JDB, Girardin SE, Philpott DJ. How autophagy controls the intestinal epithelial barrier. Autophagy. 2022;18:86–103. https://doi.org/10.1080/15548627.2021.1909406.