Knezevic NN, Candido KD, Vlaeyen JWS, Van Zundert J, Cohen SP. Low back pain. Lancet. 2021;398:78–92.
Hartvigsen J, Hancock MJ, Kongsted A, Louw Q, Ferreira ML, Genevay S, et al. What low back pain is and why we need to pay attention. Lancet. 2018;391:2356–67.
Urits I, Burshtein A, Sharma M, Testa L, Gold PA, Orhurhu V, et al. Low back pain, a comprehensive review: pathophysiology, diagnosis, and treatment. Curr Pain Headache Rep. 2019;23:23.
Risbud MV, Shapiro IM. Role of cytokines in intervertebral disc degeneration: pain and disc content. Nat Rev Rheumatol. 2014;10:44–56.
Article CAS PubMed Google Scholar
Xin J, Wang Y, Zheng Z, Wang S, Na S, Zhang S. Treatment of intervertebral disc degeneration. Orthop Surg. 2022;14:1271–80.
Article PubMed PubMed Central Google Scholar
Wu PH, Kim HS, Jang IT. Intervertebral disc diseases PART 2: a review of the current diagnostic and treatment strategies for intervertebral disc disease. Int J Mol Sci. 2020;21(6):2135.
Article CAS PubMed PubMed Central Google Scholar
Ohnishi T, Iwasaki N, Sudo H. Causes of and molecular targets for the treatment of intervertebral disc degeneration: a review. Cells. 2022;11(3):394.
Article CAS PubMed PubMed Central Google Scholar
Lundon K, Bolton K. Structure and function of the lumbar intervertebral disk in health, aging, and pathologic conditions. J Orthop Sports Phys Ther. 2001;31:291–303.
Article CAS PubMed Google Scholar
Guerrero J, Häckel S, Croft AS, Hoppe S, Albers CE, Gantenbein B. The nucleus pulposus microenvironment in the intervertebral disc: the fountain of youth? Eur Cell Mater. 2021;41:707–38.
Article CAS PubMed Google Scholar
Song C, Cai W, Liu F, Cheng K, Guo D, Liu Z. An in-depth analysis of the immunomodulatory mechanisms of intervertebral disc degeneration. JOR Spine. 2022;5: e1233.
Article CAS PubMed PubMed Central Google Scholar
Song C, Zhou Y, Cheng K, Liu F, Cai W, Zhou D, et al. Cellular senescence—molecular mechanisms of intervertebral disc degeneration from an immune perspective. Biomed Pharmacother. 2023;162: 114711.
Article CAS PubMed Google Scholar
Song C, Chen R, Cheng K, Zhou D, Mei Y, Yan J, et al. Exploring the pharmacological mechanism of Duhuo Jisheng Decoction in treating intervertebral disc degeneration based on network pharmacology. Medicine (Baltimore). 2023;102: e33917.
Article CAS PubMed Google Scholar
Zhou D, Song C, Mei Y, Cheng K, Liu F, Cai W, et al. A review of Duhuo Jisheng decoction mechanisms in intervertebral disc degeneration in vitro and animal studies. J Orthop Surg Res. 2023;18:436.
Article PubMed PubMed Central Google Scholar
Liu ZC, Wang ZL, Huang CY, Fu ZJ, Liu Y, Wei ZC, et al. Duhuo Jisheng Decoction inhibits SDF-1-induced inflammation and matrix degradation in human degenerative nucleus pulposus cells in vitro through the CXCR4/NF-κB pathway. Acta Pharmacol Sin. 2018;39:912–22.
Article CAS PubMed PubMed Central Google Scholar
Lin Z, Wang H, Song J, Xu G, Lu F, Ma X, et al. The role of mitochondrial fission in intervertebral disc degeneration. Osteoarthr Cartil. 2023;31:158–66.
Zeng Z, Zhou X, Wang Y, Cao H, Guo J, Wang P, et al. Mitophagy-a new target of bone disease. Biomolecules. 2022;12(10):1420.
Article CAS PubMed PubMed Central Google Scholar
Zhang GZ, Deng YJ, Xie QQ, Ren EH, Ma ZJ, He XG, et al. Sirtuins and intervertebral disc degeneration: roles in inflammation, oxidative stress, and mitochondrial function. Clin Chim Acta. 2020;508:33–42.
Article CAS PubMed Google Scholar
Zhang C, Peng X, Wang F, Xie Z, Chen L, Wu X. Update on the correlation between mitochondrial dysfunction and intervertebral disk degeneration. DNA Cell Biol. 2022;41:257–61.
Article CAS PubMed Google Scholar
Nunnari J, Suomalainen A. Mitochondria: in sickness and in health. Cell. 2012;148:1145–59.
Article CAS PubMed PubMed Central Google Scholar
Santos JH. Mitochondria signaling to the epigenome: a novel role for an old organelle. Free Radic Biol Med. 2021;170:59–69.
Article CAS PubMed Google Scholar
van der Bliek AM, Sedensky MM, Morgan PG. Cell Biology of the mitochondrion. Genetics. 2017;207:843–71.
Article PubMed PubMed Central Google Scholar
Csordás G, Weaver D, Hajnóczky G. Endoplasmic reticulum-mitochondrial contactology: structure and signaling functions. Trends Cell Biol. 2018;28:523–40.
Article PubMed PubMed Central Google Scholar
Greber BJ, Ban N. Structure and function of the mitochondrial ribosome. Annu Rev Biochem. 2016;85:103–32.
Article CAS PubMed Google Scholar
Szymański J, Janikiewicz J, Michalska B, Patalas-Krawczyk P, Perrone M, Ziółkowski W, et al. Interaction of mitochondria with the endoplasmic reticulum and plasma membrane in calcium homeostasis, lipid trafficking and mitochondrial structure. Int J Mol Sci. 2017;18(7):1576.
Article PubMed PubMed Central Google Scholar
Francisco V, Pino J, González-Gay M, Lago F, Karppinen J, Tervonen O, et al. A new immunometabolic perspective of intervertebral disc degeneration. Nat Rev Rheumatol. 2022;18:47–60.
Article CAS PubMed Google Scholar
Cheng Z, Xiang Q, Wang J, Zhang Y. The potential role of melatonin in retarding intervertebral disc ageing and degeneration: a systematic review. Ageing Res Rev. 2021;70: 101394.
Article CAS PubMed Google Scholar
Madhu V, Boneski PK, Silagi E, Qiu Y, Kurland I, Guntur AR, et al. Hypoxic regulation of mitochondrial metabolism and mitophagy in nucleus pulposus cells is dependent on HIF-1α-BNIP3 Axis. J Bone Miner Res. 2020;35:1504–24.
Article CAS PubMed Google Scholar
Hu B, Wang P, Zhang S, Liu W, Lv X, Shi D, et al. HSP70 attenuates compression-induced apoptosis of nucleus pulposus cells by suppressing mitochondrial fission via upregulating the expression of SIRT3. Exp Mol Med. 2022;54:309–23.
Article CAS PubMed PubMed Central Google Scholar
Song Y, Li S, Geng W, Luo R, Liu W, Tu J, et al. Sirtuin 3-dependent mitochondrial redox homeostasis protects against AGEs-induced intervertebral disc degeneration. Redox Biol. 2018;19:339–53.
Article CAS PubMed PubMed Central Google Scholar
Wang J, Toan S, Zhou H. New insights into the role of mitochondria in cardiac microvascular ischemia/reperfusion injury. Angiogenesis. 2020;23:299–314.
Forte M, Schirone L, Ameri P, Basso C, Catalucci D, Modica J, et al. The role of mitochondrial dynamics in cardiovascular diseases. Br J Pharmacol. 2021;178:2060–76.
Article CAS PubMed Google Scholar
Hu C, Huang Y, Li L. Drp1-dependent mitochondrial fission plays critical roles in physiological and pathological progresses in mammals. Int J Mol Sci. 2017;18(1):144.
Article PubMed PubMed Central Google Scholar
Nasto LA, Robinson AR, Ngo K, Clauson CL, Dong Q, St Croix C, et al. Mitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degeneration. J Orthop Res. 2013;31:1150–7.
Article CAS PubMed PubMed Central Google Scholar
Wallace DC. Mitochondria and cancer. Nat Rev Cancer. 2012;12:685–98.
Article CAS PubMed PubMed Central Google Scholar
Feng C, Yang M, Lan M, Liu C, Zhang Y, Huang B, et al. ROS: crucial intermediators in the pathogenesis of intervertebral disc degeneration. Oxid Med Cell Longev. 2017;2017:5601593.
Article PubMed PubMed Central Google Scholar
Wang Y, Cheng H, Wang T, Zhang K, Zhang Y, Kang X. Oxidative stress in intervertebral disc degeneration: molecular mechanisms, pathogenesis and treatment. Cell Prolif. 2023. https://doi.org/10.1111/cpr.13448.
Comments (0)