Provan D, Arnold DM, Bussel JB, Chong BH, Cooper N, Gernsheimer T, Ghanima W, Godeau B, Gonzalez-Lopez TJ, Grainger J, et al. Updated international consensus report on the investigation and management of primary immune thrombocytopenia. Blood Adv. 2019;3(22):3780–817.

Article  PubMed  PubMed Central  Google Scholar 

Semple JW, Rebetz J, Maouia A, Kapur R. An update on the pathophysiology of immune thrombocytopenia. Curr Opin Hematol. 2020;27(6):423–9.

Article  CAS  PubMed  Google Scholar 

Wang N, Tall AR. Cholesterol in platelet biogenesis and activation. Blood. 2016;127(16):1949–53.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Slatter DA, Aldrovandi M, O’Connor A, Allen SM, Brasher CJ, Murphy RC, Mecklemann S, Ravi S, Darley-Usmar V, O’Donnell VB. Mapping the human platelet lipidome reveals cytosolic phospholipase A2 as a Regulator of mitochondrial bioenergetics during activation. Cell Metabol. 2016;23(5):930–44.

Article  CAS  Google Scholar 

Münzer P, Walker-Allgaier B, Geue S, Langhauser F, Geuss E, Stegner D, Aurbach K, Semeniak D, Chatterjee M, Gonzalez Menendez I, et al. CK2β regulates thrombopoiesis and Ca-triggered platelet activation in arterial thrombosis. Blood. 2017;130(25):2774–85.

Article  PubMed  Google Scholar 

Morgan PK, Fang L, Lancaster GI, Murphy AJ. Hematopoiesis is regulated by cholesterol efflux pathways and lipid rafts: connections with cardiovascular diseases. J Lipid Res. 2020;61(5):667–75.

Article  CAS  PubMed  Google Scholar 

Cakirca G, Celik MM. Lipid profile and atherogenic indices and their association with platelet indices in familial Mediterranean fever. Turk Kardiyol Dern Ars. 2018;46(3):184–90.

PubMed  Google Scholar 

Kaito K, Otsubo H, Usui N, Yoshida M, Tanno J, Kurihara E, Matsumoto K, Hirata R, Domitsu K, Kobayashi M. Platelet size deviation width, platelet large cell ratio, and mean platelet volume have sufficient sensitivity and specificity in the diagnosis of immune thrombocytopenia. Br J Haematol. 2005;128(5):698–702.

Article  PubMed  Google Scholar 

Chen C, Song J, Wang Q, Wang L-H, Guo P-X. Mean platelet volume at baseline and immune thrombocytopenia relapse in chinese newly-diagnosed patients: a retrospective cohort study. Hematol (Amsterdam Netherlands). 2018;23(9):646–52.

Google Scholar 

Emdin CA, Khera AV, Kathiresan S. Mendelian randomization. JAMA. 2017;318(19):1925–6.

Article  PubMed  Google Scholar 

Georgakis MK, Gill D. Mendelian randomization studies in stroke: exploration of risk factors and drug targets with Human Genetic Data. Stroke. 2021;52(9):2992–3003.

Article  PubMed  Google Scholar 

Sekula P, Del Greco MF, Pattaro C, Köttgen A. Mendelian randomization as an Approach to assess causality using Observational Data. J Am Soc Nephrol. 2016;27(11):3253–65.

Article  PubMed  PubMed Central  Google Scholar 

Burgess S, Small DS, Thompson SG. A review of instrumental variable estimators for mendelian randomization. Stat Methods Med Res. 2017;26(5):2333–55.

Article  PubMed  Google Scholar 

Didelez V, Sheehan N. Mendelian randomization as an instrumental variable approach to causal inference. Stat Methods Med Res. 2007;16(4):309–30.

Article  PubMed  Google Scholar 

Elsworth B, Lyon M, Alexander T, Liu Y, Matthews P, Hallett J, Bates P, Palmer T, Haberland V, Smith GD et al. The MRC IEU OpenGWAS data infrastructure. bioRxiv 2020:2020.2008.2010.244293.

Astle WJ, Elding H, Jiang T, Allen D, Ruklisa D, Mann AL, Mead D, Bouman H, Riveros-Mckay F, Kostadima MA, et al. The allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. Cell. 2016;167(5):1415–1429e1419.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brion MJ, Shakhbazov K, Visscher PM. Calculating statistical power in mendelian randomization studies. Int J Epidemiol. 2013;42(5):1497–501.

Article  PubMed  Google Scholar 

Papadimitriou N, Dimou N, Tsilidis KK, Banbury B, Martin RM, Lewis SJ, Kazmi N, Robinson TM, Albanes D, Aleksandrova K, et al. Physical activity and risks of breast and colorectal cancer: a mendelian randomisation analysis. Nat Commun. 2020;11(1):597–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shardell M, Ferrucci L. Instrumental variable analysis of multiplicative models with potentially invalid instruments. Stat Med. 2016;35(29):5430–47.

Article  PubMed  PubMed Central  Google Scholar 

Hemani G, Zheng J, Elsworth B, Wade KH, Haberland V, Baird D, Laurin C, Burgess S, Bowden J, Langdon R et al. The MR-Base platform supports systematic causal inference across the human phenome. Elife 2018, 7.

Fessler MB, Rose K, Zhang Y, Jaramillo R, Zeldin DC. Relationship between serum cholesterol and indices of erythrocytes and platelets in the US population. J Lipid Res. 2013;54(11):3177–88.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bora K, Jitani AK, Raphael V, Ruram AA, Borah P, Khonglah Y. Association between lipid profile and platelet indices: the importance of considering the influence of lipid profile while evaluating the clinical utility of platelet indices. Int J Lab Hematol. 2016;38(4):E80–3.

Article  CAS  PubMed  Google Scholar 

Gisterå A, Hansson GK. The immunology of atherosclerosis. Nat Rev Nephrol. 2017;13(6):368–80.

Article  PubMed  Google Scholar 

Qiu Y-J, Luo J-Y, Luo F, Tian X-X, Zeng L, Zhang Z-R, Li X-M, Yang Y-N. Prognostic value of the PDW/HDL-C ratio in patients with chest pain symptoms and coronary artery calcification. Front Cardiovasc Med. 2022;9:824955.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kohlmorgen C, Gerfer S, Feldmann K, Twarock S, Hartwig S, Lehr S, Klier M, Krüger I, Helten C, Keul P, et al. Dapagliflozin reduces thrombin generation and platelet activation: implications for cardiovascular risk reduction in type 2 diabetes mellitus. Diabetologia. 2021;64(8):1834–49.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Plubell DL, Fenton AM, Rosario S, Bergstrom P, Wilmarth PA, Clark WM, Zakai NA, Quinn JF, Minnier J, Alkayed NJ, et al. High-density lipoprotein carries markers that Track with Recovery from Stroke. Circul Res. 2020;127(10):1274–87.

Article  CAS  Google Scholar 

Yao Y, Li X, Wang Z, Ji Q, Xu Q, Yan Y, Lv Q. Interaction of lipids, Mean platelet volume, and the severity of coronary artery disease among chinese adults: a mediation analysis. Front Cardiovasc Med. 2022;9:753171.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Şahin EA, Mavi D, Kara E, Sönmezer MÇ, İnkaya AÇ, Ünal S. Integrase inhibitor-based regimens are related to favorable systemic inflammatory index and platecrit scores in people living with HIV (PLWH) up to 2 years. Postgrad Med. 2022;134(6):635–40.

Article  PubMed  Google Scholar 

Wang Z, Wang W, Gong R, Yao H, Fan M, Zeng J, Xu S, Lin R. Eradication of Helicobacter pylori alleviates lipid metabolism deterioration: a large-cohort propensity score-matched analysis. Lipids Health Dis. 2022;21(1):34.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nagata Y, Yoshikawa J, Hashimoto A, Yamamoto M, Payne AH, Todokoro K. Proplatelet formation of megakaryocytes is triggered by autocrine-synthesized estradiol. Genes Dev. 2003;17(23):2864–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Frelinger AL 3rd, Grace RF, Gerrits AJ, Berny-Lang MA, Brown T, Carmichael SL, Neufeld EJ, Michelson AD. Platelet function tests, independent of platelet count, are associated with bleeding severity in ITP. Blood. 2015;126(7):873–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang S, Lv Y, Luo X, Weng X, Qi J, Bai X, Zhao C, Zeng M, Bao X, Dai X, et al. Homocysteine promotes atherosclerosis through macrophage pyroptosis via endoplasmic reticulum stress and calcium disorder. Mol Med. 2023;29(1):73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

de Pereira CJ, Flauzino WL, Alfieri T, Oliveira DF, Kallaur SR, Simão AP, Lozovoy ANC, Kaimen-Maciel MAB, Maes DR, Reiche M. Immune-inflammatory, metabolic and hormonal biomarkers are associated with the clinical forms and disability progression in patients with multiple sclerosis: a follow-up study. J Neurol Sci. 2020;410:116630.

Article  CAS  Google Scholar 

Ryu H, Kim J, Kim D, Lee J-E, Chung Y. Cellular and Molecular Links between autoimmunity and lipid metabolism. Mol Cells. 2019;42(11):747–54.

CAS  PubMed  PubMed Central  Google Scholar 

Xu P, Zhao Y, Yu T, Yu Y, Ni X, Wang H, Sun L, Han P, Wang L, Sun T et al. Atorvastatin restores imbalance of cluster of differentiation 4 (CD4) T cells in immune thrombocytopenia in vivo and in vitro. British journal of haematology 2021.

Kong Y, Cao X-N, Zhang X-H, Shi M-M, Lai Y-Y, Wang Y, Xu L-P, Chang Y-J, Huang X-J. Atorvastatin enhances bone marrow endothelial cell function in corticosteroid-resistant immune thrombocytopenia patients. Blood. 2018;131(11):1219–33.

Article  CAS  PubMed  Google Scholar