Wald G. The photoreceptor process in vision. In: Handbook physiology. Washington D.C.: American Physiological Society; 1959. p. 671–692.

Wald G. Human vision and the spectrum. Science. 1945;101:653–8.

Article  CAS  PubMed  Google Scholar 

Wald G. Vitamin a in eye tissues. J Gen Physiol. 1935;18:905–15.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Petkovich M, Brand NJ, Krust A, Chambon P. A human retinoic acid receptor which belongs to the family of nuclear receptors. Nature. 1987;330:444–50.

Article  CAS  PubMed  Google Scholar 

Giguere V, Ong ES, Segui P, Evans RM. Identification of a receptor for the morphogen retinoic acid. Nature. 1987;330:624–9.

Article  CAS  PubMed  Google Scholar 

Petkovich M. Regulation of gene expression by vitamin A: the role of nuclear retinoic acid receptors. Annu Rev Nutr. 1992;12:443–71.

Article  CAS  PubMed  Google Scholar 

Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schutz G, Umesono K, Blumberg B, Kastner P, Mark M, Chambon P, et al. The nuclear receptor superfamily: the second decade. Cell. 1995;83:835–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mangelsdorf DJ, Evans RM. The RXR heterodimers and orphan receptors. Cell. 1995;83:841–50.

Article  CAS  PubMed  Google Scholar 

Evans RM, Mangelsdorf DJ. Nuclear receptors, RXR, and the big bang. Cell. 2014;157:255–66.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Evans RM. The nuclear receptor superfamily: a rosetta stone for physiology. Mol Endocrinol. 2005;19:1429–38.

Article  CAS  PubMed  Google Scholar 

Shulman AI, Mangelsdorf DJ. Retinoid x receptor heterodimers in the metabolic syndrome. N Engl J Med. 2005;353:604–15.

Article  CAS  PubMed  Google Scholar 

Chawla A, Repa JJ, Evans RM, Mangelsdorf DJ. Nuclear receptors and lipid physiology: opening the X-files. Science. 2001;294:1866–70.

Article  CAS  PubMed  Google Scholar 

Kastner P, Messaddeq N, Mark M, Wendling O, Grondona JM, Ward S, Ghyselinck N, Chambon P. Vitamin A deficiency and mutations of RXRalpha, RXRbeta and RARalpha lead to early differentiation of embryonic ventricular cardiomyocytes. Development. 1997;124:4749–58.

Article  CAS  PubMed  Google Scholar 

Ghyselinck NB, Dupe V, Dierich A, Messaddeq N, Garnier JM, Rochette-Egly C, Chambon P, Mark M. Role of the retinoic acid receptor beta (RARbeta) during mouse development. Int J Dev Biol. 1997;41:425–47.

CAS  PubMed  Google Scholar 

McCarthy P, Cerecedo LR. Vitamin A deficiency in the mouse. J Nutr. 1952;46:361–76.

Article  CAS  PubMed  Google Scholar 

Aykroyd WR. Functional night-blindness due to vitamin A deficiency. Lancet. 1930;1:824.

Google Scholar 

Wolfe JM, Salter HP. Vitamin A deficiency in the Albino mouse. J Nutr. 1930;4:185–92.

Article  Google Scholar 

Blackfan KD, Wolbach SB. Vitamin A deficiency in infants. J Pediatr. 1933;3:679–706.

Article  Google Scholar 

Mukherjee S, Date A, Patravale V, Korting HC, Roeder A, Weindl G. Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clin Interv Aging. 2006;1:327–48.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zasada M, Budzisz E. Retinoids: active molecules influencing skin structure formation in cosmetic and dermatological treatments. Postepy Dermatol Alergol. 2019;36:392–7.

Article  PubMed  PubMed Central  Google Scholar 

Beckenbach L, Baron JM, Merk HF, Loffler H, Amann PM. Retinoid treatment of skin diseases. Eur J Dermatol. 2015;25:384–91.

Article  CAS  PubMed  Google Scholar 

Altucci L, Leibowitz MD, Ogilvie KM, de Lera AR, Gronemeyer H. RAR and RXR modulation in cancer and metabolic disease. Nat Rev Drug Discov. 2007;6:793–810.

Article  CAS  PubMed  Google Scholar 

Altucci L, Gronemeyer H. The promise of retinoids to fight against cancer. Nat Rev Cancer. 2001;1:181–93.

Article  CAS  PubMed  Google Scholar 

Bohn T, Desmarchelier C, El SN, Keijer J, van Schothorst EM, Rühl R, Borel P. B-carotene in the human body-metabolic acitivation pathways—from digestion to tissue distribution. Proc Nutr Soc. 2019;78:68–87.

Article  CAS  PubMed  Google Scholar 

Bohn T, Desmarchelier C, Dragsted LO, Nielsen CS, Stahl W, Ruhl R, Keijer J, Borel P. Host-related factors explaining interindividual variability of carotenoid bioavailability and tissue concentrations in humans. Mol Nutr Food Res. 2017;61:1600685.

Article  PubMed  PubMed Central  Google Scholar 

Böhm V, Lietz G, Olmedilla-Alonso B, Phelan D, Reboul E, Banati D, Borel P, Corte-Real J, de Lera AR, Desmarchelier C, et al. From carotenoid intake to carotenoid blood and tissue concentrations-implications for dietary intake recommendations. Nutr Rev. 2020;79:544–73.

Article  PubMed Central  Google Scholar 

Rollman O, Vahlquist A. Vitamin A in skin and serum–studies of acne vulgaris, atopic dermatitis, ichthyosis vulgaris and lichen planus. Br J Dermatol. 1985;113:405–13.

Article  CAS  PubMed  Google Scholar 

Escaron AL, Green MH, Tanumihardjo SA. Plasma turnover of 3,4-didehydroretinol (vitamin A2) increases in vitamin A-deficient rats fed low versus high dietary fat. J Lipid Res. 2009;50:694–703.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Howell JM, Thompson JN, Pitt GA. Reproduction and vision in rats maintained on a retinol-free diet containing 3-dehydroretinol (vitamin A2). Br J Nutr. 1967;21:373–6.

Article  CAS  PubMed  Google Scholar 

Cama HR, Dalvi PD, Morton RA, Salah MK. Studies in vitamin A. XXI. Retinene2 and vitamin A2. Biochem J. 1952;52:542–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shantz EM. Isolation of pure vitamin A2. Science. 1948;108:417–9.

Article  CAS  PubMed  Google Scholar 

Moise AR, Isken A, Dominguez M, de Lera AR, von Lintig J, Palczewski K. Specificity of zebrafish retinol saturase: formation of all-trans-13,14-dihydroretinol and all-trans-7,8- dihydroretinol. Biochemistry. 2007;46:1811–20.

Article  CAS  PubMed  Google Scholar 

Babino D, Golczak M, Kiser PD, Wyss A, Palczewski K, von Lintig J. The biochemical basis of vitamin A3 production in athopod vision. ACS Chem Biol. 2016; in press.

WHO. Vitamin and mineral requirements in human nutrition; report of a joint FAO/WHO expert consultation. Bankok: WHO/FAO of the UN; 1998.

Krezel W, Rivas A, Szklenar M, Ciancia M, Alvarez R, de Lera AR, Rühl R. Vitamin A5/X, a new food to lipid hormone concept for a nutritional ligand to control RXR-mediated signaling. Nutrients. 2021;13:925.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Codex-alimentarius. Guidelines on nutrient labelling CAC/GL 2-1985. WHO/FAO. 2017.

EFSA. Scientific opinion on dietary reference values for vitamin A. 13 2015: 4028.

Krezel W, Rühl R, de Lera AR. Alternative retinoid X receptor (RXR) ligands. Mol Cell Endocrinol. 2019;491: 110436.

Article  CAS  PubMed  Google Scholar 

de Lera AR, Krezel W, Rühl R. An endogenous mammalian retinoid X receptor ligand, at last! ChemMedChem. 2016;11:1027–37.

Article  PubMed  Google Scholar 

Rühl R, Krezel W, de Lera AR. 9-Cis-13,14-dihydroretinoic acid, a new endogenous mammalian ligand of retinoid X receptor and the active ligand of a potential new vitamin A category: vitamin A5. Nutr Rev. 2018;76:929–41.

PubMed  Google Scholar 

Rühl R, Krzyzosiak A, Niewiadomska-Cimicka A, Rochel N, Szeles L, Vaz B, Wietrzych-Schindler M, Alvarez S, Szklenar M, Nagy L, et al. 9-cis-13,14-dihydroretinoic acid is an endogenous retinoid acting as RXR ligand in mice. PLoS Genet. 2015;11: e1005213.

Article  PubMed  PubMed Central  Google Scholar 

Bohn T, de Lera ÁR, Landrier JF, Carlsen H, Merk D, Todt T, Renaut J, Rühl R. State-of-the-art methodological investigation of carotenoid activity and metabolism—from organic synthesis via metabolism to biological activity—exemplified by a novel retinoid signalling pathway. Food Funct. 2023; in press.

Bohn T, de Lera AR, Landrier JF, Rühl R. Carotenoid metabolites, their tissue and blood concentrations in humans and further bioactivity via retinoid receptor-mediated signalling. Nutr Res Rev. 2022. https://doi.org/10.1017/s095442242200021x:1-14.

Article  PubMed