Imagine beyond: recent breakthroughs and next challenges in mammary gland biology and breast cancer research

Rosen JM, Roarty K. Paracrine signaling in mammary gland development: what can we learn about intratumoral heterogeneity? Breast Cancer Research. 2014;16:202.

Article  PubMed  PubMed Central  Google Scholar 

Brown SB, Hankinson SE. Endogenous estrogens and the risk of breast, endometrial, and ovarian cancers. Steroids. 2015;99:8–10.

Article  CAS  PubMed  Google Scholar 

Schneider J, Martín-Gutiérrez S, Tresguerres JA, García-Velasco JA. Circulating estradiol defines the tumor phenotype in menopausal breast cancer patients. Maturitas. 2009;64:43–5.

Article  CAS  PubMed  Google Scholar 

Obradović MMS, Hamelin B, Manevski N, Couto JP, Sethi A, Coissieux MM, et al. Glucocorticoids promote breast cancer metastasis. Nature. 2019;567:540–4.

Article  PubMed  Google Scholar 

Giulianelli S, Lamb CA, Lanari C. Progesterone receptors in normal breast development and breast cancer. Essays in Biochemistry. 2021;65:951–69.

Article  CAS  PubMed  Google Scholar 

Michmerhuizen AR, Spratt DE, Pierce LJ, Speers CW. ARe we there yet? Understanding androgen receptor signaling in breast cancer. NPJ Breast Cancer. 2020;6:47.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Noureddine LM, Trédan O, Hussein N, Badran B, Le Romancer M, Poulard C. Glucocorticoid Receptor: A Multifaceted Actor in Breast Cancer. International Journal of Molecular Sciences. 2021;22:4446.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Font-Díaz J, Jiménez-Panizo A, Caelles C, Vivanco M dM, Pérez P, Aranda A, et al. Nuclear receptors: Lipid and hormone sensors with essential roles in the control of cancer development. Semin Cancer Biol. 2021;73:58–75.

Pan H, Gray R, Braybrooke J, Davies C, Taylor C, McGale P, et al. 20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years. The New England Journal of Medicine. 2017;377:1836–46.

Article  PubMed  PubMed Central  Google Scholar 

Shackleton M, Vaillant F, Simpson KJ, Stingl J, Smyth GK, Asselin-Labat ML, et al. Generation of a functional mammary gland from a single stem cell. Nature. 2006;439:84–8.

Article  CAS  PubMed  Google Scholar 

Stingl J, Eirew P, Ricketson I, Shackleton M, Vaillant F, Choi D, et al. Purification and unique properties of mammary epithelial stem cells. Nature. 2006;439:993–7.

Article  CAS  PubMed  Google Scholar 

Hannezo E, Scheele CLGJ, Moad M, Drogo N, Heer R, Sampogna RV, et al. A Unifying Theory of Branching Morphogenesis. Cell. 2017;171:242-255.e27.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Simões BM, Piva M, Iriondo O, Comaills V, López-Ruiz JA, Zabalza I, et al. Effects of estrogen on the proportion of stem cells in the breast. Breast Cancer Research and Treatment. 2011;129:23–35.

Article  PubMed  Google Scholar 

Shehata M, van Amerongen R, Zeeman AL, Giraddi RR, Stingl J. The influence of tamoxifen on normal mouse mammary gland homeostasis. Breast Cancer Research. 2014;16:411.

Article  PubMed  PubMed Central  Google Scholar 

Rios AC, Fu NY, Lindeman GJ, Visvader JE. In situ identification of bipotent stem cells in the mammary gland. Nature. 2014;506:322–7.

Article  CAS  PubMed  Google Scholar 

Van Keymeulen A, Rocha AS, Ousset M, Beck B, Bouvencourt G, Rock J, et al. Distinct stem cells contribute to mammary gland development and maintenance. Nature. 2011;479:189–93.

Article  PubMed  Google Scholar 

van Amerongen R, Bowman AN, Nusse R. Developmental stage and time dictate the fate of Wnt/beta-catenin-responsive stem cells in the mammary gland. Cell Stem Cell. 2012;11:387–400.

Article  PubMed  Google Scholar 

Šale S, Lafkas D, Artavanis-Tsakonas S. Notch2 genetic fate mapping reveals two previously unrecognized mammary epithelial lineages. Nature Cell Biology. 2013;15:451–60.

Article  PubMed  PubMed Central  Google Scholar 

Lafkas D, Rodilla V, Huyghe M, Mourao L, Kiaris H, Fre S. Notch3 marks clonogenic mammary luminal progenitor cells in vivo. The Journal of Cell Biology. 2013;203:47–56.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wuidart A, Ousset M, Rulands S, Simons BD, Van Keymeulen A, Blanpain C. Quantitative lineage tracing strategies to resolve multipotency in tissue-specific stem cells. Genes & Development. 2016;30:1261–77.

Article  CAS  Google Scholar 

Scheele CLGJ, Hannezo E, Muraro MJ, Zomer A, Langedijk NSM, Van Oudenaarden A, et al. Identity and dynamics of mammary stem cells during branching morphogenesis. Nature. 2017;542:313–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang D, Cai C, Dong X, Yu QC, Zhang XO, Yang L, et al. Identification of multipotent mammary stemcells by protein C receptor expression. Nature. 2015;517:81–4.

Article  CAS  PubMed  Google Scholar 

Nguyen QH, Pervolarakis N, Blake K, Ma D, Davis RT, James N, et al. Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity. Nature Communications. 2018;9:2028.

Article  PubMed  PubMed Central  Google Scholar 

Kumar B, Prasad M, Bhat-Nakshatri P, Anjanappa M, Kalra M, Marino N, et al. Normal Breast-Derived Epithelial Cells with Luminal and Intrinsic Subtype-Enriched Gene Expression Document Interindividual Differences in Their Differentiation Cascade. Cancer Research. 2018;78:5107–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang C, Christin JR, Oktay MH, Guo W. Lineage-Biased Stem Cells Maintain Estrogen-Receptor-Positive and -Negative Mouse Mammary Luminal Lineages. Cell Reports. 2017;18:2825–35.

Article  CAS  PubMed  Google Scholar 

Van Keymeulen A, Fioramonti M, Centonze A, Bouvencourt G, Achouri Y, Blanpain C. Lineage-Restricted Mammary Stem Cells Sustain the Development, Homeostasis, and Regeneration of the Estrogen Receptor Positive Lineage. Cell Reports. 2017;20:1525–32.

Article  PubMed  Google Scholar 

Lloyd-Lewis B, Davis FM, Harris OB, Hitchcock JR, Watson CJ. Neutral lineage tracing of proliferative embryonic and adult mammary stem/progenitor cells. Development. 2018;145:dev164079.

Davis FM, Lloyd-Lewis B, Harris OB, Kozar S, Winton DJ, Muresan L, et al. Single-cell lineage tracing in the mammary gland reveals stochastic clonal dispersion of stem/progenitor cell progeny. Nature Communications. 2016;7:13053.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rodilla V, Dasti A, Huyghe M, Lafkas D, Laurent C, Reyal F, et al. Luminal progenitors restrict their lineage potential during mammary gland development. PLoS Biology. 2015;13.

Article  PubMed  PubMed Central  Google Scholar 

Centonze A, Lin S, Tika E, Sifrim A, Fioramonti M, Malfait M, et al. Heterotypic cell–cell communication regulates glandular stem cell multipotency. Nature. 2020;584(7822):608–13.

Benítez S, Cordero A, Santamaría PG, Redondo-Pedraza J, Rocha AS, Collado-Solé A, et al. RANK links senescence to stemness in the mammary epithelia, delaying tumor onset but increasing tumor aggressiveness. Developmental Cell. 2021;56:1727-1741.e7.

Article  PubMed  PubMed Central  Google Scholar 

Koren S, Reavie L, Couto JP, De Silva D, Stadler MB, Roloff T, et al. PIK3CAH1047R induces multipotency and multi-lineage mammary tumours. Nature. 2015;525:114–8.

Article  CAS  PubMed  Google Scholar 

Van Keymeulen A, Lee MY, Ousset M, Brohée S, Rorive S, Giraddi RR, et al. Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity. Nature. 2015;525:119–23.

Article  PubMed  Google Scholar 

Lilja AM, Rodilla V, Huyghe M, Hannezo E, Landragin C, Renaud O, et al. Clonal analysis of Notch1-expressing cells reveals the existence of unipotent stem cells that retain long-term plasticity in the embryonic mammary gland. Nature Cell Biology. 2018;20:677–87.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fridriksdottir AJ, Villadsen R, Morsing M, Klitgaard MC, Kim J, Petersen OW, et al. Proof of region-specific multipotent progenitors in human breast epithelia. Proceedings of the National academy of Sciences of the United States of America. 2017;114:E10102–11.

CAS  PubMed  PubMed Central  Google Scholar 

Cereser B, Jansen M, Austin E, Elia G, McFarlane T, van Deurzen CHM, et al. Analysis of clonal expansions through the normal and premalignant human breast epithelium reveals the presence of luminal stem cells. The Journal of Pathology. 2018;244:61–70.

Article  CAS  PubMed  Google Scholar 

Palafox M, Ferrer I, Pellegrini P, Vila S, Hernandez-Ortega S, Urruticoechea A, et al. RANK induces epithelial-mesenchymal transition and stemness in human mammary epithelial cells and promotes tumorigenesis and metastasis. Cancer Research. 2012;72:2879–88.

Article  CAS  PubMed  Google Scholar 

Liu S, Cong Y, Wang D, Sun Y, Deng L, Liu Y, et al. Breast cancer stem cells transition between epithelial and mesenchymal states reflective of their normal counterparts. Stem Cell Rep. 2014;2:78–91.

Article  CAS  Google Scholar 

Comments (0)

No login
gif