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Article / Publication Details

First-Page Preview

Received: October 06, 2022
Accepted: January 09, 2023
Published online: March 06, 2023

Number of Print Pages: 9
Number of Figures: 1
Number of Tables: 4

ISSN: 0254-4962 (Print)
eISSN: 1423-033X (Online)

For additional information: https://www.karger.com/PSP

Abstract

Introduction: Psychometric properties of the Self-evaluation of Negative Symptoms (SNS) in subjects with the deficit subtype of schizophrenia (SCZ-D) have not been investigated so far. This study had the following aims: (1) to assess psychometric properties of SNS in subjects with SCZ-D and (2) to explore the usefulness of SNS, in comparison with other clinical characteristics, in screening for SCZ-D. Methods: Participants were 82 stable outpatients with schizophrenia, including 40 individuals with SCZ-D and 42 individuals with the non-deficit subtype (SCZ-ND). Results: Internal consistency was acceptable-to-good in both groups. Factor analysis revealed two dimensions (apathy and emotional). There were significant positive correlations of the SNS total score with the subscore of negative symptoms from the Positive and Negative Syndrome Scale (PANSS) and significant negative correlations with scores of the Social and Occupational Functioning Assessment Scale (SOFAS) in both groups, indicating good convergent validity. The following measures were found to be appropriate screening tools for differentiating SCZ-D and SCZ-ND (p < 0.001): the SNS total score (area under the curve [AUC]: 0.849, cut-off ≥16, sensitivity: 80.0%, specificity: 78.6%), the PANSS subscore of negative symptoms (AUC: 0.868, cut-off ≥11, sensitivity: 90.0%, specificity: 78.6%), and the SOFAS (AUC: 0.779, cut-off ≤59, sensitivity: 69.2%, specificity: 82.5%). Also, adding the SOFAS (cut-off ≤59) to the SNS (cut-off: ≥16) further improved sensitivity and specificity (AUC: 0.898, p < 0.001, sensitivity = 87.5%, specificity = 82.2%). Cognitive performance and age of psychosis onset were not found to be suitable measures for differentiating SCZ-D and SCZ-ND. Conclusion: The present findings indicate that the SNS has good psychometric properties in subjects with SCZ-D and those with SCZ-ND. Moreover, the SNS, the PANSS, and the SOFAS might be used as screening tools for SCZ-D.

© 2023 S. Karger AG, Basel

References Kirkpatrick B, Mucci A, Galderisi S. Primary, enduring negative symptoms: an update on research. Schizophr Bull. 2017;43(4):730–6. Carpenter WT, Heinrichs DW, Wagman AMI. Deficit and nondeficit forms of schizophrenia: the concept. Am J Psychiatry. 1988;145(5):578–83. López-Díaz Á, Lara I, Lahera G. Is the prevalence of the deficit syndrome in schizophrenia higher than estimated? Results of a meta-analysis. Psychiatry Investig. 2018;15(1):94–8. Bora E, Binnur Akdede B, Alptekin K. Neurocognitive impairment in deficit and non-deficit schizophrenia: a meta-analysis. Psychol Med. 2017;47(14):2401–13. Galderisi S, Mucci A, Buchanan RW, Arango C. Negative symptoms of schizophrenia: new developments and unanswered research questions. Lancet Psychiatry. 2018;5(8):664–77. Galderisi S, Sabé M, Bitter I, Nordentoft M, Mucci A, Kaiser S, et al. EPA guidance on treatment of negative symptoms in schizophrenia. Eur Psychiatry. 2021;64(1):e21. Cohen AS, Docherty NM. Deficit versus negative syndrome in schizophrenia: prediction of attentional impairment. Schizophr Bull. 2004;30(4):827–35. Goetz RR, Corcoran C, Yale S, Stanford AD, Kimhy D, Amador X, et al. Validity of a “proxy” for the deficit syndrome derived from the positive and negative syndrome scale (PANSS). Schizophr Res. 2007;93(1–3):169–77. Hovington CL, Bodnar M, Joober R, Malla AK, Lepage M. Identifying persistent negative symptoms in first episode psychosis. BMC Psychiatry. 2012;12:224. Subotnik KL, Nuechterlein KH, Ventura J, Green MF, Hwang SS. Prediction of the deficit syndrome from initial deficit symptoms in the early course of schizophrenia. Psychiatry Res. 1998;80(1):53–9. Carpenter WT, Blanchard JJ, Kirkpatrick B. New standards for negative symptom assessment. Schizophr Bull. 2016;42:1–3. Dollfus S, Mach C, Morello R. Self-evaluation of negative symptoms: a novel tool to assess negative symptoms. Schizophr Bull. 2016;42(3):571–8. Rodríguez-Testal JF, Perona-Garcelán S, Dollfus S, Valdés-Díaz M, García-Martínez J, Ruíz-Veguilla M, et al. Spanish validation of the self-evaluation of negative symptoms scale SNS in an adolescent population. BMC Psychiatry. 2019;19(1):327. Dollfus S, Delouche C, Hervochon C, Mach C, Bourgeois V, Rotharmel M, et al. Specificity and sensitivity of the self-assessment of negative symptoms (SNS) in patients with schizophrenia. Schizophr Res. 2019;211:51–5. Mallet J, Guessoum SB, Tebeka S, Le Strat Y, Dubertret C. Self-evaluation of negative symptoms in adolescent and young adult first psychiatric episodes. Prog Neuropsychopharmacol Biol Psychiatry. 2020;103:109988. Goldring A, Borne S, Hefner A, Thanju A, Khan A, Lindenmayer JP. The psychometric properties of the Self-Evaluation of Negative Symptoms Scale (SNS) in treatment-resistant schizophrenia (TRS). Schizophr Res. 2020;224:159–66. McGuffin P, Farmer A, Harvey I. A polydiagnostic application of operational criteria in studies of psychotic illness. Development and reliability of the OPCRIT system. Arch Gen Psychiatry. 1991;48(8):764–70. Andreasen NC, Carpenter WT, Kane JM, Lasser RA, Marder SR, Weinberger DR. Remission in schizophrenia: proposed criteria and rationale for consensus. Am J Psychiatry. 2005;162(3):441–9. Kirkpatrick B, Buchanan RW, McKenney PD, Alphs LD, Carpenter WT. The schedule for the deficit syndrome: an instrument for research in schizophrenia. Psychiatry Res. 1989;30(2):119–23. Kay SR, Fiszbein A, Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull. 1987;13(2):261–76. Wallwork RS, Fortgang R, Hashimoto R, Weinberger DR, Dickinson D. Searching for a consensus five-factor model of the positive and negative syndrome scale for schizophrenia. Schizophr Res. 2012;137(1–3):246–50. Addington D, Addington J, Maticka-Tyndale E, Joyce J. Reliability and validity of a depression rating scale for schizophrenics. Schizophr Res. 1992;6(3):201–8. Goldman HH, Skodol AE, Lave TR. Revising axis V for DSM-IV: a review of measures of social functioning. Am J Psychiatry. 1992;149(9):1148–56. Randolph C, Tierney MC, Mohr E, Chase TN. The repeatable battery for the assessment of neuropsychological status (RBANS): preliminary clinical validity. J Clin Exp Neuropsychol. 1998;20(3):310–9. Wójciak P, Górna K, Domowicz K, Jaracz K, Szpalik R, Michalak M, et al. Polish version of the self-evaluation of negative symptoms (SNS). Psychiatr Pol. 2019;53(3):551–9. Hajj A, Hallit S, Chamoun K, Sacre H, Obeid S, Haddad C, et al. Validation of the Arabic version of the “self-evaluation of negative symptoms” scale (SNS). BMC Psychiatry. 2020;20(1):240. García-Álvarez L, Martínez-Cao C, Bobes-Bascarán T, Portilla A, Courtet P, de la Fuente-Tomás L, et al. Validation of a European Spanish-version of the self-evaluation of negative symptoms (SNS) in patients with schizophrenia. Rev Psiquiatr Salud Ment. 2022;15(1):14–21. Blanchard JJ, Cohen AS. The structure of negative symptoms within schizophrenia: implications for assessment. Schizophr Bull. 2006;32(2):238–45. Kirkpatrick B, Strauss GP, Nguyen L, Fischer BA, Daniel DG, Cienfuegos A, et al. The brief negative symptom scale: psychometric properties. Schizophr Bull. 2011;37(2):300–5. Li SB, Liu C, Zhang JB, Wang LL, Hu HX, Chu MY, et al. Revisiting the latent structure of negative symptoms in schizophrenia: evidence from two second-generation clinical assessments. Schizophr Res. 2022;248:131–9. Kring AM, Gur RE, Blanchard JJ, Horan WP, Reise SP. The clinical assessment interview for negative symptoms (CAINS): final development and validation. Am J Psychiatry. 2013;170(2):165–72. Addington D, Addington J, Maticka-Tyndale E. Assessing depression in schizophrenia: the calgary depression scale. Br J Psychiatry. 1993;163(S22):39–44. Dollfus S, Mucci A, Giordano GM, Bitter I, Austin SF, Delouche C, et al. European validation of the self-evaluation of negative symptoms (SNS): a large multinational and multicenter study. Front Psychiatry. 2022;13:826465. Tam MHW, Ling-Ling W, Cheng KM, Wong JOY, Cheung EFC, Lui SSY, et al. Latent structure of self-report negative symptoms in patients with schizophrenia: a preliminary study. Asian J Psychiatr. 2021;61:102680. Smith GN, Ehmann TS, Flynn SW, MacEwan GW, Tee K, Kopala LC, et al. The assessment of symptom severity and functional impairment with DSM-IV Axis V. Psychiatr Serv. 2011;62(4):411–7. Article / Publication Details

First-Page Preview

Received: October 06, 2022
Accepted: January 09, 2023
Published online: March 06, 2023

Number of Print Pages: 9
Number of Figures: 1
Number of Tables: 4

ISSN: 0254-4962 (Print)
eISSN: 1423-033X (Online)

For additional information: https://www.karger.com/PSP