Abdelaleem M et al (2019) Prospects for repurposing CNS drugs for cancer treatment. Oncol Rev. https://doi.org/10.4081/oncol.2019.411

Abdul M, Hoosein N (2002) Expression and activity of potassium ion channels in human prostate cancer. Cancer Lett. https://doi.org/10.1016/s0304-3835(02)00348-8

Abu El Maaty MA, Wölfl S (2017) Effects of 1, 25(OH)2D3 on cancer cells and potential applications in combination with established and putative anti-cancer agents’. Nutrients. https://doi.org/10.3390/nu9010087

Aissaoui D et al (2018) Functional role of Kv1.1 and Kv1.3 channels in the neoplastic progression steps of three cancer cell lines, elucidated by scorpion peptides. Int J Biol Macromol. https://doi.org/10.1016/j.ijbiomac.2018.01.144

Allard B et al (2016) Immunosuppressive activities of adenosine in cancer. Curr Opin Pharmacol. https://doi.org/10.1016/j.coph.2016.04.001

Almasi S et al (2018) TRPM2 channel–mediated regulation of autophagy maintains mitochondrial function and promotes gastric cancer cell survival via the JNK-signaling pathway. J Biol Chem. https://doi.org/10.1074/jbc.M117.817635

Almasi S, Sterea AM et al (2019a) TRPM2 ion channel promotes gastric cancer migration, invasion and tumor growth through the AKT signaling pathway. Sci Rep. https://doi.org/10.1038/s41598-019-40330-1

Almasi S, Long CY et al (2019b) TRPM2 silencing causes G2/M arrest and apoptosis in lung cancer cells via increasing intracellular ROS and RNS levels and activating the JNK pathway. Cell Physiol Biochem. https://doi.org/10.33594/000000052

An L et al (2017) Terfenadine combined with epirubicin impedes the chemo-resistant human non-small cell lung cancer both in vitro and in vivo through EMT and Notch reversal. Pharmacol Res. https://doi.org/10.1016/j.phrs.2017.07.021

Arbabian A et al (2013) Modulation of endoplasmic reticulum calcium pump expression during lung cancer cell differentiation. FEBS J. https://doi.org/10.1111/febs.12064

Arcangeli A, Becchetti A (2010) New trends in cancer therapy: targeting ion channels and transporters. Pharmaceuticals. https://doi.org/10.3390/ph3041202

Arora A et al (2005) Modulation of P-glycoprotein-mediated multidrug resistance in K562 leukemic cells by indole-3-carbinol. Toxicol Appl Pharmacol. https://doi.org/10.1016/j.taap.2004.06.017

Asher V et al (2010) Eag and HERG potassium channels as novel therapeutic targets in cancer. World J Surg Oncol. https://doi.org/10.1186/1477-7819-8-113

Asher V et al (2011) The role of Eag and HERG channels in cell proliferation and apoptotic cell death in SK-OV-3 ovarian cancer cell line. Cancer Cell Int. https://doi.org/10.1186/1475-2867-11-6

Averaimo S et al (2010) Chloride intracellular channel 1 (CLIC1): sensor and effector during oxidative stress. FEBS Lett. https://doi.org/10.1016/j.febslet.2010.02.073

Avila E et al (2010) Calcitriol down-regulates human ether a go-go 1 potassium channel expression in cervical cancer cells. Anticancer Res. https://doi.org/10.1016/j.yexcr.2009.11.008

Azimi I, Roberts-Thomson SJ, Monteith GR (2014) Calcium influx pathways in breast cancer: opportunities for pharmacological intervention. Br J Pharmacol. https://doi.org/10.1111/bph.12486

Azimi I et al (2019) ORAI1 and ORAI3 in breast cancer molecular subtypes and the identification of ORAI3 as a hypoxia sensitive gene and a regulator of hypoxia responses. Cancer. https://doi.org/10.3390/cancers11020208

Bachmann M et al (2018) Targeting mitochondrial ion channels to fight cancer. Int J Mol Sci. https://doi.org/10.3390/ijms19072060

Baffy G (2010) Uncoupling protein-2 and cancer. Mitochondrion. https://doi.org/10.1016/j.mito.2009.12.143

Bao XX et al (2012) Nifedipine induced autophagy through Beclin1 and mTOR pathway in endometrial carcinoma cells. Chin Med J (Engl). https://doi.org/10.3760/cma.j.issn.0366-6999.2012.17.028

Bao L et al (2016) Depletion of the human ion channel TRPM2 in neuroblastoma demonstrates its key role in cell survival through modulation of mitochondrial reactive oxygen species and bioenergetics. J Biol Chem. https://doi.org/10.1074/jbc.M116.747147

Barbado M et al (2009) Gene regulation by voltage-dependent calcium channels. Biochim Biophys Acta. https://doi.org/10.1016/j.bbamcr.2009.02.004

Barlaz Us S et al (2019) Effect of imipramine on radiosensitivity of prostate cancer: an in vitro study. Cancer Invest. https://doi.org/10.1080/07357907.2019.1662434

Basrai D et al (2002) BK channel blockers inhibit potassium-induced proliferation of human astrocytoma cells. Neuroreport. https://doi.org/10.1097/00001756-200203250-00008

Beatty GL, Gladney WL (2015) Immune escape mechanisms as a guide for cancer immunotherapy. Clin Cancer Res. https://doi.org/10.1158/1078-0432.CCR-14-1860

Belpomme D et al (2000) Verapamil increases the survival of patients with anthracycline-resistant metastatic breast carcinoma. Ann Oncol. https://doi.org/10.1023/a:1026556119020

Benzerdjeb, N. et al. (2016) ‘Orai3 is a predictive marker of metastasis and survival in resectable lung adenocarcinoma’, Oncotarget. doi: https://doi.org/10.18632/oncotarget.13149

Bernal-Ramos G et al (2017) Astemizole inhibits cell proliferation in human prostate tumorigenic cells expressing ether a-go-go-1 potassium channels. Cell Mol Biol (Noisy-le-Grand). https://doi.org/10.14715/cmb/2017.63.12.4

Bernardi P et al (2015) The mitochondrial permeability transition pore: channel formation by F-ATP synthase, integration in signal transduction, and role in pathophysiology. Physiol Rev. https://doi.org/10.1152/physrev.00001.2015

Berry BJ et al (2018) Use the protonmotive force: mitochondrial uncoupling and reactive oxygen species. J Mol Biol. https://doi.org/10.1016/j.jmb.2018.03.025

Bertolesi GE et al (2002) The Ca(2+) channel antagonists mibefradil and pimozide inhibit cell growth via different cytotoxic mechanisms. Mol Pharmacol. https://doi.org/10.1124/mol.62.2.210

Berul CI, Morad M (1995) Regulation of potassium channels by nonsedating antihistamines. Circulation. https://doi.org/10.1161/01.CIR.91.8.2220

Binyamin L et al (2004) Targeting an extracellular epitope of the human multidrug resistance protein 1 (MRP1) in malignant cells with a novel recombinant single chain Fv antibody. Int J Cancer. https://doi.org/10.1002/ijc.20177

Birben E et al (2012) Oxidative stress and antioxidant defense. World Allergy Organ J. https://doi.org/10.1097/WOX.0b013e3182439613

Bjelakovic G et al (2007) Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA. https://doi.org/10.1001/jama.297.8.842

Blake SD et al (2017) Transient receptor potential, Melastatin-2 (TRPM2) blockade: perspectives on potential novel clinical utility in cancer. Transl Cancer Res. https://doi.org/10.21037/tcr.2017.03.11

Blaya B et al (2010) Histamine and histamine receptor antagonists in cancer biology. Inflamm Allergy Drug Targets. https://doi.org/10.2174/187152810792231869

Bloch M et al (2007) KCNMA1 gene amplification promotes tumor cell proliferation in human prostate cancer. Oncogene. https://doi.org/10.1038/sj.onc.1210036

Bogeski I et al (2010) Differential redox regulation of ORAI ion channels: a mechanism to tune cellular calcium signaling. Sci Signal. https://doi.org/10.1126/scisignal.2000672

Bootman MD et al (2001) Calcium signalling – an overview. Semin Cell Dev Biol. https://doi.org/10.1006/scdb.2000.0211

Bowen CV et al (2013) In vivo detection of human TRPV6-rich tumors with anti-cancer peptides derived from soricidin. PLoS One. https://doi.org/10.1371/journal.pone.0058866

Buchanan PJ, McCloskey KD (2016) CaV channels and cancer: canonical functions indicate benefits of repurposed drugs as cancer therapeutics. Eur Biophys J. https://doi.org/10.1007/s00249-016-1144-z

Cairo MS et al (1989) Clinical trial of continuous infusion verapamil, bolus vinblastine, and continuous infusion VP-16 in drug-resistant pediatric tumors. Cancer Res 49(4):1063–1066

CAS  PubMed  Google Scholar 

Camacho J (2006) Ether a go-go potassium channels and cancer. Cancer Lett. https://doi.org/10.1016/j.canlet.2005.02.016

Camara AKS et al (2017) Mitochondrial VDAC1: a key gatekeeper as potential therapeutic target. Front Physiol. https://doi.org/10.3389/fphys.2017.00460

Cannon B et al (2006) Uncoupling proteins: a role in protection against reactive oxygen species-or not? Biochim Biophys Acta Bioenerg. https://doi.org/10.1016/j.bbabio.2006.05.016

Cazares-Ordonez V et al (2015) A cis-acting element in the promoter of human ether a go-go 1 potassium channel gene mediates repression by calcitriol in human cervical cancer cells. Biochem Cell Biol. https://doi.org/10.1139/bcb-2014-0073

Chai R et al (2018) Remote-controlling potassium channels in living cells through photothermal inactivation of calmodulin. Adv Healthc Mater. https://doi.org/10.1002/adhm.201800674

Chavez-Lopez MG et al (2014) Antiproliferative and proapoptotic effects of astemizole on cervical cancer cells. Int J Gynecol Cancer. https://doi.org/10.1097/IGC.0000000000000151

Chavez-Lopez MG et al (2015) Astemizole-based anticancer therapy for hepatocellular carcinoma (HCC), and Eag1 channels as potential early-stage markers of HCC. Tumour Biol. https://doi.org/10.1007/s13277-015-3299-0

Chavez-Lopez MG et al (2017) The combination astemizole-gefitinib as a potential therapy for human lung cancer. Onco Targets Ther. https://doi.org/10.2147/OTT.S144506

Chen CD et al (2007) Overexpression of CLIC1 in human gastric carcinoma and its clinicopathological significance. Proteomics. https://doi.org/10.1002/pmic.200600663

Chen SJ et al (2013) Role of TRPM2 in cell proliferation and susceptibility to oxidative stress. Am J Physiol Cell Physiol. https://doi.org/10.1152/ajpcell.00069.2012

Chen SJ et al (2014) A splice variant of the human ion channel TRPM2 modulates neuroblastoma tumor growth through hypoxia-inducible factor (HIF)-1/2α. J Biol Chem. https://doi.org/10.1074/jbc.M114.620922

Chen N et al (2018) Animal protein toxins: origins and therapeutic applications. Biophys Rep. https://doi.org/10.1007/s41048-018-0067-x

Chen YF et al (2019) Store-operated Ca2+ entry in tumor progression: From molecular mechanisms to clinical implications. Cancer. https://doi.org/10.3390/cancers11070899

Cheng WC et al (2019) Uncoupling protein 2 reprograms the tumor microenvironment to support the anti-tumor immune cycle. Nat Immunol. https://doi.org/10.1038/s41590-018-0290-0

Chiang EY et al (2017) Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions. Nat Commun. https://doi.org/10.1038/ncomms14644

Chimote AA et al (2013) Selective inhibition of KCa3.1 channels mediates adenosine regulation of the motility of human T cells. J Immunol. https://doi.org/10.4049/jimmunol.1300702

Chimote AA et al (2018) A defect in KCa3.1 channel activity limits the ability of CD8+ T cells from cancer patients to infiltrate an adenosine-rich microenvironment. Sci Signal. https://doi.org/10.1126/scisignal.aaq1616

Chio IIC, Tuveson DA (2017) ROS in cancer: the burning question. Trends Mol Med. https://doi.org/10.1016/j.molmed.2017.03.004

Chioni AM et al (2005) A novel polyclonal antibody specific for the Nav1.5 voltage-gated Na+ channel “neonatal” splice form. J Neurosci Methods. https://doi.org/10.1016/j.jneumeth.2005.03.010

Chung FY et al (2006) Sarco/endoplasmic reticulum calcium-ATPase 2 expression as a tumor marker in colorectal cancer. Am J Surg Pathol. https://doi.org/10.1097/00000478-200608000-00006

Clapham DE (2003) TRP channels as cellular sensors. Nature. https://doi.org/10.1038/nature02196

Comes N et al (2013) The voltage-dependent K(+) channels Kv1.3 and Kv1.5 in human cancer. Front Physiol. https://doi.org/10.3389/fphys.2013.00283

Crociani O et al (2014) hERG1 channels regulate VEGF-A secretion in human gastric cancer: clinicopathological correlations and therapeutical implications. Clin Cancer Res. https://doi.org/10.1158/1078-0432.CCR-13-2633

Cui C et al (2019) Progress in understanding mitochondrial calcium uniporter complex-mediated calcium signalling: a potential target for cancer treatment. Br J Pharmacol. https://doi.org/10.1111/bph.14632

Curry MC et al (2012) Distinct regulation of cytoplasmic calcium signals and cell death pathways by different plasma membrane calcium ATPase isoforms in MDA-MB-231 breast cancer cells. J Biol Chem. https://doi.org/10.1074/jbc.M112.364737

Curry M, Roberts-Thomson SJ, Monteith GR (2016) PMCA2 silencing potentiates MDA-MB-231 breast cancer cell death initiated with the Bcl-2 inhibitor ABT-263. Biochem Biophys Res Commun. https://doi.org/10.1016/j.bbrc.2016.09.030

D’Alessandro G et al (2019) Radiation increases functional KCa3.1 expression and invasiveness in glioblastoma. Cancer. https://doi.org/10.3390/cancers11030279

D’Amico M, Gasparoli L, Arcangeli A (2013) Potassium channels: novel emerging biomarkers and targets for therapy in cancer. Recent Pat Anticancer Drug Discov 8(1):53–65

CrossRef  Google Scholar 

Dalla Pozza E et al (2012) Role of mitochondrial uncoupling protein 2 in cancer cell resistance to gemcitabine. Biochim Biophys Acta Mol Cell Res. https://doi.org/10.1016/j.bbamcr.2012.06.007

Dang D, Rao R (2016) Calcium-ATPases: gene disorders and dysregulation in cancer. Biochim Biophys Acta Mol Cell Res. https://doi.org/10.1016/j.bbamcr.2015.11.016

Dardevet L et al (2015) Chlorotoxin: a helpful natural scorpion peptide to diagnose glioma and fight tumor invasion. Toxins (Basel). https://doi.org/10.3390/toxins7041079

David CJ, Manley JL (2010) Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged. Genes Dev. https://doi.org/10.1101/gad.1973010

Debes JD et al (2004) Inverse association between prostate cancer and the use of calcium channel blockers. Cancer Epidemiol Biomarkers. https://doi.org/10.1158/1055-9965.epi-03-0093

Deeb KK, Trump DL, Johnson CS (2007) Vitamin D signalling pathways in cancer: potential for anticancer therapeutics. Nat Rev Cancer. https://doi.org/10.1038/nrc2196

Deliot N, Constantin B (2015) Plasma membrane calcium channels in cancer: alterations and consequences for cell proliferation and migration. Biochim Biophys Acta. https://doi.org/10.1016/j.bbamem.2015.06.009

Denicola GM et al (2011) Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature. https://doi.org/10.1038/nature10189

Denmeade SR, Isaacs JT (2005) The SERCA pump as a therapeutic target: making a “smart bomb” for prostate cancer. Cancer Biol Ther. https://doi.org/10.4161/cbt.4.1.1505

Denmeade SR et al (2012) Engineering a prostate-specific membrane antigen-activated tumor endothelial cell prodrug for cancer therapy. Sci Transl Med. https://doi.org/10.1126/scitranslmed.3003886

Derdak Z et al (2008) The mitochondrial uncoupling protein-2 promotes chemoresistance in cancer cells. Cancer Res. https://doi.org/10.1158/0008-5472.CAN-08-0053

Deshane J, Garner CC, Sontheimer H (2003) Chlorotoxin inhibits glioma cell invasion via matrix metalloproteinase-2. J Biol Chem. https://doi.org/10.1074/jbc.M205662200

Diaz L et al (2009) Estrogens and human papilloma virus oncogenes regulate human ether-a-go-go-1 potassium channel expression. Cancer Res. https://doi.org/10.1158/0008-5472.CAN-08-2036

Diaz L et al (2015) Mechanistic effects of calcitriol in cancer biology. Nutrients. https://doi.org/10.3390/nu7065020

Diez-Bello R et al (2019) (−)-Oleocanthal inhibits proliferation and migration by modulating Ca2+ entry through TRPC6 in breast cancer cells. Biochim Biophys Acta Mol Cell Res. https://doi.org/10.1016/j.bbamcr.2018.10.010

Ding XW et al (2008) Overexpression of hERG1 in resected esophageal squamous cell carcinomas: a marker for poor prognosis. J Surg Oncol. https://doi.org/10.1002/jso.20891

Ding J et al (2014) Scorpion venoms as a potential source of novel cancer therapeutic compounds. Exp Biol Med (Maywood). https://doi.org/10.1177/1535370213513991

Diochot S et al (2003) APETx1, a new toxin from the sea anemone Anthopleura elegantissima, blocks voltage-gated human ether-a-go-go-related gene potassium channels. https://doi.org/10.1124/mol.64.1.59

Dixon SJ et al (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. https://doi.org/10.1016/j.cell.2012.03.042

Downie BR et al (2008) Eag1 expression interferes with hypoxia homeostasis and induces angiogenesis in tumors. J Biol Chem. https://doi.org/10.1074/jbc.M801830200

Dubois C et al (2014) Remodeling of channel-forming ORAI proteins determines an oncogenic switch in prostate cancer. Cancer Cell. https://doi.org/10.1016/j.ccr.2014.04.025

Durie BG, Dalton WS (1988) Reversal of drug-resistance in multiple myeloma with verapamil. Br J Haematol. https://doi.org/10.1111/j.1365-2141.1988.tb06190.x

Dutta S et al (2014) Interactions between exosomes from breast cancer cells and primary mammary epithelial cells leads to generation of reactive oxygen species which induce DNA damage response, stabilization of p53 and autophagy in epithelial cells. PLoS One. https://doi.org/10.1371/journal.pone.0097580

Ellegaard AM et al (2016) Repurposing cationic amphiphilic antihistamines for cancer treatment. EBioMedicine. https://doi.org/10.1016/j.ebiom.2016.06.013

Enfissi A et al (2004) The blocking of capacitative calcium entry by 2-aminoethyl diphenylborate (2-APB) and carboxyamidotriazole (CAI) inhibits proliferation in Hep G2 and Huh-7 human hepatoma cells. Cell Calcium. https://doi.org/10.1016/j.ceca.2004.04.004

Ermak G, Davies KJA (2002) Calcium and oxidative stress: from cell signaling to cell death. Mol Immunol. https://doi.org/10.1016/S0161-5890(01)00108-0

Faouzi M, Penner R (2014) TRPM2. Handb Exp Pharmacol. https://doi.org/10.1007/978-3-642-54215-2_16

Farias LM et al (2004) Ether a go-go potassium channels as human cervical cancer markers. Cancer Res. https://doi.org/10.1158/0008-5472.CAN-04-1204

Faustino-Rocha AI et al (2017) Antihistamines as promising drugs in cancer therapy. Life Sci. https://doi.org/10.1016/j.lfs.2016.12.008

Fernández-Nogueira P et al (2018) Histamine receptor 1 inhibition enhances antitumor therapeutic responses through extracellular signal-regulated kinase (ERK) activation in breast cancer. Cancer Lett. https://doi.org/10.1016/j.canlet.2018.03.014

Feske S, Wulff H, Skolnik EY (2015) Ion channels in innate and adaptive immunity. Annu Rev Immunol. https://doi.org/10.1146/annurev-immunol-032414-112212

Fiorio Pla A, Kondratska K, Prevarskaya N (2016) STIM and ORAI proteins: crucial roles in hallmarks of cancer. Am J Physiol Cell Physiol. https://doi.org/10.1152/ajpcell.00364.2015

Fitzpatrick AL et al (2001) Hypertension, heart rate, use of antihypertensives, and incident prostate cancer. Ann Epidemiol. https://doi.org/10.1016/s1047-2797(01)00246-0

Fraser SP, Grimes JA, Djamgoz MBA (2000) Effects of voltage-gated ion channel modulators on rat prostatic cancer cell proliferation: comparison of strongly and weakly metastatic cell lines. Prostate. https://doi.org/10.1002/1097-0045(20000615)44:1<61::aid-pros9>3.0.co;2-3

Freitas RA Jr (2005) What is nanomedicine? Nanomedicine. https://doi.org/10.1016/j.nano.2004.11.003

Frisch J et al (2019) STIM-Orai channels and reactive oxygen species in the tumor microenvironment. Cancer. https://doi.org/10.3390/cancers11040457

Fu S et al (2017a) Erratum to: first-in-human phase I study of SOR-C13, a TRPV6 calcium channel inhibitor, in patients with advanced solid tumors. Invest New Drugs. https://doi.org/10.1007/s10637-017-0455-y

Fu S et al (2017b) First-in-human phase I study of SOR-C13, a TRPV6 calcium channel inhibitor, in patients with advanced solid tumors. Invest New Drugs. https://doi.org/10.1007/s10637-017-0438-z

Fukushiro-Lopes DF et al (2018) Preclinical study of a Kv11.1 potassium channel activator as antineoplastic approach for breast cancer. Oncotarget. https://doi.org/10.18632/oncotarget.22925

Gao T et al (2000) Role of the C terminus of the alpha 1C (CaV1.2) subunit in membrane targeting of cardiac L-type calcium channels. J Biol Chem. https://doi.org/10.1074/jbc.M003465200

Gao T et al (2001) C-terminal fragments of the alpha 1C (CaV1.2) subunit associate with and regulate L-type calcium channels containing C-terminal-truncated alpha 1C subunits. J Biol Chem. https://doi.org/10.1074/jbc.M008000200

Garcia-Becerra R et al (2010) Calcitriol inhibits ether-a go-go potassium channel expression and cell proliferation in human breast cancer cells. Exp Cell Res. https://doi.org/10.1016/j.yexcr.2009.11.008

Garcia-Ferreiro RE et al (2004) Mechanism of block of hEag1 K+ channels by imipramine and astemizole. J Gen Physiol. https://doi.org/10.1085/jgp.200409041

Garcia-Quiroz J, Camacho J (2011) Astemizole: an old anti-histamine as a new promising anti-cancer drug. Anticancer Agents Med Chem. https://doi.org/10.2174/187152011795347513

Garcia-Quiroz J et al (2012) Astemizole synergizes calcitriol antiproliferative activity by inhibiting CYP24A1 and upregulating VDR: a novel approach for breast cancer therapy. PLoS One. https://doi.org/10.1371/journal.pone.0045063

Garcia-Quiroz J et al (2014) In vivo dual targeting of the oncogenic ether-a-go-go-1 potassium channel by calcitriol and astemizole results in enhanced antineoplastic effects in breast tumors. BMC Cancer. https://doi.org/10.1186/1471-2407-14-745

Garcia-Quiroz J et al (2016) Calcitriol stimulates gene expression of cathelicidin antimicrobial peptide in breast cancer cells with different phenotype. J Biomed Sci. https://doi.org/10.1186/s12929-016-0298-4

Garcia-Quiroz J et al (2019) Astemizole, an inhibitor of ether-a-go-go-1 potassium channel, increases the activity of the tyrosine kinase inhibitor gefitinib in breast cancer cells. Rev Invest Clin. https://doi.org/10.24875/RIC.18002840

García-Quiroz J et al (2019) Synergistic antitumorigenic activity of calcitriol with curcumin or resveratrol is mediated by angiogenesis inhibition in triple negative breast cancer xenografts. Cancer. https://doi.org/10.3390/cancers11111739

Gasparoli L et al (2015) New pyrimido-indole compound CD-160130 preferentially inhibits the KV11.1B isoform and produces antileukemic effects without cardiotoxicity. Mol Pharmacol. https://doi.org/10.1124/mol.114.094920

Gavrilova-Ruch O et al (2002) Effects of imipramine on ion channels and proliferation of IGR1 melanoma cells. J Membr Biol. https://doi.org/10.1007/s00232-001-0181-3

Ge L et al (2012) Glioma big potassium channel expression in human cancers and possible T cell epitopes for their immunotherapy. J Immunol. https://doi.org/10.4049/jimmunol.1102965

Gélébart P et al (2002) Expression of endomembrane calcium pumps in colon and gastric cancer cells. Induction of SERCA3 expression during differentiation. J Biol Chem. https://doi.org/10.1074/jbc.M201747200

Gentile S et al (2016) hERG1 potassium channel in cancer cells: a tool to reprogram immortality. Eur Biophys J. https://doi.org/10.1007/s00249-016-1169-3

Gessner G, Heinemann SH (2003) Inhibition of hEAG1 and hERG1 potassium channels by clofilium and its tertiary analogue LY97241. Br J Pharmacol 138(1):161–171. https://doi.org/10.1038/sj.bjp.0705025

CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

Gilbert SM et al (2017) A phase I clinical trial demonstrates that nfP2X7-targeted antibodies provide a novel, safe and tolerable topical therapy for basal cell carcinoma. Br J Dermatol. https://doi.org/10.1111/bjd.15364

Gillman PK (2007) Tricyclic antidepressant pharmacology and therapeutic drug interactions updated. Br J Pharmacol. https://doi.org/10.1038/sj.bjp.0707253

Glowka E, Stasiak J, Lulek J (2019) Drug delivery systems for vitamin D supplementation and therapy. Pharmaceutics. https://doi.org/10.3390/pharmaceutics11070347

Gomes FR et al (2015) Alternatively spliced isoforms of KV10.1 potassium channels modulate channel properties and can activate cyclin-dependent kinase in Xenopus oocytes. J Biol Chem. https://doi.org/10.1074/jbc.M115.668749

Gómez-Lagunas F et al (2017) Gating modulation of the tumor-related Kv10.1 channel by mibefradil. J Cell Physiol. https://doi.org/10.1002/jcp.25448

Gomez-Ospina N et al (2013) A promoter in the coding region of the calcium channel gene CACNA1C generates the transcription factor CCAT. PLoS One. https://doi.org/10.1371/journal.pone.0060526

Gomez-Varela D et al (2006) Different relevance of inactivation and F468 residue in the mechanisms of hEag1 channel blockage by astemizole, imipramine and dofetilide. FEBS Lett. https://doi.org/10.1016/j.febslet.2006.08.030

Gomez-Varela D et al (2007) Monoclonal antibody blockade of the human Eag1 potassium channel function exerts antitumor activity. Cancer. https://doi.org/10.1158/0008-5472.CAN-07-0107

Gorrini C, Harris IS, Mak TW (2013) Modulation of oxidative stress as an anticancer strategy. Nat Rev Drug Discov. https://doi.org/10.1038/nrd4002

Graf N et al (2012) Platinum(IV)-chlorotoxin (CTX) conjugates for targeting cancer cells. J Inorg Biochem. https://doi.org/10.1016/j.jinorgbio.2012.02.012

Gritti M et al (2014) Metformin repositioning as antitumoral agent: Selective antiproliferative effects in human glioblastoma stem cells, via inhibition of CLIC1-mediated ion current. Oncotarget. https://doi.org/10.18632/oncotarget.2617

Grössinger EM et al (2014) Targeting proliferation of chronic lymphocytic leukemia (CLL) cells through KCa3.1 blockade. Leukemia. https://doi.org/10.1038/leu.2014.37

Gualdani R et al (2019) Store-operated calcium entry contributes to cisplatin-induced cell death in non-small cell lung carcinoma. Cancer. https://doi.org/10.3390/cancers11030430

Guan J et al (2009) The xc- cystine/glutamate antiporter as a potential therapeutic target for small-cell lung cancer: use of sulfasalazine. Cancer Chemother Pharmacol. https://doi.org/10.1007/s00280-008-0894-4

Guo Q et al (2019) A comprehensive evaluation of clinical efficacy and safety of celecoxib in combination with chemotherapy in metastatic or postoperative recurrent gastric cancer patients: a preliminary, three-center, clinical trial study. Medicine (Baltimore). https://doi.org/10.1097/MD.0000000000016234

Gupta SC et al (2013) Cancer drug discovery by repurposing: teaching new tricks to old dogs. Trends Pharmacol Sci. https://doi.org/10.1016/j.tips.2013.06.005

Hara Y et al (2002) LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death. Mol Cell. https://doi.org/10.1016/S1097-2765(01)00438-5

Harr MW, Distelhorst CW (2010) Apoptosis and autophagy: decoding calcium signals that mediate life or death. Cold Spring Harb Perspect Biol. https://doi.org/10.1101/cshperspect.a005579

Harris IS et al (2015) Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression. Cancer Cell. https://doi.org/10.1016/j.ccell.2014.11.019

Hartung F, Pardo LA (2016) Guiding TRAIL to cancer cells through Kv10.1 potassium channel overcomes resistance to doxorubicin. Eur Biophys J. https://doi.org/10.1007/s00249-016-1149-7

Hartung F, Stühmer W, Pardo LA (2011) Tumor cell-selective apoptosis induction through targeting of KV10.1 via bifunctional TRAIL antibody. Mol Cancer. https://doi.org/10.1186/1476-4598-10-109

Hasna J et al (2018) Orai3 calcium channel and resistance to chemotherapy in breast cancer cells: the p53 connection. Cell Death Differ. https://doi.org/10.1038/s41418-017-0007-1

He YM et al (2018) Effect of CLIC1 gene silencing on proliferation, migration, invasion and apoptosis of human gallbladder cancer cells. J Cell Mol Med. https://doi.org/10.1111/jcmm.13499

He S et al (2020) HERG channel and cancer: a mechanistic review of carcinogenic processes and therapeutic potential. Biochim Biophys Acta Rev Cancer. https://doi.org/10.1016/j.bbcan.2020.188355

Hemmerlein B et al (2006) Overexpression of Eag1 potassium channels in clinical tumours. Mol Cancer. https://doi.org/10.1186/1476-4598-5-41

Hirschler-Laszkiewicz I et al (2018) The human ion channel TRPM2 modulates neuroblastoma cell survival and mitochondrial function through Pyk2, CREB, and MCU activation. Am J Physiol Cell Physiol.