Ambrosio AL, Boyle JA, Aradi AE, Christian KA, Di Pietro SM (2016) TPC2 controls pigmentation by regulating melanosome pH and size. Proc Natl Acad Sci U S A 113(20):5622–5627

CAS  Google Scholar 

Amorim MJ, Bruce EA, Read EK, Foeglein A, Mahen R, Stuart AD, Digard P (2011) A Rab11- and microtubule-dependent mechanism for cytoplasmic transport of influenza A virus viral RNA. J Virol 85(9):4143–4156

CAS  Google Scholar 

Arredouani A, Ruas M, Collins SC, Parkesh R, Clough F, Pillinger T, Coltart G, Rietdorf K, Royle A, Johnson P, Braun M, Zhang Q, Sones W, Shimomura K, Morgan AJ, Lewis AM, Chuang KT, Tunn R, Gadea J, Teboul L, Heister PM, Tynan PW, Bellomo EA, Rutter GA, Rorsman P, Churchill GC, Parrington J, Galione A (2015) Nicotinic acid adenine dinucleotide phosphate (NAADP) and Endolysosomal two-pore channels modulate membrane excitability and stimulus-secretion coupling in mouse pancreatic beta cells. J Biol Chem 290(35):21376–21392

CAS  Google Scholar 

Bae M, Patel N, Xu H, Lee M, Tominaga-Yamanaka K, Nath A, Geiger J, Gorospe M, Mattson MP, Haughey NJ (2014) Activation of TRPML1 clears intraneuronal abeta in preclinical models of HIV infection. J Neurosci 34(34):11485–11503

Google Scholar 

Bellono NW, Escobar IE, Oancea E (2016) A melanosomal two-pore sodium channel regulates pigmentation. Sci Rep 6:26570

CAS  Google Scholar 

Bharati K, Ganguly NK (2011) Cholera toxin: a paradigm of a multifunctional protein. Indian J Med Res 33:179–187

Google Scholar 

Bottcher-Friebertshauser E, Garten W, Matrosovich M, Klenk HD (2014) The hemagglutinin: a determinant of pathogenicity. Curr Top Microbiol Immunol 385:3–34

Google Scholar 

Bretou M, Saez PJ, Sanseau D, Maurin M, Lankar D, Chabaud M, Spampanato C, Malbec O, Barbier L, Muallem S, Maiuri P, Ballabio A, Helft J, Piel M, Vargas P, Lennon-Dumenil AM (2017) Lysosome signaling controls the migration of dendritic cells. Sci Immunol 2(16):eaak9573

Google Scholar 

Bui M, Whittaker G, Helenius A (1996) Effect of M1 protein and low pH on nuclear transport of influenza virus ribonucleoproteins. J Virol 70(12):8391–8401

CAS  Google Scholar 

Bullough PA, Hughson FM, Skehel JJ, Wiley DC (1994) Structure of influenza haemagglutinin at the pH of membrane fusion. Nature 371(6492):37–43

CAS  Google Scholar 

Bussi C, Gutierrez MG (2019) Mycobacterium tuberculosis infection of host cells in space and time. FEMS Microbiol Rev 43(4):341–361

CAS  Google Scholar 

Calcraft PJ, Ruas M, Pan Z, Cheng X, Arredouani A, Hao X, Tang J, Rietdorf K, Teboul L, Chuang KT, Lin P, Xiao R, Wang C, Zhu Y, Lin Y, Wyatt CN, Parrington J, Ma J, Evans AM, Galione A, Zhu MX (2009) NAADP mobilizes calcium from acidic organelles through two-pore channels. Nature 459(7246):596–600

CAS  Google Scholar 

Cang C, Zhou Y, Navarro B, Seo YJ, Aranda K, Shi L, Battaglia-Hsu S, Nissim I, Clapham DE, Ren D (2013) mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state. Cell 152(4):778–790

CAS  Google Scholar 

Cang C, Aranda K, Seo YJ, Gasnier B, Ren D (2015) TMEM175 is an organelle K(+) channel regulating Lysosomal function. Cell 162(5):1101–1112

CAS  Google Scholar 

Cao Q, Zhong XZ, Zou Y, Murrell-Lagnado R, Zhu MX, Dong XP (2015a) Calcium release through P2X4 activates calmodulin to promote endolysosomal membrane fusion. J Cell Biol 209(6):879–894

CAS  Google Scholar 

Cao Q, Zhong XZ, Zou Y, Zhang Z, Toro L, Dong XP (2015b) BK channels alleviate Lysosomal storage diseases by providing positive feedback regulation of Lysosomal Ca2+ release. Dev Cell 33(4):427–441

CAS  Google Scholar 

Capurro MI, Greenfield LK, Prashar A, Xia S, Abdullah M, Wong H, Zhong XZ, Bertaux-Skeirik N, Chakrabarti J, Siddiqui I, O'Brien C, Dong X, Robinson L, Peek RM Jr, Philpott DJ, Zavros Y, Helmrath M, Jones NL (2019) VacA generates a protective intracellular reservoir for helicobacter pylori that is eliminated by activation of the lysosomal calcium channel TRPML1. Nat Microbiol 4(8):1411–1423

CAS  Google Scholar 

Carette JE, Raaben M, Wong AC, Herbert AS, Obernosterer G, Mulherkar N, Kuehne AI, Kranzusch PJ, Griffin AM, Ruthel G, Dal Cin P, Dye JM, Whelan SP, Chandran K, Brummelkamp TR (2011) Ebola virus entry requires the cholesterol transporter Niemann-pick C1. Nature 477(7364):340–343

CAS  Google Scholar 

Castonguay J, Orth JHC, Muller T, Sleman F, Grimm C, Wahl-Schott C, Biel M, Mallmann RT, Bildl W, Schulte U, Klugbauer N (2017) The two-pore channel TPC1 is required for efficient protein processing through early and recycling endosomes. Sci Rep 7(1):10038

Google Scholar 

Chen C, Zhuang X (2008) Epsin 1 is a cargo-specific adaptor for the clathrin-mediated endocytosis of the influenza virus. Proc Natl Acad Sci U S A 105(33):11790–11795

CAS  Google Scholar 

Chen CC, Keller M, Hess M, Schiffmann R, Urban N, Wolfgardt A, Schaefer M, Bracher F, Biel M, Wahl-Schott C, Grimm C (2014) A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV. Nat Commun 5:4681

CAS  Google Scholar 

Chen CC, Butz ES, Chao YK, Grishchuk Y, Becker L, Heller S, Slaugenhaupt SA, Biel M, Wahl-Schott C, Grimm C (2017) Small molecules for early endosome-specific patch clamping. Cell Chem Biol 24(7):907–916.e904

CAS  Google Scholar 

Csoka B, Nemeth ZH, Szabo I, Davies DL, Varga ZV, Paloczi J, Falzoni S, Di Virgilio F, Muramatsu R, Yamashita T, Pacher P, Hasko G (2018) Macrophage P2X4 receptors augment bacterial killing and protect against sepsis. JCI Insight 3(11)

Google Scholar 

Cuajungco MP, Silva J, Habibi A, Valadez JA (2016) The mucolipin-2 (TRPML2) ion channel: a tissue-specific protein crucial to normal cell function. Pflugers Arch 468(2):177–192

CAS  Google Scholar 

Dayam RM, Saric A, Shilliday RE, Botelho RJ (2015) The Phosphoinositide-gated Lysosomal Ca(2+) channel, TRPML1, is required for Phagosome maturation. Traffic 16(9):1010–1026

CAS  Google Scholar 

Dayam RM, Sun CX, Choy CH, Mancuso G, Glogauer M, Botelho RJ (2017) The lipid kinase PIKfyve coordinates the neutrophil immune response through the activation of the Rac GTPase. J Immunol 199(6):2096–2105

CAS  Google Scholar 

de Castro Martin IF, Fournier G, Sachse M, Pizarro-Cerda J, Risco C, Naffakh N (2017) Influenza virus genome reaches the plasma membrane via a modified endoplasmic reticulum and Rab11-dependent vesicles. Nat Commun 8(1):1396

Google Scholar 

De Haan L, Hirst TR (2004) Cholera toxin: a paradigm for multi-functional engagement of cellular mechanisms. Mol Membr Biol 21(2):77–92

Google Scholar 

de Vries E, Tscherne DM, Wienholts MJ, Cobos-Jimenez V, Scholte F, Garcia-Sastre A, Rottier PJ, de Haan CA (2011) Dissection of the influenza A virus endocytic routes reveals macropinocytosis as an alternative entry pathway. PLoS Pathog 7(3):e1001329

Google Scholar 

Dong XP, Shen D, Wang X, Dawson T, Li X, Zhang Q, Cheng X, Zhang Y, Weisman LS, Delling M, Xu H (2010) PI(3,5)P(2) controls membrane trafficking by direct activation of mucolipin Ca(2+) release channels in the endolysosome. Nat Commun 1:38

Google Scholar 

Eisfeld AJ, Kawakami E, Watanabe T, Neumann G, Kawaoka Y (2011) RAB11A is essential for transport of the influenza virus genome to the plasma membrane. J Virol 85(13):6117–6126

CAS  Google Scholar 

Favia A, Desideri M, Gambara G, D'Alessio A, Ruas M, Esposito B, Del Bufalo D, Parrington J, Ziparo E, Palombi F, Galione A, Filippini A (2014) VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2-dependent Ca2+ signaling. Proc Natl Acad Sci U S A 111(44):E4706–E4715

CAS  Google Scholar 

Goodridge JP, Jacobs B, Saetersmoen ML, Clement D, Hammer Q, Clancy T, Skarpen E, Brech A, Landskron J, Grimm C, Pfefferle A, Meza-Zepeda L, Lorenz S, Wiiger MT, Louch WE, Ask EH, Liu LL, Oei VYS, Kjallquist U, Linnarsson S, Patel S, Tasken K, Stenmark H, Malmberg KJ (2019) Remodeling of secretory lysosomes during education tunes functional potential in NK cells. Nat Commun 10(1):514

CAS  Google Scholar 

Grimm C, Jors S, Saldanha SA, Obukhov AG, Pan B, Oshima K, Cuajungco MP, Chase P, Hodder P, Heller S (2010) Small molecule activators of TRPML3. Chem Biol 17(2):135–148

CAS  Google Scholar 

Grimm C, Hassan S, Wahl-Schott C, Biel M (2012) Role of TRPML and two-pore channels in endolysosomal cation homeostasis. J Pharmacol Exp Ther 342(2):236–244

CAS  Google Scholar 

Grimm C, Holdt LM, Chen CC, Hassan S, Muller C, Jors S, Cuny H, Kissing S, Schroder B, Butz E, Northoff B, Castonguay J, Luber CA, Moser M, Spahn S, Lullmann-Rauch R, Fendel C, Klugbauer N, Griesbeck O, Haas A, Mann M, Bracher F, Teupser D, Saftig P, Biel M, Wahl-Schott C (2014) High susceptibility to fatty liver disease in two-pore channel 2-deficient mice. Nat Commun 5:4699

CAS  Google Scholar 

Gunaratne GS, Yang Y, Li F, Walseth TF, Marchant JS (2018) NAADP-dependent Ca(2+) signaling regulates Middle East respiratory syndrome-coronavirus pseudovirus translocation through the endolysosomal system. Cell Calcium 75:30–41

CAS  Google Scholar 

Herbert AS, Davidson C, Kuehne AI, Bakken R, Braigen SZ, Gunn KE, Whelan SP, Brummelkamp TR, Twenhafel NA, Chandran K, Walkley SU, Dye JM (2015) Niemann-pick C1 is essential for ebolavirus replication and pathogenesis in vivo. MBio 6(3):e00565–e00515

CAS  Google Scholar 

Huang P, Zou Y, Zhong XZ, Cao Q, Zhao K, Zhu MX, Murrell-Lagnado R, Dong XP (2014) P2X4 forms functional ATP-activated cation channels on lysosomal membranes regulated by luminal pH. J Biol Chem 289(25):17658–17667

CAS  Google Scholar 

Karacsonyi C, Miguel AS, Puertollano R (2007) Mucolipin-2 localizes to the Arf6-associated pathway and regulates recycling of GPI-APs. Traffic 8(10):1404–1414

CAS  Google Scholar 

Khan N, Lakpa KL, Halcrow PW, Afghah Z, Miller NM, Geiger JD, Chen X (2019) BK channels regulate extracellular tat-mediated HIV-1 LTR transactivation. Sci Rep 9(1):12285

Google Scholar 

Kim HJ, Soyombo AA, Tjon-Kon-Sang S, So I, Muallem S (2009) The Ca(2+) channel TRPML3 regulates membrane trafficking and autophagy. Traffic 10(8):1157–1167

CAS  Google Scholar 

Kim GH, Dayam RM, Prashar A, Terebiznik M, Botelho RJ (2014) PIKfyve inhibition interferes with phagosome and endosome maturation in macrophages. Traffic 15(10):1143–1163

CAS  Google Scholar 

Kiselyov KK, Ahuja M, Rybalchenko V, Patel S, Muallem S (2012) The intracellular Ca(2)(+) channels of membrane traffic. Channels (Austin) 6(5):344–351

CAS  Google Scholar 

Lakadamyali M, Rust MJ, Babcock HP, Zhuang X (2003) Visualizing infection of individual influenza viruses. Proc Natl Acad Sci U S A 100(16):9280–9285

CAS  Google Scholar 

Lange I, Yamamoto S, Partida-Sanchez S, Mori Y, Fleig A, Penner R (2009) TRPM2 functions as a lysosomal Ca2+-release channel in beta cells. Sci Signal 2(71):ra23

Google Scholar 

Lee C, Guo J, Zeng W, Kim S, She J, Cang C, Ren D, Jiang Y (2017) The lysosomal potassium channel TMEM175 adopts a novel tetrameric architecture. Nature 547(7664):472–475

CAS  Google Scholar 

Li X, Saitoh S, Shibata T, Tanimura N, Fukui R, Miyake K (2015) Mucolipin 1 positively regulates TLR7 responses in dendritic cells by facilitating RNA transportation to lysosomes. Int Immunol 27(2):83–94

CAS  Google Scholar 

Lin PH, Duann P, Komazaki S, Park KH, Li H, Sun M, Sermersheim M, Gumpper K, Parrington J, Galione A, Evans AM, Zhu MX, Ma J (2015) Lysosomal two-pore channel subtype 2 (TPC2) regulates skeletal muscle autophagic signaling. J Biol Chem 290(6):3377–3389

CAS  Google Scholar 

Lindvall JM, Blomberg KE, Wennborg A, Smith CI (2005) Differential expression and molecular characterisation of Lmo7, Myo1e, Sash1, and Mcoln2 genes in Btk-defective B-cells. Cell Immunol 235(1):46–55

CAS  Google Scholar