Anoopkumar-Dukie S, Conere T, Sisk GD et al (2009) Mitochondrial modulation of oxygen-dependent radiosensitivity in some human tumour cell lines. Br J Radiol 82:847–854
Archer SL, Gomberg-Maitland M, Maitland ML et al (2008) Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1alpha-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer. Am J Physiol Heart Circ Physiol 294:H570–H578
Arif T, Stern O, Pittala S et al (2019) Rewiring of cancer cell metabolism by mitochondrial VDAC1 depletion results in time-dependent tumor reprogramming: Glioblastoma as a proof of concept. Cell 8:1330
Arthur GK, Duffy SM, Roach KM et al (2015) KCa3.1 K+ channel expression and function in human bronchial epithelial cells. PLoS One 10:e0145259
PubMed PubMed Central Google Scholar
Ataga KI, Smith WR, De Castro LM et al (2008) Efficacy and safety of the Gardos channel blocker, senicapoc (ICA-17043), in patients with sickle cell anemia. Blood 111:3991–3997
Averaimo S, Milton RH, Duchen MR et al (2010) Chloride intracellular channel 1 (CLIC1): sensor and effector during oxidative stress. FEBS Lett 584:2076–2084
Baffy G (2017) Mitochondrial uncoupling in cancer cells: liabilities and opportunities. Biochim Biophys Acta Bioenerg 1858:655–664
Bauer TM, Murphy E (2020) Role of mitochondrial calcium and the permeability transition pore in regulating cell death. Circ Res 126:280–293
CAS PubMed PubMed Central Google Scholar
Birch JL, Strathdee K, Gilmour L et al (2018) A novel small-molecule inhibitor of MRCK prevents radiation-driven invasion in Glioblastoma. Cancer Res 78:6509–6522
Bouchard G, Therriault H, Geha S et al (2017) Radiation-induced lung metastasis development is MT1-MMP-dependent in a triple-negative breast cancer mouse model. Br J Cancer 116:479–488
CAS PubMed PubMed Central Google Scholar
Brahimi-Horn MC, Ben-Hail D, Ilie M et al (2012) Expression of a truncated active form of VDAC1 in lung cancer associates with hypoxic cell survival and correlates with progression to chemotherapy resistance. Cancer Res 72:2140–2150
Braun N, Klumpp D, Hennenlotter J et al (2015) UCP-3 uncoupling protein confers hypoxia resistance to renal epithelial cells and is upregulated in renal cell carcinoma. Sci Rep 5:13450
CAS PubMed PubMed Central Google Scholar
Brisson L, Gillet L, Calaghan S et al (2011) NaV1.5 enhances breast cancer cell invasiveness by increasing NHE1-dependent H+ efflux in caveolae. Oncogene 30:2070–2076
Brisson L, Driffort V, Benoist L et al (2013) NaV1.5 Na+ channels allosterically regulate the NHE-1 exchanger and promote the activity of breast cancer cell invadopodia. J Cell Sci 126:4835–4842
Britschgi A, Bill A, Brinkhaus H et al (2013) Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling. Proc Natl Acad Sci U S A 110:E1026–E1034
CAS PubMed PubMed Central Google Scholar
Brown A, Geiger H (2018) Chromosome integrity checkpoints in stem and progenitor cells: transitions upon differentiation, pathogenesis, and aging. Cell Mol Life Sci 75:3771–3779
CAS PubMed PubMed Central Google Scholar
Cadenas S (2018) Mitochondrial uncoupling, ROS generation and cardioprotection. Biochim Biophys Acta Bioenerg 1859:940–950
Campbell TM, Main MJ, Fitzgerald EM (2013) Functional expression of the voltage-gated Na+-channel Nav1.7 is necessary for EGF-mediated invasion in human non-small cell lung cancer cells. J Cell Sci 126:4939–4949
Chao HX, Poovey CE, Privette AA et al (2017) Orchestration of DNA damage checkpoint dynamics across the human cell cycle. Cell Syst 5:445–459.e445
CAS PubMed PubMed Central Google Scholar
Chen JM, Sepramaniam S, Armugam A et al (2008) Water and ion channels: crucial in the initiation and progression of apoptosis in central nervous system? Curr Neuropharmacol 6:102–116
Chen TJ, He HL, Shiue YL et al (2018) High chloride channel accessory 1 expression predicts poor prognoses in patients with rectal cancer receiving chemoradiotherapy. Int J Med Sci 15:1171–1178
CAS PubMed PubMed Central Google Scholar
Cheng Y, Debska-Vielhaber G, Siemen D (2010) Interaction of mitochondrial potassium channels with the permeability transition pore. FEBS Lett 584:2005–2012
Cloos CR, Daniels DH, Kalen A et al (2009) Mitochondrial DNA depletion induces radioresistance by suppressing G2 checkpoint activation in human pancreatic cancer cells. Radiat Res 171:581–587
CAS PubMed PubMed Central Google Scholar
Cone CD Jr, Cone CM (1976) Induction of mitosis in mature neurons in central nervous system by sustained depolarization. Science 192:155–158
Cone CD Jr, Tongier M Jr (1971) Control of somatic cell mitosis by simulated changes in the transmembrane potential level. Oncology 25:168–182
Coultrap SJ, Bayer KU (2012) CaMKII regulation in information processing and storage. Trends Neurosci 35:607–618
CAS PubMed PubMed Central Google Scholar
Crottes D, Jan LY (2019) The multifaceted role of TMEM16A in cancer. Cell Calcium 82:102050
CAS PubMed PubMed Central Google Scholar
Cruz-Gregorio A, Martinez-Ramirez I, Pedraza-Chaverri J et al (2019) Reprogramming of energy metabolism in response to radiotherapy in head and neck squamous cell carcinoma. Cancers (Basel) 11:182
Cuddapah VA, Sontheimer H (2010) Molecular interaction and functional regulation of ClC-3 by Ca2+/calmodulin-dependent protein kinase II (CaMKII) in human malignant glioma. J Biol Chem 285:11188–11196
CAS PubMed PubMed Central Google Scholar
Cuddapah VA, Habela CW, Watkins S et al (2012) Kinase activation of ClC-3 accelerates cytoplasmic condensation during mitotic cell rounding. Am J Physiol Cell Physiol 302:C527–C538
Cuddapah VA, Turner KL, Seifert S et al (2013) Bradykinin-induced chemotaxis of human gliomas requires the activation of KCa3.1 and ClC-3. J Neurosci 33:1427–1440
CAS PubMed PubMed Central Google Scholar
D’alessandro G, Catalano M, Sciaccaluga M et al (2013) KCa3.1 channels are involved in the infiltrative behavior of glioblastoma in vivo. Cell Death Dis 4:e773
PubMed PubMed Central Google Scholar
D’alessandro G, Monaco L, Catacuzzeno L et al (2019) Radiation increases functional KCa3.1 expression and invasiveness in glioblastoma. Cancers (Basel) 11:279
Davies A, Hendrich J, Van Minh AT et al (2007) Functional biology of the alpha2delta subunits of voltage-gated calcium channels. Trends Pharmacol Sci 28:220–228
Davis FM, Peters AA, Grice DM et al (2012) Non-stimulated, agonist-stimulated and store-operated Ca2+ influx in MDA-MB-468 breast cancer cells and the effect of EGF-induced EMT on calcium entry. PLoS One 7:e36923
CAS PubMed PubMed Central Google Scholar
Denko NC (2008) Hypoxia, HIF1 and glucose metabolism in the solid tumour. Nat Rev Cancer 8:705–713
Dittmann K, Mayer C, Kehlbach R et al (2008) Radiation-induced caveolin-1 associated EGFR internalization is linked with nuclear EGFR transport and activation of DNA-PK. Mol Cancer 7:69
PubMed PubMed Central Google Scholar
Dittmann K, Mayer C, Kehlbach R et al (2009) Radiation-induced lipid peroxidation activates SRC kinase and triggers nuclear EGFR transport. Radiother Oncol 92:379–382
Dittmann K, Mayer C, Rodemann HP et al (2013) EGFR cooperates with glucose transporter SGLT1 to enable chromatin remodeling in response to ionizing radiation. Radiother Oncol 107:247–251
Dittmann K, Mayer C, Paasch A et al (2015) Nuclear EGFR renders cells radio-resistant by binding mRNA species and triggering a metabolic switch to increase lactate production. Radiother Oncol 116:431–437
Djamgoz MBA, Fraser SP, Brackenbury WJ (2019) In vivo evidence for voltage-gated Sodium Channel expression in carcinomas and potentiation of metastasis. Cancers (Basel) 11:1675
Driffort V, Gillet L, Bon E et al (2014) Ranolazine inhibits NaV1.5-mediated breast cancer cell invasiveness and lung colonization. Mol Cancer 13:264
PubMed PubMed Central Google Scholar
Dupre AM, Hempling HG (1978) Osmotic properties of Ehrlich ascites tumor cells during the cell cycle. J Cell Physiol 97:381–396
Eckert F, Schilbach K, Klumpp L et al (2018) Potential role of CXCR4 targeting in the context of radiotherapy and immunotherapy of cancer. Front Immunol 9:3018
CAS PubMed PubMed Central Google Scholar
Eckert F, Zwirner K, Boeke S et al (2019) Rationale for combining radiotherapy and immune checkpoint inhibition for patients with hypoxic tumors. Front Immunol 10:407
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