Introduction

Exclusive enteral nutrition (EEN) is considered an effective, low-risk therapy in the treatment of Crohn's Disease (CD). Frequent dietetic support may assistadults to succeed. This observational study aimed to compare whether frequency of dietetic support during EEN therapy was associated with differences in clinical and nutritional outcomes across two gastroenterologyinflammatory bowel disease services. Site Aprovided ≥3 visits plus more if clinically indicated and Site B provided weekly support.

Methods

Eligible patients were adults with active CD recommended to be treated with oral EEN for ≥6weeks between February 2018 to December 2019.Demographic, anthropometric, clinical, medications, pathology and EEN treatment descriptors were sourced from the medical chart. Descriptive statistics, chi-squared and t-tests were used to compare data between sites.

Results

Eighty-four CD patients were eligible (44±14yrs, 54% female, baseline Crohn's Disease Activity Index (CDAI) 259.5±113.1, n=51Site A) and completed EEN for median(range) 6.1(1-12) weeks. Most patients (82%, n=69/84) completed ≥6 weeks of EEN treatment. CDAI score and calprotectin improved across the total sample from pre- to post-EEN by -109.8±92.1 (p<0.001) and -65µg/g(-65230-4370) (p=0.002), respectively. Dietitian occasions of service were more frequent at Site B (7(4-12) occasions vs. 3(1-8), p<0.001). However, changes in clinicaland biomarker datawere similar between sites (p<0.05).

Conclusions

EEN with regular dietetic input resulted in clinical and biochemical improvements for patients with active CD. Tailoring dietetic support based on the client'sneeds and preference may achieve similar clinical improvements as providing weekly dietetic support to adults on EEN.

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