Background

This study aimed to investigate the influence of food intake on body weight loss and the association of gene polymorphisms, 1 year after Roux-en-Y gastric bypass (RYGB) surgery.

Methods

In total, ninety-five obese women (age ranged 20–50 years) in a Brazilian cohort underwent RYGB surgery and completed the study. Anthropometric measurements and food intake were assessed before and 1 year after surgery. Twelve gene polymorphisms (GHRL rs26802; GHSR rs572169; LEP rs7799039; LEPR rs1137101; 5-HT2C rs3813929; UCP2 rs659366; UCP2 rs660339; UCP3 rs1800849; SH2B1 rs7498665; TAS1R2 rs35874116; TAS1R2 rs9701796; and FTO rs9939609) were determined using a real-time PCR reaction and a TaqMan assay. The subjects were divided into quartiles regarding to percentage of excess weight loss (%EWL). The effect of genetic variants on energy and macronutrient intake was evaluated by simple logistic regression, followed by multiple logistic regression.

Results

It was found that subjects in the first and second quartile showed a higher initial body mass index (BMI). Energy and macronutrient intake before and 1 year after RYGB surgery did not differ between the %EWL quartiles. None of gene polymorphisms investigated showed an association with the estimated energy intake 1 year after surgery.

Conclusion

In conclusion, the estimate energy and food intake did not predict a greater body weight loss 1 year after RYGB surgery. In addition, the 12 gene polymorphism investigated did not affect the energy intake among female patients.

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