Comparison of standardised milk‐based, standardised non‐milk based and hospital‐based formulations on the anthropometric indices of under‐fives with moderate acute malnutrition: A randomised clinical trial

Background

Moderate acute malnutrition (MAM) causes impaired anthropometry, which can be reversed by supplementary feeding. The present study aimed to compare the effect of a standardised milk-based formulation (SMBF), standardised non-milk based formulation (SNMBF) and hospital-based formulation (HBF) on anthropometric indices of children aged <5 years with MAM.

Methods

This was a randomised clinical trial during which eligible children aged 6–59 months with MAM received SMBF, SNMBF or HBF over 4 months. They were followed up on a biweekly basis during which their weight, mid upper arm circumference (MUAC) and length/height were measured. The effect of the formulations was determined at the end of the period by the change in their anthropometric indices using ‘per protocol’ analysis. p < 0.05 was considered statistically significant.

Results

There were 157 evaluable participants of whom 54 received the SMBF, 57 received the SNMBF and 46 received the HBF. The overall result showed a significant improvement in the mean weight and MUAC of the children. Subgroup analysis showed a significant improvement in mean weight and MUAC among children aged 6–23 months (p = 0.013) and improvement in MUAC only among those aged 24–59 months (p = 0.03).

Conclusions

The formulations significantly improved the mean weight and MUAC of children with MAM.

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