Arnold JN, Wormald MR, Sim RB, Rudd PM, Dwek RA. The impact of glycosylation on the biological function and structure of human immunoglobulins. Annu Rev Immunol. 2007;25:21–50. https://doi.org/10.1146/annurev.immunol.25.022106.141702.
Article CAS PubMed Google Scholar
Schwab I, Nimmerjahn F. Intravenous immunoglobulin therapy: how does IgG modulate the immune system? Nat Rev Immunol. 2013;13(3):176–89. https://doi.org/10.1038/nri3401.
Article CAS PubMed Google Scholar
Wang J, Huang C, Zhou J, Zhao K, Li Y. Causal link between immunoglobulin G glycosylation and cancer: a potential glycobiomarker for early tumor detection. Cell Immunol. 2021;361:104282. https://doi.org/10.1016/j.cellimm.2021.104282.
Article CAS PubMed Google Scholar
Kljaković-Gašpić Batinjan M, Petrović T, Vučković F, Hadžibegović I, Radovani B, Jurin I, et al. Differences in immunoglobulin G glycosylation between influenza and COVID-19 patients. Engineering (Beijing, China). 2022. https://doi.org/10.1016/j.eng.2022.08.007.
Apweiler R, Hermjakob H, Sharon N. On the frequency of protein glycosylation, as deduced from analysis of the SWISS-PROT database. Biochem Biophys Acta. 1999;1473(1):4–8. https://doi.org/10.1016/s0304-4165(99)00165-8.
Article CAS PubMed Google Scholar
Helenius A, Aebi M. Intracellular functions of N-linked glycans. Science (New York, NY). 2001;291(5512):2364–9. https://doi.org/10.1126/science.291.5512.2364.
Scott DW, Vallejo MO, Patel RP. Heterogenic endothelial responses to inflammation: role for differential N-glycosylation and vascular bed of origin. J Am Heart Assoc. 2013;2(4):e000263. https://doi.org/10.1161/jaha.113.000263.
Article PubMed PubMed Central Google Scholar
Kaneko Y, Nimmerjahn F, Ravetch JV. Anti-inflammatory activity of immunoglobulin G resulting from Fc sialylation. Science (New York, NY). 2006;313(5787):670–3. https://doi.org/10.1126/science.1129594.
Gonzalez-Quintela A, Alende R, Gude F, Campos J, Rey J, Meijide LM, et al. Serum levels of immunoglobulins (IgG, IgA, IgM) in a general adult population and their relationship with alcohol consumption, smoking and common metabolic abnormalities. Clin Exp Immunol. 2008;151(1):42–50. https://doi.org/10.1111/j.1365-2249.2007.03545.x.
Article CAS PubMed PubMed Central Google Scholar
Schroeder HW Jr, Cavacini L. Structure and function of immunoglobulins. J Allergy Clin Immunol. 2010;125(2 Suppl 2):S41-52. https://doi.org/10.1016/j.jaci.2009.09.046.
Article PubMed PubMed Central Google Scholar
Boune S, Hu P, Epstein AL, Khawli LA. Principles of N-linked glycosylation variations of IgG-based therapeutics: pharmacokinetic and functional considerations. Antibodies (Basel, Switzerland). 2020;9(2): 22. https://doi.org/10.3390/antib9020022.
Article CAS PubMed Google Scholar
Wada R, Matsui M, Kawasaki N. Influence of N-glycosylation on effector functions and thermal stability of glycoengineered IgG1 monoclonal antibody with homogeneous glycoforms. MAbs. 2019;11(2):350–72. https://doi.org/10.1080/19420862.2018.1551044.
Article CAS PubMed Google Scholar
Zheng K, Bantog C, Bayer R. The impact of glycosylation on monoclonal antibody conformation and stability. MAbs. 2011;3(6):568–76. https://doi.org/10.4161/mabs.3.6.17922.
Article PubMed PubMed Central Google Scholar
Pinho SS, Reis CA. Glycosylation in cancer: mechanisms and clinical implications. Nat Rev Cancer. 2015;15(9):540–55. https://doi.org/10.1038/nrc3982.
Article CAS PubMed Google Scholar
Huffman JE, Pučić-Baković M, Klarić L, Hennig R, Selman MH, Vučković F, et al. Comparative performance of four methods for high-throughput glycosylation analysis of immunoglobulin G in genetic and epidemiological research. Mol Cell Proteomics. 2014;13(6):1598–610. https://doi.org/10.1074/mcp.M113.037465.
Article CAS PubMed PubMed Central Google Scholar
Ha S, Ou Y, Vlasak J, Li Y, Wang S, Vo K, et al. Isolation and characterization of IgG1 with asymmetrical Fc glycosylation. Glycobiology. 2011;21(8):1087–96. https://doi.org/10.1093/glycob/cwr047.
Article CAS PubMed Google Scholar
Reily C, Stewart TJ, Renfrow MB, Novak J. Glycosylation in health and disease. Nat Rev Nephrol. 2019;15(6):346–66. https://doi.org/10.1038/s41581-019-0129-4.
Article PubMed PubMed Central Google Scholar
Liu D, Li Q, Dong J, Li D, Xu X, Xing W, et al. The association between normal BMI with central adiposity and proinflammatory potential immunoglobulin G N-glycosylation. Diabetes Metab Syndr Obes. 2019. https://doi.org/10.2147/dmso.S216318.
Article PubMed PubMed Central Google Scholar
Golubnitschaja O, Potuznik P, Polivka J Jr, Pesta M, Kaverina O, Pieper CC, et al. Ischemic stroke of unclear aetiology: a case-by-case analysis and call for a multi-professional predictive, preventive and personalised approach. EPMA J. 2022;13(4):535–45. https://doi.org/10.1007/s13167-022-00307-z.
Article PubMed PubMed Central Google Scholar
Evsevieva M, Sergeeva O, Mazurakova A, Koklesova L, Prokhorenko-Kolomoytseva I, Shchetinin E, et al. Pre-pregnancy check-up of maternal vascular status and associated phenotype is crucial for the health of mother and offspring. EPMA J. 2022;13(3):351–66. https://doi.org/10.1007/s13167-022-00294-1.
Article PubMed PubMed Central Google Scholar
Koklesova L, Mazurakova A, Samec M, Biringer K, Samuel SM, Büsselberg D, et al. Homocysteine metabolism as the target for predictive medical approach, disease prevention, prognosis, and treatments tailored to the person. EPMA J. 2021;12(4):477–505. https://doi.org/10.1007/s13167-021-00263-0.
Article PubMed PubMed Central Google Scholar
Golubnitschaja O, Baban B, Boniolo G, Wang W, Bubnov R, Kapalla M, et al. Medicine in the early twenty-first century: paradigm and anticipation - EPMA position paper 2016. EPMA J. 2016;7(1):23. https://doi.org/10.1186/s13167-016-0072-4.
Article PubMed PubMed Central Google Scholar
Wu Z, Guo Z, Zheng Y, Wang Y, Zhang H, Pan H, et al. IgG n-glycosylation cardiovascular age tracks cardiovascular risk beyond calendar age. Engineering. 2023;26:99–107. https://doi.org/10.1016/j.eng.2022.12.004.
Ercan A, Cui J, Chatterton DE, Deane KD, Hazen MM, Brintnell W, et al. Aberrant IgG galactosylation precedes disease onset, correlates with disease activity, and is prevalent in autoantibodies in rheumatoid arthritis. Arthritis Rheum. 2010;62(8):2239–48. https://doi.org/10.1002/art.27533.
Article CAS PubMed PubMed Central Google Scholar
Lu X, Wang L, Wang M, Li Y, Zhao Q, Shi Y, et al. Association between immunoglobulin G N-glycosylation and lupus nephritis in female patients with systemic lupus erythematosus: a case-control study. Front Immunol. 2023;14:1257906. https://doi.org/10.3389/fimmu.2023.1257906.
Article CAS PubMed PubMed Central Google Scholar
Wang M, Chen X, Tang Z, Zhang W, Hou H, Sun X, et al. Association between immunoglobulin G N-glycosylation and vascular cognitive impairment in a sample with atherosclerosis: a case-control study. Front Aging Neurosci. 2022;14:823468. https://doi.org/10.3389/fnagi.2022.823468.
Article CAS PubMed PubMed Central Google Scholar
Zhang X, Yuan H, Lyu J, Meng X, Tian Q, Li Y, et al. Association of dementia with immunoglobulin G N-glycans in a Chinese Han population. NPJ Aging Mech Dis. 2021;7(1):3. https://doi.org/10.1038/s41514-021-00055-w.
Article CAS PubMed PubMed Central Google Scholar
Meng X, Cao W, Liu D, Elijah IM, Xing W, Hou H, et al. Bidirectional causality between immunoglobulin G N-glycosylation and metabolic traits: a Mendelian randomization study. Engineering. 2023;26:74–88.
Comments (0)