Glioma angiogenesis phosphoproteome landscape and biomarker sets identified with phenome-centered multiomics toward 3P medical approaches

Lapointe S, Perry A, Butowski NA. Primary brain tumours in adults. Lancet. 2018;392(10145):432–46. https://doi.org/10.1016/S0140-6736(18)30990-5.

Article  PubMed  Google Scholar 

Nicholson JG, Fine HA. Diffuse glioma heterogeneity and its therapeutic implications. Cancer Discov. 2021;11(3):575–90. https://doi.org/10.1158/2159-8290.CD-20-1474.

Article  CAS  PubMed  Google Scholar 

Gusyatiner O, Hegi ME. Glioma epigenetics: from subclassification to novel treatment options. Semin Cancer Biol. 2018;51:50–8.  https://doi.org/10.1016/j.semcancer.2017.11.010.

Malta TM, de Souza CF, Sabedot TS, Silva TC, Mosella MS, Kalkanis SN, et al. Glioma CpG island methylator phenotype (G-CIMP): biological and clinical implications. Neuro Oncol. 2018;20(5):608–20. https://doi.org/10.1093/neuonc/nox183.

Article  CAS  PubMed  Google Scholar 

Jiang X, Wang J, Deng X, Xiong F, Zhang S, Gong Z, et al. The role of microenvironment in tumor angiogenesis. J Exp Clin Cancer Res. 2020;39(1):204. https://doi.org/10.1186/s13046-020-01709-5.

Article  PubMed  PubMed Central  Google Scholar 

Viallard C, Larrivée B. Tumor angiogenesis and vascular normalization: alternative therapeutic targets. Angiogenesis. 2017;20(4):409–26. https://doi.org/10.1007/s10456-017-9562-9.

Article  CAS  PubMed  Google Scholar 

Ramjiawan RR, Griffioen AW, Duda DG. Anti-angiogenesis for cancer revisited: is there a role for combinations with immunotherapy? Angiogenesis. 2017;20(2):185–204. https://doi.org/10.1007/s10456-017-9552-y.

Article  PubMed  PubMed Central  Google Scholar 

Liu D, Li J, Li N, Lu M, Wen S, Zhan X. Integration of quantitative phosphoproteomics and transcriptomics revealed phosphorylation-mediated molecular events as useful tools for a potential patient stratification and personalized treatment of human nonfunctional pituitary adenomas. EPMA J. 2020;11(3):419–67. https://doi.org/10.1007/s13167-020-00215-0.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang Y, Li N, Yang L, Jia W, Li Z, Shao Q, Zhan X. Quantitative phosphoproteomics reveals molecular pathway network alterations in human early-stage primary hepatic carcinomas: potential for 3P medical approach. EPMA J. 2023;14(3):477–502. https://doi.org/10.1007/s13167-023-00335-3.

Article  PubMed  PubMed Central  Google Scholar 

Golubnitschaja O, Costigliola V, EPMA. General report & recommendations in predictive, preventive and personalised medicine 2012: white paper of the European Association for Predictive, Preventive and Personalised Medicine. EPMA J. 2012;3(1): 14. https://doi.org/10.1186/1878-5085-3-14.

Article  PubMed  PubMed Central  Google Scholar 

Liu X, Zhang Y, Wang Y, Yang M, Hong F, Yang S. Protein phosphorylation in cancer: role of nitric oxide signaling pathway. Biomolecules. 2021;11(7):1009. https://doi.org/10.3390/biom11071009.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang LB, Karpova A, Gritsenko MA, Kyle JE, Cao S, Li Y, et al. Proteogenomic and metabolomic characterization of human glioblastoma. Cancer Cell. 2021;39(4):509-528.e20. https://doi.org/10.1016/j.ccell.2021.01.006.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Parma L, Peters HAB, Johansson ME, Gutiérrez S, Meijerink H, de Kimpe S, et al. Bis(maltolato)oxovanadium(IV) induces angiogenesis via phosphorylation of VEGFR2. Int J Mol Sci. 2020;21(13):4643. https://doi.org/10.3390/ijms21134643.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Simons M, Schwartz MA. Profilin phosphorylation as a VEGFR effector in angiogenesis. Nat Cell Biol. 2012;14(10):985–7. https://doi.org/10.1038/ncb2596.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li N, Jia W, Wang J, Shao Q, Feng X, Li Z, Sun W, Kang M, Hu D, Xing L, Zhan X. Clinically relevant immune subtypes based on alternative splicing landscape of immune-related genes for lung cancer advanced PPPM approach. EPMA J. 2024;15(2):345–73. https://doi.org/10.1007/s13167-024-00366-4.

Article  PubMed  PubMed Central  Google Scholar 

Jia W, Li N, Wang J, Gong X, Ouedraogo SY, Wang Y, Zhao J, Grech G, Chen L, Zhan X. Immune-related gene methylation prognostic instrument for stratification and targeted treatment of ovarian cancer patients toward advanced 3PM approach. EPMA J. 2024;15(2):375–404. https://doi.org/10.1007/s13167-024-00359-3.

Article  PubMed  PubMed Central  Google Scholar 

Jia W, Gong X, Ye Z, Li N, Zhan X. Nitroproteomics is instrumental for stratification and targeted treatments of astrocytoma patients: expert recommendations for advanced 3PM approach with improved individual outcomes. EPMA J. 2023;14(4):673–96. https://doi.org/10.1007/s13167-023-00348-y.

Article  PubMed  PubMed Central  Google Scholar 

Lu M, Zhan X. The crucial role of multiomic approach in cancer research and clinically relevant outcomes. EPMA J. 2018;9(1):77–102. https://doi.org/10.1007/s13167-018-0128-8.

Article  PubMed  PubMed Central  Google Scholar 

Cheng T, Zhan X. Pattern recognition for predictive, preventive, and personalized medicine in cancer. EPMA J. 2017;8(1):51–60. https://doi.org/10.1007/s13167-017-0083-9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu R, Wang X, Zhan X. Multi-parameter systematic strategies for predictive, preventive and personalised medicine in cancer. EPMA J. 2013;4(1): 2. https://doi.org/10.1186/1878-5085-4-2.

Article  PubMed  PubMed Central  Google Scholar 

Zhan X, Li J, Guo Y, Golubnitschaja O. Mass spectrometry analysis of human tear fluid biomarkers specific for ocular and systemic diseases in the context of 3P medicine. EPMA J. 2021;12(4):449–75. https://doi.org/10.1007/s13167-021-00265-y.

Article  PubMed  PubMed Central  Google Scholar 

Li N, Desiderio DM, Zhan X. The use of mass spectrometry in a proteome-centered multiomics study of human pituitary adenomas. Mass Spectrom Rev. 2022;41(6):964–1013. https://doi.org/10.1002/mas.21710.

Article  CAS  PubMed  Google Scholar 

Wei GX, Liu YY, Ji XW, Li QX, Xing Y, Xue YL, Liu HQ. Micro-morphological feature visualization, auto-classification, and evolution quantitative analysis of tumors by using SR-PCT. Cancer Med. 2021;10(7):2319–31. https://doi.org/10.1002/cam4.3796.

Article  PubMed  PubMed Central  Google Scholar 

Lerond J, Sarkaria JN, Ceccarelli M, Sanson M, Lasorella A, Iavarone A. Integrative multi-omics networks identify PKCδ and DNA-PK as master kinases of glioblastoma subtypes and guide targeted cancer therapy. Nat Cancer. 2023;4(2):181–202. https://doi.org/10.1038/s43018-022-00510-x.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao W, Gu X, Chen S, Wu J, Zhou Z. MODIG: integrating multi-omics and multi-dimensional gene network for cancer driver gene identification based on graph attention network model. Bioinformatics. 2022;38(21):4901–4907. https://doi.org/10.1093/bioinformatics/btac622 .

Olivier M, Asmis R, Hawkins GA, Howard TD, Cox LA. The need for multi-omics biomarker signatures in precision medicine. Int J Mol Sci. 2019;20(19):4781. https://doi.org/10.3390/ijms20194781.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dumitru CS, Raica M. A splice form of VEGF, a potential anti-angiogenetic form of head and neck squamous cell cancer inhibition. Int J Mol Sci. 2024;25(16): 8855. https://doi.org/10.3390/ijms25168855.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Turtoi A, Mottet D, Matheus N, Dumont B, Peixoto P, Hennequière V, Deroanne C, Colige A, De Pauw E, Bellahcène A, Castronovo V. The angiogenesis suppressor gene AKAP12 is under the epigenetic control of HDAC7 in endothelial cells. Angiogenesis. 2012;15(4):543–54. https://doi.org/10.1007/s10456-012-9279-8.

Article  CAS 

Comments (0)

No login
gif