Rajasekaran AK, Anilkumar G, Christiansen JJ. Is prostate-specific membrane antigen a multifunctional protein? Am J Physiol Cell Physiol. 2005;288(5):C975–81.

PubMed  CAS  Google Scholar 

Bostwick DG, Pacelli A, Blute M, Roche P, Murphy GP. Prostate specific membrane antigen expression in prostatic intraepithelial neoplasia and adenocarcinoma: a study of 184 cases. Cancer. 1998;82(11):2256–61.

PubMed  CAS  Google Scholar 

Ross JS, Sheehan CE, Fisher HA, Kaufman RP Jr, Kaur P, Gray K, et al. Correlation of primary tumor prostate-specific membrane antigen expression with disease recurrence in prostate cancer. Clin Cancer Res. 2003;9(17):6357–62.

PubMed  CAS  Google Scholar 

Naik M, Khan SR, Lewington V, Challapalli A, Eccles A, Barwick TD. Imaging and therapy in prostate cancer using prostate specific membrane antigen radioligands. Br J Radiol. 2024;97(1160):1391–404.

PubMed  PubMed Central  Google Scholar 

Van de Wiele C, Sathekge M, de Spiegeleer B, De Jonghe PJ, Debruyne PR, Borms M, et al. PSMA expression on neovasculature of solid tumors. Histol Histopathol. 2020;35(9):919–27.

PubMed  Google Scholar 

Silver DA, Pellicer I, Fair WR, Heston WD, Cordon-Cardo C. Prostate-specific membrane antigen expression in normal and malignant human tissues. Clin Cancer Res. 1997;3(1):81–5.

PubMed  CAS  Google Scholar 

Chang SS, O’Keefe DS, Bacich DJ, Reuter VE, Heston WD, Gaudin PB. Prostate-specific membrane antigen is produced in tumor-associated neovasculature. Clin Cancer Res. 1999;5(10):2674–81.

PubMed  CAS  Google Scholar 

Bychkov A, Vutrapongwatana U, Tepmongkol S, Keelawat S. PSMA expression by microvasculature of thyroid tumors - potential implications for PSMA theranostics. Sci Rep. 2017;7(1):5202.

PubMed  PubMed Central  Google Scholar 

Spatz S, Tolkach Y, Jung K, Stephan C, Busch J, Ralla B, et al. Comprehensive evaluation of prostate specific membrane antigen expression in the vasculature of renal tumors: implications for imaging studies and prognostic role. J Urol. 2018;199(2):370–7.

PubMed  Google Scholar 

Jiao D, Li Y, Yang F, Han D, Wu J, Shi S, et al. Expression of prostate-specific membrane antigen in tumor-associated vasculature predicts poor prognosis in hepatocellular carcinoma. Clin Transl Gastroenterol. 2019;10(5):1–7.

PubMed  Google Scholar 

Abdel-Hadi M, Ismail Y, Younis L. Prostate-specific membrane antigen (PSMA) immunoexpression in the neovasculature of colorectal carcinoma in Egyptian patients. Pathol Res Pract. 2014;210(11):759–63.

PubMed  CAS  Google Scholar 

Haffner MC, Kronberger IE, Ross JS, Sheehan CE, Zitt M, Mühlmann G, et al. Prostate-specific membrane antigen expression in the neovasculature of gastric and colorectal cancers. Hum Pathol. 2009;40(12):1754–61.

PubMed  CAS  Google Scholar 

Backhaus P, Noto B, Avramovic N, Grubert LS, Huss S, Bögemann M, et al. Targeting PSMA by radioligands in non-prostate disease-current status and future perspectives. Eur J Nucl Med Mol Imaging. 2018;45(5):860–77.

PubMed  CAS  Google Scholar 

Wang JH, Kiess AP. PSMA-targeted therapy for non-prostate cancers. Front Oncol. 2023;13:1220586.

PubMed  PubMed Central  CAS  Google Scholar 

Arçay A, Eiber M, Langbein T. Incidental finding of colon carcinoma related to high uptake in 18F-PSMA-1007 PET. Clin Nucl Med. 2020;45(7):561–2.

PubMed  Google Scholar 

Hangaard L, Jochumsen MR, Vendelbo MH, Bouchelouche K. Metastases from colorectal cancer avid on 68Ga-PSMA PET/CT. Clin Nucl Med. 2017;42(7):532–3.

PubMed  Google Scholar 

Tamas K, Walenkamp AM, de Vries EG, van Vugt MA, Beets-Tan RG, van Etten B, et al. Rectal and colon cancer: not just a different anatomic site. Cancer Treat Rev. 2015;41(8):671–9.

PubMed  CAS  Google Scholar 

Kmeid M, Brar R, Sullivan L, Arslan ME, Shrestha N, Lee EC, et al. Diagnostic yield and repeat biopsies in rectal and nonrectal colorectal adenocarcinoma: are we hedging on rectal biopsies? Acad Pathol. 2023;10(1):100063.

PubMed  PubMed Central  Google Scholar 

Benson AB, Venook AP, Al-Hawary MM, Azad N, Chen YJ, Ciombor KK, et al. Rectal Cancer, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2022;20(10):1139–67.

PubMed  CAS  Google Scholar 

Sauer R, Liersch T, Merkel S, Fietkau R, Hohenberger W, Hess C, et al. Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: results of the German CAO/ARO/AIO-94 randomized phase III trial after a median follow-up of 11 years. J Clin Oncol. 2012;30(16):1926–33.

PubMed  CAS  Google Scholar 

Park IJ, You YN, Agarwal A, Skibber JM, Rodriguez-Bigas MA, Eng C, et al. Neoadjuvant treatment response as an early response indicator for patients with rectal cancer. J Clin Oncol. 2012;30(15):1770–6.

PubMed  PubMed Central  CAS  Google Scholar 

Oronsky B, Reid T, Larson C, Knox SJ. Locally advanced rectal cancer: the past, present, and future. Semin Oncol. 2020;47(1):85–92.

PubMed  Google Scholar 

Smith HG, Nilsson PJ, Shogan BD, Harji D, Gambacorta MA, Romano A, Brandl A, Qvortrup C. Neoadjuvant treatment of colorectal cancer: comprehensive review. BJS Open. 2024;8(3):zrae038. https://doi.org/10.1093/bjsopen/zrae038.

Hanly AM, Ryan EM, Rogers AC, McNamara DA, Madoff RD, Winter DC. Multicenter Evaluation of Rectal cancer ReImaging pOst Neoadjuvant (MERRION) Therapy. Ann Surg. 2014;259(4):723–7.

PubMed  Google Scholar 

de Jong EA, ten Berge JC, Dwarkasing RS, Rijkers AP, van Eijck CH. The accuracy of MRI, endorectal ultrasonography, and computed tomography in predicting the response of locally advanced rectal cancer after preoperative therapy: a metaanalysis. Surgery. 2016;159(3):688–99.

PubMed  Google Scholar 

Ryan JE, Warrier SK, Lynch AC, Heriot AG. Assessing pathological complete response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer: a systematic review. Colorectal Dis. 2015;17(10):849–61.

PubMed  CAS  Google Scholar 

Franklin JM, Anderson EM, Gleeson FV. MRI features of the complete histopathological response of locally advanced rectal cancer to neoadjuvant chemoradiotherapy. Clin Radiol. 2012;67(6):546–52.

PubMed  CAS  Google Scholar 

van den Broek JJ, van der Wolf FS, Lahaye MJ, Heijnen LA, Meischl C, Heitbrink MA, et al. Accuracy of MRI in restaging locally advanced rectal cancer after preoperative chemoradiation. Dis Colon Rectum. 2017;60(3):274–83.

PubMed  Google Scholar 

Dickman R, Kundel Y, Levy-Drummer R, Purim O, Wasserberg N, Fenig E, et al. Restaging locally advanced rectal cancer by different imaging modalities after preoperative chemoradiation: a comparative study. Radiat Oncol. 2013;8:278.

PubMed  PubMed Central  Google Scholar 

Uijen MJM, Derks YHW, Merkx RIJ, Schilham MGM, Roosen J, Privé BM, et al. PSMA radioligand therapy for solid tumors other than prostate cancer: background, opportunities, challenges, and first clinical reports. Eur J Nucl Med Mol Imaging. 2021;48(13):4350–68.

PubMed  PubMed Central  CAS  Google Scholar 

Kirchner J, Schaarschmidt BM, Sawicki LM, Heusch P, Hautzel H, Ermert J, et al. Evaluation of practical interpretation hurdles in 68Ga-PSMA PET/CT in 55 patients: physiological tracer distribution and incidental tracer uptake. Clin Nucl Med. 2017;42(7):e322–7.

PubMed  Google Scholar 

AJCC. Cancer Staging Manual. 8 ed. New York, Springer Cham; 2017.

Sullivan L, Pacheco RR, Kmeid M, Chen A, Lee H. Tumor stroma ratio and its significance in locally advanced colorectal cancer. Curr Oncol. 2022;29(5):3232–41.

PubMed  PubMed Central  Google Scholar 

Kmeid M, Park YN, Chung T, Lukose G, Sullivan L, Brar R, et al. PSMA immunohistochemistry in hepatic neoplasms: a promising diagnostic marker with potential theranostic applications. Am J Surg Pathol. 2022;46(12):1688–99.

PubMed  Google Scholar 

Holzgreve A, Biczok A, Ruf VC, Liesche-Starnecker F, Steiger K, Kirchner MA, et al. PSMA expression in glioblastoma as a basis for theranostic approaches: a retrospective, correlational panel study including immunohistochemistry, clinical parameters and PET imaging. Front Oncol. 2021;11:646387.

PubMed  PubMed Central  CAS  Google Scholar 

Morgantetti G, Ng KL, Samaratunga H, Rhee H, Gobe GC, Wood ST. Prostate specific membrane antigen (PSMA) expression in vena cava tumour thrombi of clear cell renal cell carcinoma suggests a role for PSMA-driven tumour neoangiogenesis. Transl Androl Urol. 2019;8(Suppl 2):S147–55.

PubMed  PubMed Central  Google Scholar 

Gelibter AJ, Caponnetto S, Urbano F, Emiliani A, Scagnoli S, Sirgiovanni G, et al. Adjuvant chemotherapy in resected colon cancer: when, how and how long? Surg Oncol. 2019;30:100–7.

PubMed  Google Scholar 

Ueno H, Nagtegaal ID, Quirke P, Sugihara K, Ajioka Y. Tumor deposits in colorectal cancer: refining their definition in the TNM system. Ann Gastroenterol Surg. 2023;7(2):225–35.

PubMed  PubMed Central  Google Scholar 

Gao Y, Zheng H, Li L, Feng M, Chen X, Hao B, et al. Prostate-specific membrane antigen (PSMA) promotes angiogenesis of glioblastoma through interacting with ITGB4 and regulating NF-κB signaling pathway. Front Cell Dev Biol. 2021;9:598377.

PubMed  PubMed Central