Current Understanding of the Pathophysiology of Idiopathic Intracranial Hypertension

Yiangou A, Mollan SP, Sinclair AJ. Idiopathic intracranial hypertension: a step change in understanding the disease mechanisms. Nat Rev Neurol. 2023;19:769–85. https://doi.org/10.1038/s41582-023-00893-0.

Article  PubMed  Google Scholar 

Subramanian PS. Novel approaches to the treatment of idiopathic intracranial hypertension. Curr Neurol Neurosci Rep. 2024;24:265–72. https://doi.org/10.1007/s11910-024-01347-w.

Article  PubMed  Google Scholar 

Adderley NJ, Subramanian A, Nirantharakumar K, Yiangou A, Gokhale KM, Mollan SP et al. Association between idiopathic intracranial hypertension and risk of cardiovascular diseases in women in the United Kingdom. JAMA Neurol. 2019;76:1088–98. https://doi.org/10.1001/jamaneurol.2019.1812.

Article  PubMed  PubMed Central  Google Scholar 

Mollan SP, Mytton J, Tsermoulas G, Sinclair AJ. Idiopathic intracranial hypertension: evaluation of admissions and emergency readmissions through the hospital episode statistic dataset between 2002–2020. Life. 2021;11:417. https://doi.org/10.3390/life11050417.

Article  PubMed  PubMed Central  Google Scholar 

Bonelli L, Menon V, Arnold AC, Mollan SP. Managing idiopathic intracranial hypertension in the eye clinic. Eye. 2024. https://doi.org/10.1038/s41433-024-03140-y.

Article  PubMed  PubMed Central  Google Scholar 

Abbott S, Denton A, Wong SH, Mollan SP, Bul KC. Weight management communications in idiopathic intracranial hypertension: challenges and recommendations from the patients’ perspective. BMJ Neurol Open. 2023;5:e000527. https://doi.org/10.1136/bmjno-2023-000527.

Article  PubMed  PubMed Central  Google Scholar 

Lyons HS, Mollan SLP, Liu GT, Bowman R, Thaller M, Sinclair AJ, et al. Different characteristics of pre-pubertal and post-pubertal idiopathic intracranial hypertension: a narrative review. Neuro-Ophthalmology. 2023;47:63–74. https://doi.org/10.1080/01658107.2022.2153874.

Article  PubMed  Google Scholar 

Fargen KM, Midtlien JP, Margraf CR, Hui FK. Idiopathic intracranial hypertension pathogenesis: the jugular hypothesis. Interv Neuroradiol. 2024. https://doi.org/10.1177/15910199241270660.

Article  PubMed  PubMed Central  Google Scholar 

Thaller M, Homer V, Abbott S, Hazlehurst J, Mollan SP, Sinclair AJ. Does a healthy weight body mass index at onset of idiopathic intracranial hypertension change the outcomes? A United Kingdom prospective cohort study. Neuro-Ophthalmology. 2024;1–12. https://doi.org/10.1080/01658107.2024.2341775.

Potter O, Menon V, Mollan SP. Risk factors and disease associations in people living with idiopathic intracranial hypertension. Expert Rev Neurother. 2024;24:681–9. https://doi.org/10.1080/14737175.2024.2359420.

Article  CAS  PubMed  Google Scholar 

Kesler A, Kliper E, Shenkerman G, Stern N. Idiopathic intracranial hypertension is associated with lower body adiposity. Ophthalmology. 2010;117:169–74. https://doi.org/10.1016/j.ophtha.2009.06.030.

Article  PubMed  Google Scholar 

Hornby C, Botfield H, O’Reilly MW, Westgate C, Mitchell J, Mollan SP, et al. Evaluating the fat distribution in idiopathic intracranial hypertension using dual-energy X-ray absorptiometry scanning. Neuro-Ophthalmology. 2018;42:99–104. https://doi.org/10.1080/01658107.2017.1334218.

Article  PubMed  Google Scholar 

Manolopoulos KN, Karpe F, Frayn KN. Gluteofemoral body fat as a determinant of metabolic health. Int J Obes. 2010;34:949–59. https://doi.org/10.1038/ijo.2009.286.

Article  CAS  Google Scholar 

Westgate CSJ, Botfield HF, Alimajstorovic Z, Yiangou A, Walsh M, Smith G, et al. Systemic and adipocyte transcriptional and metabolic dysregulation in idiopathic intracranial hypertension. JCI Insight. 2021;6:e145346. https://doi.org/10.1172/jci.insight.145346.

Article  PubMed  PubMed Central  Google Scholar 

Cornier MA, Dabelea D, Hernandez TL, Lindstrom RC, Steig AJ, Stob NR, et al. The metabolic syndrome. Endocr Rev. 2008;29:777–822. https://doi.org/10.1210/er.2008-0024.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Thaller M, Mytton J, Wakerley BR, Mollan SP, Sinclair AJ. Idiopathic intracranial hypertension: evaluation of births and fertility through the hospital episode statistics dataset. BJOG. 2022;129:2019–27. https://doi.org/10.1111/1471-0528.17241.

Article  PubMed  PubMed Central  Google Scholar 

Dhungana S, Sharrack B, Woodroofe N. Cytokines and chemokines in idiopathic intracranial hypertension. Headache. 2009;49:282–5. https://doi.org/10.1111/j.1526-4610.2008.001329.x.

Article  PubMed  Google Scholar 

Sinclair AJ, Ball AK, Curnow SJ, Tomlinson JW, Burdon MA, Walker EA, et al. Elevated cerebrospinal fluid (CSF) leptin in idiopathic intracranial hypertension (IIH): evidence for hypothalamic leptin resistance? Clin Endocrinol (Oxf). 2009;70:863–9. https://doi.org/10.1111/j.1365-2265.2008.03401.x.

Article  CAS  PubMed  Google Scholar 

Abdelghaffar M, Hussein M, Abdelkareem SA, Elshebawy H. Sex hormones, CSF and serum leptin in patients with idiopathic intracranial hypertension. Egypt J Neurol Psychiatry Neurosurg. 2022;58. https://doi.org/10.1186/s41983-022-00473-x.

Hornby C, Mollan SP, Botfield H, O’Reilly MW, Sinclair AJ. Metabolic concepts in idiopathic intracranial hypertension and their potential for therapeutic intervention. J Neuroophthalmol. 2018;38:522–30. https://doi.org/10.1097/WNO.0000000000000684.

Article  PubMed  PubMed Central  Google Scholar 

Grech O, Seneviratne SY, Alimajstorovic Z, Yiangou A, Mitchell JL, Smith TB, et al. Nuclear magnetic resonance spectroscopy metabolomics in idiopathic intracranial hypertension to identify markers of disease and headache. Neurology. 2022;99:E1702–14. https://doi.org/10.1212/WNL.0000000000201007.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mollan SP, Mitchell JL, Ottridge RS, Aguiar M, Yiangou A, Alimajstorovic Z, et al. Effectiveness of bariatric surgery vs community weight management intervention for the treatment of idiopathic intracranial hypertension: a randomized clinical trial. JAMA Neurol. 2021;78:678–86. https://doi.org/10.1001/jamaneurol.2021.0659.

Article  PubMed  PubMed Central  Google Scholar 

Alimajstorovic Z, Mollan SP, Grech O, Mitchell JL, Yiangou A, Thaller M, et al. Dysregulation of amino acid, lipid, and acylpyruvate metabolism in idiopathic intracranial hypertension: a non-targeted case control and longitudinal metabolomic study. J Proteome Res. 2023;22:1127–37. https://doi.org/10.1021/acs.jproteome.2c00449.

Article  CAS  PubMed  Google Scholar 

Alimajstorovic Z, Mitchell JL, Yiangou A, Hancox T, Southam AD, Grech O et al. Determining the role of novel metabolic pathways in driving intracranial pressure reduction after weight loss. Brain Commun 2023;5. https://doi.org/10.1093/braincomms/fcad272.

Mitchell JL, Lyons HS, Walker JK, Yiangou A, Grech O, Alimajstorovic Z, et al. The effect of GLP-1RA exenatide on idiopathic intracranial hypertension: a randomized clinical trial. Brain. 2023;146:1821–30. https://doi.org/10.1093/brain/awad003.

Article  PubMed  PubMed Central  Google Scholar 

Kershaw EE, Flier JS. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab. 2004;89:2548–56. https://doi.org/10.1210/jc.2004-0395.

Article  CAS  PubMed  Google Scholar 

Li J, Papadopoulos V, Vihma V. Steroid biosynthesis in adipose tissue. Steroids. 2015;103:89–104. https://doi.org/10.1016/j.steroids.2015.03.016.

Article  CAS  PubMed  Google Scholar 

O’Reilly MW, House PJ, Tomlinson JW. Understanding androgen action in adipose tissue. J Steroid Biochem Mol Biol. 2014;143:277–84. https://doi.org/10.1016/j.jsbmb.2014.04.008.

Article  CAS  PubMed  Google Scholar 

Quinkler M, Sinha B, Tomlinson JW, Bujalska IJ, Stewart PM, Arlt W. Androgen generation in adipose tissue in women with simple obesity - a site-specific role for 17β-hydroxysteroid dehydrogenase type 5. J Endocrinol. 2004;183:331–42. https://doi.org/10.1677/joe.1.05762.

Article  CAS  PubMed  Google Scholar 

Amer SA, Alzanati NG, Warren A, Tarbox R, Khan R. Excess androgen production in subcutaneous adipose tissue of women with polycystic ovarian syndrome is not related to insulin or LH. J Endocrinol. 2019;241:99–109. https://doi.org/10.1530/JOE-18-0674.

Article  CAS  Google Scholar 

Comments (0)

No login
gif