Recent Advances in Diagnosis, Management, Treatment, and Prevention of Neuropathies in Cancer Patients

D’Souza RS, Saini C, Hussain N, Javed S, Prokop L, Her YF. Global estimates of prevalence of chronic painful neuropathy among patients with chemotherapy-induced peripheral neuropathy: systematic review and meta-analysis of data from 28 countries, 2000-24. Reg Anesth Pain Med. 2025;rapm-2024-106229.

Hung HW, Liu CY, Chen HF, Chang CC, Chen SC. Impact of chemotherapy-Induced peripheral neuropathy on quality of life in patients with advanced lung Cancer receiving Platinum-Based chemotherapy. Int J Environ Res Public Health. 2021;18(11):5677.

Article  PubMed  PubMed Central  Google Scholar 

Bonhof CS, van de Poll-Franse LV, Wasowicz DK, Beerepoot LV, Vreugdenhil G, Mols F. The course of peripheral neuropathy and its association with health-related quality of life among colorectal cancer patients. J Cancer Surviv. 2021;15(2):190–200.

Article  PubMed  Google Scholar 

Prieto-Callejero B, Rivera F, Fagundo-Rivera J, Romero A, Romero-Martín M, Gómez-Salgado J, et al. Relationship between chemotherapy-induced adverse reactions and health-related quality of life in patients with breast cancer. Med (Baltim). 2020;99(33):e21695.

Article  Google Scholar 

Chen X, Gan Y, Au NPB, Ma CHE. Current Understanding of the molecular mechanisms of chemotherapy-induced peripheral neuropathy. Front Mol Neurosci. 2024;17:1345811.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Smith EML, Pang H, Cirrincione C, Fleishman S, Paskett ED, Ahles T, et al. Effect of Duloxetine on pain, function, and quality of life among patients with chemotherapy-induced painful peripheral neuropathy: a randomized clinical trial. JAMA. 2013;309(13):1359–67.

Article  PubMed  PubMed Central  Google Scholar 

Engvall K, Gréen H, Fredrikson M, Lagerlund M, Lewin F, Åvall-Lundqvist E. Impact of persistent peripheral neuropathy on health-related quality of life among early-stage breast cancer survivors: a population-based cross-sectional study. Breast Cancer Res Treat. 2022;195(3):379–91.

Article  CAS  PubMed  PubMed Central  Google Scholar 

van de Graaf DL, Engelen V, de Boer A, Vreugdenhil G, Smeets T, van der Lee ML, et al. Experiences of cancer survivors with chemotherapy-induced peripheral neuropathy in the netherlands: symptoms, daily limitations, involvement of healthcare professionals, and social support. J Cancer Surviv. 2024;18(5):1630–9.

Article  PubMed  Google Scholar 

Suzuki K, Morishita S, Nakano J, Okayama T, Inoue J, Tanaka T, et al. Neurological outcomes of Chemotherapy-Induced peripheral neuropathy in patients with cancer: A systematic review and Meta-Analysis. Integr Cancer Ther. 2023;22:15347354231185110.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Speck RM, Sammel MD, Farrar JT, Hennessy S, Mao JJ, Stineman MG, et al. Impact of Chemotherapy-Induced peripheral neuropathy on treatment delivery in nonmetastatic breast Cancer. JOP. 2013;9(5):e234–40.

Article  PubMed  Google Scholar 

Shah A, Hoffman EM, Mauermann ML, Loprinzi CL, Windebank AJ, Klein CJ, et al. Incidence and disease burden of chemotherapy-induced peripheral neuropathy in a population-based cohort. J Neurol Neurosurg Psychiatry. 2018;89(6):636–41.

Article  PubMed  Google Scholar 

Vahdat LT, Thomas ES, Roché HH, Hortobagyi GN, Sparano JA, Yelle L, et al. Ixabepilone-associated peripheral neuropathy: data from across the phase II and III clinical trials. Support Care Cancer. 2012;20(11):2661–8.

Article  PubMed  PubMed Central  Google Scholar 

Chen Y, Ren X, Dai Y, Wang Y. Pharmacovigilance study of the association between peripheral neuropathy and antibody–drug conjugates using the FDA adverse event reporting system. Sci Rep. 2024;14:21386.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mo H, Yan X, Zhao F, Teng Y, Sun X, Lv Z, et al. Association of taxane type with Patient-Reported Chemotherapy-Induced peripheral neuropathy among patients with breast Cancer. JAMA Netw Open. 2022;5(11):e2239788.

Article  PubMed  PubMed Central  Google Scholar 

Lixian S, Xiaoqian Y, Luyan G, Lizhi Z, Rui D, Hongyue Y et al. Risk factors of paclitaxel-induced peripheral neuropathy in patients with breast cancer: a prospective cohort study. Front Oncol [Internet]. 2024 Mar 7 [cited 2025 Apr 15];14. Available from: https://www.frontiersin.orghttps://www.frontiersin.org/journals/oncology/articles/https://doi.org/10.3389/fonc.2024.1327318/full

Kleckner IR, Jusko TA, Culakova E, Chung K, Kleckner AS, Asare M, et al. Longitudinal study of inflammatory, behavioral, clinical and psychosocial risk factors for Chemotherapy-Induced peripheral neuropathy. Breast Cancer Res Treat. 2021;189(2):521–32.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vargas-Aliaga A, De la Haba M, Contreras MJ, Morales Estevez C, Porras I, Cano MT et al. NeuroPredict: study of the predictive value of ABCB1 genetic polymorphisms and associated clinical factors in chronic chemotherapy-induced peripheral neuropathy (CIPN). Front Pharmacol [Internet]. 2024 Feb 26 [cited 2025 May 7];15. Available from: https://www.frontiersin.orghttps://www.frontiersin.org/journals/pharmacology/articles/https://doi.org/10.3389/fphar.2024.1352939/full

Delanian S, Lefaix JL, Pradat PF. Radiation-induced neuropathy in cancer survivors. Radiother Oncol. 2012;105(3):273–82.

Article  PubMed  Google Scholar 

Skolka M, Shelly S, Pinto MV, Dubey D, Oishi T, Uhm JH et al. Clinical, Neurophysiologic, and Pathologic Features in Patients With Early-Onset Postradiation Neuropathy. Neurology [Internet]. 2023 Oct 3 [cited 2025 May 5];101(14). Available from: https://www.neurology.org/doi/https://doi.org/10.1212/WNL.0000000000207545

Graus F, Vogrig A, Muñiz-Castrillo S, Antoine JCG, Desestret V, Dubey D, et al. Updated diagnostic criteria for paraneoplastic neurologic syndromes. Neurol Neuroimmunol Neuroinflammation. 2021;8(4):e1014.

Article  Google Scholar 

Graus F, Keime-Guibert F, Reñe R, Benyahia B, Ribalta T, Ascaso C, et al. Anti-Hu-associated paraneoplastic encephalomyelitis: analysis of 200 patients. Brain. 2001;124(Pt 6):1138–48.

Article  CAS  PubMed  Google Scholar 

Amato AA, Ropper AH. Sensory ganglionopathy. N Engl J Med. 2020;383(17):1657–62.

Article  PubMed  Google Scholar 

Farina A, Villagrán-García M, Vogrig A, Zekeridou A, Muñiz-Castrillo S, Velasco R, et al. Neurological adverse events of immune checkpoint inhibitors and the development of paraneoplastic neurological syndromes. Lancet Neurol. 2024;23(1):81–94.

Article  CAS  PubMed  Google Scholar 

Dubey D, Lennon VA, Gadoth A, Pittock SJ, Flanagan EP, Schmeling JE, et al. Autoimmune CRMP5 neuropathy phenotype and outcome defined from 105 cases. Neurology. 2018;90(2):e103–10.

Article  CAS  PubMed  Google Scholar 

Dubey D, Jitprapaikulsan J, Bi H, Do Campo RV, McKeon A, Pittock SJ, et al. Amphiphysin-IgG autoimmune neuropathy: A recognizable clinicopathologic syndrome. Neurology. 2019;93(20):e1873–80.

Article  CAS  PubMed  Google Scholar 

Shah S, Vazquez Do Campo R, Kumar N, McKeon A, Flanagan EP, Klein C, et al. Paraneoplastic myeloneuropathies: clinical, oncologic, and serologic accompaniments. Neurology. 2021;96(4):e632–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jitprapaikulsan J, Klein CJ, Pittock SJ, Gadoth A, McKeon A, Mills JR, et al. Phenotypic presentations of paraneoplastic neuropathies associated with MAP1B-IgG. J Neurol Neurosurg Psychiatry. 2020;91(3):328–30.

Article  PubMed  Google Scholar 

Marini A, Bernardini A, Gigli GL, Valente M, Muñiz-Castrillo S, Honnorat J, et al. Neurologic adverse events of immune checkpoint inhibitors: A systematic review. Neurology. 2021;96(16):754–66.

Article  CAS  PubMed  Google Scholar 

Rossi S, Gelsomino F, Rinaldi R, Muccioli L, Comito F, Di Federico A, et al. Peripheral nervous system adverse events associated with immune checkpoint inhibitors. J Neurol. 2023;270(6):2975–86.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Johnson DB, Manouchehri A, Haugh AM, Quach HT, Balko JM, Lebrun-Vignes B, et al. Neurologic toxicity associated with immune checkpoint inhibitors: a pharmacovigilance study. J Immunotherapy cancer. 2019;7(1):134.

Article  Google Scholar 

Dubey D, David WS, Amato AA, Reynolds KL, Clement NF, Chute DF et al. Varied phenotypes and management of immune checkpoint inhibitor-associated neuropathies. Neurology [Internet]. 2019 Sep 10 [cited 2025 Apr 27];93(11). Available from: https://www.neurology.org/doi/https://doi.org/10.1212/WNL.0000000000008091

Staff NP, Windebank AJ. Peripheral neuropathy due to vitamin deficiency, toxins, and medications: CONTINUUM: lifelong learning in neurology. 2014;20:1293–306.

Hammond N, Wang Y, Dimachkie MM, Barohn RJ. Nutritional neuropathies. Neurol Clin. 2013;31(2):477–89.

Article  PubMed  PubMed Central  Google Scholar 

Bossi P, De Luca R, Ciani O, D’Angelo E, Caccialanza R. Malnutrition management in oncology: an expert view on controversial issues and future perspectives. Front Oncol. 2022;12:910770.

Article  PubMed  PubMed Central  Google Scholar 

Rino Y, Oshima T, Yoshikawa T. Changes in fat-soluble vitamin levels after gastrectomy for gastric cancer. Surg Today

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