Pardoll, D. M. The blockade of immune checkpoints in cancer immunotherapy. Nat. Rev. Cancer 12, 252–264 (2012).
Article CAS PubMed PubMed Central Google Scholar
Zhao, L., Singh, V., Ricca, A. & Lee, P. Survival benefit of pembrolizumab for patients with pancreatic adenocarcinoma: a case series. J. Med. Cases 13, 240–243 (2022).
Article PubMed PubMed Central Google Scholar
Storandt, M. H., Tran, N., Martin, N. & Jatoi, A. Pembrolizumab near the end of life in patients with metastatic pancreatic cancer: a multi-site consecutive series to examine survival and patient treatment burden. Cancer Immunol. Immunother. 72, 2515–2520 (2023).
Article CAS PubMed PubMed Central Google Scholar
Emens, L. A. et al. Challenges and opportunities in cancer immunotherapy: a Society for Immunotherapy of Cancer (SITC) strategic vision. J. Immunother. Cancer 12, e009063 (2024).
Article PubMed PubMed Central Google Scholar
Young, H. H. On the presence of nerves in tumors and of other structures in them as revealed by a modification of Ehrlich’s method of ‘vital staining’ with methylene blue. J. Exp. Med. 2, 1–12 (1897).
Article CAS PubMed PubMed Central Google Scholar
Baraldi, J. H., Martyn, G. V., Shurin, G. V. & Shurin, M. R. Tumor innervation: history, methodologies, and significance. Cancers 14, 1979 (2022).
Article CAS PubMed PubMed Central Google Scholar
Lucido, C. T. et al. Innervation of cervical carcinoma is mediated by cancer-derived exosomes. Gynecol. Oncol. 154, 228–235 (2019).
Article CAS PubMed PubMed Central Google Scholar
Zhao, Q. et al. The clinicopathological significance of neurogenesis in breast cancer. BMC Cancer 14, 484 (2014). This study provides early evidence suggesting that tumour denervation modulates tumour growth.
Article PubMed PubMed Central Google Scholar
Ayala, G. E. et al. Cancer-related axonogenesis and neurogenesis in prostate cancer. Clin. Cancer Res. 14, 7593–7603 (2008). This seminal study serves as an early example of human tumour innervation, identifying semaphorin 4F as a molecular driver of this process.
Article CAS PubMed Google Scholar
Entschladen, F., Palm, D., Lang, K., Drell, T. L. & Zaenker, K. S. Neoneurogenesis: tumors may initiate their own innervation by the release of neurotrophic factors in analogy to lymphangiogenesis and neoangiogenesis. Med. Hypotheses 67, 33–35 (2006).
Article CAS PubMed Google Scholar
Madeo, M. et al. Cancer exosomes induce tumor innervation. Nat. Commun. 9, 4284 (2018). This article highlights cancer-derived exosomes as a driver of tumour innervation.
Article PubMed PubMed Central Google Scholar
Amit, M. et al. Loss of p53 drives neuron reprogramming in head and neck cancer. Nature 578, 449–454 (2020).
Article CAS PubMed PubMed Central Google Scholar
Mauffrey, P. et al. Progenitors from the central nervous system drive neurogenesis in cancer. Nature 569, 672–678 (2019).
Article CAS PubMed Google Scholar
Dobrenis, K., Gauthier, L. R., Barroca, V. & Magnon, C. Granulocyte colony‐stimulating factor off‐target effect on nerve outgrowth promotes prostate cancer development. Int. J. Cancer 136, 982–988 (2015).
Article CAS PubMed Google Scholar
Hanahan, D. & Monje, M. Cancer hallmarks intersect with neuroscience in the tumor microenvironment. Cancer Cell 41, 573–580 (2023).
Article CAS PubMed PubMed Central Google Scholar
Winkler, F. et al. Cancer neuroscience: state of the field, emerging directions. Cell 186, 1689–1707 (2023).
Article CAS PubMed PubMed Central Google Scholar
Magnon, C. & Hondermarck, H. The neural addiction of cancer. Nat. Rev. Cancer 23, 317–334 (2023).
Article CAS PubMed Google Scholar
Borovikova, L. V. et al. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 405, 458–462 (2000).
Article CAS PubMed Google Scholar
Zhao, C.-M. et al. Denervation suppresses gastric tumorigenesis. Sci. Transl. Med. 6, 250ra115 (2014).
Article PubMed PubMed Central Google Scholar
Khanmammadova, N., Islam, S., Sharma, P. & Amit, M. Neuro-immune interactions and immuno-oncology. Trends Cancer 9, 636–649 (2023).
Article CAS PubMed PubMed Central Google Scholar
Saloman, J. L. et al. Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer. Proc. Natl Acad. Sci. USA 113, 3078–3083 (2016). This work is the first demonstration that denervation of nociceptor neurons reduces tumour growth.
Article CAS PubMed PubMed Central Google Scholar
Erin, N. et al. Activation of neuroimmune pathways increases therapeutic effects of radiotherapy on poorly differentiated breast carcinoma. Brain. Behav. Immun. 48, 174–185 (2015).
Article CAS PubMed Google Scholar
Magnon, C. et al. Autonomic nerve development contributes to prostate cancer progression. Science 341, 1236361 (2013). This article presents the first demonstration that tumours are innervated and that this innervation controls tumour growth.
Renz, B. W. et al. β2 adrenergic-neurotrophin feedforward loop promotes pancreatic cancer. Cancer Cell 33, 75–90.e7 (2018).
Article CAS PubMed Google Scholar
Partecke, L. I. et al. Subdiaphragmatic vagotomy promotes tumor growth and reduces survival via TNFα in a murine pancreatic cancer model. Oncotarget 8, 22501–22512 (2017).
Article PubMed PubMed Central Google Scholar
Sampson, J. H., Gunn, M. D., Fecci, P. E. & Ashley, D. M. Brain immunology and immunotherapy in brain tumours. Nat. Rev. Cancer 20, 12–25 (2020).
Article CAS PubMed Google Scholar
Strickland, M. R., Alvarez-Breckenridge, C., Gainor, J. F. & Brastianos, P. K. Tumor immune microenvironment of brain metastases: toward unlocking antitumor immunity. Cancer Discov. 12, 1199–1216 (2022).
Article CAS PubMed PubMed Central Google Scholar
Basbaum, A. I. & Julius, D. Toward better pain control. Sci. Am. 294, 60–67 (2006).
Article CAS PubMed Google Scholar
Julius, D. & Basbaum, A. I. Molecular mechanisms of nociception. Nature 413, 203–210 (2001).
Article CAS PubMed Google Scholar
Caterina, M. J. & Julius, D. The vanilloid receptor: a molecular gateway to the pain pathway. Annu. Rev. Neurosci. 24, 487–517 (2001).
Article CAS PubMed Google Scholar
Story, G. M. et al. ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell 112, 819–829 (2003).
Comments (0)