Lopez-Soto, A., Gonzalez, S., Smyth, M. J. & Galluzzi, L. Control of metastasis by NK cells. Cancer Cell 32, 135–154 (2017).
Article CAS PubMed Google Scholar
Liu, S. et al. NK cell-based cancer immunotherapy: from basic biology to clinical development. J. Hematol. Oncol. 14, 7 (2021).
Article CAS PubMed PubMed Central Google Scholar
Wu, S. Y., Fu, T., Jiang, Y. Z. & Shao, Z. M. Natural killer cells in cancer biology and therapy. Mol. Cancer 19, 120 (2020).
Article CAS PubMed PubMed Central Google Scholar
Menard, C. et al. Natural killer cell IFN-gamma levels predict long-term survival with imatinib mesylate therapy in gastrointestinal stromal tumor-bearing patients. Cancer Res. 69, 3563–3569 (2009).
Article CAS PubMed Google Scholar
Smyth, M. J. et al. Perforin is a major contributor to NK cell control of tumor metastasis. J. Immunol. 162, 6658–6662 (1999).
Article CAS PubMed Google Scholar
Street, S. E., Cretney, E. & Smyth, M. J. Perforin and interferon-gamma activities independently control tumor initiation, growth, and metastasis. Blood 97, 192–197 (2001).
Article CAS PubMed Google Scholar
Seaman, W. E., Sleisenger, M., Eriksson, E. & Koo, G. C. Depletion of natural killer cells in mice by monoclonal antibody to NK-1.1. Reduction in host defense against malignancy without loss of cellular or humoral immunity. J. Immunol. 138, 4539–4544 (1987).
Article CAS PubMed Google Scholar
Liu, Y. et al. Increased expression of programmed cell death protein 1 on NK cells inhibits NK-cell-mediated anti-tumor function and indicates poor prognosis in digestive cancers. Oncogene 36, 6143–6153 (2017).
Article CAS PubMed PubMed Central Google Scholar
Zhang, Q. et al. Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity. Nat. Immunol. 19, 723–732 (2018).
Article CAS PubMed Google Scholar
Judge, S. J., Murphy, W. J. & Canter, R. J. Characterizing the dysfunctional NK cell: assessing the clinical relevance of exhaustion, anergy, and senescence. Front. Cell Infect. Microbiol. 10, 49 (2020).
Article CAS PubMed PubMed Central Google Scholar
Bi, J. & Tian, Z. NK cell exhaustion. Front. Immunol. 8, 760 (2017).
Article PubMed PubMed Central Google Scholar
Ardolino, M. et al. Cytokine therapy reverses NK cell anergy in MHC-deficient tumors. J. Clin. Invest. 124, 4781–4794 (2014).
Article PubMed PubMed Central Google Scholar
da Silva, I. P. et al. Reversal of NK-cell exhaustion in advanced melanoma by Tim-3 blockade. Cancer Immunol. Res 2, 410–422 (2014).
Article PubMed PubMed Central Google Scholar
Komita, H. et al. Expression of immune checkpoint molecules of T cell immunoglobulin and mucin protein 3/galectin-9 for NK cell suppression in human gastrointestinal stromal tumors. Oncol. Rep. 34, 2099–2105 (2015).
Article CAS PubMed Google Scholar
Benson, D. M. Jr. et al. The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibody. Blood 116, 2286–2294 (2010).
Article CAS PubMed PubMed Central Google Scholar
Kondo, M., Weissman, I. L. & Akashi, K. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell 91, 661–672 (1997).
Article CAS PubMed Google Scholar
Abel, A. M., Yang, C., Thakar, M. S. & Malarkannan, S. Natural killer cells: development, maturation, and clinical utilization. Front Immunol. 9, 1869 (2018).
Article PubMed PubMed Central Google Scholar
Chiossone, L. et al. Maturation of mouse NK cells is a 4-stage developmental program. Blood 113, 5488–5496 (2009).
Article CAS PubMed Google Scholar
Fu, B. et al. CD11b and CD27 reflect distinct population and functional specialization in human natural killer cells. Immunology 133, 350–359 (2011).
Article CAS PubMed PubMed Central Google Scholar
Tamura, T., Yanai, H., Savitsky, D. & Taniguchi, T. The IRF family transcription factors in immunity and oncogenesis. Annu. Rev. Immunol. 26, 535–584 (2008).
Article CAS PubMed Google Scholar
Ohteki, T. et al. The transcription factor interferon regulatory factor 1 (IRF-1) is important during the maturation of natural killer 1.1+ T cell receptor-alpha/beta+ (NK1+ T) cells, natural killer cells, and intestinal intraepithelial T cells. J. Exp. Med. 187, 967–972 (1998).
Article CAS PubMed PubMed Central Google Scholar
Lohoff, M. et al. Deficiency in the transcription factor interferon regulatory factor (IRF)-2 leads to severely compromised development of natural killer and T helper type 1 cells. J. Exp. Med. 192, 325–336 (2000).
Article CAS PubMed PubMed Central Google Scholar
Taki, S., Nakajima, S., Ichikawa, E., Saito, T. & Hida, S. IFN regulatory factor-2 deficiency revealed a novel checkpoint critical for the generation of peripheral NK cells. J. Immunol. 174, 6005–6012 (2005).
Article CAS PubMed Google Scholar
Adams, N. M. et al. Transcription factor IRF8 orchestrates the adaptive natural killer cell response. Immunity 48, 1172–1182.e1176 (2018).
Article CAS PubMed PubMed Central Google Scholar
Santosa, E. K. et al. Control of nutrient uptake by IRF4 orchestrates innate immune memory. Nat. Immunol. 24, 1685–1697 (2023).
Article CAS PubMed PubMed Central Google Scholar
Geary, C. D. et al. Non-redundant ISGF3 components promote NK cell survival in an auto-regulatory manner during viral infection. Cell Rep. 24, 1949–1957.e1946 (2018).
Article CAS PubMed PubMed Central Google Scholar
Yan, H. et al. The transcription factor IRF4 determines the anti-tumor immunity of CD8+ T cells. iScience 26, 108087 (2023).
Article CAS PubMed PubMed Central Google Scholar
Yu, A. et al. Continuous expression of interferon regulatory factor 4 sustains CD8+ T cell immunity against tumor. Research (Wash. DC) 6, 0271 (2023).
Wang, G. et al. IRF4 ablation in B cells abrogates allogeneic B cell responses and prevents chronic transplant rejection. J. Heart Lung Transpl. 40, 1122–1132 (2021).
Rosmaraki, E. E. et al. Identification of committed NK cell progenitors in adult murine bone marrow. Eur. J. Immunol. 31, 1900–1909 (2001).
Article CAS PubMed Google Scholar
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