Favorable response to nivolumab combined with radiotherapy for retroperitoneal leiomyosarcoma

Improta L, Tzanis D, Bouhadiba T, Abdelhafidh K, Bonvalot S (2020) Overview of primary adult retroperitoneal tumours. Eur J Surg Oncol J Eur Soc Surg Oncol Br Assoc Surg Oncol 46:1573–1579

Google Scholar 

Schmitz E, Nessim C (2022) Retroperitoneal sarcoma care in 2021. Cancers (Basel). 14:1293

Article  PubMed  PubMed Central  Google Scholar 

Bonvalot S, Gronchi A, Le Péchoux C, Swallow CJ, Strauss D, Meeus P et al (2020) Preoperative radiotherapy plus surgery versus surgery alone for patients with primary retroperitoneal sarcoma (EORTC-62092: STRASS): a multicentre, open-label, randomised, phase 3 trial. Lancet Oncol 21:1366–1377

Article  PubMed  Google Scholar 

Perhavec A, Provenzano S, Baia M, Sangalli C, Morosi C, Barisella M et al (2021) Inoperable primary retroperitoneal sarcomas: clinical characteristics and reasons against resection at a single referral institution. Ann Surg Oncol 28:1151–1157

Article  PubMed  Google Scholar 

Twyman-Saint Victor C, Rech AJ, Maity A, Rengan R, Pauken KE, Stelekati E et al (2015) Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer. Nature 520:373–377

Article  CAS  PubMed  Google Scholar 

Wang Y, Deng W, Li N, Neri S, Sharma A, Jiang W et al (2018) Combining immunotherapy and radiotherapy for cancer treatment: current challenges and future directions. Front Pharmacol 9:185

Article  PubMed  PubMed Central  Google Scholar 

Kim JR, Moon YJ, Kwon KS, Bae JS, Wagle S, Kim KM et al (2013) Tumor infiltrating PD1-positive lymphocytes and the expression of PD-L1 predict poor prognosis of soft tissue sarcomas. PLoS ONE 8:e82870

Article  PubMed  PubMed Central  Google Scholar 

Ishihara S, Yamada Y, Iwasaki T, Yoshimoto M, Toda Y, Kohashi K et al (2020) PD-L1 and IDO-1 expression in undifferentiated pleomorphic sarcoma: the associations with tumor infiltrating lymphocytes, dMMR and HLA class I. Oncol Rep. https://doi.org/10.3892/or.2020.7837

Article  PubMed  Google Scholar 

Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J et al (2017) Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial. Lancet Oncol 18:1493–1501

Article  CAS  PubMed  PubMed Central  Google Scholar 

Toulmonde M, Penel N, Adam J, Chevreau C, Blay J-Y, Le Cesne A et al (2018) Use of PD-1 targeting, macrophage infiltration, and IDO pathway activation in sarcomas: a phase 2 clinical trial. JAMA Oncol 4:93–97

Article  PubMed  Google Scholar 

Kelly CM, Qin L-X, Whiting KA, Richards AL, Avutu V, Chan JE et al (2023) A phase II study of epacadostat and pembrolizumab in patients with advanced sarcoma. Clin Cancer Res Off J Am Assoc Cancer Res. 29:2043–2051

Article  CAS  Google Scholar 

Keung EZ, Burgess M, Salazar R, Parra ER, Rodrigues-Canales J, Bolejack V et al (2020) Correlative analyses of the SARC028 trial reveal an association between sarcoma-associated immune infiltrate and response to pembrolizumab. Clin Cancer Res 26:1258–1266

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pollack SM, Redman MW, Baker KK, Wagner MJ, Schroeder BA, Loggers ET et al (2020) Assessment of doxorubicin and pembrolizumab in patients with advanced anthracycline-naive sarcoma: a phase 1/2 nonrandomized clinical trial. JAMA Oncol 6:1778–1782

Article  PubMed  Google Scholar 

De Marco P, Merello E, Rossi A, Piatelli G, Cama A, Kibar Z et al (2012) FZD6 is a novel gene for human neural tube defects. Hum Mutat 33:384–390

Article  PubMed  Google Scholar 

Takeuchi Y, Tanegashima T, Sato E, Irie T, Sai A, Itahashi K et al (2021) Highly immunogenic cancer cells require activation of the WNT pathway for immunological escape. Sci Immunol 6:eabc6424

Article  CAS  PubMed  Google Scholar 

Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA et al (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A 102:15545–15550

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dobin A, Davis CA, Schlesinger F, Drenkow J, Zaleski C, Jha S et al (2013) STAR: ultrafast universal RNA-seq aligner. Bioinformatics 29:15–21

Article  CAS  PubMed  Google Scholar 

Frankish A, Diekhans M, Ferreira A-M, Johnson R, Jungreis I, Loveland J et al (2019) GENCODE reference annotation for the human and mouse genomes. Nucleic Acids Res 47:D766–D773

Article  CAS  PubMed  Google Scholar 

Haas BJ, Dobin A, Li B, Stransky N, Pochet N, Regev A (2019) Accuracy assessment of fusion transcript detection via read-mapping and de novo fusion transcript assembly-based methods. Genome Biol 20:213

Article  PubMed  PubMed Central  Google Scholar 

Pertea M, Pertea GM, Antonescu CM, Chang T-C, Mendell JT, Salzberg SL (2015) StringTie enables improved reconstruction of a transcriptome from RNA-seq reads. Nat Biotechnol 33:290–295

Article  CAS  PubMed  PubMed Central  Google Scholar 

Newman AM, Steen CB, Liu CL, Gentles AJ, Chaudhuri AA, Scherer F et al (2019) Determining cell type abundance and expression from bulk tissues with digital cytometry. Nat Biotechnol 37:773–782

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hendrikse LD, Haldipur P, Saulnier O, Millman J, Sjoboen AH, Erickson AW et al (2022) Failure of human rhombic lip differentiation underlies medulloblastoma formation. Nature 609:1021–1028

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang K, Li M, Hakonarson H (2010) ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res 38:e164

Article  PubMed  PubMed Central  Google Scholar 

Robinson JT, Thorvaldsdóttir H, Wenger AM, Zehir A, Mesirov JP (2017) Variant review with the integrative genomics viewer. Cancer Res 77:e31–e34

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li H, Durbin R (2009) Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics 25:1754–1760

Article  CAS  PubMed  PubMed Central  Google Scholar 

Danecek P, Bonfield JK, Liddle J, Marshall J, Ohan V, Pollard MO et al (2021) Twelve years of SAMtools and BCFtools. Gigascience. https://doi.org/10.1093/gigascience/giab008

Article  PubMed  PubMed Central  Google Scholar 

Arora A, Shen R, Seshan VE (2022) FACETS: fraction and allele-specific copy number estimates from tumor sequencing. Methods Mol Biol 2493:89–105

Article  CAS  PubMed  Google Scholar 

Angell HK, Bruni D, Barrett JC, Herbst R, Galon J (2020) The immunoscore: colon cancer and beyond. Clin Cancer Res Off J Am Assoc Cancer Res. 26:332–339

Article  CAS  Google Scholar 

Mlecnik B, Bifulco C, Bindea G, Marliot F, Lugli A, Lee JJ et al (2020) Multicenter international society for immunotherapy of cancer study of the consensus immunoscore for the prediction of survival and response to chemotherapy in stage III colon cancer. J Clin Oncol Off J Am Soc Clin Oncol 38:3638–3651

Article  CAS  Google Scholar 

Hijazi A, Antoniotti C, Cremolini C, Galon J (2023) Light on life: immunoscore immune-checkpoint, a predictor of immunotherapy response. Oncoimmunology 12:2243169

Article  PubMed  PubMed Central  Google Scholar 

Hellmann MD, Ciuleanu T-E, Pluzanski A, Lee JS, Otterson GA, Audigier-Valette C et al (2018) Nivolumab plus ipilimumab in lung cancer with a high tumor mutational burden. N Engl J Med 378:2093–2104

Article  CAS 

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