A rare case of ALK-positive histiocytosis with neurological involvement in a 70-year-old woman successfully managed with partial resection and alectinib

Chan JKC, Lamant L, Algar E et al (2008) ALK+ histiocytosis: a novel type of systemic histiocytic proliferative disorder of early infancy. Blood 112:2965–2968

Article  CAS  PubMed  Google Scholar 

Chang KTE, Tay AZE, Kuick CH et al (2019) ALK-positive histiocytosis: an expanded clinicopathologic spectrum and frequent presence of KIF5B-ALK fusion. Mod Pathol 32:598–608

Article  PubMed  Google Scholar 

Kemps PG, Picarsic J, Durham BH et al (2022) ALK-positive histiocytosis: a new clinicopathologic spectrum highlighting neurologic involvement and responses to ALK inhibition. Blood 139:256–280

Article  CAS  PubMed  PubMed Central  Google Scholar 

WHO Classification of Tumours Editorial Board (2024) Haematolymphoid tumours, WHO classification of tumours. World Health Organization 11:245–255

Google Scholar 

Jaber OI, Jarrah DA, Hiasat M, Hussaini MA (2021) ALK-positive histiocytosis: a case report and literature review. Turk Patoloji Derg 37:172–177

PubMed  PubMed Central  Google Scholar 

Lucas CG, Gilani A, Solomon DA et al (2019) ALK-positive histiocytosis with KIF5B-ALK fusion in the central nervous system. Acta Neuropathol 138:335–337

Article  PubMed  PubMed Central  Google Scholar 

Rossi S, Gessi M, Barresi S et al (2021) ALK-rearranged histiocytosis: report of two cases with involvement of the central nervous system. Neuropathol Appl Neurobiol 47:878–881

Article  PubMed  Google Scholar 

Luo Y, Wang P, Zhan Q, Luo J, Luo B (2025) ALK-positive histiocytosis: report of a rare case with exclusive involvement of the central nervous system in an adult woman. Neuropathology 45:55–59

Article  CAS  PubMed  Google Scholar 

Zhao D, Sun J, Cao X (2024) ALK-positive histiocytosis with central nervous system involvement successfully treated with alectinib: a rare case report. Neurol Sci 45:5963–5966

Article  PubMed  Google Scholar 

Feng X, Tao J, He N, Wang J, He L, Zhang N (2024) ALK-positive histiocytosis in 12 Asian children. Hum Pathol 152:105637

Article  CAS  PubMed  Google Scholar 

Zhou Y, Hurtado-Castillo M, Pandey O (2023) Case report: ALK-positive histiocytosis presented as bilateral synchronous breast masses with long-term remission on crizotinib. Front Med (Lausanne) 10:1288849

Article  Google Scholar 

Wei Y, Zhang R, Lin D, Chen X, Li L, Huang H (2024) Case report: systemic presentation of ALK-positive histiocytosis. Front Oncol 14:1366766

Article  PubMed  PubMed Central  Google Scholar 

Bai Y, Sun W, Niu D et al (2021) Localized ALK-positive histiocytosis in a Chinese woman: report of a case in the lung with a novel EML4-ALK rearrangement. Virchows Arch 479:1079–1083

Article  PubMed  Google Scholar 

Swain F, Williams B, Barbaro P (2021) ALK-positive histiocytosis with peripheral blood histiocytes: a case report. Acta Haematol 144:218–221

Article  PubMed  Google Scholar 

He Q, Zhang W, Li Q (2022) Failure of crizotinib based systemic treatment in ALK positive histiocytosis involving the central nervous system: a case report and literature review. BMC Pediatr 22:308

Article  PubMed  PubMed Central  Google Scholar 

Guo Y, Qu HB, Ning G et al (2022) Case report: ALK-positive histiocytosis with KIF5B-ALK fusion in cerebrum-disseminated lesions in a child. Front Oncol 12:858939

Article  PubMed  PubMed Central  Google Scholar 

Tu Y, Lu Y (2024) Anaplastic lymphoma kinase-positive histiocytosis with multisystem involvement: a case report. Pediatr Dermatol 41:551–553

Article  PubMed  Google Scholar 

Kumagai E, Tanaka M, Iwasaki F et al (2024) Localized anaplastic lymphoma kinase-positive histiocytosis in a cerebellar hemisphere with long-term treatment: illustrative case. J Neurosurg Case Lessons 7:CASE23466

Article  PubMed  PubMed Central  Google Scholar 

Wang J, Zheng Y, Xiong Y (2024) Imaging features of ALK-positive histiocytosis with neurological involvement: a case report and literature review. Front Oncol 14:1333519

Article  PubMed  PubMed Central  Google Scholar 

Alizadeh M, Ravindran A, Chkheidze R et al (2023) ALK-positive histiocytosis involving the cavernous sinus: A deceptive radiologic mimic of meningioma. Radiol Case Rep 18:2259–2263

Article  PubMed  PubMed Central  Google Scholar 

Qiu L, Weitzman SP, Nastoupil LJ, Williams MD, Medeiros LJ, Vega F (2021) Disseminated ALK-positive histiocytosis with KIF5B-ALK fusion in an adult. Leuk Lymphoma 62:1234–1238

Article  CAS  PubMed  Google Scholar 

Aoki Y, Maeda M, Kishi S et al (2022) Central nervous system involvement of systemic ALK-positive histiocytosis with KIF5B-ALK fusion. Radiol Case Rep 17:3867–3870

Article  PubMed  PubMed Central  Google Scholar 

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