So WZ, Wong NS, Tan HC, Yu Lin MT, Yu Lee IX, Mehta JS, et al. Diabetic corneal neuropathy as a surrogate marker for diabetic peripheral neuropathy. Neural Regen Res. 2022;17(10):2172–8.
Article CAS PubMed PubMed Central Google Scholar
Ponirakis G, Al-Janahi I, Elgassim E, Homssi M, Petropoulos IN, Gad H, et al. Sustained corneal nerve loss predicts the development of diabetic neuropathy in type 2 diabetes. Front Neurosci. 2024;18:1393105.
Article PubMed PubMed Central Google Scholar
Che NN, Jiang QH, Ding GX, Chen SY, Zhao ZX, Li X, et al. Corneal nerve fiber loss relates to cognitive impairment in patients with Parkinson’s disease. NPJ Parkinsons Dis. 2021;7(1):80.
Article PubMed PubMed Central Google Scholar
Schneider C, Bucher F, Cursiefen C, Fink GR, Heindl LM, Lehmann HC. Corneal confocal microscopy detects small fiber damage in chronic inflammatory demyelinating polyneuropathy (CIDP). J Peripher Nerv Syst. 2014;19(4):322–7.
Eghrari AO, Riazuddin SA, Gottsch JD. Overview of the cornea: structure, function, and development. Prog Mol Biol Transl Sci. 2015;134:7–23.
Zhou T, Lee A, Lo ACY, Kwok JSWJ. Diabetic corneal neuropathy: pathogenic mechanisms and therapeutic strategies. Front Pharmacol. 2022;13:816062.
Article CAS PubMed PubMed Central Google Scholar
Mansoor H, Lee IXY, Lin MT, Ang HP, Xue YC, Krishaa L, et al. Topical and oral peroxisome proliferator-activated receptor-α agonist ameliorates diabetic corneal neuropathy. Sci Rep. 2024;14(1):13435.
Article CAS PubMed PubMed Central Google Scholar
Bonomo R, Kramer S, Aubert VM. Obesity-associated neuropathy: recent preclinical studies and proposed mechanisms. Antioxid Redox Signal. 2022;37(7–9):597–612.
Article CAS PubMed PubMed Central Google Scholar
Liu C, Lin MT, Lee IXY, Wong JHF, Lu D, Lam TC, et al. Neuropathic corneal pain: tear proteomic and neuromediator profiles, imaging features, and clinical manifestations. Am J Ophthalmol. 2024;265:6–20.
Article CAS PubMed Google Scholar
Callaghan BC, Reynolds E, Banerjee M, Chant E, Villegas-Umana E, Feldman EL. Central obesity is associated with neuropathy in the severely obese. Mayo Clin Proc. 2020;95(7):1342–53.
Lim JZM, Burgess J, Ooi CG, Ponirakis G, Malik RA, Wilding JPH, et al. The peripheral neuropathy prevalence and characteristics are comparable in people with obesity and long-duration type 1 diabetes. Adv Ther. 2022;39(9):4218–29.
Article CAS PubMed PubMed Central Google Scholar
Lawal Y, Mshelia-Reng R, Omonua SO, Odumodu K, Shuaibu R, Itanyi UD, et al. Comparison of waist-height ratio and other obesity indices in the prediction of diabetic peripheral neuropathy. Front Nutr. 2022;9:949315.
Article PubMed PubMed Central Google Scholar
Callaghan BC, Xia R, Reynolds E, Banerjee M, Rothberg AE, Burant CF, et al. Association between metabolic syndrome components and polyneuropathy in an obese population. JAMA Neurol. 2016;73(12):1468–76.
Article PubMed PubMed Central Google Scholar
Callaghan BC, Xia R, Banerjee M, de Rekeneire N, Harris TB, Newman AB, et al. Metabolic syndrome components are associated with symptomatic polyneuropathy independent of glycemic status. Diabetes Care. 2016;39(5):801–7.
Article CAS PubMed PubMed Central Google Scholar
Elafros MA, Andersen H, Bennett DL, Savelieff MG, Viswanathan V, Callaghan BC, et al. Towards prevention of diabetic peripheral neuropathy: clinical presentation, pathogenesis, and new treatments. Lancet Neurol. 2022;21(10):922–36.
Article PubMed PubMed Central Google Scholar
Hargrave A, Courson JA, Pham V, Landry P, Magadi S, Shankar P, et al. Corneal dysfunction precedes the onset of hyperglycemia in a mouse model of diet-induced obesity. PLoS One. 2020;15(9):e0238750.
Article CAS PubMed PubMed Central Google Scholar
Yorek MS, Obrosov A, Shevalye H, Holmes A, Harper MM, Kardon RH, et al. Effect of diet-induced obesity or type 1 or type 2 diabetes on corneal nerves and peripheral neuropathy in C57Bl/6J mice. J Peripher Nerv Syst. 2015;20(1):24–31.
Article PubMed PubMed Central Google Scholar
Iqbal Z, Kalteniece A, Ferdousi M, Adam S, D’Onofrio L, Ho JH, et al. Corneal keratocyte density and corneal nerves are reduced in patients with severe obesity and improve after bariatric surgery. Invest Ophthalmol Vis Sci. 2021;62(1):20.
Article CAS PubMed PubMed Central Google Scholar
Azmi S, Ferdousi M, Liu Y, Adam S, Iqbal Z, Dhage S, et al. Bariatric surgery leads to an improvement in small nerve fibre damage in subjects with obesity. Int J Obes (Lond). 2021;45(3):631–8.
Article CAS PubMed Google Scholar
Misra SL, Slater JA, Makam R, Braatvedt GD, Beban G, Pradhan M, et al. Remission of corneal and peripheral neuropathy after bariatric surgery in people with diabetes. Ocul Surf. 2024;34:140–5.
Chin JY, Yang LWY, Ji AJS, Nubile M, Mastropasqua L, Allen JC, et al. Validation of the use of automated and manual quantitative analysis of corneal nerve plexus following refractive surgery. Diagnostics (Basel). 2020;10(7):493.
Liu YC, Lin MT, Mehta JS. Analysis of corneal nerve plexus in corneal confocal microscopy images. Neural Regen Res. 2020;16(4):690–1.
Article PubMed Central Google Scholar
Chin JY, Lin MT, Lee IXY, Mehta JS, Liu YC. Tear neuromediator and corneal denervation following SMILE. J Refract Surg. 2021;37(8):516–23.
Chin JY, Liu C, Lee IXY, Lin MTY, Cheng CY, Wong JHF, et al. Impact of age on the characteristics of corneal nerves and corneal epithelial cells in healthy adults. Cornea. 2024;43(4):409–18.
Chao C, Wang R, Jones M, Karson N, Jussel A, Smith J, et al. The relationship between corneal nerve density and hemoglobin a1c in patients with prediabetes and type 2 diabetes. Invest Ophthalmol Vis Sci. 2020;61(12):26.
Article CAS PubMed PubMed Central Google Scholar
Lyu Y, Zeng X, Li F, Zhao S. The effect of the duration of diabetes on dry eye and corneal nerves. Cont Lens Anterior Eye. 2019;42(4):380–5.
Tavakoli M, Marshall A, Pitceathly R, Fadavi H, Gow D, Roberts ME, et al. Corneal confocal microscopy: a novel means to detect nerve fibre damage in idiopathic small fibre neuropathy. Exp Neurol. 2010;223(1):245–50.
Koliaki C, Dalamaga M, Liatis S. Update on the obesity epidemic: after the sudden rise, is the upward trajectory beginning to flatten? Curr Obes Rep. 2023;12(4):514–27.
Article PubMed PubMed Central Google Scholar
Gulkas S, Aydin FO, Turhan SA, Toker AE. In vivo corneal confocal microscopy as a non-invasive test to assess obesity induced small fibre nerve damage and inflammation. Eye (Lond). 2023;37(11):2226–32.
Callaghan B, Feldman E. The metabolic syndrome and neuropathy: therapeutic challenges and opportunities. Ann Neurol. 2013;74(3):397–403.
Article CAS PubMed Google Scholar
Smith AG, Singleton JR. Obesity and hyperlipidemia are risk factors for early diabetic neuropathy. J Diabetes Complications. 2013;27(5):436–42.
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