Treede R-D, Jensen TS, Campbell JN, Cruccu G, Dostrovsky JO, Griffin JW, et al. Neuropathic pain. Redefinition and a grading system for clinical and research purposes. Neurology. 2008;70:1630–5.

CAS  PubMed  Google Scholar 

Bates D, Schultheis BC, Hanes MC, Jolly SM, et al. A comprehensive algorithm for management of neuropathic pain. Pain Med. 2019;20:S2–12.

PubMed  PubMed Central  Google Scholar 

Szok D, Tajti J, Nyári A, Vécsei L. Therapeutic approaches for peripheral and central neuropathic pain. Behav Neurol. 2019. https://doi.org/10.1155/2019/8685954.

Article  PubMed  PubMed Central  Google Scholar 

van Hecke O, Austin SK, Khan RA, Smith BH, Torrance N. Neuropathic pain in the general population: a systematic review of epidemiological studies. Pain. 2014;155:654–62.

PubMed  Google Scholar 

Attal N, Cruccu G, Baron R, Haanpaa M, Hanssona P, Jensen TS, et al. EFNS guidelines on the pharmacological treatment of pain: 2010 revision. Eur J Neurology. 2010;17:1113–23.

CAS  Google Scholar 

Finnerup NB, Attal N, Haroutounian S, McNicol E, Baron R, Dworkin RH, et al. Pharmacotherapy for neuropathic pain in adults: systematic review, meta-analysis and updated NeuPSIG recommendations. Lancet Neurol. 2015;14:162–73.

CAS  PubMed  PubMed Central  Google Scholar 

Center for Disease Control. Nonopioid treatments for chronic pain. https://stacks.cdc.gov/view/cdc/38483/cdc_38483_DS1.pdf.

Afonso AS, Carnaval T, Sebastia VC. Combination therapy for neuropathic pain: A review of recent evidence. J Clin Med. 2021;10:3533.

Google Scholar 

Finnerup NB, Haroutounian S, Kamerman P, Baron R, et al. Neuropathic pain: an updated grading system for research and clinical practice. Pain. 2016;157:1599–606.

CAS  PubMed  PubMed Central  Google Scholar 

Johnson P, Becker L, Halpern SM. Real-world treatment of post-herpetic neuralgia with gabapentin or pregabalin. Clinical Drug Invest. 2013;33:35–44.

Google Scholar 

Tofranil-PM™ (imipramine pamoate) Prescribing Information. 2014; Mallinckrodt Inc. Hazelwood, MO 63042 USA

Cymbalta (duloxetine delayed-release) Prescribing Information. 2017; Lilly USA, LLC Indianapolis, IN 46285, USA

Neurontin (Gabapentin) Prescribing Information. 2009; Parke-Davis, a division of Pfizer, Inc. NY, NY 10017

Lyrica (Pregabalin) Capsules, Prescribing Information. 2018; Parke-Davis, Division of Pfizer Inc., NY, NY 10017.

Oxycontin® (oxycodone hydrochloride) extended-release tablets. Prescribing Information. 2021; Purdue Pharma L.P. Stamford, CT 06901–3431

ZTLIDO™ (lidocaine topical system) Prescribing information. 2018; Scilex Pharmaceuticals Inc; San Diego, CA

White WT, Patel N, Drass M, Nalamachu S. Lidocaine patch 5% with systemic analgesics such as gabapentin: A rational polypharmacy approach for the treatment of chronic pain. Pain Med. 2003;4:321–30.

PubMed  Google Scholar 

Balanaser M, Carley M, Baron R, Finnerup NB, et al. Combination pharmacotherapy for the treatment of neuropathic pain in adults: systematic review and meta-analysis. Pain. 2022;164:230–51.

PubMed  Google Scholar 

Chaparro LE, Wien PJ, Moore RA, Gilron I. Combination pharmacotherapy for the treatment of neuropathic pain in adults (Review). Cochrane Database Syst Rev. 2012. https://doi.org/10.1002/14651858.CD008943.pub2.

Article  PubMed  PubMed Central  Google Scholar 

Rehm S, Binder A, Baron R. Post-herpetic neuralgia: 5% lidocaine-medicated plaster, pregabalin, or a combination of both: a randomized, open, clinical effectiveness study. Curr Med Res Opin. 2010;26:1607–19.

CAS  PubMed  Google Scholar 

Baron R, Mayoral V, Leijon G, Binder A, Steigerwald I, Serpell M. 5% lidocaine-medicated plaster versus pregabalin in post-herpetic neuralgia and diabetic polyneuropathy: an open-label, non-inferiority two stage RCT study. Curr Med Res Opin. 2009;25:1663–76.

CAS  PubMed  Google Scholar 

Baron R, Mayoral V, Leijon G, Binder A, Steigerwald I, Serpell M. Efficacy and safety of combination therapy with 5% lidocaine-medicated plaster and pregabalin in post-herpetic neuralgia and diabetic polyneuropathy. Curr Med Res Opin. 2009;25:1677–87.

CAS  PubMed  Google Scholar 

Baron R, Martin-Mola E, Muller M, Dubois C, Falke D, Steigerwald I. Effectiveness and safety of tapentadol prolonged release (PR) versus a combination of tapentadol PR and pregabalin for the management of severe, chronic low back pain with a neuropathic component: a randomized, double-blind, phase 3b study. Pain Pract. 2015;15:455–70.

PubMed  Google Scholar 

Dou Z, Jiang Z, Zhong J. Efficacy and safety of pregabalin in patients with neuropathic cancer pain undergoing morphine therapy. Asia-Pac J Clin Oncology. 2017;13:357–64.

Google Scholar 

Caraceni A, Zecca E, Bonezzi C, Arcuri E, Tur RY, Maltoni M, et al. Gabapentin for neuropathic cancer pain: a randomized controlled trial from the gabapentin cancer pain study group. J Clin Oncology. 2004;22:2909–17.

CAS  Google Scholar 

Gilron I, Bailey JM, Tu D, Holden RR, Weaver DF, Houlden RI. Morphine, gabapentin or their combination for neuropathic pain. New Engl J Med. 2005;352:1324–34.

CAS  PubMed  Google Scholar 

Hanna M, O’Brien C, Wilson MC. Prolonged-release oxycodone enhances the effects of existing gabapentin therapy in painful diabetic neuropathy patients. Eur J Pain. 2008;12:804–13.

CAS  PubMed  Google Scholar 

Zin CS, Nissen LM, O’Callaghan JP, Duffull SB, Smith MT, Brendan JM. A randomized, controlled trial of oxycodone versus placebo in patients with postherpetic neuralgia and painful diabetic neuropathy treated with pregabalin. J Pain. 2010;11:462–71.

CAS  PubMed  Google Scholar 

Holbech JV, Bach FW, Finnerup NB, Brosen K, Jensen TS, Sindrup SH. Imipramine and pregabalin combination for painful polyneuropathy: a randomized controlled trial. Pain. 2015;156:958–66.

CAS  PubMed  Google Scholar 

Tesfaye S, Wilhelm S, Lledo A, Schacht A, Tölle T, Bouhassira D, et al. Duloxetine and pregabalin: High-dose monotherapy or their combination: the “COMBO-DN study” – a multinational, randomized, double-blind, parallel-group study in patients with diabetic peripheral neuropathic pain. Pain. 2013;154:2616–25.

CAS  PubMed  Google Scholar 

Gilron I, Bailey JM, Tu D, Holden RR, Jackson AC, Houlden R. Nortriptyline and gabapentin, alone and in combination for neuropathic pain: a double-blind, randomized controlled crossover trial. Lancet. 2009;374:1252–61.

CAS  PubMed  Google Scholar 

Tsai J-H, Liu I-T, Su P-F, Huang Y-T, Chiu G-L, Chen Y-Y, et al. Lidocaine transdermal patches reduced pain intensity in neuropathic cancer patients already receiving opioid treatment. BMC Palliat Care. 2023;22:4. https://doi.org/10.1186/s12904-023-01126-3.

Article  PubMed  PubMed Central  Google Scholar 

Martini A, Del Balzo G, Schweiger V, Zanzotti M, Picelli A, Parolini M, et al. Efficacy of lidocaine 5% medicated plaster (VERSATIS®) in patients with localized neuropathic pain poorly responsive to pharmacological therapy. Minerva Med. 2018;109:344–51.

PubMed  Google Scholar 

Li J, Huang Y, Lin J. Efficacy analysis of lidocaine plaster combined with gabapentin in the treatment of herpes zoster neuralgia. Zhonghua Yi Xue Za Zhi. 2022;102:3186–91.

CAS  PubMed  Google Scholar 

Nalamachu S, Gudin J. Characteristics of analgesic patch formulations. J Pain Res. 2020;13:2343–54.

PubMed  PubMed Central  Google Scholar 

Lidoderm (Lidocaine Patch 5%) Prescribing Information. 2015; Endo Pharmaceuticals Inc. Malvern, PA.

Lidocaine (Lidocaine Patch) Prescribing Information. 2018; Mylan Pharmaceuticals Inc. Morgantown, WV.

Gudin J, Webster LR, Greuber E, Vought K, Patel K, Kuritzky L. Open-label adhesion performance studies of a new lidocaine topical system 1.8% versus lidocaine patches 5% and lidocaine-medicated paster 5% in healthy subjects. J Pain Res. 2021;14:513–26.

PubMed  PubMed Central  Google Scholar 

US Food and Drug Administration. Guidance for Industry. Assessing adhesion with transdermal and topical delivery systems for ANDAs, October 2018. Accessed June 17, 2019.

Fudin J, Wegrzyn EL, Greuber E, et al. A randomized, crossover, pharmacokinetic and adhesion performance study of a lidocaine topical system 1.8% during physical activity and heat treatment in healthy subjects. J Pain Res. 2020;13:1359–67.

CAS  PubMed  PubMed Central  Google Scholar 

Vought K, Greuber E, Patel K, Argoff C, Lissin DJA. Randomized, crossover, adhesion performance and pharmacokinetic study of a lidocaine topical system under conditions of water exposure in healthy subjects. Pain Res. 2021;14:2459–67.

Google Scholar