Funding

No external funding was used in the preparation of this article.

Conflict of interest

C. Ciccarese: Advisory board, invited speaker, meetings traveling: IPSEN, Merck Sharp & Dohme, Astellas, AstraZeneca, Pfizer, Janssen, and Bristol Myers Squibb, Novartis, EISAI. R. Iacovelli: Advisory board, invited speaker, meetings traveling: Pfizer, Janssen, Sanofi, IPSEN, Merck, Sharp & Dohme, Novartis, AstraZeneca, Astellas, and Bristol Myers Squibb, EISAI. G. Tortora: Consultant for BMS, MSD, Astra Zeneca, Servier, Merck Serono, Dompé. R. Berardi: Advisory board, invited speaker, meetings traveling: AstraZeneca, Boeringher, MSD, Lilly, Roche, Amgen, GSK, Eisai, BMS. L. Tagliaferri: Advisory board, invited speaker, meetings traveling: Elekta, Igea Medical, SunPharma, Sanofi, Roche, Molipharma, Nanobiotix, Novartis. G. Pinterpe, F. Migliaccio, R.R. Pedone, R. Belletto, P. Russo, A. Totaro, C. Sighinolfi, L. Formisano and B. Rocco declare that they have no conflicts of interest that might be relevant to the contents of this article.

Ethics approval

Not applicable.

Consent to participate

Not applicable.

Consent for publication

Not applicable.

Availability of data and material

The datasets generated and analyzed during the current study are available from the corresponding author on reasonable request.

Code availability

Not applicable.

Author contributions

Giada Pinterpe, Fortuna Migliaccio, and Chiara Ciccarese: Conceptualization, data curation, formal analysis, methodology, project administration, software, investigation, writing—review and editing. Romina Rose Pedone and Rachele Belletto: Resources, data curation, writing—original draft. Pierluigi Russo, Angelo Totaro, Luca Tagliaferri, Chiara Sighinolfi, Luigi Formisano, Rossana Berardi and Bernardo Rocco: Methodology, investigation, resources, data curation, writing—original draft, visualization. Giampaolo Tortora: Methodology, data curation, writing—review and editing, visualization, supervision. Roberto Iacovelli: Conceptualization, validation, writing—review and editing, visualization, supervision, project administration.