Congdon N, O’Colmain B, Klaver CCW, Klein R, Muñoz B, Friedman DS, et al. Causes and prevalence of visual impairment among adults in the United States. Arch Ophthalmol. 2004;122:477–85.
Bloch SB, Larsen M, Munch IC. Incidence of legal blindness from age-related macular degeneration in Denmark: year 2000 to 2010. Am J Ophthalmol. 2012;153:209– 13.e2.
Jonas JB, Cheung CMG, Panda-Jonas S. Updates on the epidemiology of age-related macular degeneration. Asia Pac J Ophthalmol (Phila). 2017;6:493–7.
Barash A, Chui TYP, Garcia P, Rosen RB. Acute macular and peripapillary angiographic changes with intravitreal injections. Retina. 2020;40:648–56.
Pirinen I, Leinonen S, Helminen M, Hujanen P, Vaajanen A, Tuulonen A, et al. Glaucoma progression in patients receiving intravitreal anti-VEGF treatment for neovascular age-related macular degeneration. Acta Ophthalmol. 2023;101:261–5.
Article PubMed CAS Google Scholar
Baek SK, Kim JH, Kim JW, Kim CG. Increase in the population of patients with neovascular age-related macular degeneration who underwent long-term active treatment. Sci Rep. 2019;9:13264.
Article PubMed PubMed Central Google Scholar
Joussen AM, Ricci F, Paris LP, Korn C, Quezada-Ruiz C, Zarbin M. Angiopoietin/Tie2 signalling and its role in retinal and choroidal vascular diseases: a review of preclinical data. Eye (Lond). 2021;35:1305–16.
Regula JT, von Lundh P, Foxton R, Barathi VA, Cheung CMG, Bo Tun SB, et al. Targeting key angiogenic pathways with a bispecific CrossMAb optimized for neovascular eye diseases. EMBO Mol Med. 2016;8:1265–88.
Article PubMed PubMed Central CAS Google Scholar
Thomson BR, Heinen S, Jeansson M, Ghosh AK, Fatima A, Sung HK, et al. A lymphatic defect causes ocular hypertension and glaucoma in mice. J Clin Invest. 2014;124:4320–4.
Article PubMed PubMed Central CAS Google Scholar
Thomson BR, Souma T, Tompson SW, Onay T, Kizhatil K, Siggs OM, et al. Angiopoietin-1 is required for Schlemm’s canal development in mice and humans. J Clin Invest. 2017;127:4421–36.
Article PubMed PubMed Central Google Scholar
Souma T, Tompson SW, Thomson BR, Siggs OM, Kizhatil K, Yamaguchi S, et al. Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity. J Clin Invest. 2016;126:2575–87.
Article PubMed PubMed Central Google Scholar
Kim J, Park D-Y, Bae H, Park DY, Kim D, Lee C-K, et al. Impaired angiopoietin/Tie2 signaling compromises Schlemm’s canal integrity and induces glaucoma. J Clin Invest. 2017;127:3877–96.
Article PubMed PubMed Central Google Scholar
Kapiainen E, Elamaa H, Miinalainen I, Izzi V, Eklund L. Cooperation of angiopoietin-2 and angiopoietin-4 in Schlemm’s canal maintenance. Invest Ophthalmol Vis Sci. 2022;63:1.
Article PubMed PubMed Central CAS Google Scholar
Freund KB, Hoang QV, Saroj N, Thompson D. Intraocular pressure in patients with neovascular age-related macular degeneration receiving intravitreal aflibercept or ranibizumab. Ophthalmology. 2015;122:1802–10.
Matsumoto H, Hoshino J, Nakamura K, Nagashima T, Akiyama H. Short-term outcomes of intravitreal faricimab for treatment-naïve neovascular age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol. 2023;261:2945–52.
Article PubMed CAS Google Scholar
Mukai R, Kataoka K, Tanaka K, Miyara Y, Maruko I, Nakayama M, et al. Three-month outcomes of faricimab loading therapy for wet age-related macular degeneration in Japan. Sci Rep. 2023;13:8747.
Article PubMed PubMed Central CAS Google Scholar
Gabrielle P-H, Nguyen V, Wolff B, Essex R, Young S, Hunt A, et al. Intraocular pressure changes and vascular endothelial growth factor inhibitor use in various retinal diseases: long-term outcomes in routine clinical practice: data from the Fight Retinal Blindness! Registry. Ophthalmol Retina. 2020;4:861–70.
Novais EA, Baumal CR, Sarraf D, Freund KB, Duker JS. Multimodal imaging in retinal disease: A consensus definition. Ophthalmic Surg Lasers Imaging Retina. 2016;47:201–5.
Yannuzzi NA, Patel SN, Bhavsar KV, Sugiguchi F, Freund KB. Predictors of sustained intraocular pressure elevation in eyes receiving intravitreal anti-vascular endothelial growth factor therapy. Am J Ophthalmol. 2014;158:319–e3272.
Article PubMed CAS Google Scholar
Ramsey DJ, McCullum JC, Steinberger EE, Zhang Y, Alwreikat AM, Cooper ML, et al. Intraocular pressure decreases in eyes with glaucoma-related diagnoses after conversion to aflibercept for treatment-resistant age-related macular degeneration. Eye (Lond). 2022;36:1813–9.
Article PubMed CAS Google Scholar
Rusu IM, Deobhakta A, Yoon D, Lee M, Slakter JS, Klancnik JM, et al. Intraocular pressure in patients with neovascular age-related macular degeneration switched to aflibercept injection after previous anti-vascular endothelial growth factor treatments. Retina. 2014;34:2161–6.
Article PubMed CAS Google Scholar
Honjo J, Mukai R, Itagaki K, Tanaka K, Norikawa K, Kato Y, et al. Intraocular pressure changes during intravitreal aflibercept injection based on treat-and-extend regimen in Japanese patients with neovascular age-related macular degeneration and glaucoma. Jpn J Ophthalmol. 2024;68:91–5.
Article PubMed CAS Google Scholar
Fogli S, Del Re M, Rofi E, Posarelli C, Figus M, Danesi R. Clinical pharmacology of intravitreal anti-VEGF drugs. Eye (Lond). 2018;32:1010–20.
Article PubMed CAS Google Scholar
Van Bergen T, Jonckx B, Hollanders K, Sijnave D, Van de Velde S, Vandewalle E, et al. Inhibition of placental growth factor improves surgical outcome of glaucoma surgery. J Cell Mol Med. 2013;17:1632–43.
Article PubMed PubMed Central Google Scholar
Van Bergen T, Etienne I, Cunningham F, Moons L, Schlingemann RO, Feyen JHM, et al. The role of placental growth factor (PlGF) and its receptor system in retinal vascular diseases. Prog Retin Eye Res. 2019;69:116–36.
Batchelor TT, Sorensen AG, di Tomaso E, Zhang W-T, Duda DG, Cohen KS, et al. AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell. 2007;11:83–95.
Article PubMed PubMed Central CAS Google Scholar
Heier JS, Khanani AM, Quezada Ruiz C, Basu K, Ferrone PJ, Brittain C, et al. Efficacy, durability, and safety of intravitreal faricimab up to every 16 weeks for neovascular age-related macular degeneration (TENAYA and Lucerne): two randomised, double-masked, phase 3, non-inferiority trials. Lancet. 2022;399:729–40.
Article PubMed CAS Google Scholar
Khawaja AP, Cooke Bailey JN, Wareham NJ, Scott RA, Simcoe M, Igo RP, et al. Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma. Nat Genet. 2018;50:778–82.
Article PubMed PubMed Central CAS Google Scholar
Thackaberry EA, Zhou Y, Zuch de Zafra CL, Fuh G, Lee CV, Sanowar S, et al. Rapid development of glaucoma via ITV nonselective ANGPT 1/2 antibody: A potential role for ANGPT/Tie2 signaling in primate aqueous humor outflow. Invest Ophthalmol Vis Sci. 2019;60:4097–108.
Comments (0)