Apostolidis A, Popat R, Yiangou Y, Cockayne D, Ford AP, Davis JB, Dasgupta P, Fowler CJ, Anand P (2005) Decreased sensory receptors P2X3 and TRPV1 in suburothelial nerve fibers following intradetrusor injections of botulinum toxin for human detrusor overactivity. J Urol 174:977–982 (discussion 982–973)

Article  CAS  PubMed  Google Scholar 

Asfaha S, Cenac N, Houle S, Altier C, Papez MD, Nguyen C, Steinhoff M, Chapman K, Zamponi GW, Vergnolle N (2007) Protease-activated receptor-4: a novel mechanism of inflammatory pain modulation. Br J Pharmacol 150(2):176–185. https://doi.org/10.1038/sj.bjp.0706975. (Epub 2006. PMID: 17179954; PMCID: PMC2042908)

Article  CAS  PubMed  Google Scholar 

Ashraf S, Clarkson T, Malykhina AP (2024) Therapeutic approaches for UCPPS management. J Pharmacol Exp Ther. https://doi.org/10.1124/jpet.123.002081

Article  PubMed  Google Scholar 

Augé C, Chene G, Dubourdeau M, Desoubzdanne D, Corman B, Palea S, Lluel P, Vergnolle N, Coelho AM (2013) Relevance of the cyclophosphamide-induced cystitis model for pharmacological studies targeting inflammation and pain of the bladder. Eur J Pharmacol 707(1–3):32–40. https://doi.org/10.1016/j.ejphar.2013.03.008

Augé C, Gamé X, Vergnolle N, Lluel P, Chabot S (2020) Characterization and validation of a chronic model of cyclophosphamide-induced interstitial cystitis/bladder pain syndrome in rats. Front Pharmacol 11:1305. https://doi.org/10.3389/fphar.2020.01305. (PMID: 32982733; PMCID: PMC7485435)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Augé C, Basso L, Blanpied C, Vergnolle N, Gamé X, Chabot S, Lluel P, Dietrich G (2021) Pain management in a model of interstitial cystitis/bladder pain syndrome by a vaccinal strategy. Front Pain Res (Lausanne) 2:642706. https://doi.org/10.3389/fpain.2021.64270

Article  PubMed  Google Scholar 

Berry SH, Elliott MN, Suttorp M, Bogart LM, Stoto MA, Eggers P, Nyberg L, Clemens JQ (2011) Prevalence of symptoms of bladder pain syndrome/interstitial cystitis among adult females in the United States. J Urol 186(2):540–544. https://doi.org/10.1016/j.juro.2011.03.132

Article  PubMed  PubMed Central  Google Scholar 

Chiu B, Tai HC, Chung SD, Birder LA (2016) Botulinum toxin A for bladder pain syndrome/interstitial cystitis. Toxins (Basel) 8(7):201. https://doi.org/10.3390/toxins8070201

Article  CAS  PubMed  Google Scholar 

Chuang YC, Yoshimura N, Huang CC, Chiang PH, Chancellor MB (2004) Intravesical botulinum toxin a administration produces analgesia against acetic acid induced bladder pain responses in rats. J Urol 172(4 Pt 1):1529–1532. https://doi.org/10.1097/01.ju.0000137844.77524.97. (PMID: 15371885)

Article  CAS  PubMed  Google Scholar 

Chuang YC, Tyagi P, Huang CC, Yoshimura N, Wu M, Kaufman J, Chancellor MB (2009) Urodynamic and immunohistochemical evaluation of intravesical botulinum toxin A delivery using liposomes. J Urol 182(2):786–792. https://doi.org/10.1016/j.juro.2009.03.083. (Epub 2009 Jun 18 PMID: 19539320)

Article  CAS  PubMed  Google Scholar 

Chuang YC, Huang TL, Tyagi P, Huang CC (2016) Urodynamic and immunohistochemical evaluation of intravesical botulinum toxin a delivery using low energy shock waves. J Urol 196(2):599–608. https://doi.org/10.1016/j.juro.2015.12.078. (Epub 2015 Dec 24 PMID: 26724396)

Article  CAS  PubMed  Google Scholar 

Compérat E, Reitz A, Delcourt A, Capron F, Denys P, Chartier-Kastler E (2006) Histologic features in the urinary bladder wall affected from neurogenic overactivity—a comparison of inflammation, oedema and fibrosis with and without injection of botulinum toxin type A. Eur Urol 50(5):1058–1064. https://doi.org/10.1016/j.eururo.2006.01.025. (Epub 2006 Feb 6 PMID: 16517054)

Article  CAS  PubMed  Google Scholar 

Cruz F, Pinto R, Mendes PA (2023) Bladder pain syndrome: interstitial cystitis. In: Martins FE, Holm HV, Sandhu J, McCammon KA (eds) Female genitourinary and pelvic floor reconstruction. Springer, Cham

Google Scholar 

Digesu GA, Tailor V, Bhide AA, Khullar V (2020) The role of bladder instillation in the treatment of bladder pain syndrome: Is intravesical treatment an effective option for patients with bladder pain as well as LUTS? Int Urogynecol J 31(7):1387–1392

Dorner MB, Schulz KM, Kull S, Dorner BG (2013) Complexity of botulinum neurotoxins: challenges for detection technology. Curr Top Microbiol Immunol 364:219–255. https://doi.org/10.1007/978-3-642-33570-9_11

Article  PubMed  Google Scholar 

Field M, Splevins A, Picaut P, van der Schans M, Langenberg J, Noort D, Snyder D, Foster K (2018) AbobotulinumtoxinA (Dysport®), OnabotulinumtoxinA (Botox®), and IncobotulinumtoxinA (Xeomin®) Neurotoxin Content and Potential Implications for Duration of Response in Patients. Toxins (Basel) 10(12):535

Frevert J, Dressler D (2010) Complexing proteins in botulinum toxin type A drugs: a help or a hindrance? Biologics 4:325–332. https://doi.org/10.2147/BTT.S14902

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gabella G (2019) Afferent nerve fibres in the wall of the rat urinary bladder. Cell Tissue Res 376(1):25–35. https://doi.org/10.1007/s00441-018-2965-0

Article  CAS  PubMed  Google Scholar 

Gafni-Kane A, Botros SM, Du H et al (2013) Measuring the success of combined intravesical dimethyl sulfoxide and triamcinolone for treatment of bladder pain syndrome/interstitial cystitis. Int Urogynecol J 24:303

Article  PubMed  Google Scholar 

Homma Y, Akiyama Y, Tomoe H, Furuta A, Ueda T, Maeda D, Lin AT, Kuo H-C, Lee M-H, Oh S-J et al (2020) Clinical guidelines for interstitial cystitis/bladder pain syndrome. Int J Urol 27:578–589. https://doi.org/10.1111/iju.14234

Article  PubMed  Google Scholar 

Hu JC, Tzeng HT, Lee WC, Li JR, Chuang YC (2024) Promising experimental treatment in animal models and human studies of interstitial cystitis/bladder pain syndrome. Int J Mol Sci 25(15):8015. https://doi.org/10.3390/ijms25158015. (PMID: 39125584; PMCID: PMC11312208)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ibrahim H, Retailleau K, Hornby F, Maignel J, Beard M, Daly DM (2024) A novel catalytically inactive construct of botulinum neurotoxin A (BoNT/A) directly inhibits visceral sensory signalling. Toxins (Basel) 16(1):30. https://doi.org/10.3390/toxins16010030

Article  CAS  PubMed  Google Scholar 

Jhang J-F, Ho H-C, Jiang Y-H, Lee C-L, Hsu Y-H, Kuo H-C (2018) Electron microscopic characteristics of interstitial cystitis/bladder pain syndrome and their association with clinical condition. PLoS ONE 13(6):e0198816. https://doi.org/10.1371/journal.pone.0198816

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang YH, Jhang JF, Lee YK, Kuo HC (2022) Low-energy shock wave plus intravesical instillation of botulinum toxin A for interstitial cystitis/bladder pain syndrome: pathophysiology and preliminary result of a novel minimally invasive treatment. Biomedicines 10(2):396. https://doi.org/10.3390/biomedicines10020396. (PMID: 35203604; PMCID: PMC8962423)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lacy D, Tepp W, Cohen A et al (1998) Crystal structure of botulinum neurotoxin type A and implications for toxicity. Nat Struct Mol Biol 5:898–902. https://doi.org/10.1038/2338

Article  CAS  Google Scholar 

Lamarre NS, Bjorling DE (2015) Treatment of painful bladder syndrome/interstitial cystitis with botulinum toxin A: why isn’t it effective in all patients? Transl Androl Urol 4(5):543–554. https://doi.org/10.3978/j.issn.2223-4683.2015.10.02

Article  PubMed  PubMed Central  Google Scholar 

Martin V, Carre D, Bilbault H, Oster S, Limana L, Sebal F, Favre-Guilmard C, Kalinichev M, Leveque C, Boulifard V, George C, Lezmi S (2024) Intramuscular botulinum neurotoxin serotypes E and A elicit distinct effects on SNAP25 protein fragments, muscular histology, spread and neuronal transport: an integrated histology-based study in the rat. Toxins (Basel) 16(5):225. https://doi.org/10.3390/toxins16050225

Article  CAS  PubMed  Google Scholar 

Matak I, Lacković Z (2014) Botulinum toxin A, brain and pain. Prog Neurobiol 119–120:39–59. https://doi.org/10.1016/j.pneurobio.2014.06.001

Article  CAS  PubMed  Google Scholar 

Matak I, Lacković Z (2015) Botulinum neurotoxin type A: actions beyond SNAP-25? Toxicology 335:79–84. https://doi.org/10.1016/j.tox.2015.07.003

Article  CAS  PubMed  Google Scholar 

Matak I, Bölcskei K, Bach-Rojecky L, Helyes Z (2019) Mechanisms of botulinum toxin type A action on pain. Toxins (Basel) 11(8):459. https://doi.org/10.3390/toxins11080459. (PMID: 31387301)

Article  CAS  PubMed  Google Scholar 

Papagiannopoulou D, Vardouli L, Dimitriadis F, Apostolidis A (2016) Retrograde transport of radiolabelled botulinum neurotoxin type A to the CNS after intradetrusor injection in rats. BJU Int 117(4):697–704. https://doi.org/10.1111/bju.13163