Efficacy and Safety of Bisphosphonates in Chronic Non-bacterial Osteomyelitis of the Mandible: A Systematic Review

Suei Y, Tanimoto K, Taguchi A, Yamada T, Yoshiga K, Ishikawa T et al (1995) Possible identity of diffuse sclerosing osteomyelitis and chronic recurrent multifocal osteomyelitis. One entity or two. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 80(4):401–408

Article  CAS  PubMed  Google Scholar 

Andreasen CM, Jurik AG, Glerup MB, Høst C, Mahler BT, Hauge EM et al (2019) Response to early-onset pamidronate treatment in chronic nonbacterial osteomyelitis: a retrospective single-center study. J Rheumatol 46(11):1515–1523

Article  CAS  PubMed  Google Scholar 

Zhao Y, Wu EY, Oliver MS, Cooper AM, Basiaga ML, Vora SS et al (2018) Consensus treatment plans for chronic nonbacterial osteomyelitis refractory to nonsteroidal antiinflammatory drugs and/or with active spinal lesions. Arthritis Care Res (Hoboken) 70(8):1228–1237

Article  PubMed  Google Scholar 

Zhao Y, Ferguson PJ (2018) Chronic nonbacterial osteomyelitis and chronic recurrent multifocal osteomyelitis in children. Pediatr Clin North Am 65:783–800

Article  PubMed  Google Scholar 

Zhao DY, McCann L, Hahn G, Hedrich CM (2021) Chronic nonbacterial osteomyelitis (CNO) and chronic recurrent multifocal osteomyelitis (CRMO). J Transl Autoimmun 4:100095

Article  CAS  PubMed  PubMed Central  Google Scholar 

Reiser C, Klotsche J, Hospach A, Berendes R, Schnabel A, Jansson AF et al (2021) First-year follow-up of children with chronic nonbacterial osteomyelitis—an analysis of the German National Pediatric Rheumatologic Database from 2009 to 2018. Arthritis Res Ther. https://doi.org/10.1186/s13075-021-02658-w

Article  PubMed  PubMed Central  Google Scholar 

Taddio A, Zennaro F, Pastore S, Cimaz R (2017) An update on the pathogenesis and treatment of chronic recurrent multifocal osteomyelitis in children. Pediatr Drugs 19(3):165–172

Article  Google Scholar 

Hofmann SR, Kapplusch F, Girschick HJ, Morbach H, Pablik J, Ferguson PJ et al (2017) Chronic recurrent multifocal osteomyelitis (CRMO): presentation, pathogenesis, and treatment. Curr Osteoporos Rep 15(6):542–554

Article  PubMed  PubMed Central  Google Scholar 

Schnabel A, Range U, Hahn G, Berner R, Hedrich CM (2017) Treatment response and longterm outcomes in children with chronic nonbacterial osteomyelitis. J Rheumatol 44(7):1058–1065

Article  CAS  PubMed  Google Scholar 

Girschick H, Finetti M, Orlando F, Schalm S, Insalaco A, Ganser G et al (2018) The multifaceted presentation of chronic recurrent multifocal osteomyelitis: a series of 486 cases from the Eurofever international registry. Rheumatology (United Kingdom) 57(7):1203–1211

Article  CAS  Google Scholar 

Buch K, Thuesen ACB, Brøns C, Schwarz P (2019) Chronic non-bacterial osteomyelitis: a review. Calcif Tissue Int 104(5):544–553

Article  CAS  PubMed  Google Scholar 

Hofmann SR, Morbach H, Schwarz T, Rösen-Wolff A, Girschick HJ, Hedrich CM (2012) Attenuated TLR4/MAPK signaling in monocytes from patients with CRMO results in impaired IL-10 expression. Clin Immunol 145(1):69–76

Article  CAS  PubMed  Google Scholar 

Concha S, Hernández-Ojeda A, Contreras O, Mendez C, Talesnik E, Borzutzky A (2020) Chronic nonbacterial osteomyelitis in children: a multicenter case series. Rheumatol Int 40(1):115–120

Article  CAS  PubMed  Google Scholar 

Skrabl-Baumgartner A, Singer P, Greimel T, Gorkiewicz G, Hermann J (2019) Chronic non-bacterial osteomyelitis: a comparative study between children and adults. Pediatr Rheumatol. https://doi.org/10.1186/s12969-019-0353-2

Article  Google Scholar 

Silier CCG, Greschik J, Gesell S, Grote V, Jansson AF (2017) Chronic non-bacterial osteitis from the patient perspective: a health services research through data collected from patient conferences. BMJ Open 7(12):e017599

Article  PubMed  PubMed Central  Google Scholar 

Jacobsson S (1984) Diffuse sclerosing osteomyelitis of the mandible. Int J Oral Surg 13(5):363–385

Article  CAS  PubMed  Google Scholar 

Takamatsu K, Sato H, Moriya T, Yasuda A, Kamatani T, Shirota T (2021) Long-term follow-up of SAPHO syndrome for 15 years led to a diagnosis of temporomandibular joint pain and trismus. Case Rep Dent 2021:1–6

CAS  Google Scholar 

Berkowitz YJ, Greenwood SJ, Cribb G, Davies K, Cassar-Pullicino VN (2018) Complete resolution and remodeling of chronic recurrent multifocal osteomyelitis on MRI and radiographs. Skeletal Radiol 47(4):563–568

Article  CAS  PubMed  Google Scholar 

Bhat CS, Anderson C, Harbinson A, McCann LJ, Roderick M, Finn A et al (2018) Chronic non bacterial osteitis: a multicentre study. Pediatr Rheumatol Online J 16(1):74

Article  PubMed  PubMed Central  Google Scholar 

Roderick MR, Sen ES, Ramanan AV (2018) Chronic recurrent multifocal osteomyelitis in children and adults: current understanding and areas for development. Rheumatology (United Kingdom) 57:41–48

Article  Google Scholar 

Padwa BL, Dentino K, Robson CD, Bin WS, Kurek K, Resnick CM (2016) Pediatric chronic nonbacterial osteomyelitis of the jaw: clinical, radiographic, and histopathologic features. J Oral Maxillofac Surg 74(12):2393–2402

Article  PubMed  Google Scholar 

Saffarzadeh M, Haydar S, Chan D, Andrews G, Ouellette H, Mallinson P et al (2024) A clinico-radiological review of chronic non-bacterial osteomyelitis in paediatrics, adolescents, and adults: demystifying a forgotten differential. Clin Radiol 79:170–178

Article  CAS  PubMed  Google Scholar 

Roderick MR, Ramanan AV (2013) Chronic recurrent multifocal osteomyelitis. Adv Exp Med Biol 764:99–107

Article  CAS  PubMed  Google Scholar 

Wu N, Shao Y, Huo J, Zhang Y, Cao Y, Jing H et al (2021) Clinical characteristics of pediatric synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome: the first Chinese case series from a single center. Clin Rheumatol 40(4):1487–1495

Article  PubMed  Google Scholar 

Wipff J, Adamsbaum C, Kahan A, Job-Deslandre C (2011) Chronic recurrent multifocal osteomyelitis. Joint Bone Spine 78(6):555–560

Article  PubMed  Google Scholar 

Koryllou A, Mejbri M, Theodoropoulou K, Hofer M, Carlomagno R (2021) Chronic nonbacterial osteomyelitis in children. Children 8(7):551

Article  PubMed  PubMed Central  Google Scholar 

Pastore S, Ferrara G, Monasta L, Meini A, Cattalini M, Martino S et al (2016) Chronic nonbacterial osteomyelitis may be associated with renal disease and bisphosphonates are a good option for the majority of patients. Acta Paediatr Int J Paediatr 105(7):e328–e333

Article  CAS  Google Scholar 

Murray GM, Schnabel A, Alessi M, Chopra M, Mahmood K, Killeen OG et al (2021) Is chronic non-infectious osteomyelitis with mandibular involvement a distinct disease? Lancet Rheumatol 3:e90–e92

Article  CAS  PubMed  Google Scholar 

Kaiser D, Bolt I, Hofer M, Relly C, Berthet G, Bolz DD et al (2015) Chronic nonbacterial osteomyelitis in children: a retrospective multicenter study. Pediatr Rheumatol. https://doi.org/10.1186/s12969-015-0023-y

Article  Google Scholar 

Ma L, Liu H, Tang H, Zhang Z, Zou L, Yu H et al (2022) Clinical characteristics and outcomes of chronic nonbacterial osteomyelitis in children: a multicenter case series. Pediatr Rheumatol. https://doi.org/10.1186/s12969-021-00657-4

Article  Google Scholar 

Rao A, Mallya P, Ranjani S, Raghuram J (2018) Chronic recurrent multifocal osteomyelitis: a case series from India. Indian J Orthop 52(6):672–677

Article  PubMed  PubMed Central  Google Scholar 

Jansen RB, Nilsson J, Buch-Larsen K, Kofod T, Schwarz P (2024) Treatment effect of zoledronic acid in chronic non-bacterial osteomyelitis of the jaw: a case series. Calcif Tissue Int 114(2):129–136

Article  CAS  PubMed  Google Scholar 

Morbach H, Stenzel M, Girschick HJ (2008) Bisphosphonate treatment for patients with chronic nonbacterial osteomyelitis. Nat Clin Pract Rheumatol 4(11):570–571

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