Ageeva, T., Rizvanov, A., Mukhamedshina, Y. (2024). NF-κB and JAK/STAT Signaling Pathways as Crucial Regulators of Neuroinflammation and Astrocyte Modulation in Spinal Cord Injury. Cells, 13(7). https://doi.org/10.3390/cells13070581

Albert-Gascó, H., Ros-Bernal, F., Castillo-Gómez, E., Olucha-Bordonau, F. E. (2020). MAP/ERK Signaling in Developing Cognitive and Emotional Function and Its Effect on Pathological and Neurodegenerative Processes. Int J Mol Sci 21(12). https://doi.org/10.3390/ijms21124471

Alenina, N., & Klempin, F. (2015). The role of serotonin in adult hippocampal neurogenesis. Behavioural Brain Research., 277, 49–57.

Article  CAS  PubMed  Google Scholar 

Amelchenko, E. M., Bezriadnov, D. V., Chekhov, O. A., Anokhin, K. V., Lazutkin, A. A., & Enikolopov, G. (2023). Age-related decline in cognitive flexibility is associated with the levels of hippocampal neurogenesis. Frontiers in Neuroscience., 17, 1232670.

Article  PubMed  PubMed Central  Google Scholar 

Azargoonjahromi, A., Abutalebian, F., Hoseinpour, F. (2024). The role of resveratrol in neurogenesis: a systematic review. Nutrition Reviews, nuae025. https://doi.org/10.1093/nutrit/nuae025

Azargoonjahromi, A. (2023). Dual role of nitric oxide in Alzheimer’s disease. Nitric Oxide, 134–135, 23–37. https://doi.org/10.1016/j.niox.2023.03.003

Article  CAS  PubMed  Google Scholar 

Azargoonjahromi, A. (2024a). The duality of amyloid-β: Its role in normal and Alzheimer’s disease states. Molecular Brain, 17(1), 44. https://doi.org/10.1186/s13041-024-01118-1

Article  CAS  PubMed  PubMed Central  Google Scholar 

Azargoonjahromi, A. (2024b). For the Alzheimer’s Disease Neuroimaging I. Serotonin enhances neurogenesis biomarkers, hippocampal volumes, and cognitive functions in Alzheimer’s disease. Molecular Brain, 17(1), 93. https://doi.org/10.1186/s13041-024-01169-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Azargoonjahromi, A., & Abutalebian, F. (2024). Unraveling the therapeutic efficacy of resveratrol in Alzheimer’s disease: An umbrella review of systematic evidence. Nutrition & Metabolism., 21(1), 15. https://doi.org/10.1186/s12986-024-00792-1

Article  Google Scholar 

Benninghoff, J., Van Der Ven, A., Schloesser, R. J., Moessner, R., Möller, H. J., & Rujescu, D. (2012). The complex role of the serotonin transporter in adult neurogenesis and neuroplasticity. A critical review. The World Journal of Biological Psychiatry, 13(4), 240–247.

Article  PubMed  Google Scholar 

Berron, D., Vogel, J. W., Insel, P. S., Pereira, J. B., Xie, L., Wisse, L. E. M., et al. (2021). Early stages of tau pathology and its associations with functional connectivity, atrophy and memory. Brain, 144(9), 2771–2783. https://doi.org/10.1093/brain/awab114

Article  PubMed  PubMed Central  Google Scholar 

Biomarkers. https://research.nightingalehealth.com/blood-analysis-service Accessed.

Bloom, G. S. (2014). Amyloid-β and tau: The trigger and bullet in Alzheimer disease pathogenesis. JAMA Neurology., 71(4), 505–508.

Article  PubMed  Google Scholar 

Bombardi, C., Grandis, A., Pivac, N., Sagud, M., Lucas, G., Chagraoui, A., et al. (2021). Chapter 3 - Serotonin modulation of hippocampal functions: From anatomy to neurotherapeutics. In G. Di Giovanni & P. De Deurwaerdere (Eds.), Progress in Brain Research (pp. 83–158). Elsevier.

Google Scholar 

Bruel-Jungerman, E., Veyrac, A., Dufour, F., Horwood, J., Laroche, S., & Davis, S. (2009). Inhibition of PI3K-Akt signaling blocks exercise-mediated enhancement of adult neurogenesis and synaptic plasticity in the dentate gyrus. PLoS ONE, 4(11), e7901.

Article  PubMed  PubMed Central  Google Scholar 

Choi, S. H., & Tanzi, R. E. (2023). Adult neurogenesis in Alzheimer’s disease. Hippocampus, 33(4), 307–21. https://doi.org/10.1002/hipo.23504

Article  PubMed  Google Scholar 

Chojnacki, C., Gąsiorowska, A., Popławski, T., Konrad, P., Chojnacki, M., Fila, M., & Blasiak, J. (2023). Beneficial effect of increased tryptophan intake on its metabolism and mental state of the elderly. Nutrients, 15(4), 847.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Christensen, G. E., Joshi, S. C., & Miller, M. I. (1997). Volumetric transformation of brain anatomy. IEEE Transactions on Medical Imaging, 16(6), 864–877. https://doi.org/10.1109/42.650882

Article  CAS  PubMed  Google Scholar 

Colavitta, M. F., & Barrantes, F. J. (2023). Therapeutic strategies aimed at improving neuroplasticity in Alzheimer disease. Pharmaceutics., 15(8), 2052.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dale, E., Pehrson, A. L., Jeyarajah, T., Li, Y., Leiser, S. C., Smagin, G., et al. (2016). Effects of serotonin in the hippocampus: How SSRIs and multimodal antidepressants might regulate pyramidal cell function. CNS Spectrums, 21(2), 143–161. https://doi.org/10.1017/s1092852915000425

Article  PubMed  Google Scholar 

Danieli, K., Guyon, A., & Bethus, I. (2023). Episodic Memory formation: A review of complex Hippocampus input pathways. Progress in Neuro-Psychopharmacology and Biological Psychiatry., 126, 110757.

Article  PubMed  Google Scholar 

Delghandi, M. P., Johannessen, M., & Moens, U. (2005). The cAMP signalling pathway activates CREB through PKA, p38 and MSK1 in NIH 3T3 cells. Cellular Signalling, 17(11), 1343–1351. https://doi.org/10.1016/j.cellsig.2005.02.003

Article  CAS  PubMed  Google Scholar 

Fiedler, D., Sasi, M., Blum, R., Klinke, C. M., Andreatta, M., Pape, H. C., & Lange, M. D. (2021). Brain-Derived Neurotrophic Factor/Tropomyosin Receptor Kinase B Signaling Controls Excitability and Long-Term Depression in Oval Nucleus of the BNST. Journal of Neuroscience, 41(3), 435–445. https://doi.org/10.1523/jneurosci.1104-20.2020

Article  CAS  PubMed  Google Scholar 

Finkbeiner, S., Tavazoie, S. F., Maloratsky, A., Jacobs, K. M., Harris, K. M., & Greenberg, M. E. (1997). CREB: A major mediator of neuronal neurotrophin responses. Neuron, 19(5), 1031–1047. https://doi.org/10.1016/s0896-6273(00)80395-5

Article  CAS  PubMed  Google Scholar 

Furcila, D., Domínguez-Álvaro, M., DeFelipe, J., & Alonso-Nanclares, L. (2019). Subregional density of neurons, neurofibrillary tangles and amyloid plaques in the hippocampus of patients with Alzheimer’s disease. Frontiers in Neuroanatomy., 13, 99.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hardcastle, C., O’Shea, A., Kraft, J. N., Albizu, A., Evangelista, N. D., Hausman, H. K., et al. (2020). Contributions of Hippocampal Volume to Cognition in Healthy Older Adults. Frontiers in Aging Neuroscience, 12. https://doi.org/10.3389/fnagi.2020.593833

Harith, M. (2023). The Interplay of Tau and Amyloid Beta Pathologies in Alzheimer's Disease. Journal of Student Research. 12(4).

Höglund E, Øverli Ø, Winberg S. Tryptophan Metabolic Pathways and Brain Serotonergic Activity: A Comparative Review. Frontiers in Endocrinology, 10. https://doi.org/10.3389/fendo.2019.00158

Hollands, C., Tobin, M. K., Hsu, M., Musaraca, K., Yu, T.-S., Mishra, R., et al. (2017). Depletion of adult neurogenesis exacerbates cognitive deficits in Alzheimer’s disease by compromising hippocampal inhibition. Molecular Neurodegeneration., 12(1), 64. https://doi.org/10.1186/s13024-017-0207-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Horwood, J. M., Dufour, F., Laroche, S., & Davis, S. (2006). Signalling mechanisms mediated by the phosphoinositide 3-kinase/Akt cascade in synaptic plasticity and memory in the rat. European Journal of Neuroscience., 23(12), 3375–3384. https://doi.org/10.1111/j.1460-9568.2006.04859.x

Article  PubMed  Google Scholar 

Hsu, Y. Y., Schuff, N., Du, A. T., Mark, K., Zhu, X., Hardin, D., & Weiner, M. W. (2002). Comparison of automated and manual MRI volumetry of hippocampus in normal aging and dementia. Journal of Magnetic Resonance Imaging, 16(3), 305–310. https://doi.org/10.1002/jmri.10163

Article  PubMed  Google Scholar 

https://research.nightingalehealth.com/ Accessed.

Hughes, C. P., Berg, L., Danziger, W., Coben, L. A., & Martin, R. L. (1982). A new clinical scale for the staging of dementia. The British Journal of Psychiatry., 140(6), 566–572.

Article  CAS  PubMed  Google Scholar 

Iroegbu, J. D., Ijomone, O. K., Femi-Akinlosotu, O. M., & Ijomone, O. M. (2021). ERK/MAPK signalling in the developing brain: Perturbations and consequences. Neuroscience & Biobehavioral Reviews., 131, 792–805. https://doi.org/10.1016/j.neubiorev.2021.10.009

Article  CAS  Google Scholar 

Jenkins, T. A., Nguyen, J. C., Polglaze, K. E., Bertrand. P. P. (2016). Influence of Tryptophan and Serotonin on Mood and Cognition with a Possible Role of the Gut-Brain Axis. Nutrients, 8(1). https://doi.org/10.3390/nu8010056

Kalyanaraman, B., Cheng, G., Hardy, M., Ouari, O., Bennett, B., & Zielonka, J. (2018). Teaching the basics of reactive oxygen species and their relevance to cancer biology: Mitochondrial reactive oxygen species detection, redox signaling, and targeted therapies. Redox Biology., 15, 347–362. https://doi.org/10.1016/j.redox.2017.12.012

Article  CAS  PubMed  Google Scholar