Jensen ET, Stafford JM, Saydah S, et al. Increase in prevalence of diabetic ketoacidosis at diagnosis among youth with type 1 diabetes: the SEARCH for diabetes in Youth study. Diabetes Care. 2021;44(7):1573–8. https://doi.org/10.2337/dc20-0389.
Article PubMed PubMed Central Google Scholar
Benoit SR, Zhang Y, Geiss LS, Gregg EW, Albright A. Trends in Diabetic Ketoacidosis hospitalizations and In-Hospital mortality — United States, 2000–2014. MMWR Morbidity Mortal Wkly Rep. 2018;67(12):362–5. https://doi.org/10.15585/mmwr.mm6712a3.
ElSayed NA, Aleppo G, Bannuru RR, et al. Introduction and methodology: standards of Care in Diabetes—2024. Diabetes Care. 2023;47(Supplement1):S1–4. https://doi.org/10.2337/dc24-sint.
Cnop M, Welsh N, Jonas JC, JöRns A, Lenzen S, Eizirik DL. Mechanisms of pancreatic Β-Cell death in type 1 and type 2 diabetes. Diabetes. 2005;54(suppl2):S97–107. https://doi.org/10.2337/diabetes.54.suppl_2.s97.
Article CAS PubMed Google Scholar
Clinical biochemistry: metabolic and clinical aspects. 2014. https://doi.org/10.1016/c2011-0-07946-2
Aye T, Mazaika PK, Mauras N, et al. Impact of early diabetic ketoacidosis on the developing brain. Diabetes Care. 2018;42(3):443–9. https://doi.org/10.2337/dc18-1405.
Article PubMed PubMed Central Google Scholar
Ghetti S, Kuppermann N, Rewers A, et al. Cognitive function following diabetic ketoacidosis in children with New-Onset or previously diagnosed type 1 diabetes. Diabetes Care. 2020;43(11):2768–75. https://doi.org/10.2337/dc20-0187.
Article PubMed PubMed Central Google Scholar
Matthews S, Coates MM, Bukhman A, et al. Health system capacity to manage diabetic ketoacidosis in nine low-income and lower-middle income countries: a cross-sectional analysis of nationally representative survey data. EClinicalMedicine. 2022;55:101759. https://doi.org/10.1016/j.eclinm.2022.101759.
Article PubMed PubMed Central Google Scholar
James S, Annetts K, Frakking T, et al. Diabetic ketoacidosis presentations in a low socio-economic area: are services suitable? BMC Health Serv Res. 2021;21(1). https://doi.org/10.1186/s12913-021-06715-7.
Wilcox AE, Lipska KJ, Weinzimer SA, et al. Navigating barriers to affording and obtaining insulin and diabetes supplies. J Diabetes. 2022;15(1):71–5. https://doi.org/10.1111/1753-0407.13344.
Article CAS PubMed PubMed Central Google Scholar
Lizzo JM, Goyal A, Gupta V. Adult diabetic ketoacidosis. StatPearls - NCBI Bookshelf. Published July 10, 2023. https://www.ncbi.nlm.nih.gov/books/NBK560723/
Lopes CLS, Pinheiro PP, Barberena LS, Eckert GU. Diabetic ketoacidosis in a pediatric intensive care unit. Jornal De Pediatria. 2016;93(2):179–84. https://doi.org/10.1016/j.jped.2016.05.008.
Wolfsdorf J, Craig ME, Daneman D, et al. Diabetic ketoacidosis in children and adolescents with diabetes. Pediatr Diabetes. 2009;10:118–33. https://doi.org/10.1111/j.1399-5448.2009.00569.x.
Varadarajan P, Suresh S. Delayed diagnosis of diabetic ketoacidosis in children—a cause for concern. Int J Diabetes Developing Ctries. 2014;35(2):66–70. https://doi.org/10.1007/s13410-014-0245-4.
Varadarajan JMAP. Risk factors for poor outcome in diabetic keto acidosis at the initial presentation among children with type 1 diabetes mellitus. Int J Contemp Pediatr. 2018;5(5):1745. https://doi.org/10.18203/2349-3291.ijcp20182945.
Abbas Q, Arbab S, Haque AU, Humayun KN. Spectrum of complications of severe DKA in children in pediatric Intensive Care Unit. Pakistan J Med Sci. 2018;34(1). https://doi.org/10.12669/pjms.341.13875.
Bialo SR. Rare complications of pediatric diabetic ketoacidosis. World J Diabetes. 2015;6(1):167. https://doi.org/10.4239/wjd.v6.i1.167.
Article PubMed PubMed Central Google Scholar
Kuppermann N, Ghetti S, Schunk JE, Stoner MJ, Rewers A, McManemy JK, Myers SR, Nigrovic LE, Garro A, Brown KM, Quayle KS, Trainor JL, Tzimenatos L, Bennett JE, DePiero AD, Kwok MY, Perry CS 3rd, Olsen CS, Casper TC, Dean JM, Glaser NS, PECARN DKA FLUID Study Group. Clinical Trial of Fluid Infusion Rates for Pediatric Diabetic Ketoacidosis. N Engl J Med. 2018;378(24):2275–87. https://doi.org/10.1056/NEJMoa1716816. PMID: 29897851; PMCID: PMC6051773.
Article CAS PubMed PubMed Central Google Scholar
Duck SC, Wyatt DT. Factors associated with brain herniation in the treatment of diabetic ketoacidosis. J Pediatr. 1988;113(1 Pt 1):10– 4. https://doi.org/10.1016/s0022-3476(88)80521-3. PMID: 3133455.
Glaser NS, Wootton-Gorges SL, Marcin JP, Buonocore MH, Dicarlo J, Neely EK, Barnes P, Bottomly J, Kuppermann N. Mechanism of cerebral edema in children with diabetic ketoacidosis. J Pediatr. 2004;145(2):164– 71. https://doi.org/10.1016/j.jpeds.2004.03.045. PMID: 15289761.
Glaser N, Yuen N, Anderson SE, Tancredi DJ, O’Donnell ME. Cerebral metabolic alterations in rats with diabetic ketoacidosis: effects of treatment with insulin and intravenous fluids and effects of bumetanide. Diabetes. 2010;59(3):702–9. https://doi.org/10.2337/db09-0635. Epub 2009 Dec 22. PMID: 20028943; PMCID: PMC2828650.
Article CAS PubMed Google Scholar
Libman I, Haynes A, Lyons S, Pradeep P, Rwagasor E, Tung JY, Jefferies CA, Oram RA, Dabelea D, Craig ME. ISPAD Clinical Practice Consensus Guidelines 2022: Definition, epidemiology, and classification of diabetes in children and adolescents. Pediatr Diabetes. 2022;23(8):1160–1174. https://doi.org/10.1111/pedi.13454. PMID: 36537527.
Velissaris D, Karamouzos V, Pierrakos C, Koniari I, Apostolopoulou C, Karanikolas M. Use of Sodium bicarbonate in Cardiac arrest: current guidelines and Literature Review. J Clin Med Res. 2016;8(4):277–83. https://doi.org/10.14740/jocmr2456w. Epub 2016 Feb 27. PMID: 26985247; PMCID: PMC4780490.
Article CAS PubMed PubMed Central Google Scholar
Judy L, Aschner, Ronald L. Poland; sodium bicarbonate: basically useless therapy. Pediatr Oct. 2008;122(4):831–5. https://doi.org/10.1542/peds.2007-2400.
Wardi G et al. A Review of Bicarbonate Use in Common Clinical Scenarios. Journal of Emergency Medicine, vol. 65, no. 2, 2023, pp. e71–e80. https://doi.org/10.1016/j.jemermed.2023.04.012. Accessed 30 Dec. 2024.
Morris LR, Murphy MB, Kitabchi AE. Bicarbonate therapy in severe diabetic ketoacidosis. Ann Intern Med. 1986;105(6):836– 40. https://doi.org/10.7326/0003-4819-105-6-836. PMID: 3096181.
Chua HR, Schneider A, Bellomo R. Bicarbonate in diabetic ketoacidosis - a systematic review. Ann Intensive Care. 2011;1(1):23. https://doi.org/10.1186/2110-5820-1-23. PMID: 21906367; PMCID: PMC3224469.
Article CAS PubMed PubMed Central Google Scholar
Duhon B, Attridge RL, Franco-Martinez AC, Maxwell PR, Hughes DW. Intravenous sodium bicarbonate therapy in severely acidotic diabetic ketoacidosis. Ann Pharmacother. 2013 Jul-Aug;47(7–8):970-5. https://doi.org/10.1345/aph.1S014. Epub 2013 Jun 4. PMID: 23737516.
Green SM, Rothrock SG, Ho JD, Gallant RD, Borger R, Thomas TL, Zimmerman GJ. Failure of adjunctive bicarbonate to improve outcome in severe pediatric diabetic ketoacidosis. Ann Emerg Med. 1998;31(1):41– 8. https://doi.org/10.1016/s0196-0644(98)70279-3. PMID: 9437340.
Okuda Y, Adrogue HJ, Field JB, Nohara H, Yamashita K. Counterproductive effects of sodium bicarbonate in diabetic ketoacidosis. J Clin Endocrinol Metab. 1996;81(1):314– 20. https://doi.org/10.1210/jcem.81.1.8550770. PMID: 8550770.
Goldsmith DJ, Forni LG, Hilton PJ. Bicarbonate therapy and intracellular acidosis. Clin Sci (Lond). 1997;93(6):593-8. https://doi.org/10.1042/cs0930593. PMID: 9497798.
Forni LG, Hodgson LE, Selby NM. The Janus faces of bicarbonate therapy in the ICU: not sure! Intensive Care Med. 2020;46(3):522–4. https://doi.org/10.1007/s00134-019-05885-7. Epub 2019 Dec 9. PMID: 31820031; PMCID: PMC7223965.
Azova S, Rapaport R, Wolfsdorf J. Brain injury in children with diabetic ketoacidosis: review of the literature and a proposed pathophysiologic pathway for the development of cerebral edema. Pediatr Diabetes. 2021;22(2):148–60. https://doi.org/10.1111/pedi.13152. Epub 2020 Dec 3. PMID: 33197066; PMCID: PMC10127934.
Edge JA, Jakes RW, Roy Y, et al. The UK case–control study of cerebral oedema complicating diabetic ketoacidosis in children. Diabetologia. 2006;49:2002–9. https://doi.org/10.1007/s00125-006-0363-8.
Article CAS PubMed Google Scholar
American Diabetes Association; Hyperglycemic Crises in Patients With Diabetes Mellitus. Diabetes Care 1 November. 2001;24(11):1988–96. https://doi.org/10.2337/diacare.24.11.1988.
Wilson HK, Keuer SP, Lea AS, Boyd AE, Eknoyan G. Phosphate therapy in Diabetic Ketoacidosis. Arch Intern Med. 1982;142(3):517–20. https://doi.org/10.1001/archinte.1982.00340160097021.
Article CAS PubMed Google Scholar
Fisher JN, Kitabchi AE. A randomized study of phosphate therapy in the treatment of diabetic ketoacidosis. J Clin Endocrinol Metab. 1983;57(1):177– 80. https://doi.org/10.1210/jcem-57-1-177. PMID: 6406531.
Keller U, Berger W. Prevention of hypophosphatemia by phosphate infusion during treatment of diabetic ketoacidosis and hyperosmolar coma. Diabetes. 1980;29(2):87–95. https://doi.org/10.2337/diab.29.2.87. PMID: 6766411.
Ramaesh A. Incidence and long-term outcomes of adult patients with diabetic ketoacidosis admitted to intensive care: a retrospective cohort study. J Intensive Care Soc. 2016;17(3):222–33. doi: 10.1177/1751143716644458. Epub 2016 Apr 25. PMID: 28979495; PMCID: PMC5606525.
Article PubMed PubMed Central Google Scholar
Butalia S, Johnson JA, Ghali WA, Rabi DM. Clinical and socio-demographic factors associated with diabetic ketoacidosis hospitalization in adults with type 1 diabetes. Diabet Med. 2013;30(5):567–73. https://doi.org/10.1111/dme.12127. Epub 2013 Mar 6. PMID: 23323955.
Article CAS PubMed Google Scholar
Gibb FW, Teoh WL, Graham J, et al. Risk of death following admission to a UK hospital with diabetic ketoacidosis. Diabetologia. 2016;59:2082–7. https://doi.org/10.1007/s00125-016-4034-0.
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