Intracavernosal mesenchymal stem cell therapy in ischaemic priapism: an experimental study

Burnett AL, Bivalacqua TJ (2007) Priapism: current principles and practice. Urol Clin North Am 34(4):631–642. https://doi.org/10.1016/J.UCL.2007.08.006

Article  PubMed  Google Scholar 

Eland IA, Van der Lei J, Stricker BHC, Sturkenboom MJCM (2001) Incidence of priapism in the general population. Urology 57(5):970–972. https://doi.org/10.1016/S0090-4295(01)00941-4

Article  CAS  PubMed  Google Scholar 

Broderick GA, Kadioglu A, Bivalacqua TJ, Ghanem H, Nehra A, Shamloul R (2010) Priapism: pathogenesis, epidemiology, and management. J Sex Med 7(1 Pt 2):476–500. https://doi.org/10.1111/J.1743-6109.2009.01625.X

Article  PubMed  Google Scholar 

Spycher MA, Hauri D (1986) The ultrastructure of the erectile tissue in priapism. J Urol 135(1):142–147. https://doi.org/10.1016/S0022-5347(17)45549-2

Article  CAS  PubMed  Google Scholar 

Wen J, Jiang X, Dai Y et al (2010) Increased adenosine contributes to penile fibrosis, a dangerous feature of priapism, via A2B adenosine receptor signaling. FASEB J 24(3):740–749. https://doi.org/10.1096/FJ.09-144147

Article  CAS  PubMed  PubMed Central  Google Scholar 

Egydio PH, Kuehhas FE (2013) Treatments for fibrosis of the corpora cavernosa. Arab J Urol 11(3):294–298. https://doi.org/10.1016/J.AJU.2013.05.004

Article  PubMed  PubMed Central  Google Scholar 

El-Sakka AI, Yassin AA (2010) Amelioration of penile fibrosis: myth or reality. J Androl 31(4):324–335. https://doi.org/10.2164/JANDROL.109.008730

Article  CAS  PubMed  Google Scholar 

Ryu JK, Kim DH, Song KM et al (2016) Intracavernous delivery of clonal mesenchymal stem cells rescues erectile function in the streptozotocin-induced diabetic mouse. Andrology 4(1):172–184. https://doi.org/10.1111/ANDR.12138

Article  CAS  PubMed  Google Scholar 

Yang J, Zhang Y, Zang G et al (2018) Adipose-derived stem cells improve erectile function partially through the secretion of IGF-1, bFGF, and VEGF in aged rats. Andrology 6(3):498–509. https://doi.org/10.1111/ANDR.12483

Article  CAS  PubMed  Google Scholar 

Albersen M, Fandel TM, Lin G et al (2010) Injections of adipose tissue-derived stem cells and stem cell lysate improve recovery of erectile function in a rat model of cavernous nerve injury. J Sex Med 7(10):3331–3340. https://doi.org/10.1111/J.1743-6109.2010.01875.X

Article  PubMed  Google Scholar 

Gokce A, AbdElmageed ZY, Lasker GF et al (2014) Adipose tissue-derived stem cell therapy for prevention and treatment of erectile dysfunction in a rat model of Peyronie’s disease. Andrology 2(2):244–251. https://doi.org/10.1111/J.2047-2927.2013.00181.X

Article  CAS  PubMed  Google Scholar 

Siregar S, Adriansjah R, Sibarani J, Mustafa A (2020) Effect of intracorporeal human adipose-derived stem cells (hADSCs) on corpora cavernosa transforming growth factor β1 (TGFβ1) and collagen type I concentration in wistar rat priapism model. Res Rep Urol 12:21–27. https://doi.org/10.2147/RRU.S232303

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sanli O, Armagan A, Kandirali E et al (2004) TGF-beta1 neutralizing antibodies decrease the fibrotic effects of ischemic priapism. Int J Impot Res 16(6):492–497. https://doi.org/10.1038/SJ.IJIR.3901261

Article  CAS  PubMed  Google Scholar 

Agoston DV (2017) How to translate time? The temporal aspect of human and rodent biology. Front Neurol 17(8):92. https://doi.org/10.3389/fneur.2017.00092.PMID:28367138;PMCID:PMC5355425

Article  Google Scholar 

Milenkovic U, Albersen M, Castiglione F (2019) The mechanisms and potential of stem cell therapy for penile fibrosis. Nat Rev Urol 16(2):79–97. https://doi.org/10.1038/S41585-018-0109-7

Article  PubMed  Google Scholar 

Quinlan DM, Nelson RJ, Partin AW, Mostwin JL, Walsh PC (1989) The rat as a model for the study of penile erection. J Urol 141(3):656–661. https://doi.org/10.1016/S0022-5347(17)40926-8

Article  CAS  PubMed  Google Scholar 

El-Bahnasawy MS, Dawood A, Farouk A (2002) Low-flow priapism: risk factors for erectile dysfunction. BJU Int 89(3):285–290. https://doi.org/10.1046/J.1464-4096.2001.01510.X

Article  CAS  PubMed  Google Scholar 

Muneer A, Cellek S, Dogan A, Kell PD, Ralph DJ, Minhas S (2005) Investigation of cavernosal smooth muscle dysfunction in low flow priapism using an in vitro model. Int J Impot Res 17(1):10–18. https://doi.org/10.1038/SJ.IJIR.3901231

Article  CAS  PubMed  Google Scholar 

Alnajjar HM, Muneer A (2022) Recent advances in understanding and treating priapism. Fac Rev 11:23. https://doi.org/10.12703/R/11-23

Article  PubMed  PubMed Central  Google Scholar 

Uluocak N, Atılgan D, Erdemir F et al (2010) An animal model of ischemic priapism and the effects of melatonin on antioxidant enzymes and oxidative injury parameters in rat penis. Int Urol Nephrol 42(4):889–895. https://doi.org/10.1007/S11255-010-9706-Y

Article  PubMed  Google Scholar 

Erdemir F, Firat F, Markoc F et al (2014) The effect of pentoxifylline on penile cavernosal tissues in ischemic priapism-induced rat model. Int Urol Nephrol 46(10):1961–1967. https://doi.org/10.1007/S11255-014-0769-Z

Article  CAS  PubMed  Google Scholar 

Karakeci A, Firdolas F, Ozan T, Unus I, Ogras MS, Orhan I (2013) Second pathways in the pathophysiology of ischemic priapism and treatment alternatives. Urology 82(3):625–629. https://doi.org/10.1016/J.UROLOGY.2013.06.029

Article  PubMed  Google Scholar 

Karagüzel E, Bayraktar C, Kutlu O et al (2016) The possible protective effects of dipyridamole on ischemic reperfusion injury of priapism. Int Braz J Urol 42(1):146–153. https://doi.org/10.1590/S1677-5538.IBJU.2015.0072

Article  PubMed  PubMed Central  Google Scholar 

Yilmaz Y, Taken K, Atar M, Ergün M, Söylemez H (2015) Protective effect of curcumin on priapism and ischemia-reperfusion injury in rats. Eur Rev Med Pharmacol Sci 19(23):4664–4670

CAS  PubMed  Google Scholar 

Gao L, Wu C, Fu F et al (2018) Effect of lysyl oxidase (LOX) on corpus cavernous fibrosis caused by ischaemic priapism. J Cell Mol Med 22(3):2018–2022. https://doi.org/10.1111/JCMM.13411

Article  CAS  PubMed  Google Scholar 

Kolukcu E, Kilic S, Parlaktas BS et al (2019) The effects of oxytocin on penile tissues in experimental priapism model in rats. Int Urol Nephrol 51(2):231–238. https://doi.org/10.1007/S11255-018-2046-Z

Article  CAS  PubMed  Google Scholar 

Cinar O, Bolat MS, Erdem S et al (2020) The effect of an antifibrotic agent, pirfenidone, on penile erectile function in an experimental rat model of ischemic priapism. Int J Impot Res 32(2):232–238. https://doi.org/10.1038/S41443-019-0152-9

Article  CAS  PubMed  Google Scholar 

Zakrzewski W, Dobrzyński M, Szymonowicz M, Rybak Z (2019) Stem cells: past, present, and future. Stem Cell Res Ther 10(1):68. https://doi.org/10.1186/S13287-019-1165-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Michler RE (2014) Stem cell therapy for heart failure. Cardiol Rev 22(3):105–116. https://doi.org/10.1097/CRD.0000000000000018

Article  PubMed 

Comments (0)

No login
gif