Keywords

alkyl derivatives,depsidone,lichens,protocetraric acid,toxicity,tumor cells...

How to Cite

(1)

Bogo, D.; Alcantara, G.; Camila Micheletti, A.; Honda, N.; Cepa Matos, M. de F. Cytotoxicity of Alkyl Derivatives of Protocetraric Acid. Orbital: Electron. J. Chem. 2025, 16, 267-270.

Abstract

The protocetraric acid (1) is a depsidone produced by countless species of lichens and has shown potential biological activity. In this work, we evaluated through the sulforhodamine B (SRB) assay the cytotoxic activity of seven alkyl ether derivatives of protocetraric acid (9´-O-alkyl protocetraric acid) against the following cell lines: HT-29 (colon carcinoma), 786-0 (kidney carcinoma), MCF7 (breast carcinoma), HEP2 (laryngeal carcinoma), PC-03 (prostate carcinoma), B16F10 (murine melanoma), UACC-62 (human melanoma), and NIH/3T3 (mouse embryonic fibroblast).  Most compounds were cytotoxic to tested cells, with GI50 < 100.0 μM, and did not show selectivity over them.