Atkinson MA, Mirmira RG. The pathogenic “symphony” in type 1 diabetes: a disorder of the immune system, β cells, and exocrine pancreas. Cell Metab. 2023;35(9):1500–18.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lawrence JM, Casagrande SS, Herman WH, Wexler DJ, Cefalu WT, editors. Diabetes in America [online]. Bethesda: National Institute of Diabetes and Digestive and Kidney Diseases; 2023. https://www.ncbi.nlm.nih.gov/books/NBK597413/.

Andreani D, Kolb H, Pozzilli P. Immunotherapy of type 1 diabetes. New York: Wiley; 1989.

Google Scholar 

Luckett AM, Weedon MN, Hawkes G, Leslie RD, Oram RA, Grant SFA. Utility of genetic risk scores in type 1 diabetes. Diabetologia. 2023;66(9):1589–600.

Article  PubMed  PubMed Central  Google Scholar 

Ziegler AG, Rewers M, Simell O, Simell T, Lempainen J, Steck A, et al. Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children. JAMA. 2013;309(23):2473–9.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Eisenbarth GS. Type I diabetes mellitus. A chronic autoimmune disease. N Engl J Med. 1986;314(21):1360–8.

Article  PubMed  CAS  Google Scholar 

Evans-Molina C, Oram RA. A golden hour and golden opportunity for β-cell preservation. Diabetes. 2024;73(6):834–6.

Article  PubMed  CAS  Google Scholar 

Bottazzo GF, Florin-Christensen A, Doniach D. Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet. 1974;2(7892):1279–83.

Article  PubMed  CAS  Google Scholar 

Leete P, Willcox A, Krogvold L, Dahl-Jørgensen K, Foulis AK, Richardson SJ, et al. Differential insulitic profiles determine the extent of β-cell destruction and the age at onset of type 1 diabetes. Diabetes. 2016;65(5):1362–9.

Article  PubMed  CAS  Google Scholar 

Kukreja A, Cost G, Marker J, Zhang C, Sun Z, Lin-Su K, et al. Multiple immuno-regulatory defects in type-1 diabetes. J Clin Invest. 2002;109(1):131–40.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Witebsky E, Rose NR, Terplan K, Paine JR, Egan RW. Chronic thyroiditis and autoimmunization. J Am Med Assoc. 1957;164(13):1439–47.

Article  PubMed  CAS  Google Scholar 

Wiedeman AE, Speake C, Long SA. The many faces of islet antigen-specific CD8 T cells: clues to clinical outcome in type 1 diabetes. Immunol Cell Biol. 2021;99(5):475–85.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bender C, Rajendran S, von Herrath MG. New insights into the role of autoreactive CD8 T cells and cytokines in human type 1 diabetes. Front Endocrinol (Lausanne). 2020;11: 606434.

Article  PubMed  Google Scholar 

Redondo MJ, Steck AK, Pugliese A. Genetics of type 1 diabetes. Pediatr Diabetes. 2018;19(3):346–53.

Article  PubMed  Google Scholar 

Morran MP, Vonberg A, Khadra A, Pietropaolo M. Immunogenetics of type 1 diabetes mellitus. Mol Aspects Med. 2015;42:42–60.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lemos JRN, Hirani K, von Herrath M. Immunological and virological triggers of type 1 diabetes: insights and implications. Front Immunol. 2023;14:1326711.

Article  PubMed  CAS  Google Scholar 

Abela AG, Fava S. Why is the incidence of type 1 diabetes increasing? Curr Diabetes Rev. 2021;17(8): e030521193110.

Article  PubMed  CAS  Google Scholar 

Ilonen J, Lempainen J, Veijola R. The heterogeneous pathogenesis of type 1 diabetes mellitus. Nat Rev Endocrinol. 2019;15(11):635–50.

Article  PubMed  CAS  Google Scholar 

Lehuen A, Diana J, Zaccone P, Cooke A. Immune cell crosstalk in type 1 diabetes. Nat Rev Immunol. 2010;10(7):501–13.

Article  PubMed  CAS  Google Scholar 

Katsarou A, Gudbjörnsdottir S, Rawshani A, Dabelea D, Bonifacio E, Anderson BJ, et al. Type 1 diabetes mellitus. Nat Rev Dis Primers. 2017;3:17016.

Article  PubMed  Google Scholar 

Bluestone JA, Herold K, Eisenbarth G. Genetics, pathogenesis and clinical interventions in type 1 diabetes. Nature. 2010;464(7293):1293–300.

Article  PubMed  PubMed Central  CAS  Google Scholar 

So M, O’Rourke C, Ylescupidez A, Bahnson HT, Steck AK, Wentworth JM, et al. Characterising the age-dependent effects of risk factors on type 1 diabetes progression. Diabetologia. 2022;65(4):684–94.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Leslie RD, Evans-Molina C, Freund-Brown J, Buzzetti R, Dabelea D, Gillespie KM, et al. Adult-onset type 1 diabetes: current understanding and challenges. Diabetes Care. 2021;44(11):2449–56.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Fang M, Wang D, Echouffo-Tcheugui JB, Selvin E. Age at diagnosis in US adults with type 1 diabetes. Ann Intern Med. 2023;176(11):1567–8.

Article  PubMed  PubMed Central  Google Scholar 

Leete P, Mallone R, Richardson SJ, Sosenko JM, Redondo MJ, Evans-Molina C. The effect of age on the progression and severity of type 1 diabetes: potential effects on disease mechanisms. Curr Diab Rep. 2018;18(11):115.

Article  PubMed  PubMed Central  Google Scholar 

Zhao LP, Papadopoulos GK, Skyler JS, Parikh HM, Kwok WW, Bondinas GP, et al. Oral insulin delay of stage 3 type 1 diabetes revisited in HLA DR4-DQ8 participants in the TrialNet oral insulin prevention trial (TN07). Diabetes Care. 2024;47(9):1608–16.

Article  PubMed  CAS  Google Scholar 

Kennedy EC, Hawkes CP. Approaches to measuring beta cell reserve and defining partial clinical remission in paediatric type 1 diabetes. Children (Basel). 2024;11(2):186.

PubMed  PubMed Central  Google Scholar 

Jacobsen LM, Bundy BN, Greco MN, Schatz DA, Atkinson MA, Brusko TM, et al. Comparing beta cell preservation across clinical trials in recent-onset type 1 diabetes. Diabetes Technol Ther. 2020;22(12):948–53.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Agiostratidou G, Anhalt H, Ball D, Blonde L, Gourgari E, Harriman KN, et al. Standardizing clinically meaningful outcome measures beyond HbA1c. Diabetes Care. 2017;40(12):1622–30.

Article  PubMed  PubMed Central  Google Scholar 

Eisenbarth GS, Srikanta S, Jackson R, Rabinowe S, Dolinar R, Aoki T, et al. Anti-thymocyte globulin and prednisone immunotherapy of recent onset type 1 diabetes mellitus. Diabetes Res. 1985;2(6):271–6.

PubMed  CAS  Google Scholar 

Silverstein J, Maclaren N, Riley W, Spillar R, Radjenovic D, Johnson S. Immunosuppression with azathioprine and prednisone in recent-onset insulin-dependent diabetes mellitus. N Engl J Med. 1988;319(10):599–604.

Article  PubMed  CAS  Google Scholar 

Feutren G, Papoz L, Assan R, Vialettes B, Karsenty G, Vexiau P, et al. Cyclosporin increases the rate and length of remissions in insulin-dependent diabetes of recent onset. Results of a multicentre double-blind trial. Lancet. 1986;2(8499):119–24.

Article  PubMed  CAS