The consequences of SARS-CoV-2 within-host persistence

World Health Organization. WHO COVID19 dashboard. WHO https://data.who.int/dashboards/covid19/ (2024).

Ao, D., He, X., Liu, J. & Xu, L. Strategies for the development and approval of COVID-19 vaccines and therapeutics in the post-pandemic period. Signal. Transduct. Target. Ther. 8, 466 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Graham, B. S. Rapid COVID-19 vaccine development. Science 368, 945–946 (2020).

Article  CAS  PubMed  Google Scholar 

Hadfield J. et al. Genomic epidemiology of SARS-CoV-2 with subsampling focused globally since pandemic start. Nextstrain https://nextstrain.org/ncov/gisaid/global/all-time (2024).

Sigal, A., Milo, R. & Jassat, W. Estimating disease severity of Omicron and Delta SARS-CoV-2 infections. Nat. Rev. Immunol. 22, 267–269 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sigal, A. Milder disease with Omicron: is it the virus or the pre-existing immunity? Nat. Rev. Immunol. 22, 69–71 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Telenti, A. et al. After the pandemic: perspectives on the future trajectory of COVID-19. Nature 596, 495–504 (2021).

Article  CAS  PubMed  Google Scholar 

UKHSA. UKHSA dashboard. GOV.UK https://ukhsa-dashboard.data.gov.uk/ (2024).

World Health Organization. COVID-19 epidemiological update – 17 June 2024. WHO https://www.who.int/publications/m/item/covid-19-epidemiological-update-edition-168 (2024).

Ke, R. et al. Daily longitudinal sampling of SARS-CoV-2 infection reveals substantial heterogeneity in infectiousness. Nat. Microbiol. 7, 640–652 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wölfel, R. et al. Virological assessment of hospitalized patients with COVID-2019. Nature 581, 465–469 (2020).

Article  PubMed  Google Scholar 

Puhach, O., Meyer, B. & Eckerle, I. SARS-CoV-2 viral load and shedding kinetics. Nat. Rev. Microbiol. 21, 147–161 (2023).

CAS  PubMed  Google Scholar 

Karim, F. et al. Clearance of persistent SARS-CoV-2 associates with increased neutralizing antibodies in advanced HIV disease post-ART initiation. Nat. Commun. 15, 2360 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Machkovech, H. M. et al. Persistent SARS-CoV-2 infection: significance and implications. Lancet Infect. Dis. 24, e453–e462 (2024).

Article  CAS  PubMed  Google Scholar 

Al-Aly, Z. et al. Long COVID science, research and policy. Nat. Med. 30, 2148–2164 (2024).

Article  CAS  PubMed  Google Scholar 

Cai, M., Xie, Y., Topol, E. J. & Al-Aly, Z. Three-year outcomes of post-acute sequelae of COVID-19. Nat. Med. 30, 1564–1573 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cele, S. et al. SARS-CoV-2 prolonged infection during advanced HIV disease evolves extensive immune escape. Cell Host Microbe 30, 154–162.e5 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Van Cleemput, J. et al. Organ-specific genome diversity of replication-competent SARS-CoV-2. Nat. Commun. 12, 6612 (2021).

Article  PubMed  PubMed Central  Google Scholar 

Nkosi, T. et al. Unsuppressed HIV infection impairs T cell responses to SARS-CoV-2 infection and abrogates T cell cross-recognition. eLife 11, e78374 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Raglow, Z. et al. SARS-CoV-2 shedding and evolution in patients who were immunocompromised during the Omicron period: a multicentre, prospective analysis. Lancet Microbe 5, e235–e246 (2024).

Article  PubMed  Google Scholar 

Lee, D. S. W., Rojas, O. L. & Gommerman, J. L. B cell depletion therapies in autoimmune disease: advances and mechanistic insights. Nat. Rev. Drug. Discov. 20, 179–199 (2021).

Article  CAS  PubMed  Google Scholar 

Natarajan, A. et al. Gastrointestinal symptoms and fecal shedding of SARS-CoV-2 RNA suggest prolonged gastrointestinal infection. Med 3, 371–387.e9 (2022).

Article  CAS  PubMed  Google Scholar 

Gaebler, C. et al. Evolution of antibody immunity to SARS-CoV-2. Nature 591, 639–644 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Proal, A. D. et al. SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC). Nat. Immunol. 24, 1616–1627 (2023).

Article  CAS  PubMed  Google Scholar 

van Kampen, J. J. A. et al. Duration and key determinants of infectious virus shedding in hospitalized patients with coronavirus disease-2019 (COVID-19). Nat. Commun. 12, 267 (2021).

Article  PubMed  PubMed Central  Google Scholar 

Zollner, A. et al. Postacute COVID-19 is characterized by gut viral antigen persistence in inflammatory bowel diseases. Gastroenterology 163, 495–506.e8 (2022).

Article  CAS  PubMed  Google Scholar 

Avanzato, V. A. et al. Case study: prolonged infectious SARS-CoV-2 shedding from an asymptomatic immunocompromised individual with cancer. Cell 183, 1901–1912.e9 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baang, J. H. et al. Prolonged severe acute respiratory syndrome coronavirus 2 replication in an immunocompromised patient. J. Infect. Dis. 223, 23–27 (2021).

Article  CAS  PubMed  Google Scholar 

Bazykin, G. A. et al. Emergence of Y453F and Δ69–70HV mutations in a lymphoma patient with long-term COVID-19. Virological https://virological.org/t/emergence-of-y453f-and-69-70hv-mutations-in-a-lymphoma-patient-with-long-term-covid-19/580 (2021).

Borges, V. et al. Long-term evolution of SARS-CoV-2 in an immunocompromised patient with non-hodgkin Lymphoma. mSphere 6, e0024421 (2021).

Article  PubMed  Google Scholar 

Chaguza, C. et al. Accelerated SARS-CoV-2 intrahost evolution leading to distinct genotypes during chronic infection. Cell Rep. Med. 4, 100943 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen, L. et al. Emergence of multiple SARS-CoV-2 antibody escape variants in an immunocompromised host undergoing convalescent plasma treatment. mSphere 6, e0048021 (2021).

Article  PubMed  Google Scholar 

Choi, B. et al. Persistence and evolution of SARS-CoV-2 in an immunocompromised host. N. Engl. J. Med. 383, 2291–2293 (2020).

Article  PubMed  Google Scholar 

D’Abramo, A. et al. B-cell-depleted patients with persistent SARS-CoV-2 infection: combination therapy or monotherapy? A real-world experience. Front. Med. 11, 1344267 (2024).

Article  Google Scholar 

Gonzalez-Reiche, A. S. et al. Sequential intrahost evolution and onward transmission of SARS-CoV-2 variants. Nat. Commun. 14, 3235 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kemp, S. A. et al. SARS-CoV-2 evolution during treatment of chronic infection. Nature 592, 277–

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