Diagnostic and Prognostic Accuracy of MMPs and TIMPs in Oral Cancer Patients on Enzyme-Linked Immunosorbent Assay (ELISA) as Compared to Immunohistochemistry (IHC)

WHO GLOBOCAN (2020) Global cancer observatory: Cancer today. International agency for research on cancer. Lyon, France. https://gco.iarc.fr/today/en

Baburathinam S, Shyamsundar V, Aravindha BN, Karthika N, Vijaylakshmi R, Masthan KMK (2019) Expression of serum and salivary MMP-1 and MMP-9 in oral cancer, oral potentially malignant disorders and normal. J Biomed Pharm Res 8(3):123–131

Article  CAS  Google Scholar 

Cavusoglu E, Ruwende C, Chopra V, Yanamadala S, Eng C, Clark LT et al (2006) Tissue inhibitor of metalloproteinase-1 (TIMP-1) is an independent predictor of all-cause mortality, cardiac mortality, and myocardial infarction. Am Heart J 151(5):1101.e1-e8

Article  PubMed  Google Scholar 

Liutkevicius V, Lesauskaite V, Liutkeviciene R, Vaiciulis P, Uloza V (2020) Matrix metalloproteinases (MMP-2,-3,-9) gene polymorphisms in cases of benign vocal fold lesions and laryngeal carcinoma. In Vivo 34(1):267–274

Article  CAS  PubMed  PubMed Central  Google Scholar 

Patel BP, Shah SV, Shukla SN, Shah PM, Patel PS (2007) Clinical significance of MMP-2 and MMP-9 in patients with oral cancer. Head Neck 29(6):564–572

Article  PubMed  Google Scholar 

Chen J-Q, Zhan W-H, He Y-L, Peng J-S, Wang J-P, Cai S-R et al (2004) Expression of heparanase gene, CD44v6, MMP-7 and nm23 protein and their relationship with the invasion and metastasis of gastric carcinomas. World J Gastroenterol 10(6):776

Article  CAS  PubMed  PubMed Central  Google Scholar 

Borkakoti N (2000) Structural studies of matrix metalloproteinases. J Mol Med 78(5):261–268

Article  CAS  PubMed  Google Scholar 

Impola U, Uitto V-J, Hietanen J, Hakkinen L, Zhang L, Larjava H et al (2004) Differential expression of matrilysin-1 (MMP-7), 92 kD gelatinase (MMP-9), and metalloelastase (MMP-12) in oral verrucous and squamous cell cancer. J Pathol 202(1):14–22

Article  CAS  PubMed  Google Scholar 

Johnson JL (2007) Matrix metalloproteinases: influence on smooth muscle cells and atherosclerotic plaque stability. Expert Rev Cardiovasc Ther 5(2):265–282

Article  CAS  PubMed  Google Scholar 

Dollery CM, McEwan JR, Henney AM (1995) Matrix metalloproteinases and cardiovascular disease. Circ Res 77(5):863–868

Article  CAS  PubMed  Google Scholar 

Lennarz WJ, Lane MD (2013) Encyclopedia of biological chemistry: Academic Press, Elsevier Inc

Vu TH, Werb Z, Gelatinase B (1998) Structure, regulation, and function. In: Parks WC, Mecham RP (eds) Matrix metalloproteinases. Academic Press, San Diego, pp 115–148

Chapter  Google Scholar 

Brew K, Nagase H (2010) The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity. Biochimica Biophysica Acta Mol Cell Res 1803(1):55–71

Article  CAS  Google Scholar 

Cabral-Pacheco GA, Garza-Veloz I, Castruita-De la Rosa C, Ramirez-Acuña JM, Perez-Romero BA, Guerrero-Rodriguez JF et al (2020) The roles of matrix metalloproteinases and their inhibitors in human diseases. Int J Mol Sci 21(24):9739

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mohan V, Talmi-Frank D, Arkadash V, Papo N, Sagi I (2016) Matrix metalloproteinase protein inhibitors: highlighting a new beginning for metalloproteinases in medicine. Metalloproteinases Med 3:31–47

Saini J, Bakshi J, Panda NK, Sharma M, Yadav AK, Kamboj K et al (2024) Serum concentration of MMP-9 as a predictive biomarker for the progression of oral cancer. J Maxillofac Oral Surg 23:1079–1088

Patil R, Mahajan A, Pradeep G, Prakash N, Patil S, Khan SM (2021) Expression of matrix metalloproteinase-9 in histological grades of oral squamous cell carcinoma: an immunohistochemical study. J Oral Maxillofac Pathol 25(2):239–246

Article  PubMed  PubMed Central  Google Scholar 

Franchi A, Santucci M, Masini E, Sardi I, Paglierani M, Gallo O (2002) Expression of matrix metalloproteinase 1, matrix metalloproteinase 2, and matrix metalloproteinase 9 in carcinoma of the head and neck: correlation with p53 status, inducible nitric oxide synthase activity, and angiogenesis. Cancer 95(9):1902–1910

Article  CAS  PubMed  Google Scholar 

Omran OM, Shokry M, Ismail H, Omar G, Rezk M (2011) Expression of matrix metalloproteinases 2 and 9 in human trophoblasts of normal and preeclamptic placentas. Int J Health Sci 5(2 Suppl 1):21

Google Scholar 

Bakshi J, Goyal AK, Saini J (2022) Quality of life in oral cancer patients following surgical excision and flap reconstruction. J Maxillofac Oral Surg 21(2):326–331

Article  PubMed  Google Scholar 

Bakshi J, Goyal AK (2021) Clinical yoga trial aim to improve quality of life at advanced stages of oral cancer. Sport Sci Health 17(3):677–685

Article  Google Scholar 

Bakshi J, Panda NK, Goyal AK, Saini J, Prashant S, Aggarwal G (2024) Pretreatment trismus as a predictor of survival outcome in oral cancer patients. J Head Neck Physicians Surg. https://doi.org/10.4103/jhnps.jhnps_79_24

Goyal AK, Bakshi J, Panda NK, Kapoor R, Vir D, Kumar K et al (2024) Assessment of shame and stigma in head and neck cancer: a meta-analysis. J Maxillofac Oral Surg 23(1):16–22

Article  PubMed  Google Scholar 

Goyal AK, Bakshi J, Panda NK, Kapoor R, Vir D, Kumar K et al (2024) Shame and stigma over long-term survival in postoperative cases of head and neck cancer. J Maxillofac Oral Surg 23:1057–1062

Bakshi J, Tiwana H, Prashant S, Bahadur D, John J, Saini J et al (2022) Case report on surgical removal of 3.5 kg benign mesenchymal tumor from the mandible region. Egypt J Otolaryngol 38(1):134

Article  Google Scholar 

Goyal AK, Bakshi J, Panda NK, Kapoor R, Vir D, Kumar K et al (2022) Stigmatic impact of COVID-19 pandemic on head & neck cancers survivors. Indian J Otolaryngol Head Neck Surg 74(2):2912–2916

Article  PubMed  Google Scholar 

Saini J, Bakshi J, Panda NK, Sharma M, Vir D, Goyal AK (2024) Cut-off points to classify numeric values of quality of life into normal, mild, moderate, and severe categories: an update for EORTC-QLQ-H&N35. Egypt J Otolaryngol 40(1):83

Article  Google Scholar 

Goyal AK, Bakshi J, Panda NK, Kapoor R, Vir D, Kumar K et al (2023) Accuracy of a self-reported measure in psychological assessment when the instrument is self-administered by the patient or when administrated by the clinician. Indian J Otolaryngol Head Neck Surg 75(2):1266–1270

Article  PubMed  Google Scholar 

Goyal AK, Bakshi J, Panda NK, Kapoor R, Vir D, Kumar K et al (2021) Translation and validation of shame and stigma scale for head and neck cancer into the Hindi language. J Maxillofac Oral Surg. https://doi.org/10.1007/s12663-021-01588-z

Goyal AK, Bakshi J, Panda NK, Kapoor R, Vir D, Kumar K et al (2021) A hybrid method for the cross-cultural adaptation of self-report measures. Int J Appl Posit Psychol 6(1):45–54

Article  Google Scholar 

Goyal AK, Bakshi J, Panda NK, Kapoor R, Vir D, Kumar K et al (2022) Media commercials conveying awareness regarding prevention of head and neck cancer by focusing on stigmatized perspective of disease: right or wrong? Indian J Otolaryngol Head Neck Surg 74(3):5990–5993

Article  PubMed  Google Scholar 

Lotfi A, Mohammadi G, Tavassoli A, Chavoshi H, Saniee L (2015) Serum levels of MMP9 and MMP2 in patients with oral squamous cell carcinoma. Asian Pac J Cancer Prev 16(4):1327–1330

Article  PubMed  Google Scholar 

Peisker A, Raschke GF, Fahmy MD, Guentsch A, Roshanghias K, Hennings J et al (2017) Salivary MMP-9 in the detection of oral squamous cell carcinoma. Med Oral Patol Oral Cir Bucal 22(3):e270

CAS  PubMed  PubMed Central  Google Scholar 

Shpitzer T, Bahar G, Feinmesser R, Nagler RM (2007) A comprehensive salivary analysis for oral cancer diagnosis. J Cancer Res Clin Oncol 133(9):613–617

Article  CAS  PubMed  Google Scholar 

Shpitzer T, Hamzany Y, Bahar G, Feinmesser R, Savulescu D, Borovoi I et al (2009) Salivary analysis of oral cancer biomarkers. Br J Cancer 101(7):1194–1198

Article  CAS  PubMed  PubMed Central  Google Scholar 

Smriti K, Ray M, Chatterjee T, Shenoy R-P, Gadicherla S, Pentapati K-C et al (2020) Salivary MMP-9 as a biomarker for the diagnosis of oral potentially malignant disorders and oral squamous cell carcinoma. Asian Pac J Cancer Prev 21(1):233

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dalirsani Z, Pakfetrat A, Delavarian Z, Hashemy SI, Mostaan LV, Abdollahnejad M et al (2019) Comparison of matrix metalloproteinases 2 and 9 levels in saliva and serum of patients with head and neck squamous cell carcinoma and healthy subjects. Int J Cancer Manag 12(5):e90249

Pornchai O, Rhys-Evans PH, Eccles SA (2001) Expression of matrix metalloproteinases and their inhibitors correlates with invasion and metastasis in squamous cell carcinoma of the head and neck. Arch Otolaryngol Head Neck Surg 127(7):813–820

Google Scholar 

Kato K, Hara A, Kuno T, Kitaori N, Huilan Z, Mori H et al (2005) Matrix metalloproteinases 2 and 9 in oral squamous cell carcinomas: manifestation and localization of their activity. J Cancer Res Clin Oncol 131(6):340–346

Article  CAS  PubMed  Google Scholar 

Ikebe T, Shinohara M, Takeuchi H, Beppu M, Kurahara S-I, Nakamura S et al (1999) Gelatinolytic activity of matrix metalloproteinase in tumor tissues correlates with the invasiveness of oral cancer. Clin Exp Metastasis 17(4):315–22

Comments (0)

No login
gif